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Vulvar Soft Tissue Neoplasm

MedGen UID:: 276997
•Concept ID:: C1520095
•: Neoplastic Process

Synonym:

Vulvar Soft Tissue Tumor

Definition

A benign or malignant mesenchymal neoplasm of the vulva. Representative examples include leiomyoma, cellular angiofibroma, angiomyxoma, leiomyosarcoma, liposarcoma, and childhood botryoid-type embryonal rhabdomyosarcoma. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVVulvar Soft Tissue Neoplasm

Pathological process
- Disease
  - Disorder by Site
    - Connective and Soft Tissue Disorder
      - Connective and soft tissue neoplasm
        Soft tissue neoplasm
        Vulvar Soft Tissue Neoplasm
        Vulva sarcoma
        Vulvar alveolar soft part sarcoma
        Vulvar Angiosarcoma
        Vulvar Epithelioid Sarcoma
        Vulvar Distal-Type Epithelioid Sarcoma
        Vulvar proximal-type epithelioid sarcoma
        Vulvar Ewing Sarcoma
        Vulvar Kaposi Sarcoma
        Vulvar leiomyosarcoma
        Vulvar liposarcoma
        Vulvar Rhabdomyosarcoma
        Vulvar Alveolar Rhabdomyosarcoma
        Vulvar childhood botryoid-type embryonal rhabdomyosarcoma
        Vulvar Angiomyofibroblastoma
        Vulvar Angiomyxoma
        Vulvar Deep (Aggressive) Angiomyxoma
        Vulvar Superficial Angiomyxoma
        Vulvar Cellular Angiofibroma
        Vulvar leiomyoma
        Vulvar Lipoblastoma-Like Tumor
        Vulvar Lipoma
        Vulvar Fibrolipoma
        Vulvar Prepubertal Fibroma
        Vulvar Rhabdomyoma
        Vulvar Smooth Muscle Tumor of Uncertain Malignant Potential
        Vulvar Solitary Fibrous Tumor
        Vulvar Superficial Myofibroblastoma

Professional guidelines

PubMed

Dilemmas in the management of patients with vulval epithelioid sarcoma: a literature review.

Iavazzo C, Gkegkes ID, Vrachnis N
Eur J Obstet Gynecol Reprod Biol 2014 May;176:1-4. Epub 2014 Feb 20 doi: 10.1016/j.ejogrb.2014.02.013. PMID: 24636595

Management of congenital venous malformations of the vulva.

Marrocco-Trischitta MM, Nicodemi EM, Nater C, Stillo F
Obstet Gynecol 2001 Nov;98(5 Pt 1):789-93. PMID: 11704170

The role of fine needle aspiration cytology in the management of gynecologic malignancies.

Moriarty AT, Glant MD, Stehman FB
Acta Cytol 1986 Jan-Feb;30(1):59-64. PMID: 3456185

See all (3)

Recent clinical studies

Etiology

Mesenchymal lesions of the vulva.

Chapel DB, Cipriani NA, Bennett JA
Semin Diagn Pathol 2021 Jan;38(1):85-98. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.003. PMID: 32958293

Vulvar leiomyoma: a case report.

Ammouri S, Elkarkri C, Zeraidi N, Lakhdar A, Baydada A
Pan Afr Med J 2019;32:208. Epub 2019 Apr 29 doi: 10.11604/pamj.2019.32.208.18480. PMID: 31312320 Free PMC Article

A contemporary review of myxoid adipocytic tumors.

Creytens D
Semin Diagn Pathol 2019 Mar;36(2):129-141. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.008. PMID: 30853315

Outcome of vulvar reconstruction in patients with advanced and recurrent vulvar malignancies.

Zhang W, Zeng A, Yang J, Cao D, He X, Wang X, You Y, Chen J, Lang J, Shen K
BMC Cancer 2015 Nov 5;15:851. doi: 10.1186/s12885-015-1792-x. PMID: 26542779 Free PMC Article

Vulvar soft tissue tumors.

Behranwala KA, Latifaj B, Blake P, Barton DP, Shepherd JH, Thomas JM
Int J Gynecol Cancer 2004 Jan-Feb;14(1):94-9. doi: 10.1111/j.1048-891x.2004.14946.x. PMID: 14764035

See all (61)

Diagnosis

Mesenchymal lesions of the vulva.

Chapel DB, Cipriani NA, Bennett JA
Semin Diagn Pathol 2021 Jan;38(1):85-98. Epub 2020 Sep 6 doi: 10.1053/j.semdp.2020.09.003. PMID: 32958293

MRI for Radiation Therapy Planning in Human Papillomavirus-associated Gynecologic Cancers.

Venkatesan AM, Menias CO, Jones KM, Rauch GM, Stafford RJ, Klopp AH
Radiographics 2019 Sep-Oct;39(5):1476-1500. doi: 10.1148/rg.2019180121. PMID: 31498740

A contemporary review of myxoid adipocytic tumors.

Creytens D
Semin Diagn Pathol 2019 Mar;36(2):129-141. Epub 2019 Feb 28 doi: 10.1053/j.semdp.2019.02.008. PMID: 30853315

Imaging of the female perineum in adults.

Hosseinzadeh K, Heller MT, Houshmand G
Radiographics 2012 Jul-Aug;32(4):E129-68. doi: 10.1148/rg.324115134. PMID: 22787005

Mesenchymal lesions of the vulva.

Fitzhugh VA, Heller DS
J Low Genit Tract Dis 2011 Apr;15(2):134-45. doi: 10.1097/LGT.0b013e3181f6f2d0. PMID: 21478700

See all (142)

Therapy

High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity.

Rishi A, Rollins M, Ahmed KA, Hunt DC, Sarkar P, Fernandez DC, Hoffman MS, Apte SM, Shahzad MMK, Chon HS, Chern JY, Wenham RM, Montejo ME
Gynecol Oncol 2020 Feb;156(2):349-356. Epub 2019 Nov 23 doi: 10.1016/j.ygyno.2019.11.027. PMID: 31771865

Novel HMGA2-YAP1 fusion gene in aggressive angiomyxoma.

Lee MY, da Silva B, Ramirez DC, Maki RG
BMJ Case Rep 2019 May 28;12(5) doi: 10.1136/bcr-2018-227475. PMID: 31142482 Free PMC Article

Cancer Risk After Pediatric Solid Organ Transplantation.

Yanik EL, Smith JM, Shiels MS, Clarke CA, Lynch CF, Kahn AR, Koch L, Pawlish KS, Engels EA
Pediatrics 2017 May;139(5) doi: 10.1542/peds.2016-3893. PMID: 28557749 Free PMC Article

Outcome of vulvar reconstruction in patients with advanced and recurrent vulvar malignancies.

Zhang W, Zeng A, Yang J, Cao D, He X, Wang X, You Y, Chen J, Lang J, Shen K
BMC Cancer 2015 Nov 5;15:851. doi: 10.1186/s12885-015-1792-x. PMID: 26542779 Free PMC Article

Groin angiosarcoma following radiotherapy for vulvar cancer.

Sanz C, Moreno F, Armas A, Casado A, Castillo MC
Gynecol Oncol 2005 May;97(2):677-80. doi: 10.1016/j.ygyno.2004.12.061. PMID: 15863181

See all (18)

Prognosis

Myxoepithelioid tumour with chordoid features: a clinicopathological, immunohistochemical and genetic study of 14 cases of SMARCB1/INI1-deficient soft-tissue neoplasm.

Kinoshita I, Kohashi K, Yamamoto H, Yamada Y, Inoue T, Higaki K, Teramoto N, Oshiro Y, Nakashima Y, Oda Y
Histopathology 2021 Oct;79(4):629-641. Epub 2021 Jul 5 doi: 10.1111/his.14393. PMID: 33932047

Vulvar leiomyoma: a case report.

Ammouri S, Elkarkri C, Zeraidi N, Lakhdar A, Baydada A
Pan Afr Med J 2019;32:208. Epub 2019 Apr 29 doi: 10.11604/pamj.2019.32.208.18480. PMID: 31312320 Free PMC Article

Outcome of vulvar reconstruction in patients with advanced and recurrent vulvar malignancies.

Zhang W, Zeng A, Yang J, Cao D, He X, Wang X, You Y, Chen J, Lang J, Shen K
BMC Cancer 2015 Nov 5;15:851. doi: 10.1186/s12885-015-1792-x. PMID: 26542779 Free PMC Article

Vulvar soft tissue tumors.

Behranwala KA, Latifaj B, Blake P, Barton DP, Shepherd JH, Thomas JM
Int J Gynecol Cancer 2004 Jan-Feb;14(1):94-9. doi: 10.1111/j.1048-891x.2004.14946.x. PMID: 14764035

Vulvovaginal soft tissue tumours: update and review.

Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

See all (58)

Clinical prediction guides

Myoepithelioma-like tumors of the vulvar region: A case report and review of the literature.

Liu X, Chen L, Zhou Q, Liu J, Hu Y
J Obstet Gynaecol Res 2022 Jul;48(7):2015-2020. Epub 2022 May 17 doi: 10.1111/jog.15286. PMID: 35581677

High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity.

Outcome of vulvar reconstruction in patients with advanced and recurrent vulvar malignancies.

Zhang W, Zeng A, Yang J, Cao D, He X, Wang X, You Y, Chen J, Lang J, Shen K
BMC Cancer 2015 Nov 5;15:851. doi: 10.1186/s12885-015-1792-x. PMID: 26542779 Free PMC Article

Vulvar soft tissue tumors.

Behranwala KA, Latifaj B, Blake P, Barton DP, Shepherd JH, Thomas JM
Int J Gynecol Cancer 2004 Jan-Feb;14(1):94-9. doi: 10.1111/j.1048-891x.2004.14946.x. PMID: 14764035

Vulvovaginal soft tissue tumours: update and review.

Nucci MR, Fletcher CD
Histopathology 2000 Feb;36(2):97-108. doi: 10.1046/j.1365-2559.2000.00865.x. PMID: 10672053

See all (29)

Recent systematic reviews

Prognostic implications of extranodal extension in node-positive squamous cell carcinoma of the vulva: A systematic review and meta-analysis.

Luchini C, Nottegar A, Solmi M, Sergi G, Manzato E, Capelli P, Scarpa A, Veronese N
Surg Oncol 2016 Mar;25(1):60-5. Epub 2015 Sep 14 doi: 10.1016/j.suronc.2015.09.005. PMID: 26394825

Benign granular cell tumor of the vulva: first report of multiple cases in a family.

Kardhashi A, Assunta Deliso M, Renna A, Trojano G, Zito FA, Trojano V
Gynecol Obstet Invest 2012;73(4):341-8. Epub 2012 Apr 20 doi: 10.1159/000336256. PMID: 22517025

See all (2)

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Vulvar Soft Tissue Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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