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Malignant Mixed Tumor of the Major Salivary Gland

MedGen UID:
235299
•Concept ID:
C1334604
•
Neoplastic Process
Synonyms: Malignant Major Salivary Gland Mixed Neoplasm; Malignant Major Salivary Gland Mixed Tumor; Malignant Mixed Neoplasm of Major Salivary Gland; Malignant Mixed Neoplasm of the Major Salivary Gland; Malignant Mixed Tumor of Major Salivary Gland

Definition

A malignant tumor arising from the parotid gland, submandibular gland, or sublingual gland. It includes carcinoma ex pleomorphic adenoma, a malignant epithelial tumor arising from a pre-existing pleomorphic adenoma and carcinosarcoma which is characterized by a mixture of malignant epithelial and sarcomatous elements. [from NCI]

Professional guidelines

PubMed

Vinorelbine treatment of recurrent salivary gland carcinomas.
Airoldi M, Bumma C, Bertetto O, Gabriele P, Succo G, Pedani F
Bull Cancer 1998 Oct;85(10):892-4. PMID: 9835866
PLACE AND TECHNICS OF RADIATION THERAPY IN THE MANAGEMENT OF MALIGNANT TUMORS OF THE MAJOR SALIVARY GLANDS.
ALANIZ F, FLETCHER GH
Radiology 1965 Mar;84:412-9. doi: 10.1148/84.3.412. PMID: 14280711

Recent clinical studies

Etiology

Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands.
Talwar A, Patel E, Tam M, Zhou F, Hu K, Persky M, Vaezi A, Jacobson A, Givi B
Otolaryngol Head Neck Surg 2023 Apr;168(4):775-781. Epub 2023 Jan 29 doi: 10.1177/01945998221120646. PMID: 35998038
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Survival and prognostic factors of salivary gland malignant mixed tumor-not otherwise specified: A population-based analysis.
Soffer JM, Nassif SJ, Von Plato M, Chisholm J, O'Leary MA
Am J Otolaryngol 2021 Nov-Dec;42(6):103135. Epub 2021 Jun 19 doi: 10.1016/j.amjoto.2021.103135. PMID: 34171696
Myoepithelial neoplasms of soft tissue: an updated review of the clinicopathologic, immunophenotypic, and genetic features.
Jo VY, Fletcher CD
Head Neck Pathol 2015 Mar;9(1):32-8. Epub 2015 Mar 25 doi: 10.1007/s12105-015-0618-0. PMID: 25804378Free PMC Article
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929

Diagnosis

Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands.
Talwar A, Patel E, Tam M, Zhou F, Hu K, Persky M, Vaezi A, Jacobson A, Givi B
Otolaryngol Head Neck Surg 2023 Apr;168(4):775-781. Epub 2023 Jan 29 doi: 10.1177/01945998221120646. PMID: 35998038
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Survival and prognostic factors of salivary gland malignant mixed tumor-not otherwise specified: A population-based analysis.
Soffer JM, Nassif SJ, Von Plato M, Chisholm J, O'Leary MA
Am J Otolaryngol 2021 Nov-Dec;42(6):103135. Epub 2021 Jun 19 doi: 10.1016/j.amjoto.2021.103135. PMID: 34171696
Major salivary gland cancer.
Witt RL
Surg Oncol Clin N Am 2004 Jan;13(1):113-27. doi: 10.1016/S1055-3207(03)00126-1. PMID: 15062365
Malignant mixed tumors arising in salivary glands. I. Carcinomas arising in benign mixed tumors: a clinicopathologic study.
LiVolsi VA, Perzin KH
Cancer 1977 May;39(5):2209-30. doi: 10.1002/1097-0142(197705)39:5<2209::aid-cncr2820390540>3.0.co;2-8. PMID: 192443

Therapy

Patterns of Care and Outcomes of Carcinosarcoma of the Major Salivary Glands.
Talwar A, Patel E, Tam M, Zhou F, Hu K, Persky M, Vaezi A, Jacobson A, Givi B
Otolaryngol Head Neck Surg 2023 Apr;168(4):775-781. Epub 2023 Jan 29 doi: 10.1177/01945998221120646. PMID: 35998038
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929
Vinorelbine treatment of recurrent salivary gland carcinomas.
Airoldi M, Bumma C, Bertetto O, Gabriele P, Succo G, Pedani F
Bull Cancer 1998 Oct;85(10):892-4. PMID: 9835866
Chemotherapy for recurrent salivary gland malignancies: experience of the ENT Department of Turin University.
Airoldi M, Brando V, Giordano C, Gabriele P, Bussi M, Cortesina G
ORL J Otorhinolaryngol Relat Spec 1994 Mar-Apr;56(2):105-11. doi: 10.1159/000276620. PMID: 8177583
Cisplatin, epirubicin and 5-fluorouracil combination chemotherapy for recurrent carcinoma of the salivary gland.
Airoldi M, Pedani F, Brando V, Gabriele P, Giordano C
Tumori 1989 Jun 30;75(3):252-6. doi: 10.1177/030089168907500312. PMID: 2475951

Prognosis

Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Survival and prognostic factors of salivary gland malignant mixed tumor-not otherwise specified: A population-based analysis.
Soffer JM, Nassif SJ, Von Plato M, Chisholm J, O'Leary MA
Am J Otolaryngol 2021 Nov-Dec;42(6):103135. Epub 2021 Jun 19 doi: 10.1016/j.amjoto.2021.103135. PMID: 34171696
Salivary Carcinosarcoma: An Extremely Rare and Highly Aggressive Malignancy.
Gupta A, Koochakzadeh S, Neskey DM, Nguyen SA, Lentsch EJ
Laryngoscope 2020 May;130(5):E335-E339. Epub 2019 Jul 10 doi: 10.1002/lary.28183. PMID: 31291005
Myoepithelial neoplasms of soft tissue: an updated review of the clinicopathologic, immunophenotypic, and genetic features.
Jo VY, Fletcher CD
Head Neck Pathol 2015 Mar;9(1):32-8. Epub 2015 Mar 25 doi: 10.1007/s12105-015-0618-0. PMID: 25804378Free PMC Article
Malignant mixed tumors arising in salivary glands. I. Carcinomas arising in benign mixed tumors: a clinicopathologic study.
LiVolsi VA, Perzin KH
Cancer 1977 May;39(5):2209-30. doi: 10.1002/1097-0142(197705)39:5<2209::aid-cncr2820390540>3.0.co;2-8. PMID: 192443

Clinical prediction guides

Adenoid cystic carcinoma of the Bartholin's gland is easily misdiagnosed: A case report and literature review.
Wang W, Chen H, Guo H, Chen L, Zhu M, Zhu Y
Medicine (Baltimore) 2022 Nov 11;101(45):e31744. doi: 10.1097/MD.0000000000031744. PMID: 36397326Free PMC Article
Salivary gland myoepithelial neoplasms: a clinical and cytopathologic study of 15 cases and review of the literature.
Khademi B, Kazemi T, Bayat A, Bahranifard H, Daneshbod Y, Mohammadianpanah M
Acta Cytol 2010 Nov-Dec;54(6):1111-7. doi: 10.1159/000325253. PMID: 21428157
Mesenchymal neoplasms of the major salivary glands: clinicopathological features of 18 cases.
Cho KJ, Ro JY, Choi J, Choi SH, Nam SY, Kim SY
Eur Arch Otorhinolaryngol 2008 Jul;265 Suppl 1:S47-56. Epub 2007 Oct 13 doi: 10.1007/s00405-007-0488-5. PMID: 17934743
Local-regional recurrence after surgery without postoperative irradiation for carcinomas of the major salivary glands: implications for adjuvant therapy.
Chen AM, Granchi PJ, Garcia J, Bucci MK, Fu KK, Eisele DW
Int J Radiat Oncol Biol Phys 2007 Mar 15;67(4):982-7. Epub 2007 Jan 22 doi: 10.1016/j.ijrobp.2006.10.043. PMID: 17241753
First insights into the molecular basis of pleomorphic adenomas of the salivary glands.
Voz ML, Van de Ven WJ, Kas K
Adv Dent Res 2000 Dec;14:81-3. doi: 10.1177/08959374000140011301. PMID: 11842929

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