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Transplant-Related Malignant Neoplasm

MedGen UID:
234961
•Concept ID:
C1336814
•
Neoplastic Process
Synonyms: Transplant-Related Cancer; Transplant-Related Malignancy

Definition

A malignant neoplasm that arises in a patient with a history of organ transplantation. [from NCI]

Professional guidelines

PubMed

Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes - Advances in treatment.
McCullough KB, Patnaik MM
Best Pract Res Clin Haematol 2020 Jun;33(2):101130. Epub 2019 Dec 3 doi: 10.1016/j.beha.2019.101130. PMID: 32460984
Myelodysplastic syndromes: moving towards personalized management.
Hellström-Lindberg E, Tobiasson M, Greenberg P
Haematologica 2020 Jul;105(7):1765-1779. Epub 2020 May 21 doi: 10.3324/haematol.2020.248955. PMID: 32439724Free PMC Article
Treatment of relapsed/refractory acute myeloid leukaemia in adults.
Rashidi A, Weisdorf DJ, Bejanyan N
Br J Haematol 2018 Apr;181(1):27-37. Epub 2018 Jan 9 doi: 10.1111/bjh.15077. PMID: 29318584

Recent clinical studies

Etiology

Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia: Who, When, and How?
Loke J, Buka R, Craddock C
Front Immunol 2021;12:659595. Epub 2021 May 3 doi: 10.3389/fimmu.2021.659595. PMID: 34012445Free PMC Article
Post-renal transplant malignancies: Opportunities for prevention and early screening.
Turshudzhyan A
Cancer Treat Res Commun 2021;26:100283. Epub 2020 Dec 11 doi: 10.1016/j.ctarc.2020.100283. PMID: 33338850
Consolidation Therapy in Primary Central Nervous System Lymphoma.
Kim P, Omuro A
Curr Treat Options Oncol 2020 Jul 28;21(9):74. doi: 10.1007/s11864-020-00758-4. PMID: 32725379
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes - Advances in treatment.
McCullough KB, Patnaik MM
Best Pract Res Clin Haematol 2020 Jun;33(2):101130. Epub 2019 Dec 3 doi: 10.1016/j.beha.2019.101130. PMID: 32460984
Non-myeloablative transplantation.
Maloney DG, Sandmaier BM, Mackinnon S, Shizuru JA
Hematology Am Soc Hematol Educ Program 2002:392-421. doi: 10.1182/asheducation-2002.1.392. PMID: 12446434

Diagnosis

NCCN Guidelines® Insights: Hematopoietic Cell Transplantation, Version 3.2022.
Saad A, Loren A, Bolaños-Meade J, Chen G, Couriel D, Di Stasi A, El-Jawahri A, Elmariah H, Farag S, Gundabolu K, Gutman J, Ho V, Hoeg R, Horwitz M, Hsu J, Kassim A, Kharfan Dabaja M, Magenau J, Martin T, Mielcarek M, Moreira J, Nakamura R, Nieto Y, Ninos C, Oliai C, Patel S, Randolph B, Schroeder M, Tzachanis D, Varshavsky-Yanovsky AN, Vusirikala M, Algieri F, Pluchino LA
J Natl Compr Canc Netw 2023 Feb;21(2):108-115. doi: 10.6004/jnccn.2023.0007. PMID: 36791762
Randomized Phase III BMT CTN Trial of Calcineurin Inhibitor-Free Chronic Graft-Versus-Host Disease Interventions in Myeloablative Hematopoietic Cell Transplantation for Hematologic Malignancies.
Luznik L, Pasquini MC, Logan B, Soiffer RJ, Wu J, Devine SM, Geller N, Giralt S, Heslop HE, Horowitz MM, Jones RJ, Litzow MR, Mendizabal A, Muffly L, Nemecek ER, O'Donnell L, O'Reilly RJ, Palencia R, Schetelig J, Shune L, Solomon SR, Vasu S, Ho VT, Perales MA
J Clin Oncol 2022 Feb 1;40(4):356-368. Epub 2021 Dec 2 doi: 10.1200/JCO.21.02293. PMID: 34855460Free PMC Article
Post-renal transplant malignancies: Opportunities for prevention and early screening.
Turshudzhyan A
Cancer Treat Res Commun 2021;26:100283. Epub 2020 Dec 11 doi: 10.1016/j.ctarc.2020.100283. PMID: 33338850
Myelodysplastic syndromes: moving towards personalized management.
Hellström-Lindberg E, Tobiasson M, Greenberg P
Haematologica 2020 Jul;105(7):1765-1779. Epub 2020 May 21 doi: 10.3324/haematol.2020.248955. PMID: 32439724Free PMC Article
Evaluation after Orthotopic Heart Transplant: What the Radiologist Should Know.
Smith JD, Stowell JT, Martínez-Jiménez S, Desouches SL, Rosado-de-Christenson ML, Jain KK, Magalski A
Radiographics 2019 Mar-Apr;39(2):321-343. Epub 2019 Feb 8 doi: 10.1148/rg.2019180141. PMID: 30735469

Therapy

NCCN Guidelines® Insights: Hematopoietic Cell Transplantation, Version 3.2022.
Saad A, Loren A, Bolaños-Meade J, Chen G, Couriel D, Di Stasi A, El-Jawahri A, Elmariah H, Farag S, Gundabolu K, Gutman J, Ho V, Hoeg R, Horwitz M, Hsu J, Kassim A, Kharfan Dabaja M, Magenau J, Martin T, Mielcarek M, Moreira J, Nakamura R, Nieto Y, Ninos C, Oliai C, Patel S, Randolph B, Schroeder M, Tzachanis D, Varshavsky-Yanovsky AN, Vusirikala M, Algieri F, Pluchino LA
J Natl Compr Canc Netw 2023 Feb;21(2):108-115. doi: 10.6004/jnccn.2023.0007. PMID: 36791762
Next-day manufacture of a novel anti-CD19 CAR-T therapy for B-cell acute lymphoblastic leukemia: first-in-human clinical study.
Yang J, He J, Zhang X, Li J, Wang Z, Zhang Y, Qiu L, Wu Q, Sun Z, Ye X, Yin W, Cao W, Shen L, Sersch M, Lu P
Blood Cancer J 2022 Jul 7;12(7):104. doi: 10.1038/s41408-022-00694-6. PMID: 35798714Free PMC Article
Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia: Who, When, and How?
Loke J, Buka R, Craddock C
Front Immunol 2021;12:659595. Epub 2021 May 3 doi: 10.3389/fimmu.2021.659595. PMID: 34012445Free PMC Article
Myeloablative versus Reduced-Intensity Conditioning for Hematopoietic Cell Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndromes-Long-Term Follow-Up of the BMT CTN 0901 Clinical Trial.
Scott BL, Pasquini MC, Fei M, Fraser R, Wu J, Devine SM, Porter DL, Maziarz RT, Warlick E, Fernandez HF, Soiffer RJ, Alyea E, Hamadani M, Bashey A, Giralt S, Geller NL, Leifer E, Hourigan CS, Gui G, Mendizabal A, Horowitz MM, Deeg HJ, Horwitz ME
Transplant Cell Ther 2021 Jun;27(6):483.e1-483.e6. Epub 2021 Feb 26 doi: 10.1016/j.jtct.2021.02.031. PMID: 33775615Free PMC Article
Revisiting autologous transplantation in acute myeloid leukemia.
Ganzel C, Rowe JM
Curr Opin Hematol 2018 Mar;25(2):95-102. doi: 10.1097/MOH.0000000000000408. PMID: 29324476

Prognosis

Myeloablative versus Reduced-Intensity Conditioning for Hematopoietic Cell Transplantation in Acute Myelogenous Leukemia and Myelodysplastic Syndromes-Long-Term Follow-Up of the BMT CTN 0901 Clinical Trial.
Scott BL, Pasquini MC, Fei M, Fraser R, Wu J, Devine SM, Porter DL, Maziarz RT, Warlick E, Fernandez HF, Soiffer RJ, Alyea E, Hamadani M, Bashey A, Giralt S, Geller NL, Leifer E, Hourigan CS, Gui G, Mendizabal A, Horowitz MM, Deeg HJ, Horwitz ME
Transplant Cell Ther 2021 Jun;27(6):483.e1-483.e6. Epub 2021 Feb 26 doi: 10.1016/j.jtct.2021.02.031. PMID: 33775615Free PMC Article
Post-renal transplant malignancies: Opportunities for prevention and early screening.
Turshudzhyan A
Cancer Treat Res Commun 2021;26:100283. Epub 2020 Dec 11 doi: 10.1016/j.ctarc.2020.100283. PMID: 33338850
Secondary Neoplasms of the Female Lower Genital Tract After Hematopoietic Cell Transplantation.
Chang HA, Armenian SH, Dellinger TH
J Natl Compr Canc Netw 2018 Feb;16(2):211-218. doi: 10.6004/jnccn.2018.7005. PMID: 29439180
Biologic vs physiologic age in the transplant candidate.
Artz AS
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):99-105. doi: 10.1182/asheducation-2016.1.99. PMID: 27913468Free PMC Article
Organ transplant-related lymphoma.
Swinnen LJ
Curr Treat Options Oncol 2001 Aug;2(4):301-8. doi: 10.1007/s11864-001-0023-7. PMID: 12057110

Clinical prediction guides

Human Effectors of Acute and Chronic GVHD Overexpress CD83 and Predict Mortality.
Holtan SG, Savid-Frontera C, Walton K, Eaton AA, Demorest C, Hoeschen A, Zhang L, Reid K, Kurian T, Sayegh Z, Julia E, Maakaron J, Bachanova V, Jurdi NE, MacMillan ML, Weisdorf DJ, Felices M, Miller JS, Blazar BR, Davila ML, Betts BC
Clin Cancer Res 2023 Mar 14;29(6):1114-1124. doi: 10.1158/1078-0432.CCR-22-2837. PMID: 36622700Free PMC Article
New approaches to the treatment of older adults with acute lymphoblastic leukemia.
Schwartz M, Wieduwilt MJ
Semin Hematol 2020 Jul;57(3):122-129. Epub 2020 Sep 5 doi: 10.1053/j.seminhematol.2020.09.001. PMID: 33256901
Hematopoietic Cell Transplant-Related Toxicities and Mortality in Frail Recipients.
Pamukcuoglu M, Bhatia S, Weisdorf DJ, DeFor TE, Ustun C, Nayar M, Holtan SG, Jurdi NE, Thyagarajan B, Brunstein CG, Bachanova V, Warlick ED, Severseike B, Te HS, Lund T, Arora M
Biol Blood Marrow Transplant 2019 Dec;25(12):2454-2460. Epub 2019 Aug 5 doi: 10.1016/j.bbmt.2019.07.030. PMID: 31394273Free PMC Article
Hematopoietic Cell Transplant (HCT) in the Elderly: Myths, Controversies and Unknowns.
Al-Mansour Z, Ramanathan M, Cerny J
Drugs Aging 2018 Dec;35(12):1055-1064. doi: 10.1007/s40266-018-0596-5. PMID: 30302674
Therapy-related myeloid neoplasms: pathobiology and clinical characteristics.
Sill H, Olipitz W, Zebisch A, Schulz E, Wölfler A
Br J Pharmacol 2011 Feb;162(4):792-805. doi: 10.1111/j.1476-5381.2010.01100.x. PMID: 21039422Free PMC Article

Recent systematic reviews

Autologous followed by allogeneic versus tandem-autologous transplantation in high-risk, newly diagnosed multiple myeloma: a systematic review and meta-analysis.
Wei M, Xie C, Huang J, Liu Q, Lai Y
Hematology 2023 Dec;28(1):2269509. Epub 2023 Oct 18 doi: 10.1080/16078454.2023.2269509. PMID: 37850613
The association of intestinal microbiota diversity and outcomes of allogeneic hematopoietic cell transplantation: a systematic review and meta-analysis.
Wang S, Yue X, Zhou H, Chen X, Chen H, Hu L, Pan W, Zhao X, Xiao H
Ann Hematol 2023 Dec;102(12):3555-3566. Epub 2023 Sep 28 doi: 10.1007/s00277-023-05460-7. PMID: 37770617
Biological research on the occurrence and development of multiple myeloma and its treatment.
Wu Y, Shi X, Yao X, Du X
Immun Inflamm Dis 2023 May;11(5):e850. doi: 10.1002/iid3.850. PMID: 37249283Free PMC Article
Impact of HLA-DPB1 Matching on Outcome of Unrelated Transplant for Hematologic Malignant Diseases: A Systematic Review and Meta-analysis.
Wang Y, Xu S, Fang P
Transplant Proc 2019 Jul-Aug;51(6):1982-1989. doi: 10.1016/j.transproceed.2019.04.053. PMID: 31399180
Health-Related Quality of Life after Autologous Stem Cell Transplantation for Multiple Myeloma.
Chakraborty R, Hamilton BK, Hashmi SK, Kumar SK, Majhail NS
Biol Blood Marrow Transplant 2018 Aug;24(8):1546-1553. Epub 2018 Apr 4 doi: 10.1016/j.bbmt.2018.03.027. PMID: 29626515Free PMC Article

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