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Benign Uveal Neoplasm

MedGen UID:
673328
Concept ID:
C0686467
Neoplastic Process
Synonyms: Benign Neoplasm of the Uvea; Benign Neoplasm of Uvea; Benign neoplasm of uveal tract; Benign Tumor of the Uvea; Benign Tumor of Uvea; Benign Uvea Neoplasm; Benign Uvea Tumor; Benign Uveal Tract Neoplasm; Benign Uveal Tumor
SNOMED CT: Benign neoplasm of uveal tract (92471004)

Definition

A neoplasm that arises from the uvea and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Zhang L, Ran QB, Lei CY, Zhang MX
Surv Ophthalmol 2023 Nov-Dec;68(6):1084-1092. Epub 2023 Jun 14 doi: 10.1016/j.survophthal.2023.06.002. PMID: 37321477
García Caride S, Fernández-Vigo JI, Valverde-Megías A
Arch Soc Esp Oftalmol (Engl Ed) 2023 May;98(5):281-291. Epub 2023 Apr 14 doi: 10.1016/j.oftale.2023.04.006. PMID: 37062411
Mishra KK, Daftari IK
Chin Clin Oncol 2016 Aug;5(4):50. doi: 10.21037/cco.2016.07.06. PMID: 27558251

Recent clinical studies

Etiology

Mukhana L, Aissa AA, Ahmed AAM, Saakyan SV, Tsygankov AY, Blagonravov ML, Azova MM
Bull Exp Biol Med 2023 Jul;175(3):399-403. Epub 2023 Aug 10 doi: 10.1007/s10517-023-05875-2. PMID: 37561379
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Mishra KK, Daftari IK
Chin Clin Oncol 2016 Aug;5(4):50. doi: 10.21037/cco.2016.07.06. PMID: 27558251
Schoenfield L
Adv Anat Pathol 2014 Mar;21(2):138-43. doi: 10.1097/PAP.0000000000000010. PMID: 24508696
Smith JH, Padnick-Silver L, Newlin A, Rhodes K, Rubinstein WS
Ophthalmology 2007 Apr;114(4):774-9. Epub 2007 Jan 3 doi: 10.1016/j.ophtha.2006.08.041. PMID: 17207529

Diagnosis

Zhang L, Ran QB, Lei CY, Zhang MX
Surv Ophthalmol 2023 Nov-Dec;68(6):1084-1092. Epub 2023 Jun 14 doi: 10.1016/j.survophthal.2023.06.002. PMID: 37321477
García Caride S, Fernández-Vigo JI, Valverde-Megías A
Arch Soc Esp Oftalmol (Engl Ed) 2023 May;98(5):281-291. Epub 2023 Apr 14 doi: 10.1016/j.oftale.2023.04.006. PMID: 37062411
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Seregard S, Pelayes DE, Singh AD
Dev Ophthalmol 2013;52:36-57. Epub 2013 Aug 26 doi: 10.1159/000351055. PMID: 23989126
Kadrmas EF, Weiter JJ
Int Ophthalmol Clin 1997 Fall;37(4):171-82. doi: 10.1097/00004397-199703740-00015. PMID: 9429940

Therapy

Görgec B, Hansen IS, Kemmerich G, Syversveen T, Abu Hilal M, Belt EJT, Bosscha K, Burgmans MC, Cappendijk VC, D'Hondt M, Edwin B, van Erkel AR, Gielkens HAJ, Grünhagen DJ, Gobardhan PD, Hartgrink HH, Horsthuis K, Klompenhouwer EG, Kok NFM, Kint PAM, Kuhlmann K, Leclercq WKG, Lips DJ, Lutin B, Maas M, Marsman HA, Meijerink M, Meyer Y, Morone M, Peringa J, Sijberden JP, van Delden OM, van den Bergh JE, Vanhooymissen IJS, Vermaas M, Willemssen FEJA, Dijkgraaf MGW, Bossuyt PM, Swijnenburg RJ, Fretland ÅA, Verhoef C, Besselink MG, Stoker J; CAMINO Study Group
Lancet Oncol 2024 Jan;25(1):137-146. Epub 2023 Dec 8 doi: 10.1016/S1470-2045(23)00572-7. PMID: 38081200
Parker T, Rigney G, Kallos J, Stefko ST, Kano H, Niranjan A, Green AL, Aziz T, Rath P, Lunsford LD
Lancet Oncol 2020 Nov;21(11):1526-1536. doi: 10.1016/S1470-2045(20)30459-9. PMID: 33152286
Sen M, Honavar SG
Indian J Ophthalmol 2019 Dec;67(12):1965-1973. doi: 10.4103/ijo.IJO_2036_19. PMID: 31755430Free PMC Article
Kindler HL
Am Soc Clin Oncol Educ Book 2013:182-8. doi: 10.14694/EdBook_AM.2013.33.182. PMID: 23714495
Suit H, Urie M
J Natl Cancer Inst 1992 Feb 5;84(3):155-64. doi: 10.1093/jnci/84.3.155. PMID: 1311773

Prognosis

García Caride S, Fernández-Vigo JI, Valverde-Megías A
Arch Soc Esp Oftalmol (Engl Ed) 2023 May;98(5):281-291. Epub 2023 Apr 14 doi: 10.1016/j.oftale.2023.04.006. PMID: 37062411
Gelmi MC, Houtzagers LE, Strub T, Krossa I, Jager MJ
Int J Mol Sci 2022 May 26;23(11) doi: 10.3390/ijms23116001. PMID: 35682684Free PMC Article
Bresler SC, Simon C, Shields CL, McHugh JB, Stagner AM, Patel RM
Arch Pathol Lab Med 2022 May 1;146(5):632-646. doi: 10.5858/arpa.2021-0006-RA. PMID: 34424954
Tomar AS, Finger PT, Iacob CE
Surv Ophthalmol 2020 Jul-Aug;65(4):421-437. Epub 2020 Jan 7 doi: 10.1016/j.survophthal.2019.12.008. PMID: 31923479
Singh AD, Kaiser PK, Sears JE
Ophthalmol Clin North Am 2005 Mar;18(1):151-61, ix. doi: 10.1016/j.ohc.2004.07.004. PMID: 15763200

Clinical prediction guides

Goto H, Yamakawa N, Tsubota K, Umazume K, Usui Y
Jpn J Ophthalmol 2021 Mar;65(2):237-249. Epub 2021 Feb 19 doi: 10.1007/s10384-021-00814-y. PMID: 33606097
Udyaver S, Lim LS, Milman T, Mashayekhi A, Shields JA, Shields CL
Eur J Ophthalmol 2021 Sep;31(5):NP9-NP13. Epub 2020 Apr 28 doi: 10.1177/1120672120920211. PMID: 32345045
Schoenfield L
Adv Anat Pathol 2014 Mar;21(2):138-43. doi: 10.1097/PAP.0000000000000010. PMID: 24508696
Smith JH, Padnick-Silver L, Newlin A, Rhodes K, Rubinstein WS
Ophthalmology 2007 Apr;114(4):774-9. Epub 2007 Jan 3 doi: 10.1016/j.ophtha.2006.08.041. PMID: 17207529
Mashayekhi A, Shields CL
Curr Opin Ophthalmol 2003 Jun;14(3):142-9. doi: 10.1097/00055735-200306000-00006. PMID: 12777933

Recent systematic reviews

Zhang L, Ran QB, Lei CY, Zhang MX
Surv Ophthalmol 2023 Nov-Dec;68(6):1084-1092. Epub 2023 Jun 14 doi: 10.1016/j.survophthal.2023.06.002. PMID: 37321477
Parker T, Rigney G, Kallos J, Stefko ST, Kano H, Niranjan A, Green AL, Aziz T, Rath P, Lunsford LD
Lancet Oncol 2020 Nov;21(11):1526-1536. doi: 10.1016/S1470-2045(20)30459-9. PMID: 33152286

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