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Laryngeal Undifferentiated Carcinoma

MedGen UID:
473543
•Concept ID:
C2188069
•
Neoplastic Process

Definition

An undifferentiated carcinoma that arises from the larynx. This category includes lymphoepithelial carcinoma and giant cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLaryngeal Undifferentiated Carcinoma

Professional guidelines

PubMed

Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248
Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment.
Marur S, Forastiere AA
Mayo Clin Proc 2016 Mar;91(3):386-96. doi: 10.1016/j.mayocp.2015.12.017. PMID: 26944243

Recent clinical studies

Etiology

Mucoepidermoid Carcinomas of the Larynx.
Richards HW, Bertelsen C, Hamilton B, Sauer D, Schindler J
Ann Otol Rhinol Laryngol 2022 Dec;131(12):1398-1403. Epub 2022 Jan 6 doi: 10.1177/00034894211069459. PMID: 34991344
Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.
Petruzzi G, Costantino A, De Virgilio A, Zocchi J, Campo F, Mercante G, Spriano G, Pellini R
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1157-1166. Epub 2021 Aug 2 doi: 10.1007/s00405-021-07011-0. PMID: 34338877
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer.
Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, Thorstad W, Wagner H, Ensley JF, Cooper JS
J Clin Oncol 2013 Mar 1;31(7):845-52. Epub 2012 Nov 26 doi: 10.1200/JCO.2012.43.6097. PMID: 23182993Free PMC Article
Laryngeal carcinoma and laryngo-pharyngeal reflux disease.
Galli J, Cammarota G, Volante M, De Corso E, Almadori G, Paludetti G
Acta Otorhinolaryngol Ital 2006 Oct;26(5):260-3. PMID: 17345929Free PMC Article

Diagnosis

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Mucoepidermoid Carcinomas of the Larynx.
Richards HW, Bertelsen C, Hamilton B, Sauer D, Schindler J
Ann Otol Rhinol Laryngol 2022 Dec;131(12):1398-1403. Epub 2022 Jan 6 doi: 10.1177/00034894211069459. PMID: 34991344
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
NUT midline carcinoma of the larynx: an international series and review of the literature.
Hellquist H, French CA, Bishop JA, Coca-Pelaz A, Propst EJ, Paiva Correia A, Ngan BY, Grant R, Cipriani NA, Vokes D, Henrique R, Pardal F, Vizcaino JR, Rinaldo A, Ferlito A
Histopathology 2017 May;70(6):861-868. Epub 2017 Feb 21 doi: 10.1111/his.13143. PMID: 27926786Free PMC Article
Laryngeal imaging.
Yousem DM, Tufano RP
Magn Reson Imaging Clin N Am 2002 Aug;10(3):451-65. doi: 10.1016/s1064-9689(02)00007-7. PMID: 12530229

Therapy

Induction chemotherapy in head and neck cancers: Results and controversies.
Gau M, Karabajakian A, Reverdy T, Neidhardt EM, Fayette J
Oral Oncol 2019 Aug;95:164-169. Epub 2019 Jun 25 doi: 10.1016/j.oraloncology.2019.06.015. PMID: 31345386
Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248
Hypopharyngeal cancer: A state of the art review.
Garneau JC, Bakst RL, Miles BA
Oral Oncol 2018 Nov;86:244-250. Epub 2018 Oct 4 doi: 10.1016/j.oraloncology.2018.09.025. PMID: 30409307
Laryngeal cancer: United Kingdom National Multidisciplinary guidelines.
Jones TM, De M, Foran B, Harrington K, Mortimore S
J Laryngol Otol 2016 May;130(S2):S75-S82. doi: 10.1017/S0022215116000487. PMID: 27841116Free PMC Article
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer.
Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, Thorstad W, Wagner H, Ensley JF, Cooper JS
J Clin Oncol 2013 Mar 1;31(7):845-52. Epub 2012 Nov 26 doi: 10.1200/JCO.2012.43.6097. PMID: 23182993Free PMC Article

Prognosis

Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.
Petruzzi G, Costantino A, De Virgilio A, Zocchi J, Campo F, Mercante G, Spriano G, Pellini R
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1157-1166. Epub 2021 Aug 2 doi: 10.1007/s00405-021-07011-0. PMID: 34338877
Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Machiels JP, René Leemans C, Golusinski W, Grau C, Licitra L, Gregoire V; EHNS Executive Board. Electronic address: secretariat@ehns.org; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org; ESTRO Executive Board. Electronic address: info@estro.org
Ann Oncol 2020 Nov;31(11):1462-1475. Epub 2020 Oct 23 doi: 10.1016/j.annonc.2020.07.011. PMID: 33239190
Treatment of early-stage laryngeal cancer: A comparison of treatment options.
Baird BJ, Sung CK, Beadle BM, Divi V
Oral Oncol 2018 Dec;87:8-16. Epub 2018 Oct 16 doi: 10.1016/j.oraloncology.2018.09.012. PMID: 30527248
Laryngeal melanosis.
Cordes S, Halum S, Hansen L
Otolaryngol Head Neck Surg 2013 Nov;149(5):733-8. Epub 2013 Jul 26 doi: 10.1177/0194599813497921. PMID: 23894146
Long-term results of RTOG 91-11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer.
Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, Morrison W, Glisson B, Trotti A, Ridge JA, Thorstad W, Wagner H, Ensley JF, Cooper JS
J Clin Oncol 2013 Mar 1;31(7):845-52. Epub 2012 Nov 26 doi: 10.1200/JCO.2012.43.6097. PMID: 23182993Free PMC Article

Clinical prediction guides

Update from the 5th Edition of the World Health Organization Classification of Head and Neck Tumors: Hypopharynx, Larynx, Trachea and Parapharyngeal Space.
Zidar N, Gale N
Head Neck Pathol 2022 Mar;16(1):31-39. Epub 2022 Mar 21 doi: 10.1007/s12105-021-01405-6. PMID: 35312977Free PMC Article
Laryngopharyngeal Reflux in Hypertrophic Laryngeal Diseases.
Han H, Lyu Q, Zhao J
Ear Nose Throat J 2022 May;101(4):NP158-NP163. Epub 2020 Aug 31 doi: 10.1177/0145561320953232. PMID: 32865459
Clinical Analysis of Laryngeal Spindle Cell Carcinoma.
Chen L, Chen Q, Li C, Zhou L, Wang S, Zhang M
ORL J Otorhinolaryngol Relat Spec 2020;82(6):310-317. Epub 2020 Sep 2 doi: 10.1159/000508134. PMID: 32877904
Clinical outcome and comparison between squamous and non-squamous cell carcinoma of the larynx.
Chen L, Deng W, Li C, Lau H, Tao L, Wang S, Zhou L, Zhang M
Acta Otolaryngol 2020 Feb;140(2):195-201. Epub 2019 Dec 18 doi: 10.1080/00016489.2019.1700305. PMID: 31852360
Lymphoepithelial-like carcinomas of the head and neck.
Wenig BM
Semin Diagn Pathol 2015 Jan;32(1):74-86. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.004. PMID: 25804344

Recent systematic reviews

NBI and Laryngeal Papillomatosis: A Diagnostic Challenge: A Systematic Review.
Saraniti C, Gallina S, Verro B
Int J Environ Res Public Health 2022 Jul 18;19(14) doi: 10.3390/ijerph19148716. PMID: 35886569Free PMC Article
Prophylactic Central Neck Dissection for Clinically Node-Negative Papillary Thyroid Carcinoma.
Alsubaie KM, Alsubaie HM, Alzahrani FR, Alessa MA, Abdulmonem SK, Merdad MA, Al-Khatib T, Marzouki HZ, Algarni MA, Alherabi AZ
Laryngoscope 2022 Jun;132(6):1320-1328. Epub 2021 Oct 28 doi: 10.1002/lary.29912. PMID: 34708877
Lymphoepithelial carcinoma of larynx and hypopharynx: a systematic review and pooled analysis.
Petruzzi G, Costantino A, De Virgilio A, Zocchi J, Campo F, Mercante G, Spriano G, Pellini R
Eur Arch Otorhinolaryngol 2022 Mar;279(3):1157-1166. Epub 2021 Aug 2 doi: 10.1007/s00405-021-07011-0. PMID: 34338877
Laryngeal Verrucous Carcinoma.
Echanique KA, Desai SV, Marchiano E, Spinazzi EF, Strojan P, Baredes S, Eloy JA
Otolaryngol Head Neck Surg 2017 Jan;156(1):38-45. Epub 2016 Aug 9 doi: 10.1177/0194599816662631. PMID: 27484231
HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis.
Ndiaye C, Mena M, Alemany L, Arbyn M, Castellsagué X, Laporte L, Bosch FX, de Sanjosé S, Trottier H
Lancet Oncol 2014 Nov;15(12):1319-31. Epub 2014 Oct 16 doi: 10.1016/S1470-2045(14)70471-1. PMID: 25439690

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