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Germ cell benign neoplasm

MedGen UID:
272358
Concept ID:
C1332505
Neoplastic Process
Synonyms: Benign germ cell neoplasm; Benign Germ Cell Neoplasm; Benign Germ Cell Tumor; Benign Neoplasm of Germ Cell; Benign Neoplasm of the Germ Cell; Benign Tumor of Germ Cell; Benign Tumor of the Germ Cell; germ cell benign neoplasm
SNOMED CT: Benign germ cell neoplasm (713588001)
 
Monarch Initiative: MONDO:0850144

Definition

A germ cell tumor without evidence of atypia and metastatic potential. [from NCI]

Professional guidelines

PubMed

Chovanec M, Cheng L
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Recent clinical studies

Etiology

Leiendecker L, Neumann T, Jung PS, Cronin SM, Steinacker TL, Schleiffer A, Schutzbier M, Mechtler K, Kervarrec T, Laurent E, Bachiri K, Coyaud E, Murali R, Busam KJ, Itzinger-Monshi B, Kirnbauer R, Cerroni L, Calonje E, Rütten A, Stubenrauch F, Griewank KG, Wiesner T, Obenauf AC
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Yang Y, Zhang G, Hu C, Luo W, Jiang H, Liu S, Yang H
BMC Urol 2022 Nov 30;22(1):196. doi: 10.1186/s12894-022-01141-1. PMID: 36451132Free PMC Article
Li P, Brown S, Williams M, White T, Xie W, Cui W, Peker D, Lei L, Kunder CA, Wang HY, Murray SS, Vagher J, Kovacsovics T, Patel JL
Blood 2022 Aug 18;140(7):716-755. doi: 10.1182/blood.2021015135. PMID: 35671390Free PMC Article
Guindalini RSC, Viana DV, Kitajima JPFW, Rocha VM, López RVM, Zheng Y, Freitas É, Monteiro FPM, Valim A, Schlesinger D, Kok F, Olopade OI, Folgueira MAAK
Sci Rep 2022 Mar 9;12(1):4190. doi: 10.1038/s41598-022-07383-1. PMID: 35264596Free PMC Article
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428

Diagnosis

Li P, Brown S, Williams M, White T, Xie W, Cui W, Peker D, Lei L, Kunder CA, Wang HY, Murray SS, Vagher J, Kovacsovics T, Patel JL
Blood 2022 Aug 18;140(7):716-755. doi: 10.1182/blood.2021015135. PMID: 35671390Free PMC Article
Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P
J Thorac Oncol 2022 Feb;17(2):200-213. Epub 2021 Oct 22 doi: 10.1016/j.jtho.2021.10.010. PMID: 34695605
El-Zaatari ZM, Ro JY
Adv Anat Pathol 2021 Sep 1;28(5):335-350. doi: 10.1097/PAP.0000000000000304. PMID: 34029275
Al-Obaidy KI, Idrees MT
Adv Anat Pathol 2021 Jul 1;28(4):258-275. doi: 10.1097/PAP.0000000000000302. PMID: 33871428
Huang L, Ma F, Chapman A, Lu S, Xie XS
Annu Rev Genomics Hum Genet 2015;16:79-102. Epub 2015 Jun 11 doi: 10.1146/annurev-genom-090413-025352. PMID: 26077818

Therapy

Geyer CE Jr, Garber JE, Gelber RD, Yothers G, Taboada M, Ross L, Rastogi P, Cui K, Arahmani A, Aktan G, Armstrong AC, Arnedos M, Balmaña J, Bergh J, Bliss J, Delaloge S, Domchek SM, Eisen A, Elsafy F, Fein LE, Fielding A, Ford JM, Friedman S, Gelmon KA, Gianni L, Gnant M, Hollingsworth SJ, Im SA, Jager A, Jóhannsson ÓÞ, Lakhani SR, Janni W, Linderholm B, Liu TW, Loman N, Korde L, Loibl S, Lucas PC, Marmé F, Martinez de Dueñas E, McConnell R, Phillips KA, Piccart M, Rossi G, Schmutzler R, Senkus E, Shao Z, Sharma P, Singer CF, Španić T, Stickeler E, Toi M, Traina TA, Viale G, Zoppoli G, Park YH, Yerushalmi R, Yang H, Pang D, Jung KH, Mailliez A, Fan Z, Tennevet I, Zhang J, Nagy T, Sonke GS, Sun Q, Parton M, Colleoni MA, Schmidt M, Brufsky AM, Razaq W, Kaufman B, Cameron D, Campbell C, Tutt ANJ; OlympiA Clinical Trial Steering Committee and Investigators
Ann Oncol 2022 Dec;33(12):1250-1268. Epub 2022 Oct 10 doi: 10.1016/j.annonc.2022.09.159. PMID: 36228963Free PMC Article
Kindler HL, Hammel P, Reni M, Van Cutsem E, Macarulla T, Hall MJ, Park JO, Hochhauser D, Arnold D, Oh DY, Reinacher-Schick A, Tortora G, Algül H, O'Reilly EM, Bordia S, McGuinness D, Cui K, Locker GY, Golan T
J Clin Oncol 2022 Dec 1;40(34):3929-3939. Epub 2022 Jul 14 doi: 10.1200/JCO.21.01604. PMID: 35834777Free PMC Article
Khan HM, Cheng HH
Prostate 2022 Aug;82 Suppl 1(Suppl 1):S3-S12. doi: 10.1002/pros.24340. PMID: 35657157Free PMC Article
Litton JK, Hurvitz SA, Mina LA, Rugo HS, Lee KH, Gonçalves A, Diab S, Woodward N, Goodwin A, Yerushalmi R, Roché H, Im YH, Eiermann W, Quek RGW, Usari T, Lanzalone S, Czibere A, Blum JL, Martin M, Ettl J
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Chahoud J, Zhang M, Shah A, Lin SH, Pisters LL, Tu SM
Curr Opin Oncol 2018 May;30(3):181-188. doi: 10.1097/CCO.0000000000000446. PMID: 29538040

Prognosis

Thompson C, Ariagno S, Kohorst MA
Curr Hematol Malig Rep 2022 Dec;17(6):266-274. Epub 2022 Sep 19 doi: 10.1007/s11899-022-00681-5. PMID: 36117229
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Looijenga LH
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Strollo DC, Rosado-de-Christenson ML
J Thorac Imaging 1999 Jul;14(3):152-71. doi: 10.1097/00005382-199907000-00002. PMID: 10404501

Clinical prediction guides

Garcia-Pelaez J, Barbosa-Matos R, Lobo S, Dias A, Garrido L, Castedo S, Sousa S, Pinheiro H, Sousa L, Monteiro R, Maqueda JJ, Fernandes S, Carneiro F, Pinto N, Lemos C, Pinto C, Teixeira MR, Aretz S, Bajalica-Lagercrantz S, Balmaña J, Blatnik A, Benusiglio PR, Blanluet M, Bours V, Brems H, Brunet J, Calistri D, Capellá G, Carrera S, Colas C, Dahan K, de Putter R, Desseignés C, Domínguez-Garrido E, Egas C, Evans DG, Feret D, Fewings E, Fitzgerald RC, Coulet F, Garcia-Barcina M, Genuardi M, Golmard L, Hackmann K, Hanson H, Holinski-Feder E, Hüneburg R, Krajc M, Lagerstedt-Robinson K, Lázaro C, Ligtenberg MJL, Martínez-Bouzas C, Merino S, Michils G, Novaković S, Patiño-García A, Ranzani GN, Schröck E, Silva I, Silveira C, Soto JL, Spier I, Steinke-Lange V, Tedaldi G, Tejada MI, Woodward ER, Tischkowitz M, Hoogerbrugge N, Oliveira C
Lancet Oncol 2023 Jan;24(1):91-106. Epub 2022 Nov 24 doi: 10.1016/S1470-2045(22)00643-X. PMID: 36436516Free PMC Article
Makishima H, Saiki R, Nannya Y, Korotev S, Gurnari C, Takeda J, Momozawa Y, Best S, Krishnamurthy P, Yoshizato T, Atsuta Y, Shiozawa Y, Iijima-Yamashita Y, Yoshida K, Shiraishi Y, Nagata Y, Kakiuchi N, Onizuka M, Chiba K, Tanaka H, Kon A, Ochi Y, Nakagawa MM, Okuda R, Mori T, Yoda A, Itonaga H, Miyazaki Y, Sanada M, Ishikawa T, Chiba S, Tsurumi H, Kasahara S, Müller-Tidow C, Takaori-Kondo A, Ohyashiki K, Kiguchi T, Matsuda F, Jansen JH, Polprasert C, Blombery P, Kamatani Y, Miyano S, Malcovati L, Haferlach T, Kubo M, Cazzola M, Kulasekararaj AG, Godley LA, Maciejewski JP, Ogawa S
Blood 2023 Feb 2;141(5):534-549. doi: 10.1182/blood.2022018221. PMID: 36322930Free PMC Article
Kindler HL, Hammel P, Reni M, Van Cutsem E, Macarulla T, Hall MJ, Park JO, Hochhauser D, Arnold D, Oh DY, Reinacher-Schick A, Tortora G, Algül H, O'Reilly EM, Bordia S, McGuinness D, Cui K, Locker GY, Golan T
J Clin Oncol 2022 Dec 1;40(34):3929-3939. Epub 2022 Jul 14 doi: 10.1200/JCO.21.01604. PMID: 35834777Free PMC Article
Lobo J, Leão R, Jerónimo C, Henrique R
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Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article

Recent systematic reviews

Fraison E, Huberlant S, Labrune E, Cavalieri M, Montagut M, Brugnon F, Courbiere B
Hum Reprod 2023 Mar 1;38(3):489-502. doi: 10.1093/humrep/deac249. PMID: 36421038Free PMC Article
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J Clin Oncol 2020 Apr 10;38(11):1222-1245. Epub 2020 Jan 27 doi: 10.1200/JCO.19.02960. PMID: 31986064Free PMC Article
Ghasemiesfe M, Barrow B, Leonard S, Keyhani S, Korenstein D
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J Natl Cancer Inst 2013 Nov 6;105(21):1607-16. Epub 2013 Oct 17 doi: 10.1093/jnci/djt277. PMID: 24136893

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