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Transplant-Related Hematologic Malignancy

MedGen UID:
277831
•Concept ID:
C1336810
•
Neoplastic Process

Definition

A hematologic malignancy that arises in a patient with a history of organ transplantation. [from NCI]

Professional guidelines

PubMed

HLA-Haploidentical Hematopoietic Cell Transplantation for Treatment of Nonmalignant Diseases Using Nonmyeloablative Conditioning and Post-Transplant Cyclophosphamide.
Mallhi KK, Srikanthan MA, Baker KK, Frangoul HA, Torgerson TR, Petrovic A, Geddis AE, Carpenter PA, Baker KS, Sandmaier BM, Thakar MS, Skoda-Smith S, Kiem HP, Storb R, Woolfrey AE, Burroughs LM
Biol Blood Marrow Transplant 2020 Jul;26(7):1332-1341. Epub 2020 Mar 28 doi: 10.1016/j.bbmt.2020.03.018. PMID: 32234377Free PMC Article
Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation.
Corbacioglu S, Carreras E, Ansari M, Balduzzi A, Cesaro S, Dalle JH, Dignan F, Gibson B, Guengoer T, Gruhn B, Lankester A, Locatelli F, Pagliuca A, Peters C, Richardson PG, Schulz AS, Sedlacek P, Stein J, Sykora KW, Toporski J, Trigoso E, Vetteranta K, Wachowiak J, Wallhult E, Wynn R, Yaniv I, Yesilipek A, Mohty M, Bader P
Bone Marrow Transplant 2018 Feb;53(2):138-145. Epub 2017 Jul 31 doi: 10.1038/bmt.2017.161. PMID: 28759025Free PMC Article
Mucosal barrier injury: biology, pathology, clinical counterparts and consequences of intensive treatment for haematological malignancy: an overview.
Blijlevens NM, Donnelly JP, De Pauw BE
Bone Marrow Transplant 2000 Jun;25(12):1269-78. doi: 10.1038/sj.bmt.1702447. PMID: 10871732Free PMC Article

Recent clinical studies

Etiology

Contemporary haploidentical stem cell transplant strategies in children with hematological malignancies.
Shah RM
Bone Marrow Transplant 2021 Jul;56(7):1518-1534. Epub 2021 Mar 5 doi: 10.1038/s41409-021-01246-5. PMID: 33674791
Hematopoietic Cell Transplant-Related Toxicities and Mortality in Frail Recipients.
Pamukcuoglu M, Bhatia S, Weisdorf DJ, DeFor TE, Ustun C, Nayar M, Holtan SG, Jurdi NE, Thyagarajan B, Brunstein CG, Bachanova V, Warlick ED, Severseike B, Te HS, Lund T, Arora M
Biol Blood Marrow Transplant 2019 Dec;25(12):2454-2460. Epub 2019 Aug 5 doi: 10.1016/j.bbmt.2019.07.030. PMID: 31394273Free PMC Article
Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation.
Corbacioglu S, Carreras E, Ansari M, Balduzzi A, Cesaro S, Dalle JH, Dignan F, Gibson B, Guengoer T, Gruhn B, Lankester A, Locatelli F, Pagliuca A, Peters C, Richardson PG, Schulz AS, Sedlacek P, Stein J, Sykora KW, Toporski J, Trigoso E, Vetteranta K, Wachowiak J, Wallhult E, Wynn R, Yaniv I, Yesilipek A, Mohty M, Bader P
Bone Marrow Transplant 2018 Feb;53(2):138-145. Epub 2017 Jul 31 doi: 10.1038/bmt.2017.161. PMID: 28759025Free PMC Article
Nonmyeloablative alternative donor transplants.
Luznik L, O'Donnell PV, Fuchs EJ
Curr Opin Oncol 2003 Mar;15(2):121-6. doi: 10.1097/00001622-200303000-00001. PMID: 12601275
Non-myeloablative transplantation.
Maloney DG, Sandmaier BM, Mackinnon S, Shizuru JA
Hematology Am Soc Hematol Educ Program 2002:392-421. doi: 10.1182/asheducation-2002.1.392. PMID: 12446434

Diagnosis

Randomized Phase III BMT CTN Trial of Calcineurin Inhibitor-Free Chronic Graft-Versus-Host Disease Interventions in Myeloablative Hematopoietic Cell Transplantation for Hematologic Malignancies.
Luznik L, Pasquini MC, Logan B, Soiffer RJ, Wu J, Devine SM, Geller N, Giralt S, Heslop HE, Horowitz MM, Jones RJ, Litzow MR, Mendizabal A, Muffly L, Nemecek ER, O'Donnell L, O'Reilly RJ, Palencia R, Schetelig J, Shune L, Solomon SR, Vasu S, Ho VT, Perales MA
J Clin Oncol 2022 Feb 1;40(4):356-368. Epub 2021 Dec 2 doi: 10.1200/JCO.21.02293. PMID: 34855460Free PMC Article
Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation.
Corbacioglu S, Carreras E, Ansari M, Balduzzi A, Cesaro S, Dalle JH, Dignan F, Gibson B, Guengoer T, Gruhn B, Lankester A, Locatelli F, Pagliuca A, Peters C, Richardson PG, Schulz AS, Sedlacek P, Stein J, Sykora KW, Toporski J, Trigoso E, Vetteranta K, Wachowiak J, Wallhult E, Wynn R, Yaniv I, Yesilipek A, Mohty M, Bader P
Bone Marrow Transplant 2018 Feb;53(2):138-145. Epub 2017 Jul 31 doi: 10.1038/bmt.2017.161. PMID: 28759025Free PMC Article
Late effects of blood and marrow transplantation.
Inamoto Y, Lee SJ
Haematologica 2017 Apr;102(4):614-625. Epub 2017 Feb 23 doi: 10.3324/haematol.2016.150250. PMID: 28232372Free PMC Article
Arrhythmias in the setting of hematopoietic cell transplants.
Tonorezos ES, Stillwell EE, Calloway JJ, Glew T, Wessler JD, Rebolledo BJ, Pham A, Steingart RM, Lazarus H, Gale RP, Jakubowski AA, Schaffer WL
Bone Marrow Transplant 2015 Sep;50(9):1212-6. Epub 2015 Jun 1 doi: 10.1038/bmt.2015.127. PMID: 26030046Free PMC Article
Allogeneic bone marrow transplantation for hematological malignancies--controversies and recent advances.
Ringdén O
Acta Oncol 1997;36(6):549-64. doi: 10.3109/02841869709001316. PMID: 9408144

Therapy

Randomized Phase III BMT CTN Trial of Calcineurin Inhibitor-Free Chronic Graft-Versus-Host Disease Interventions in Myeloablative Hematopoietic Cell Transplantation for Hematologic Malignancies.
Luznik L, Pasquini MC, Logan B, Soiffer RJ, Wu J, Devine SM, Geller N, Giralt S, Heslop HE, Horowitz MM, Jones RJ, Litzow MR, Mendizabal A, Muffly L, Nemecek ER, O'Donnell L, O'Reilly RJ, Palencia R, Schetelig J, Shune L, Solomon SR, Vasu S, Ho VT, Perales MA
J Clin Oncol 2022 Feb 1;40(4):356-368. Epub 2021 Dec 2 doi: 10.1200/JCO.21.02293. PMID: 34855460Free PMC Article
Omidubicel vs standard myeloablative umbilical cord blood transplantation: results of a phase 3 randomized study.
Horwitz ME, Stiff PJ, Cutler C, Brunstein C, Hanna R, Maziarz RT, Rezvani AR, Karris NA, McGuirk J, Valcarcel D, Schiller GJ, Lindemans CA, Hwang WYK, Koh LP, Keating A, Khaled Y, Hamerschlak N, Frankfurt O, Peled T, Segalovich I, Blackwell B, Wease S, Freedman LS, Galamidi-Cohen E, Sanz G
Blood 2021 Oct 21;138(16):1429-1440. doi: 10.1182/blood.2021011719. PMID: 34157093Free PMC Article
Gut microbiota injury in allogeneic haematopoietic stem cell transplantation.
Shono Y, van den Brink MRM
Nat Rev Cancer 2018 May;18(5):283-295. Epub 2018 Feb 16 doi: 10.1038/nrc.2018.10. PMID: 29449660Free PMC Article
Late effects of blood and marrow transplantation.
Inamoto Y, Lee SJ
Haematologica 2017 Apr;102(4):614-625. Epub 2017 Feb 23 doi: 10.3324/haematol.2016.150250. PMID: 28232372Free PMC Article
Non-myeloablative transplantation.
Maloney DG, Sandmaier BM, Mackinnon S, Shizuru JA
Hematology Am Soc Hematol Educ Program 2002:392-421. doi: 10.1182/asheducation-2002.1.392. PMID: 12446434

Prognosis

Targeting the gut microbiome: An emerging trend in hematopoietic stem cell transplantation.
Ciernikova S, Kasperova B, Drgona L, Smolkova B, Stevurkova V, Mego M
Blood Rev 2021 Jul;48:100790. Epub 2020 Dec 26 doi: 10.1016/j.blre.2020.100790. PMID: 33573867
Hematopoietic Cell Transplant (HCT) in the Elderly: Myths, Controversies and Unknowns.
Al-Mansour Z, Ramanathan M, Cerny J
Drugs Aging 2018 Dec;35(12):1055-1064. doi: 10.1007/s40266-018-0596-5. PMID: 30302674
Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation.
Corbacioglu S, Carreras E, Ansari M, Balduzzi A, Cesaro S, Dalle JH, Dignan F, Gibson B, Guengoer T, Gruhn B, Lankester A, Locatelli F, Pagliuca A, Peters C, Richardson PG, Schulz AS, Sedlacek P, Stein J, Sykora KW, Toporski J, Trigoso E, Vetteranta K, Wachowiak J, Wallhult E, Wynn R, Yaniv I, Yesilipek A, Mohty M, Bader P
Bone Marrow Transplant 2018 Feb;53(2):138-145. Epub 2017 Jul 31 doi: 10.1038/bmt.2017.161. PMID: 28759025Free PMC Article
Biologic vs physiologic age in the transplant candidate.
Artz AS
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):99-105. doi: 10.1182/asheducation-2016.1.99. PMID: 27913468Free PMC Article
Identification and utilization of donor and recipient genetic variants to predict survival after HCT: are we ready for primetime?
Sucheston-Campbell LE, Clay A, McCarthy PL, Zhu Q, Preus L, Pasquini M, Onel K, Hahn T
Curr Hematol Malig Rep 2015 Mar;10(1):45-58. doi: 10.1007/s11899-014-0246-x. PMID: 25700678Free PMC Article

Clinical prediction guides

Epstein-Barr Virus-Associated Lymphomatoid Papules: A Sign of Immunosuppression Resembling Lymphomatoid Papulosis.
Hooper MJ, Lee WJ, LeWitt TM, Nguyen C, Griffin T, Chung C, Zhou XA, Guitart J
Am J Dermatopathol 2023 Dec 1;45(12):789-800. doi: 10.1097/DAD.0000000000002479. PMID: 37982462Free PMC Article
Factors Affecting Quality of Life in Patients Receiving Autologous Hematopoietic Stem Cell Transplantation.
Mohanraj L, Sargent L, Elswick RK Jr, Toor A, Swift-Scanlan T
Cancer Nurs 2022 Mar-Apr 01;45(2):E552-E559. doi: 10.1097/NCC.0000000000000990. PMID: 34310384
Hematopoietic Cell Transplant-Related Toxicities and Mortality in Frail Recipients.
Pamukcuoglu M, Bhatia S, Weisdorf DJ, DeFor TE, Ustun C, Nayar M, Holtan SG, Jurdi NE, Thyagarajan B, Brunstein CG, Bachanova V, Warlick ED, Severseike B, Te HS, Lund T, Arora M
Biol Blood Marrow Transplant 2019 Dec;25(12):2454-2460. Epub 2019 Aug 5 doi: 10.1016/j.bbmt.2019.07.030. PMID: 31394273Free PMC Article
Hematopoietic Cell Transplant (HCT) in the Elderly: Myths, Controversies and Unknowns.
Al-Mansour Z, Ramanathan M, Cerny J
Drugs Aging 2018 Dec;35(12):1055-1064. doi: 10.1007/s40266-018-0596-5. PMID: 30302674
Cord blood versus haploidentical stem cell transplantation for hematological malignancies.
Kekre N, Antin JH
Semin Hematol 2016 Apr;53(2):98-102. Epub 2016 Jan 15 doi: 10.1053/j.seminhematol.2016.01.007. PMID: 27000733

Recent systematic reviews

Prophylactic donor lymphocyte infusion for relapse prevention: a meta-analysis.
Poonsombudlert K, Kewcharoen J, Prueksapraopong C, Limpruttidham N
Jpn J Clin Oncol 2020 Jun 10;50(6):661-670. doi: 10.1093/jjco/hyaa022. PMID: 32100001
Impact of HLA-DPB1 Matching on Outcome of Unrelated Transplant for Hematologic Malignant Diseases: A Systematic Review and Meta-analysis.
Wang Y, Xu S, Fang P
Transplant Proc 2019 Jul-Aug;51(6):1982-1989. doi: 10.1016/j.transproceed.2019.04.053. PMID: 31399180
Single- Versus Double-Unit Umbilical Cord Blood Transplantation for Hematologic Diseases: A Systematic Review.
Wang L, Gu ZY, Liu SF, Ma DX, Zhang C, Liu CJ, Gao R, Guan LX, Zhu CY, Wang FY, Gao CJ, Wei HP
Transfus Med Rev 2019 Jan;33(1):51-60. Epub 2018 Nov 6 doi: 10.1016/j.tmrv.2018.11.001. PMID: 30482420
Bone marrow versus peripheral blood allogeneic haematopoietic stem cell transplantation for haematological malignancies in adults.
Holtick U, Albrecht M, Chemnitz JM, Theurich S, Skoetz N, Scheid C, von Bergwelt-Baildon M
Cochrane Database Syst Rev 2014 Apr 20;2014(4):CD010189. doi: 10.1002/14651858.CD010189.pub2. PMID: 24748537Free PMC Article
Nonmyeloablative allogeneic stem-cell transplantation for hematologic malignancies: a systematic review.
Djulbegovic B, Seidenfeld J, Bonnell C, Kumar A
Cancer Control 2003 Jan-Feb;10(1):17-41. doi: 10.1177/107327480301000104. PMID: 12598853

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