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Malignant Orbit Neoplasm

MedGen UID:
56314
•Concept ID:
C0153626
•
Neoplastic Process
Synonyms: Malignant Neoplasm of Orbit; Malignant Neoplasm of the Orbit; Malignant Orbit Tumor; Malignant Orbital Neoplasm; Malignant orbital tumor; Malignant Orbital Tumor; Malignant tumor of orbit; Malignant Tumor of Orbit; Malignant Tumor of the Orbit
SNOMED CT: Malignant orbital tumor (363462005); Malignant tumor of orbit (363462005)

Definition

A primary or metastatic malignant neoplasm involving the orbit. [from NCI]

Professional guidelines

PubMed

Sebaceous carcinoma: evidence-based clinical practice guidelines.
Owen JL, Kibbi N, Worley B, Kelm RC, Wang JV, Barker CA, Behshad R, Bichakjian CK, Bolotin D, Bordeaux JS, Bradshaw SH, Cartee TV, Chandra S, Cho NL, Choi JN, Council ML, Demirci H, Eisen DB, Esmaeli B, Golda N, Huang CC, Ibrahim SF, Jiang SB, Kim J, Kuzel TM, Lai SY, Lawrence N, Lee EH, Leitenberger JJ, Maher IA, Mann MW, Minkis K, Mittal BB, Nehal KS, Neuhaus IM, Ozog DM, Petersen B, Rotemberg V, Samant S, Samie FH, Servaes S, Shields CL, Shin TM, Sobanko JF, Somani AK, Stebbins WG, Thomas JR, Thomas VD, Tse DT, Waldman AH, Wong MK, Xu YG, Yu SS, Zeitouni NC, Ramsay T, Reynolds KA, Poon E, Alam M
Lancet Oncol 2019 Dec;20(12):e699-e714. doi: 10.1016/S1470-2045(19)30673-4. PMID: 31797796
Contemporary management of retinoblastoma in the context of a low-resource country.
Ademola-Popoola DS, Opocher E, Reddy MA
Niger Postgrad Med J 2019 Apr-Jun;26(2):69-79. doi: 10.4103/npmj.npmj_21_19. PMID: 31187745
Modern radiation therapy for extranodal lymphomas: field and dose guidelines from the International Lymphoma Radiation Oncology Group.
Yahalom J, Illidge T, Specht L, Hoppe RT, Li YX, Tsang R, Wirth A; International Lymphoma Radiation Oncology Group
Int J Radiat Oncol Biol Phys 2015 May 1;92(1):11-31. doi: 10.1016/j.ijrobp.2015.01.009. PMID: 25863750

Recent clinical studies

Etiology

Orbital Tumors and Tumor like Lesions: A Hospital Based Study.
Poudyal P, Hamal D, Shrestha P
J Nepal Health Res Counc 2022 Jun 2;20(1):26-32. doi: 10.33314/jnhrc.v20i01.3727. PMID: 35945849
Pediatric Orbital Primitive Neuroectodermal Tumors.
Afghani T, Mansoor H, Raza Hamdani SN
J Pediatr Ophthalmol Strabismus 2018 Mar 1;55(2):128-134. Epub 2017 Nov 14 doi: 10.3928/01913913-20170703-03. PMID: 29131914
Orbital peripheral nerve sheath tumors.
Sweeney AR, Gupta D, Keene CD, Cimino PJ, Chambers CB, Chang SH, Hanna E
Surv Ophthalmol 2017 Jan-Feb;62(1):43-57. Epub 2016 Aug 26 doi: 10.1016/j.survophthal.2016.08.002. PMID: 27570221
Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical ​pathologic review.
Andrew NH, Coupland SE, Pirbhai A, Selva D
Surv Ophthalmol 2016 Nov-Dec;61(6):778-790. Epub 2016 Apr 26 doi: 10.1016/j.survophthal.2016.04.004. PMID: 27127077
An analysis of 2,480 space-occupying lesions of the orbit from 1976 to 2011.
Bonavolontà G, Strianese D, Grassi P, Comune C, Tranfa F, Uccello G, Iuliano A
Ophthalmic Plast Reconstr Surg 2013 Mar-Apr;29(2):79-86. doi: 10.1097/IOP.0b013e31827a7622. PMID: 23470516

Diagnosis

Orbital dermoid cyst.
Bansal R, Honavar SG, Talloju SS, Mulay K
Indian J Ophthalmol 2022 Feb;70(2):709. doi: 10.4103/ijo.IJO_145_22. PMID: 35086291Free PMC Article
Rare Diseases of the Orbit.
Kisser U, Heichel J, Glien A
Laryngorhinootologie 2021 Apr;100(S 01):S1-S79. Epub 2021 Apr 30 doi: 10.1055/a-1384-4641. PMID: 34352903Free PMC Article
Orbital peripheral nerve sheath tumors.
Sweeney AR, Gupta D, Keene CD, Cimino PJ, Chambers CB, Chang SH, Hanna E
Surv Ophthalmol 2017 Jan-Feb;62(1):43-57. Epub 2016 Aug 26 doi: 10.1016/j.survophthal.2016.08.002. PMID: 27570221
Cancer of the orbit and adnexa.
Schwarcz RM, Coupland SE, Finger PT
Am J Clin Oncol 2013 Apr;36(2):197-205. doi: 10.1097/COC.0b013e31820dbf28. PMID: 22157212
Orbital tumors.
Weisman RA, Kikkawa D, Moe KS, Osguthorpe JD
Otolaryngol Clin North Am 2001 Dec;34(6):1157-74, ix-x. doi: 10.1016/s0030-6665(05)70372-8. PMID: 11728939

Therapy

PET/CT and PET/MRI in ophthalmic oncology (Review).
Kalemaki MS, Karantanas AH, Exarchos D, Detorakis ET, Zoras O, Marias K, Millo C, Bagci U, Pallikaris I, Stratis A, Karatzanis I, Perisinakis K, Koutentakis P, Kontadakis GA, Spandidos DA, Tsatsakis A, Papadakis GZ
Int J Oncol 2020 Feb;56(2):417-429. Epub 2020 Jan 3 doi: 10.3892/ijo.2020.4955. PMID: 31939615Free PMC Article
Interventions for orbital lymphangioma.
Patel SR, Rosenberg JB, Barmettler A
Cochrane Database Syst Rev 2019 May 15;5(5):CD013000. doi: 10.1002/14651858.CD013000.pub2. PMID: 31094450Free PMC Article
Targeted monoclonal antibody therapy and radioimmunotherapy for lymphoproliferative disorders of the ocular adnexa.
Shome D, Esmaeli B
Curr Opin Ophthalmol 2008 Sep;19(5):414-21. doi: 10.1097/ICU.0b013e32830b1539. PMID: 18772675
Intergroup rhabdomyosarcoma study-IV: results for patients with nonmetastatic disease.
Crist WM, Anderson JR, Meza JL, Fryer C, Raney RB, Ruymann FB, Breneman J, Qualman SJ, Wiener E, Wharam M, Lobe T, Webber B, Maurer HM, Donaldson SS
J Clin Oncol 2001 Jun 15;19(12):3091-102. doi: 10.1200/JCO.2001.19.12.3091. PMID: 11408506
Periorbital hemangiomas.
Goldberg NS, Rosanova MA
Dermatol Clin 1992 Oct;10(4):653-61. PMID: 1395149

Prognosis

Rare Diseases of the Orbit.
Kisser U, Heichel J, Glien A
Laryngorhinootologie 2021 Apr;100(S 01):S1-S79. Epub 2021 Apr 30 doi: 10.1055/a-1384-4641. PMID: 34352903Free PMC Article
Diagnosis of orbital mass lesions: clinical, radiological, and pathological recommendations.
Mombaerts I, Ramberg I, Coupland SE, Heegaard S
Surv Ophthalmol 2019 Nov-Dec;64(6):741-756. Epub 2019 Jul 2 doi: 10.1016/j.survophthal.2019.06.006. PMID: 31276737
Orbital lymphoma.
Olsen TG, Heegaard S
Surv Ophthalmol 2019 Jan-Feb;64(1):45-66. Epub 2018 Aug 23 doi: 10.1016/j.survophthal.2018.08.002. PMID: 30144455
Life expectancy following orbital exenteration.
Wong JC, Thampy R, Cook A
Br J Ophthalmol 2015 Jan;99(1):1-4. Epub 2014 May 30 doi: 10.1136/bjophthalmol-2013-304436. PMID: 24879806
Periocular infantile hemangioma.
Jockin YM, Friedlander SF
Int Ophthalmol Clin 2010 Fall;50(4):15-25. doi: 10.1097/IIO.0b013e3181e35d35. PMID: 20930577

Clinical prediction guides

Orbit Solitary Fibrous Tumor: A Proposed Risk Prediction Model Based on a Case Series and Comprehensive Literature Review.
Thompson LDR, Liou SS, Feldman KA
Head Neck Pathol 2021 Mar;15(1):138-152. Epub 2020 Jun 11 doi: 10.1007/s12105-020-01184-6. PMID: 32529350Free PMC Article
Diagnosis of orbital mass lesions: clinical, radiological, and pathological recommendations.
Mombaerts I, Ramberg I, Coupland SE, Heegaard S
Surv Ophthalmol 2019 Nov-Dec;64(6):741-756. Epub 2019 Jul 2 doi: 10.1016/j.survophthal.2019.06.006. PMID: 31276737
Interventions for orbital lymphangioma.
Patel SR, Rosenberg JB, Barmettler A
Cochrane Database Syst Rev 2019 May 15;5(5):CD013000. doi: 10.1002/14651858.CD013000.pub2. PMID: 31094450Free PMC Article
Orbital Paraganglioma.
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513
Orbital venous anomalies.
Wright JE, Sullivan TJ, Garner A, Wulc AE, Moseley IF
Ophthalmology 1997 Jun;104(6):905-13. doi: 10.1016/s0161-6420(97)30208-5. PMID: 9186428

Recent systematic reviews

Exclusively endoscopic endonasal resection of benign orbital tumors: a systematic review and meta-analysis.
Jafari A, von Sneidern M, Lehmann AE, Shen SA, Shishido S, Freitag SK, Bleier BS
Int Forum Allergy Rhinol 2021 May;11(5):924-934. Epub 2020 Dec 22 doi: 10.1002/alr.22745. PMID: 33350602
Interventions for orbital lymphangioma.
Patel SR, Rosenberg JB, Barmettler A
Cochrane Database Syst Rev 2019 May 15;5(5):CD013000. doi: 10.1002/14651858.CD013000.pub2. PMID: 31094450Free PMC Article
The epidemiology and clinical manifestations of mucormycosis: a systematic review and meta-analysis of case reports.
Jeong W, Keighley C, Wolfe R, Lee WL, Slavin MA, Kong DCM, Chen SC
Clin Microbiol Infect 2019 Jan;25(1):26-34. Epub 2018 Jul 21 doi: 10.1016/j.cmi.2018.07.011. PMID: 30036666
A systematic review of sinonasal oncocytomas and oncocytic carcinomas: Diagnosis, management, and technical considerations.
Hodzic Z, Rowan NR, Kashiwazaki R, Willson TJ, Wang EW, Lee SE
Int Forum Allergy Rhinol 2017 May;7(5):514-524. Epub 2017 Jan 16 doi: 10.1002/alr.21902. PMID: 28092140
Cutaneous malignant melanoma metastatic to the eye, lids, and orbit.
Rosenberg C, Finger PT
Surv Ophthalmol 2008 May-Jun;53(3):187-202. doi: 10.1016/j.survophthal.2008.02.003. PMID: 18501266

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