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Malignant ear neoplasm

MedGen UID:
418247
Concept ID:
C2350059
Neoplastic Process
Synonyms: Cancer of Ear; Cancer of the Ear; Ear Cancer
SNOMED CT: Malignant neoplasm of ear (443648003)
 
Monarch Initiative: MONDO:0003277

Definition

A malignant neoplasm that affects the ear. Representative examples include ceruminous adenocarcinoma and squamous cell carcinoma of the external ear and adenocarcinoma of the middle ear. [from NCI]

Professional guidelines

PubMed

Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999Free PMC Article
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article

Recent clinical studies

Etiology

Zhong S, Zuo W
Curr Treat Options Oncol 2022 Jan;23(1):43-53. Epub 2022 Feb 15 doi: 10.1007/s11864-021-00931-3. PMID: 35167009Free PMC Article
Nicoli TK, Atula T, Sinkkonen ST, Korpi J, Vnencak M, Tarkkanen J, Mäkitie AA, Jero J
Acta Otolaryngol 2022 Feb;142(2):132-139. Epub 2022 Feb 11 doi: 10.1080/00016489.2022.2032824. PMID: 35148225
Sykopetrites V, Piras G, Taibah A, Sanna M
Laryngoscope 2021 Feb;131(2):E413-E419. Epub 2020 Aug 18 doi: 10.1002/lary.28987. PMID: 32809267
Gidley PW, Thompson CR, Roberts DB, DeMonte F, Hanna EY
Laryngoscope 2012 Feb;122(2):393-400. Epub 2012 Jan 17 doi: 10.1002/lary.22402. PMID: 22252464
Prayson RA
Ann Diagn Pathol 2000 Jun;4(3):149-53. doi: 10.1016/s1092-9134(00)90037-6. PMID: 10919384

Diagnosis

Raymond M
Otolaryngol Clin North Am 2023 Oct;56(5):965-976. Epub 2023 Jul 24 doi: 10.1016/j.otc.2023.06.003. PMID: 37495430
Almajnooni A, Vega M, Cheng L, Gattuso P, Allen-Proctor MK
Diagn Cytopathol 2023 Apr;51(4):E137-E141. Epub 2023 Jan 23 doi: 10.1002/dc.25103. PMID: 36688374
Zhong S, Zuo W
Curr Treat Options Oncol 2022 Jan;23(1):43-53. Epub 2022 Feb 15 doi: 10.1007/s11864-021-00931-3. PMID: 35167009Free PMC Article
Nicoli TK, Atula T, Sinkkonen ST, Korpi J, Vnencak M, Tarkkanen J, Mäkitie AA, Jero J
Acta Otolaryngol 2022 Feb;142(2):132-139. Epub 2022 Feb 11 doi: 10.1080/00016489.2022.2032824. PMID: 35148225
Barhmi I, Abada R, Roubal M, Mahtar M
Eur Ann Otorhinolaryngol Head Neck Dis 2016 Sep;133(4):281-2. Epub 2016 Apr 13 doi: 10.1016/j.anorl.2016.03.005. PMID: 27085507

Therapy

Mao JJ, Liou KT, Baser RE, Bao T, Panageas KS, Romero SAD, Li QS, Gallagher RM, Kantoff PW
JAMA Oncol 2021 May 1;7(5):720-727. doi: 10.1001/jamaoncol.2021.0310. PMID: 33734288Free PMC Article
Wong JH, Ng TB, Chan HHL, Liu Q, Man GCW, Zhang CZ, Guan S, Ng CCW, Fang EF, Wang H, Liu F, Ye X, Rolka K, Naude R, Zhao S, Sha O, Li C, Xia L
Appl Microbiol Biotechnol 2020 Jun;104(11):4675-4703. Epub 2020 Apr 9 doi: 10.1007/s00253-020-10476-4. PMID: 32274562
Ruela LO, Iunes DH, Nogueira DA, Stefanello J, Gradim CVC
Rev Esc Enferm USP 2018 Dec 13;52:e03402. doi: 10.1590/S1980-220X2017040503402. PMID: 30570087
Hutchinson CD, Jardine DL, Hurrell M
Age Ageing 2008 Sep;37(5):602-4. Epub 2008 Jun 12 doi: 10.1093/ageing/afn105. PMID: 18556705
Mohs FE
Clin Plast Surg 1980 Jul;7(3):349-60. PMID: 7438703

Prognosis

Zhong S, Zuo W
Curr Treat Options Oncol 2022 Jan;23(1):43-53. Epub 2022 Feb 15 doi: 10.1007/s11864-021-00931-3. PMID: 35167009Free PMC Article
Toia F, Garbo G, Tripoli M, Rinaldi G, Moschella F, Cordova A
J Plast Reconstr Aesthet Surg 2015 Jul;68(7):883-94. Epub 2015 Apr 20 doi: 10.1016/j.bjps.2015.04.003. PMID: 25971418
Pelosi S, Koss S
Otolaryngol Clin North Am 2015 Apr;48(2):305-15. doi: 10.1016/j.otc.2014.12.005. PMID: 25769353
Sweeney AD, Carlson ML, Wanna GB, Bennett ML
Otolaryngol Clin North Am 2015 Apr;48(2):293-304. Epub 2015 Feb 4 doi: 10.1016/j.otc.2014.12.004. PMID: 25659513
Prayson RA
Ann Diagn Pathol 2000 Jun;4(3):149-53. doi: 10.1016/s1092-9134(00)90037-6. PMID: 10919384

Clinical prediction guides

Gioacchini FM, Kaleci S, Chiarella G, Viola P, Pisani D, Scarpa A, Tulli M, Pace A, Iannella G, Re M
Eur Arch Otorhinolaryngol 2022 Nov;279(11):5081-5088. Epub 2022 Jun 15 doi: 10.1007/s00405-022-07469-6. PMID: 35704074
Engel MSD, van der Lans RJL, Jansen JC, Leemans CR, Bloemena E, Lissenberg-Witte BI, Rijken JA, Smit CF, Hensen EF
Oral Oncol 2021 Oct;121:105465. Epub 2021 Aug 2 doi: 10.1016/j.oraloncology.2021.105465. PMID: 34352556
Sykopetrites V, Piras G, Giannuzzi A, Caruso A, Taibah A, Sanna M
Eur Arch Otorhinolaryngol 2021 Jul;278(7):2297-2304. Epub 2020 Sep 5 doi: 10.1007/s00405-020-06323-x. PMID: 32889625
Puram SV, Tirosh I, Parikh AS, Patel AP, Yizhak K, Gillespie S, Rodman C, Luo CL, Mroz EA, Emerick KS, Deschler DG, Varvares MA, Mylvaganam R, Rozenblatt-Rosen O, Rocco JW, Faquin WC, Lin DT, Regev A, Bernstein BE
Cell 2017 Dec 14;171(7):1611-1624.e24. Epub 2017 Nov 30 doi: 10.1016/j.cell.2017.10.044. PMID: 29198524Free PMC Article
Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, Pacini F, Randolph GW, Sawka AM, Schlumberger M, Schuff KG, Sherman SI, Sosa JA, Steward DL, Tuttle RM, Wartofsky L
Thyroid 2016 Jan;26(1):1-133. doi: 10.1089/thy.2015.0020. PMID: 26462967Free PMC Article

Recent systematic reviews

Lin ZC, Bennett MH, Hawkins GC, Azzopardi CP, Feldmeier J, Smee R, Milross C
Cochrane Database Syst Rev 2023 Aug 15;8(8):CD005005. doi: 10.1002/14651858.CD005005.pub5. PMID: 37585677Free PMC Article
Mäkitie AA, Alabi RO, Ng SP, Takes RP, Robbins KT, Ronen O, Shaha AR, Bradley PJ, Saba NF, Nuyts S, Triantafyllou A, Piazza C, Rinaldo A, Ferlito A
Adv Ther 2023 Aug;40(8):3360-3380. Epub 2023 Jun 8 doi: 10.1007/s12325-023-02527-9. PMID: 37291378Free PMC Article
Mäkitie AA, Alabi RO, Orell H, Youssef O, Almangush A, Homma A, Takes RP, López F, de Bree R, Rodrigo JP, Ferlito A
Adv Ther 2022 Apr;39(4):1502-1523. Epub 2022 Feb 27 doi: 10.1007/s12325-022-02074-9. PMID: 35224702Free PMC Article
Bible KC, Kebebew E, Brierley J, Brito JP, Cabanillas ME, Clark TJ Jr, Di Cristofano A, Foote R, Giordano T, Kasperbauer J, Newbold K, Nikiforov YE, Randolph G, Rosenthal MS, Sawka AM, Shah M, Shaha A, Smallridge R, Wong-Clark CK
Thyroid 2021 Mar;31(3):337-386. doi: 10.1089/thy.2020.0944. PMID: 33728999Free PMC Article
Thompson AK, Kelley BF, Prokop LJ, Murad MH, Baum CL
JAMA Dermatol 2016 Apr;152(4):419-28. doi: 10.1001/jamadermatol.2015.4994. PMID: 26762219Free PMC Article

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