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Migraine with or without aura, susceptibility to, 11

MedGen UID:
Concept ID:
Synonym: Migraine with or without aura 11
Monarch Initiative: MONDO:0012441
OMIM®: 610209

Clinical features

From HPO
MedGen UID:
Concept ID:
Sign or Symptom
A sensation of unease in the stomach together with an urge to vomit.
MedGen UID:
Concept ID:
Sign or Symptom
Forceful ejection of the contents of the stomach through the mouth by means of a series of involuntary spasmic contractions.
MedGen UID:
Concept ID:
Sign or Symptom
Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.
Migraine with aura
MedGen UID:
Concept ID:
Disease or Syndrome
A type of migraine in which there is an aura characterized by focal neurological phenomena that usually proceed, but may accompany or occur in the absence of, the headache. The symptoms of an aura may include fully reversible visual, sensory, and speech symptoms but not motor weakness. Visual symptoms may include flickering lights, spots and lines and/or loss of vision and/or unilateral sensory symptoms such as paresthesias or numbness. At least one of the symptoms of an aura develops gradually over 5 or more minutes and/or different symptoms occur in succession.
Migraine without aura
MedGen UID:
Concept ID:
Disease or Syndrome
Repeated headache attacks lasting 4-72 h fulfilling at least two of the following criteria
MedGen UID:
Concept ID:
Mental or Behavioral Dysfunction
An abnormally heightened sensitivity to loud sounds.

Professional guidelines


Hovaguimian A, Roth J
BMJ 2022 Oct 10;379:e067670. doi: 10.1136/bmj-2021-067670. PMID: 36216384
Ailani J, Burch RC, Robbins MS; Board of Directors of the American Headache Society
Headache 2021 Jul;61(7):1021-1039. Epub 2021 Jun 23 doi: 10.1111/head.14153. PMID: 34160823
Burch R
Med Clin North Am 2019 Mar;103(2):215-233. Epub 2018 Dec 3 doi: 10.1016/j.mcna.2018.10.003. PMID: 30704678

Recent clinical studies


Grangeon L, Lange KS, Waliszewska-Prosół M, Onan D, Marschollek K, Wiels W, Mikulenka P, Farham F, Gollion C, Ducros A; European Headache Federation School of Advanced Studies (EHF-SAS)
J Headache Pain 2023 Feb 20;24(1):12. doi: 10.1186/s10194-023-01547-8. PMID: 36800925Free PMC Article
Pavelic AR, Wöber C, Riederer F, Zebenholzer K
Cells 2022 Dec 29;12(1) doi: 10.3390/cells12010143. PMID: 36611935Free PMC Article
Wells RE, Beuthin J, Granetzke L
Curr Pain Headache Rep 2019 Feb 21;23(2):10. doi: 10.1007/s11916-019-0750-8. PMID: 30790138Free PMC Article
Cameron C, Kelly S, Hsieh SC, Murphy M, Chen L, Kotb A, Peterson J, Coyle D, Skidmore B, Gomes T, Clifford T, Wells G
Headache 2015 Jul-Aug;55 Suppl 4:221-35. Epub 2015 Jul 14 doi: 10.1111/head.12601. PMID: 26178694
Schwedt TJ
BMJ 2014 Mar 24;348:g1416. doi: 10.1136/bmj.g1416. PMID: 24662044


Villar-Martinez MD, Goadsby PJ
Cells 2022 Sep 5;11(17) doi: 10.3390/cells11172767. PMID: 36078174Free PMC Article
Aguilar-Shea AL, Membrilla Md JA, Diaz-de-Teran J
Aten Primaria 2022 Feb;54(2):102208. Epub 2021 Nov 16 doi: 10.1016/j.aprim.2021.102208. PMID: 34798397Free PMC Article
Mayans L, Walling A
Am Fam Physician 2018 Feb 15;97(4):243-251. PMID: 29671521
Dodick DW
Lancet 2018 Mar 31;391(10127):1315-1330. Epub 2018 Mar 6 doi: 10.1016/S0140-6736(18)30478-1. PMID: 29523342
Silberstein SD
Lancet 2004 Jan 31;363(9406):381-91. doi: 10.1016/S0140-6736(04)15440-8. PMID: 15070571


Haghdoost F, Puledda F, Garcia-Azorin D, Huessler EM, Messina R, Pozo-Rosich P
Cephalalgia 2023 Apr;43(4):3331024231159366. doi: 10.1177/03331024231159366. PMID: 36855951
Andrade C
J Clin Psychiatry 2021 Nov 30;82(6) doi: 10.4088/JCP.21f14325. PMID: 34851560
Vuralli D, Ayata C, Bolay H
J Headache Pain 2018 Nov 15;19(1):109. doi: 10.1186/s10194-018-0933-4. PMID: 30442090Free PMC Article
Puledda F, Shields K
Neurotherapeutics 2018 Apr;15(2):336-345. doi: 10.1007/s13311-018-0623-6. PMID: 29616493Free PMC Article
Maasumi K, Tepper SJ, Kriegler JS
Headache 2017 Feb;57(2):194-208. Epub 2016 Dec 2 doi: 10.1111/head.12978. PMID: 27910087


Chiang CC, Chen SP
Handb Clin Neurol 2024;199:465-474. doi: 10.1016/B978-0-12-823357-3.00021-5. PMID: 38307663
Safiri S, Pourfathi H, Eagan A, Mansournia MA, Khodayari MT, Sullman MJM, Kaufman J, Collins G, Dai H, Bragazzi NL, Kolahi AA
Pain 2022 Feb 1;163(2):e293-e309. doi: 10.1097/j.pain.0000000000002275. PMID: 34001771
Krause DN, Warfvinge K, Haanes KA, Edvinsson L
Nat Rev Neurol 2021 Oct;17(10):621-633. Epub 2021 Sep 20 doi: 10.1038/s41582-021-00544-2. PMID: 34545218
Tanos V, Raad EA, Berry KE, Toney ZA
Eur J Obstet Gynecol Reprod Biol 2019 Sep;240:248-255. Epub 2019 Jul 17 doi: 10.1016/j.ejogrb.2019.07.021. PMID: 31336231
Honaker J, Samy RN
Curr Opin Otolaryngol Head Neck Surg 2008 Oct;16(5):412-5. doi: 10.1097/MOO.0b013e32830a4a02. PMID: 18797281

Clinical prediction guides

Vanood A, Rangel IC, Starling AJ
Neurol Clin 2023 May;41(2):231-247. doi: 10.1016/j.ncl.2023.01.002. PMID: 37030955
Bae JY, Sung HK, Kwon NY, Go HY, Kim TJ, Shin SM, Lee S
Medicina (Kaunas) 2021 Dec 28;58(1) doi: 10.3390/medicina58010044. PMID: 35056352Free PMC Article
Marmura MJ
Curr Pain Headache Rep 2018 Oct 5;22(12):81. doi: 10.1007/s11916-018-0734-0. PMID: 30291562
Vilela P
Eur J Radiol 2017 Nov;96:133-144. Epub 2017 May 5 doi: 10.1016/j.ejrad.2017.05.008. PMID: 28551302
von Brevern M, Lempert T
Handb Clin Neurol 2016;137:301-16. doi: 10.1016/B978-0-444-63437-5.00022-4. PMID: 27638080

Recent systematic reviews

Sacco S, Amin FM, Ashina M, Bendtsen L, Deligianni CI, Gil-Gouveia R, Katsarava Z, MaassenVanDenBrink A, Martelletti P, Mitsikostas DD, Ornello R, Reuter U, Sanchez-Del-Rio M, Sinclair AJ, Terwindt G, Uluduz D, Versijpt J, Lampl C
J Headache Pain 2022 Jun 11;23(1):67. doi: 10.1186/s10194-022-01431-x. PMID: 35690723Free PMC Article
Shaterian N, Shaterian N, Ghanaatpisheh A, Abbasi F, Daniali S, Jahromi MJ, Sanie MS, Abdoli A
Pain Res Manag 2022;2022:3284446. Epub 2022 Mar 31 doi: 10.1155/2022/3284446. PMID: 35401888Free PMC Article
VanderPluym JH, Halker Singh RB, Urtecho M, Morrow AS, Nayfeh T, Torres Roldan VD, Farah MH, Hasan B, Saadi S, Shah S, Abd-Rabu R, Daraz L, Prokop LJ, Murad MH, Wang Z
JAMA 2021 Jun 15;325(23):2357-2369. doi: 10.1001/jama.2021.7939. PMID: 34128998Free PMC Article
Tiseo C, Vacca A, Felbush A, Filimonova T, Gai A, Glazyrina T, Hubalek IA, Marchenko Y, Overeem LH, Piroso S, Tkachev A, Martelletti P, Sacco S; European Headache Federation School of Advanced Studies (EHF-SAS)
J Headache Pain 2020 Oct 27;21(1):126. doi: 10.1186/s10194-020-01192-5. PMID: 33109076Free PMC Article
Chaibi A, Tuchin PJ, Russell MB
J Headache Pain 2011 Apr;12(2):127-33. Epub 2011 Feb 5 doi: 10.1007/s10194-011-0296-6. PMID: 21298314Free PMC Article

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