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Laryngeal Undifferentiated Carcinoma

MedGen UID:
473543
•Concept ID:
C2188069
•
Neoplastic Process

Definition

An undifferentiated carcinoma that arises from the larynx. This category includes lymphoepithelial carcinoma and giant cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal Undifferentiated Carcinoma

Professional guidelines

PubMed

Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Delineation of the primary tumour Clinical Target Volumes (CTV-P) in laryngeal, hypopharyngeal, oropharyngeal and oral cavity squamous cell carcinoma: AIRO, CACA, DAHANCA, EORTC, GEORCC, GORTEC, HKNPCSG, HNCIG, IAG-KHT, LPRHHT, NCIC CTG, NCRI, NRG Oncology, PHNS, SBRT, SOMERA, SRO, SSHNO, TROG consensus guidelines.
Grégoire V, Evans M, Le QT, Bourhis J, Budach V, Chen A, Eisbruch A, Feng M, Giralt J, Gupta T, Hamoir M, Helito JK, Hu C, Hunter K, Johansen J, Kaanders J, Laskar SG, Lee A, Maingon P, Mäkitie A, Micciche' F, Nicolai P, O'Sullivan B, Poitevin A, Porceddu S, Składowski K, Tribius S, Waldron J, Wee J, Yao M, Yom SS, Zimmermann F, Grau C
Radiother Oncol 2018 Jan;126(1):3-24. Epub 2017 Nov 24 doi: 10.1016/j.radonc.2017.10.016. PMID: 29180076
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Mu-Opioid Receptor Expression in Laryngeal Cancer.
Lahav Y, Cohen O, Huszar M, Levy I, Cata JP, Halperin D, Shoffel-Havakuk H
J Voice 2023 May;37(3):433-439. Epub 2021 Mar 7 doi: 10.1016/j.jvoice.2021.02.018. PMID: 33750623
Mucoepidermoid Carcinomas of the Larynx.
Richards HW, Bertelsen C, Hamilton B, Sauer D, Schindler J
Ann Otol Rhinol Laryngol 2022 Dec;131(12):1398-1403. Epub 2022 Jan 6 doi: 10.1177/00034894211069459. PMID: 34991344
Reconstructive Options During Nonfunctional Laryngectomy.
Escalante D, Vincent AG, Wang W, Shokri T, Ducic Y
Laryngoscope 2021 May;131(5):E1510-E1513. Epub 2020 Oct 10 doi: 10.1002/lary.29154. PMID: 33037821Free PMC Article
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer.
Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, Thorstad W, Wagner H, Ensley JF, Cooper JS
J Clin Oncol 2013 Mar 1;31(7):845-52. Epub 2012 Nov 26 doi: 10.1200/JCO.2012.43.6097. PMID: 23182993Free PMC Article

Diagnosis

Laryngeal verrucous cell carcinoma.
Lechien JR, Vaira LA, Chiesa-Estomba CM
Curr Opin Otolaryngol Head Neck Surg 2024 Apr 1;32(2):118-124. Epub 2023 Oct 10 doi: 10.1097/MOO.0000000000000910. PMID: 37820109
Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Mucoepidermoid Carcinomas of the Larynx.
Richards HW, Bertelsen C, Hamilton B, Sauer D, Schindler J
Ann Otol Rhinol Laryngol 2022 Dec;131(12):1398-1403. Epub 2022 Jan 6 doi: 10.1177/00034894211069459. PMID: 34991344
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Laryngeal imaging.
Yousem DM, Tufano RP
Magn Reson Imaging Clin N Am 2002 Aug;10(3):451-65. doi: 10.1016/s1064-9689(02)00007-7. PMID: 12530229

Therapy

Induction Toripalimab and Chemotherapy for Organ Preservation in Locally Advanced Laryngeal and Hypopharyngeal Cancer: A Single-Arm Phase II Clinical Trial.
Ou X, Zhai R, Wei W, Chen J, Ou D, Liao T, Xu T, Zhu Y, Wang Y, Huang S, Shi R, Wu B, Chen T, Li Y, Yang Z, Zhou C, Liu Y, Jiang Z, Zeng M, Liu X, Ji D, Ying H, Zhang Z, Hu C, Lu X, Ji Q, He X, Wang Y
Clin Cancer Res 2024 Jan 17;30(2):344-355. doi: 10.1158/1078-0432.CCR-23-2398. PMID: 37955629
Obesity and risk for respiratory diseases: a Mendelian randomization study.
Yang W, Yang Y, Guo Y, Guo J, Ma M, Han B
Front Endocrinol (Lausanne) 2023;14:1197730. Epub 2023 Aug 29 doi: 10.3389/fendo.2023.1197730. PMID: 37711902Free PMC Article
Xevinapant or placebo plus chemoradiotherapy in locally advanced squamous cell carcinoma of the head and neck: TrilynX phase III study design.
Bourhis J, Burtness B, Licitra LF, Nutting C, Schoenfeld JD, Omar M, Bouisset F, Nauwelaerts H, Urfer Y, Zanna C, Cohen EE
Future Oncol 2022 May;18(14):1669-1678. Epub 2022 Feb 17 doi: 10.2217/fon-2021-1634. PMID: 35172587
Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer.
Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, Thorstad W, Wagner H, Ensley JF, Cooper JS
J Clin Oncol 2013 Mar 1;31(7):845-52. Epub 2012 Nov 26 doi: 10.1200/JCO.2012.43.6097. PMID: 23182993Free PMC Article

Prognosis

Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.
Petruzzi G, Costantino A, De Virgilio A, Zocchi J, Campo F, Mercante G, Spriano G, Pellini R
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1157-1166. Epub 2021 Aug 2 doi: 10.1007/s00405-021-07011-0. PMID: 34338877
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248
Laryngeal melanosis.
Cordes S, Halum S, Hansen L
Otolaryngol Head Neck Surg 2013 Nov;149(5):733-8. Epub 2013 Jul 26 doi: 10.1177/0194599813497921. PMID: 23894146
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer.
Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, Thorstad W, Wagner H, Ensley JF, Cooper JS
J Clin Oncol 2013 Mar 1;31(7):845-52. Epub 2012 Nov 26 doi: 10.1200/JCO.2012.43.6097. PMID: 23182993Free PMC Article

Clinical prediction guides

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Laryngopharyngeal Reflux in Hypertrophic Laryngeal Diseases.
Han H, Lyu Q, Zhao J
Ear Nose Throat J 2022 May;101(4):NP158-NP163. Epub 2020 Aug 31 doi: 10.1177/0145561320953232. PMID: 32865459
Clinical Analysis of Laryngeal Spindle Cell Carcinoma.
Chen L, Chen Q, Li C, Zhou L, Wang S, Zhang M
ORL J Otorhinolaryngol Relat Spec 2020;82(6):310-317. Epub 2020 Sep 2 doi: 10.1159/000508134. PMID: 32877904
Risk factor of pharyngocutaneous fistula.
Kedous S, Turki S, Elhedhili F, Dhambri S, Jbeli S, Touati S, Gritli S
Tunis Med 2019 Mar;97(3):491-499. PMID: 31729725
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Recent systematic reviews

Epidemiological, clinical and oncological outcomes of laryngeal verrucous carcinomas: a systematic review.
Lechien JR, Hans S
J Otolaryngol Head Neck Surg 2023 Dec 13;52(1):81. doi: 10.1186/s40463-023-00666-1. PMID: 38093339Free PMC Article
NBI and Laryngeal Papillomatosis: A Diagnostic Challenge: A Systematic Review.
Saraniti C, Gallina S, Verro B
Int J Environ Res Public Health 2022 Jul 18;19(14) doi: 10.3390/ijerph19148716. PMID: 35886569Free PMC Article
Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.
Petruzzi G, Costantino A, De Virgilio A, Zocchi J, Campo F, Mercante G, Spriano G, Pellini R
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1157-1166. Epub 2021 Aug 2 doi: 10.1007/s00405-021-07011-0. PMID: 34338877
Laryngeal Verrucous Carcinoma.
Echanique KA, Desai SV, Marchiano E, Spinazzi EF, Strojan P, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2017 Jan;156(1):38-45. Epub 2016 Aug 9 doi: 10.1177/0194599816662631. PMID: 27484231
Laryngeal Adenoid Cystic Carcinoma: A Systematic Review.
Marchiano E, Chin OY, Fang CH, Park RC, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2016 Mar;154(3):433-9. Epub 2015 Dec 23 doi: 10.1177/0194599815621884. PMID: 26701176

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