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Breast carcinoma by gene expression profile

MedGen UID:
770984
•Concept ID:
C3642344
•
Neoplastic Process
Synonyms: Breast Carcinoma by Gene Expression Profile; breast carcinoma by gene expression profile
 
Monarch Initiative: MONDO:0006116

Definition

A header term that includes the following breast carcinoma subtypes determined by gene expression profiling: luminal A breast carcinoma, luminal B breast carcinoma, HER2 positive breast carcinoma, basal-like breast carcinoma, triple-negative breast carcinoma, and normal breast-like subtype of breast carcinoma. [from NCI]

Professional guidelines

PubMed

Triple-negative breast cancer: epidemiology, molecular mechanisms, and modern vaccine-based treatment strategies.
Karim AM, Eun Kwon J, Ali T, Jang J, Ullah I, Lee YG, Park DW, Park J, Jeang JW, Kang SC
Biochem Pharmacol 2023 Jun;212:115545. Epub 2023 Apr 11 doi: 10.1016/j.bcp.2023.115545. PMID: 37044296
A single-cell map of intratumoral changes during anti-PD1 treatment of patients with breast cancer.
Bassez A, Vos H, Van Dyck L, Floris G, Arijs I, Desmedt C, Boeckx B, Vanden Bempt M, Nevelsteen I, Lambein K, Punie K, Neven P, Garg AD, Wildiers H, Qian J, Smeets A, Lambrechts D
Nat Med 2021 May;27(5):820-832. Epub 2021 May 6 doi: 10.1038/s41591-021-01323-8. PMID: 33958794
Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies.
Jiang YZ, Ma D, Suo C, Shi J, Xue M, Hu X, Xiao Y, Yu KD, Liu YR, Yu Y, Zheng Y, Li X, Zhang C, Hu P, Zhang J, Hua Q, Zhang J, Hou W, Ren L, Bao D, Li B, Yang J, Yao L, Zuo WJ, Zhao S, Gong Y, Ren YX, Zhao YX, Yang YS, Niu Z, Cao ZG, Stover DG, Verschraegen C, Kaklamani V, Daemen A, Benson JR, Takabe K, Bai F, Li DQ, Wang P, Shi L, Huang W, Shao ZM
Cancer Cell 2019 Mar 18;35(3):428-440.e5. Epub 2019 Mar 7 doi: 10.1016/j.ccell.2019.02.001. PMID: 30853353

Recent clinical studies

Etiology

Single-cell transcriptome sequencing of B-cell heterogeneity and tertiary lymphoid structure predicts breast cancer prognosis and neoadjuvant therapy efficacy.
Wang Q, Sun K, Liu R, Song Y, Lv Y, Bi P, Yang F, Li S, Zhao J, Li X, Chen D, Mei J, Yang R, Chen K, Liu D, Tang S
Clin Transl Med 2023 Aug;13(8):e1346. doi: 10.1002/ctm2.1346. PMID: 37525587Free PMC Article
Exploring the causality and pathogenesis of systemic lupus erythematosus in breast cancer based on Mendelian randomization and transcriptome data analyses.
Li W, Wang R, Wang W
Front Immunol 2022;13:1029884. Epub 2023 Jan 16 doi: 10.3389/fimmu.2022.1029884. PMID: 36726984Free PMC Article
A human breast atlas integrating single-cell proteomics and transcriptomics.
Gray GK, Li CM, Rosenbluth JM, Selfors LM, Girnius N, Lin JR, Schackmann RCJ, Goh WL, Moore K, Shapiro HK, Mei S, D'Andrea K, Nathanson KL, Sorger PK, Santagata S, Regev A, Garber JE, Dillon DA, Brugge JS
Dev Cell 2022 Jun 6;57(11):1400-1420.e7. Epub 2022 May 25 doi: 10.1016/j.devcel.2022.05.003. PMID: 35617956Free PMC Article
Comprehensive metabolomics expands precision medicine for triple-negative breast cancer.
Xiao Y, Ma D, Yang YS, Yang F, Ding JH, Gong Y, Jiang L, Ge LP, Wu SY, Yu Q, Zhang Q, Bertucci F, Sun Q, Hu X, Li DQ, Shao ZM, Jiang YZ
Cell Res 2022 May;32(5):477-490. Epub 2022 Feb 1 doi: 10.1038/s41422-022-00614-0. PMID: 35105939Free PMC Article
Molecular Genomic Testing for Breast Cancer: Utility for Surgeons.
Fayanju OM, Park KU, Lucci A
Ann Surg Oncol 2018 Feb;25(2):512-519. Epub 2017 Nov 20 doi: 10.1245/s10434-017-6254-z. PMID: 29159748Free PMC Article

Diagnosis

Combined Single-Cell and Spatial Transcriptomics Reveal the Metabolic Evolvement of Breast Cancer during Early Dissemination.
Liu YM, Ge JY, Chen YF, Liu T, Chen L, Liu CC, Ma D, Chen YY, Cai YW, Xu YY, Shao ZM, Yu KD
Adv Sci (Weinh) 2023 Feb;10(6):e2205395. Epub 2023 Jan 3 doi: 10.1002/advs.202205395. PMID: 36594618Free PMC Article
Exploring the causality and pathogenesis of systemic lupus erythematosus in breast cancer based on Mendelian randomization and transcriptome data analyses.
Li W, Wang R, Wang W
Front Immunol 2022;13:1029884. Epub 2023 Jan 16 doi: 10.3389/fimmu.2022.1029884. PMID: 36726984Free PMC Article
Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery.
Zou Y, Xie J, Zheng S, Liu W, Tang Y, Tian W, Deng X, Wu L, Zhang Y, Wong CW, Tan D, Liu Q, Xie X
Int J Surg 2022 Nov;107:106936. Epub 2022 Sep 20 doi: 10.1016/j.ijsu.2022.106936. PMID: 36341760
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities.
Xu X, Zhang M, Xu F, Jiang S
Mol Cancer 2020 Nov 24;19(1):165. doi: 10.1186/s12943-020-01276-5. PMID: 33234169Free PMC Article
Multigene signatures of responses to chemotherapy derived by biochemically-inspired machine learning.
Rogan PK
Mol Genet Metab 2019 Sep-Oct;128(1-2):45-52. Epub 2019 Aug 19 doi: 10.1016/j.ymgme.2019.08.005. PMID: 31451418

Therapy

ESR1 mutations in breast cancer.
Dustin D, Gu G, Fuqua SAW
Cancer 2019 Nov 1;125(21):3714-3728. Epub 2019 Jul 18 doi: 10.1002/cncr.32345. PMID: 31318440Free PMC Article
Resistance to neoadjuvant chemotherapy in triple-negative breast cancer mediated by a reversible drug-tolerant state.
Echeverria GV, Ge Z, Seth S, Zhang X, Jeter-Jones S, Zhou X, Cai S, Tu Y, McCoy A, Peoples M, Sun Y, Qiu H, Chang Q, Bristow C, Carugo A, Shao J, Ma X, Harris A, Mundi P, Lau R, Ramamoorthy V, Wu Y, Alvarez MJ, Califano A, Moulder SL, Symmans WF, Marszalek JR, Heffernan TP, Chang JT, Piwnica-Worms H
Sci Transl Med 2019 Apr 17;11(488) doi: 10.1126/scitranslmed.aav0936. PMID: 30996079Free PMC Article
Chemoresistance Evolution in Triple-Negative Breast Cancer Delineated by Single-Cell Sequencing.
Kim C, Gao R, Sei E, Brandt R, Hartman J, Hatschek T, Crosetto N, Foukakis T, Navin NE
Cell 2018 May 3;173(4):879-893.e13. Epub 2018 Apr 19 doi: 10.1016/j.cell.2018.03.041. PMID: 29681456Free PMC Article
The transcriptome of CDK4/6 inhibition.
Knudsen ES, Witkiewicz AK
Aging (Albany NY) 2017 Aug 30;9(8):1859-1860. doi: 10.18632/aging.101285. PMID: 28860413Free PMC Article
CDK4/6 inhibition triggers anti-tumour immunity.
Goel S, DeCristo MJ, Watt AC, BrinJones H, Sceneay J, Li BB, Khan N, Ubellacker JM, Xie S, Metzger-Filho O, Hoog J, Ellis MJ, Ma CX, Ramm S, Krop IE, Winer EP, Roberts TM, Kim HJ, McAllister SS, Zhao JJ
Nature 2017 Aug 24;548(7668):471-475. Epub 2017 Aug 16 doi: 10.1038/nature23465. PMID: 28813415Free PMC Article

Prognosis

Pan-cancer classification of single cells in the tumour microenvironment.
Nofech-Mozes I, Soave D, Awadalla P, Abelson S
Nat Commun 2023 Mar 23;14(1):1615. doi: 10.1038/s41467-023-37353-8. PMID: 36959212Free PMC Article
Deciphering breast cancer: from biology to the clinic.
Nolan E, Lindeman GJ, Visvader JE
Cell 2023 Apr 13;186(8):1708-1728. Epub 2023 Mar 16 doi: 10.1016/j.cell.2023.01.040. PMID: 36931265
Exploring the causality and pathogenesis of systemic lupus erythematosus in breast cancer based on Mendelian randomization and transcriptome data analyses.
Li W, Wang R, Wang W
Front Immunol 2022;13:1029884. Epub 2023 Jan 16 doi: 10.3389/fimmu.2022.1029884. PMID: 36726984Free PMC Article
Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery.
Zou Y, Xie J, Zheng S, Liu W, Tang Y, Tian W, Deng X, Wu L, Zhang Y, Wong CW, Tan D, Liu Q, Xie X
Int J Surg 2022 Nov;107:106936. Epub 2022 Sep 20 doi: 10.1016/j.ijsu.2022.106936. PMID: 36341760
Molecular Genomic Testing for Breast Cancer: Utility for Surgeons.
Fayanju OM, Park KU, Lucci A
Ann Surg Oncol 2018 Feb;25(2):512-519. Epub 2017 Nov 20 doi: 10.1245/s10434-017-6254-z. PMID: 29159748Free PMC Article

Clinical prediction guides

Single-cell transcriptome sequencing of B-cell heterogeneity and tertiary lymphoid structure predicts breast cancer prognosis and neoadjuvant therapy efficacy.
Wang Q, Sun K, Liu R, Song Y, Lv Y, Bi P, Yang F, Li S, Zhao J, Li X, Chen D, Mei J, Yang R, Chen K, Liu D, Tang S
Clin Transl Med 2023 Aug;13(8):e1346. doi: 10.1002/ctm2.1346. PMID: 37525587Free PMC Article
Pan-cancer classification of single cells in the tumour microenvironment.
Nofech-Mozes I, Soave D, Awadalla P, Abelson S
Nat Commun 2023 Mar 23;14(1):1615. doi: 10.1038/s41467-023-37353-8. PMID: 36959212Free PMC Article
Exploring the causality and pathogenesis of systemic lupus erythematosus in breast cancer based on Mendelian randomization and transcriptome data analyses.
Li W, Wang R, Wang W
Front Immunol 2022;13:1029884. Epub 2023 Jan 16 doi: 10.3389/fimmu.2022.1029884. PMID: 36726984Free PMC Article
Leveraging diverse cell-death patterns to predict the prognosis and drug sensitivity of triple-negative breast cancer patients after surgery.
Zou Y, Xie J, Zheng S, Liu W, Tang Y, Tian W, Deng X, Wu L, Zhang Y, Wong CW, Tan D, Liu Q, Xie X
Int J Surg 2022 Nov;107:106936. Epub 2022 Sep 20 doi: 10.1016/j.ijsu.2022.106936. PMID: 36341760
Gene expression profiling predicts clinical outcome of breast cancer.
van 't Veer LJ, Dai H, van de Vijver MJ, He YD, Hart AA, Mao M, Peterse HL, van der Kooy K, Marton MJ, Witteveen AT, Schreiber GJ, Kerkhoven RM, Roberts C, Linsley PS, Bernards R, Friend SH
Nature 2002 Jan 31;415(6871):530-6. doi: 10.1038/415530a. PMID: 11823860

Recent systematic reviews

The role of mir-151a-5p in tumorigenesis; A systematic review.
Ebrahimi A, Derakhshan SM, Ghavi D, Foruzandeh Z, Hashemi S
Pathol Res Pract 2023 Sep;249:154576. Epub 2023 Jun 1 doi: 10.1016/j.prp.2023.154576. PMID: 37562284
Defining genomic, transcriptomic, proteomic, epigenetic, and phenotypic biomarkers with prognostic capability in male breast cancer: a systematic review.
Chatterji S, Krzoska E, Thoroughgood CW, Saganty J, Liu P, Elsberger B, Abu-Eid R, Speirs V
Lancet Oncol 2023 Feb;24(2):e74-e85. doi: 10.1016/S1470-2045(22)00633-7. PMID: 36725152
Gene expression signatures in older patients with breast cancer: A systematic review.
Lemij AA, Baltussen JC, de Glas NA, Kroep JR, Derks MGM, Liefers GJ, Portielje JEA
Crit Rev Oncol Hematol 2023 Jan;181:103884. Epub 2022 Nov 26 doi: 10.1016/j.critrevonc.2022.103884. PMID: 36442749
Integrated imaging and molecular analysis to decipher tumor microenvironment in the era of immunotherapy.
Wu J, Mayer AT, Li R
Semin Cancer Biol 2022 Sep;84:310-328. Epub 2020 Dec 5 doi: 10.1016/j.semcancer.2020.12.005. PMID: 33290844Free PMC Article
PD-1 protein and gene expression as prognostic factors in early breast cancer.
Matikas A, Zerdes I, Lövrot J, Sifakis E, Richard F, Sotiriou C, Rassidakis G, Bergh J, Valachis A, Foukakis T
ESMO Open 2020 Nov;5(6):e001032. doi: 10.1136/esmoopen-2020-001032. PMID: 33172959Free PMC Article

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