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Malignant ear neoplasm

MedGen UID:: 418247
•Concept ID:: C2350059
•: Neoplastic Process

Synonyms:	Cancer of Ear; Cancer of the Ear; Ear Cancer
SNOMED CT:	Malignant neoplasm of ear (443648003)

Monarch Initiative:	MONDO:0003277

Definition

A malignant neoplasm that affects the ear. Representative examples include ceruminous adenocarcinoma and squamous cell carcinoma of the external ear and adenocarcinoma of the middle ear. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMalignant ear neoplasm

Pathological process
- Disease
  - Disorder by Site
    - Head and Neck Disorder
      - Head and neck neoplasm
        Head and neck cancer
        Malignant ear neoplasm
        Ear Carcinoma
        External ear carcinoma
        Ceruminous carcinoma
        External ear basal cell carcinoma
        External ear squamous cell carcinoma
        Middle ear carcinoma
        Middle ear adenocarcinoma
        Middle Ear Carcinoma In Situ
        Middle ear squamous cell carcinoma
        External ear cancer
        Malignant Inner Ear Neoplasm
        Endolymphatic sac tumor
        Malignant Middle Ear Neoplasm

Professional guidelines

PubMed

2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer.

Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999 Free PMC Article

Papillary Thyroid Cancer-Aggressive Variants and Impact on Management: A Narrative Review.

Coca-Pelaz A, Shah JP, Hernandez-Prera JC, Ghossein RA, Rodrigo JP, Hartl DM, Olsen KD, Shaha AR, Zafereo M, Suarez C, Nixon IJ, Randolph GW, Mäkitie AA, Kowalski LP, Vander Poorten V, Sanabria A, Guntinas-Lichius O, Simo R, Zbären P, Angelos P, Khafif A, Rinaldo A, Ferlito A
Adv Ther 2020 Jul;37(7):3112-3128. Epub 2020 Jun 1 doi: 10.1007/s12325-020-01391-1. PMID: 32488657 Free PMC Article

2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer.

Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967 Free PMC Article

See all (512)

Recent clinical studies

Etiology

Treatment Strategies for Malignancies of the External Auditory Canal.

Zhong S, Zuo W
Curr Treat Options Oncol 2022 Jan;23(1):43-53. Epub 2022 Feb 15 doi: 10.1007/s11864-021-00931-3. PMID: 35167009 Free PMC Article

Ear canal and middle-ear tumors: a single-institution series of 87 patients.

Nicoli TK, Atula T, Sinkkonen ST, Korpi J, Vnencak M, Tarkkanen J, Mäkitie AA, Jero J
Acta Otolaryngol 2022 Feb;142(2):132-139. Epub 2022 Feb 11 doi: 10.1080/00016489.2022.2032824. PMID: 35148225

Nevi of special sites.

Mason AR, Mohr MR, Koch LH, Hood AF
Clin Lab Med 2011 Jun;31(2):229-42. doi: 10.1016/j.cll.2011.03.001. PMID: 21549237

Middle ear meningiomas.

Prayson RA
Ann Diagn Pathol 2000 Jun;4(3):149-53. doi: 10.1016/s1092-9134(00)90037-6. PMID: 10919384

Electrocochleography.

Kumagami H, Nakata T, Hirano Y, Tsukazaki N
Adv Otorhinolaryngol 1997;53:1-20. doi: 10.1159/000059037. PMID: 9226045

See all (3834)

Diagnosis

Treatment Strategies for Malignancies of the External Auditory Canal.

Zhong S, Zuo W
Curr Treat Options Oncol 2022 Jan;23(1):43-53. Epub 2022 Feb 15 doi: 10.1007/s11864-021-00931-3. PMID: 35167009 Free PMC Article

Ear canal and middle-ear tumors: a single-institution series of 87 patients.

Nicoli TK, Atula T, Sinkkonen ST, Korpi J, Vnencak M, Tarkkanen J, Mäkitie AA, Jero J
Acta Otolaryngol 2022 Feb;142(2):132-139. Epub 2022 Feb 11 doi: 10.1080/00016489.2022.2032824. PMID: 35148225

Acquired ear defects.

Elsahy NI
Clin Plast Surg 2002 Apr;29(2):175-86, v-vi. doi: 10.1016/s0094-1298(01)00002-5. PMID: 12120675

Temporal bone carcinoma.

Barrs DM
Otolaryngol Clin North Am 2001 Dec;34(6):1197-218, x. doi: 10.1016/s0030-6665(05)70374-1. PMID: 11728941

Endolymphatic sac tumours.

Kempermann G, Neumann HP, Volk B
Histopathology 1998 Jul;33(1):2-10. doi: 10.1046/j.1365-2559.1998.00460.x. PMID: 9726042

See all (5634)

Therapy

Immunotherapy for Non-melanoma Skin Cancer.

Shalhout SZ, Emerick KS, Kaufman HL, Miller DM
Curr Oncol Rep 2021 Aug 27;23(11):125. doi: 10.1007/s11912-021-01120-z. PMID: 34448958 Free PMC Article

Effectiveness of Electroacupuncture or Auricular Acupuncture vs Usual Care for Chronic Musculoskeletal Pain Among Cancer Survivors: The PEACE Randomized Clinical Trial.

Mao JJ, Liou KT, Baser RE, Bao T, Panageas KS, Romero SAD, Li QS, Gallagher RM, Kantoff PW
JAMA Oncol 2021 May 1;7(5):720-727. doi: 10.1001/jamaoncol.2021.0310. PMID: 33734288 Free PMC Article

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials.

Wong JH, Ng TB, Chan HHL, Liu Q, Man GCW, Zhang CZ, Guan S, Ng CCW, Fang EF, Wang H, Liu F, Ye X, Rolka K, Naude R, Zhao S, Sha O, Li C, Xia L
Appl Microbiol Biotechnol 2020 Jun;104(11):4675-4703. Epub 2020 Apr 9 doi: 10.1007/s00253-020-10476-4. PMID: 32274562

Effectiveness of auricular acupuncture in the treatment of cancer pain: randomized clinical trial.

Ruela LO, Iunes DH, Nogueira DA, Stefanello J, Gradim CVC
Rev Esc Enferm USP 2018 Dec 13;52:e03402. doi: 10.1590/S1980-220X2017040503402. PMID: 30570087

Acupuncture for cancer pain in adults.

Paley CA, Johnson MI, Tashani OA, Bagnall AM
Cochrane Database Syst Rev 2015 Oct 15;2015(10):CD007753. doi: 10.1002/14651858.CD007753.pub3. PMID: 26468973 Free PMC Article

See all (1961)

Prognosis

Treatment Strategies for Malignancies of the External Auditory Canal.

Zhong S, Zuo W
Curr Treat Options Oncol 2022 Jan;23(1):43-53. Epub 2022 Feb 15 doi: 10.1007/s11864-021-00931-3. PMID: 35167009 Free PMC Article

A systematic review on external ear melanoma.

Toia F, Garbo G, Tripoli M, Rinaldi G, Moschella F, Cordova A
J Plast Reconstr Aesthet Surg 2015 Jul;68(7):883-94. Epub 2015 Apr 20 doi: 10.1016/j.bjps.2015.04.003. PMID: 25971418

Glomus tympanicum tumors.

Sweeney AD, Carlson ML, Wanna GB, Bennett ML
Otolaryngol Clin North Am 2015 Apr;48(2):293-304. Epub 2015 Feb 4 doi: 10.1016/j.otc.2014.12.004. PMID: 25659513

Middle ear adenoma.

Berns S, Pearl G
Arch Pathol Lab Med 2006 Jul;130(7):1067-9. doi: 10.5858/2006-130-1067-MEA. PMID: 16831038

Middle ear meningiomas.

Prayson RA
Ann Diagn Pathol 2000 Jun;4(3):149-53. doi: 10.1016/s1092-9134(00)90037-6. PMID: 10919384

See all (3065)

Clinical prediction guides

External auditory canal carcinoma: clinical characteristics and long-term treatment outcomes.

Correia-Rodrigues P, Ramalho S, Montalvão P, Magalhães M
Eur Arch Otorhinolaryngol 2020 Oct;277(10):2709-2720. Epub 2020 May 4 doi: 10.1007/s00405-020-06019-2. PMID: 32367152

Clinical behaviours and prognoses of high- and low-risk parotid malignancies based on histology.

Tao L, Zhang D, Zhang M, Zhou L
Eur Arch Otorhinolaryngol 2019 Feb;276(2):497-503. Epub 2018 Dec 1 doi: 10.1007/s00405-018-5224-9. PMID: 30506411

Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer.

Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, Deschler DG, Varvares MA, Mylvaganam R, Rozenblatt-Rosen O, Rocco JW, Faquin WC, Lin DT, Regev A, Bernstein BE
Cell 2017 Dec 14;171(7):1611-1624.e24. Epub 2017 Nov 30 doi: 10.1016/j.cell.2017.10.044. PMID: 29198524 Free PMC Article

Acanthoma fissuratum.

Cerroni L, Soyer HP, Chimenti S
J Dermatol Surg Oncol 1988 Sep;14(9):1003-5. doi: 10.1111/j.1524-4725.1988.tb03738.x. PMID: 3410998

See all (1757)

Recent systematic reviews

Emerging histopathologic markers in early-stage oral tongue cancer: A systematic review and meta-analysis.

Elseragy A, Bello IO, Wahab A, Coletta RD, Mäkitie AA, Leivo I, Almangush A, Salo T
Head Neck 2022 Jun;44(6):1481-1491. Epub 2022 Feb 28 doi: 10.1002/hed.27022. PMID: 35229398 Free PMC Article

Managing Cachexia in Head and Neck Cancer: a Systematic Scoping Review.

Mäkitie AA, Alabi RO, Orell H, Youssef O, Almangush A, Homma A, Takes RP, López F, de Bree R, Rodrigo JP, Ferlito A
Adv Ther 2022 Apr;39(4):1502-1523. Epub 2022 Feb 27 doi: 10.1007/s12325-022-02074-9. PMID: 35224702 Free PMC Article

2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer.

Risk Factors for Cutaneous Squamous Cell Carcinoma Recurrence, Metastasis, and Disease-Specific Death: A Systematic Review and Meta-analysis.

Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219 Free PMC Article

Acupuncture for cancer pain in adults.

Paley CA, Johnson MI, Tashani OA, Bagnall AM
Cochrane Database Syst Rev 2015 Oct 15;2015(10):CD007753. doi: 10.1002/14651858.CD007753.pub3. PMID: 26468973 Free PMC Article

See all (120)

MedGen

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Malignant ear neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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