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Pleural mesothelioma

MedGen UID:
237179
•Concept ID:
C1377913
•
Neoplastic Process
Synonyms: Mesothelioma of Pleura; mesothelioma of pleura; Mesothelioma of the Pleura; mesothelioma of the pleura; pleura mesothelioma; Pleural Mesothelioma; pleural mesothelioma; pleural mesothelioma (disease)
 
Monarch Initiative: MONDO:0003308

Definition

A neoplasm that arises from the mesothelial cells of the pleura. The primary cause is exposure to asbestos. The major histologic variants are the epithelioid malignant mesothelioma, desmoplastic malignant mesothelioma, and sarcomatoid malignant mesothelioma. Patients present with persistent cough and shortness of breath. [from NCI]

Professional guidelines

PubMed

Perspectives on the Treatment of Malignant Pleural Mesothelioma.
Janes SM, Alrifai D, Fennell DA
N Engl J Med 2021 Sep 23;385(13):1207-1218. doi: 10.1056/NEJMra1912719. PMID: 34551230
ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma.
Scherpereel A, Opitz I, Berghmans T, Psallidas I, Glatzer M, Rigau D, Astoul P, Bölükbas S, Boyd J, Coolen J, De Bondt C, De Ruysscher D, Durieux V, Faivre-Finn C, Fennell D, Galateau-Salle F, Greillier L, Hoda MA, Klepetko W, Lacourt A, McElnay P, Maskell NA, Mutti L, Pairon JC, Van Schil P, van Meerbeeck JP, Waller D, Weder W, Cardillo G, Putora PM
Eur Respir J 2020 Jun;55(6) Epub 2020 Jun 11 doi: 10.1183/13993003.00953-2019. PMID: 32451346
Malignant pleural mesothelioma: an update on investigation, diagnosis and treatment.
Bibby AC, Tsim S, Kanellakis N, Ball H, Talbot DC, Blyth KG, Maskell NA, Psallidas I
Eur Respir Rev 2016 Dec;25(142):472-486. doi: 10.1183/16000617.0063-2016. PMID: 27903668Free PMC Article

Recent clinical studies

Etiology

Malignant peritoneal mesothelioma.
Chun CP, Song LX, Zhang HP, Guo DD, Xu GX, Li Y, Xin X, Cao J, Li F
Am J Med Sci 2023 Jan;365(1):99-103. Epub 2022 Aug 6 doi: 10.1016/j.amjms.2022.07.008. PMID: 35940275
Pleural mesothelioma classification-update and challenges.
Dacic S
Mod Pathol 2022 Jan;35(Suppl 1):51-56. Epub 2021 Aug 31 doi: 10.1038/s41379-021-00895-7. PMID: 34465883
Malignant pleural mesothelioma: recent developments.
Sinn K, Mosleh B, Hoda MA
Curr Opin Oncol 2021 Jan;33(1):80-86. doi: 10.1097/CCO.0000000000000697. PMID: 33186182
Malignant pleural mesothelioma.
Hughes RS
Am J Med Sci 2005 Jan;329(1):29-44. doi: 10.1097/00000441-200501000-00007. PMID: 15654178
Pleural mesothelioma.
Astoul P
Curr Opin Pulm Med 1999 Jul;5(4):259-68. doi: 10.1097/00063198-199907000-00015. PMID: 10407698

Diagnosis

Malignant peritoneal mesothelioma.
Chun CP, Song LX, Zhang HP, Guo DD, Xu GX, Li Y, Xin X, Cao J, Li F
Am J Med Sci 2023 Jan;365(1):99-103. Epub 2022 Aug 6 doi: 10.1016/j.amjms.2022.07.008. PMID: 35940275
Advances in pleuroscopy.
Anevlavis S, Froudarakis ME
Clin Respir J 2018 Mar;12(3):839-847. Epub 2017 Jan 11 doi: 10.1111/crj.12597. PMID: 27997741
Malignant pleural mesothelioma: an update on investigation, diagnosis and treatment.
Bibby AC, Tsim S, Kanellakis N, Ball H, Talbot DC, Blyth KG, Maskell NA, Psallidas I
Eur Respir Rev 2016 Dec;25(142):472-486. doi: 10.1183/16000617.0063-2016. PMID: 27903668Free PMC Article
Malignant pleural mesothelioma.
Klepetko W
Wien Klin Wochenschr 2016 Sep;128(17-18):609-10. doi: 10.1007/s00508-016-1039-0. PMID: 27457871
Malignant pleural mesothelioma.
Tsao AS, Wistuba I, Roth JA, Kindler HL
J Clin Oncol 2009 Apr 20;27(12):2081-90. Epub 2009 Mar 2 doi: 10.1200/JCO.2008.19.8523. PMID: 19255316Free PMC Article

Therapy

Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial.
Forde PM, Anagnostou V, Sun Z, Dahlberg SE, Kindler HL, Niknafs N, Purcell T, Santana-Davila R, Dudek AZ, Borghaei H, Lanis M, Belcaid Z, Smith KN, Balan A, White JR, Cherry C, Ashok Sivakumar IK, Shao XM, Chan HY, Singh D, Thapa S, Illei PB, Pardoll DM, Karchin R, Velculescu VE, Brahmer JR, Ramalingam SS
Nat Med 2021 Nov;27(11):1910-1920. Epub 2021 Nov 8 doi: 10.1038/s41591-021-01541-0. PMID: 34750557Free PMC Article
First-line nivolumab plus ipilimumab in unresectable malignant pleural mesothelioma (CheckMate 743): a multicentre, randomised, open-label, phase 3 trial.
Baas P, Scherpereel A, Nowak AK, Fujimoto N, Peters S, Tsao AS, Mansfield AS, Popat S, Jahan T, Antonia S, Oulkhouir Y, Bautista Y, Cornelissen R, Greillier L, Grossi F, Kowalski D, Rodríguez-Cid J, Aanur P, Oukessou A, Baudelet C, Zalcman G
Lancet 2021 Jan 30;397(10272):375-386. Epub 2021 Jan 21 doi: 10.1016/S0140-6736(20)32714-8. PMID: 33485464
Malignant pleural mesothelioma: recent developments.
Sinn K, Mosleh B, Hoda MA
Curr Opin Oncol 2021 Jan;33(1):80-86. doi: 10.1097/CCO.0000000000000697. PMID: 33186182
Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial.
Zalcman G, Mazieres J, Margery J, Greillier L, Audigier-Valette C, Moro-Sibilot D, Molinier O, Corre R, Monnet I, Gounant V, Rivière F, Janicot H, Gervais R, Locher C, Milleron B, Tran Q, Lebitasy MP, Morin F, Creveuil C, Parienti JJ, Scherpereel A; French Cooperative Thoracic Intergroup (IFCT)
Lancet 2016 Apr 2;387(10026):1405-1414. Epub 2015 Dec 21 doi: 10.1016/S0140-6736(15)01238-6. PMID: 26719230
Malignant pleural mesothelioma.
Chen SE, Pace MB
Am J Health Syst Pharm 2012 Mar 1;69(5):377-85. doi: 10.2146/ajhp110281. PMID: 22345416

Prognosis

Clinical Features and Treatment Outcome of Malignant Pleural Mesothelioma.
Mencoboni M, Filiberti RA, Taveggia P, Grosso F, Pasello G, Del Corso L, Muzio A, Polo V, Zucali P, Ceresoli GL, Soto Parra HJ, Auriati L, Simonassi C
Oncol Res Treat 2017;40(6):364-369. Epub 2017 May 9 doi: 10.1159/000464410. PMID: 28472807
Malignant pleural mesothelioma.
Chen SE, Pace MB
Am J Health Syst Pharm 2012 Mar 1;69(5):377-85. doi: 10.2146/ajhp110281. PMID: 22345416
Pericardial mesothelioma.
Vigneswaran WT, Stefanacci PR
Curr Treat Options Oncol 2000 Oct;1(4):299-302. doi: 10.1007/s11864-000-0045-6. PMID: 12057155
Pleural mesothelioma.
Astoul P
Curr Opin Pulm Med 1999 Jul;5(4):259-68. doi: 10.1097/00063198-199907000-00015. PMID: 10407698
Malignant pleural mesothelioma.
Boutin C, Schlesser M, Frenay C, Astoul P
Eur Respir J 1998 Oct;12(4):972-81. doi: 10.1183/09031936.98.12040972. PMID: 9817178

Clinical prediction guides

Malignant peritoneal mesothelioma.
Chun CP, Song LX, Zhang HP, Guo DD, Xu GX, Li Y, Xin X, Cao J, Li F
Am J Med Sci 2023 Jan;365(1):99-103. Epub 2022 Aug 6 doi: 10.1016/j.amjms.2022.07.008. PMID: 35940275
Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma.
Creaney J, Patch AM, Addala V, Sneddon SA, Nones K, Dick IM, Lee YCG, Newell F, Rouse EJ, Naeini MM, Kondrashova O, Lakis V, Nakas A, Waller D, Sharkey A, Mukhopadhyay P, Kazakoff SH, Koufariotis LT, Davidson AL, Ramarao-Milne P, Holmes O, Xu Q, Leonard C, Wood S, Grimmond SM, Bueno R, Fennell DA, Pearson JV, Robinson BW, Waddell N
Genome Med 2022 May 30;14(1):58. doi: 10.1186/s13073-022-01060-8. PMID: 35637530Free PMC Article
Advances in pleuroscopy.
Anevlavis S, Froudarakis ME
Clin Respir J 2018 Mar;12(3):839-847. Epub 2017 Jan 11 doi: 10.1111/crj.12597. PMID: 27997741
Clinical Features and Treatment Outcome of Malignant Pleural Mesothelioma.
Mencoboni M, Filiberti RA, Taveggia P, Grosso F, Pasello G, Del Corso L, Muzio A, Polo V, Zucali P, Ceresoli GL, Soto Parra HJ, Auriati L, Simonassi C
Oncol Res Treat 2017;40(6):364-369. Epub 2017 May 9 doi: 10.1159/000464410. PMID: 28472807
Malignant pleural mesothelioma: an update on investigation, diagnosis and treatment.
Bibby AC, Tsim S, Kanellakis N, Ball H, Talbot DC, Blyth KG, Maskell NA, Psallidas I
Eur Respir Rev 2016 Dec;25(142):472-486. doi: 10.1183/16000617.0063-2016. PMID: 27903668Free PMC Article

Recent systematic reviews

Prognostic impact of pleural effusion in patients with malignancy: A systematic review and meta-analysis.
Yang Y, Du J, Wang YS, Kang HY, Zhai K, Shi HZ
Clin Transl Sci 2022 Jun;15(6):1340-1354. Epub 2022 Mar 21 doi: 10.1111/cts.13260. PMID: 35212454Free PMC Article
Evidence-based diagnostic performance of novel biomarkers for the diagnosis of malignant mesothelioma in effusion cytology.
Girolami I, Lucenteforte E, Eccher A, Marletta S, Brunelli M, Graziano P, Pisapia P, Malapelle U, Troncone G, Scarpa A, Huang T, Pantanowitz L
Cancer Cytopathol 2022 Feb;130(2):96-109. Epub 2021 Sep 3 doi: 10.1002/cncy.22509. PMID: 34478240
ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma.
Scherpereel A, Opitz I, Berghmans T, Psallidas I, Glatzer M, Rigau D, Astoul P, Bölükbas S, Boyd J, Coolen J, De Bondt C, De Ruysscher D, Durieux V, Faivre-Finn C, Fennell D, Galateau-Salle F, Greillier L, Hoda MA, Klepetko W, Lacourt A, McElnay P, Maskell NA, Mutti L, Pairon JC, Van Schil P, van Meerbeeck JP, Waller D, Weder W, Cardillo G, Putora PM
Eur Respir J 2020 Jun;55(6) Epub 2020 Jun 11 doi: 10.1183/13993003.00953-2019. PMID: 32451346
Prognostication and monitoring of mesothelioma using biomarkers: a systematic review.
Arnold DT, De Fonseka D, Hamilton FW, Rahman NM, Maskell NA
Br J Cancer 2017 Mar 14;116(6):731-741. Epub 2017 Feb 7 doi: 10.1038/bjc.2017.22. PMID: 28170372Free PMC Article
A systematic review and meta-analysis of surgical treatments for malignant pleural mesothelioma.
Cao C, Tian D, Park J, Allan J, Pataky KA, Yan TD
Lung Cancer 2014 Feb;83(2):240-5. Epub 2013 Dec 6 doi: 10.1016/j.lungcan.2013.11.026. PMID: 24360321

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