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Arterial occlusion

MedGen UID:
78117
Concept ID:
C0264995
Pathologic Function
Synonyms: Arterial Occlusion; Arterial Occlusions; Occlusion, Arterial
SNOMED CT: Arterial occlusion (2929001); Blocked artery (2929001); Occlusion of artery (2929001); Obstruction of artery (2929001)
 
HPO: HP:0025324
Monarch Initiative: MONDO:0020673

Definition

Blockage of blood flow through an artery. [from HPO]

Conditions with this feature

Primary hyperoxaluria, type I
MedGen UID:
75658
Concept ID:
C0268164
Disease or Syndrome
Primary hyperoxaluria type 1 (PH1) is caused by a deficiency of the liver peroxisomal enzyme alanine:glyoxylate-aminotransferase (AGT), which catalyzes the conversion of glyoxylate to glycine. When AGT activity is absent, glyoxylate is converted to oxalate, which forms insoluble calcium oxalate crystals that accumulate in the kidney and other organs. Individuals with PH1 are at risk for recurrent nephrolithiasis (deposition of calcium oxalate in the renal pelvis / urinary tract), nephrocalcinosis (deposition of calcium oxalate in the renal parenchyma), or end-stage renal disease (ESRD). Age at onset of symptoms ranges from infancy to the sixth decade. Approximately 10% of affected individuals present in infancy or early childhood with nephrocalcinosis, with or without nephrolithiasis, and failure to thrive related to renal failure. The majority of individuals with PH1 present in childhood or early adolescence, usually with symptomatic nephrolithiasis and normal or reduced kidney function. The remainder of affected individuals present in adulthood with recurrent renal stones and a mild-to-moderate reduction in kidney function. The natural history of untreated PH1 is one of progressive decline in renal function as a result of calcium oxalate deposits in kidney tissue and complications of nephrolithiasis (e.g., obstruction and infection) with eventual progression to oxalosis (widespread tissue deposition of calcium oxalate) and death from ESRD and/or complications of oxalosis.
Hereditary antithrombin deficiency
MedGen UID:
75781
Concept ID:
C0272375
Disease or Syndrome
Deficiency of antithrombin III is a major risk factor for venous thromboembolic disease. Two categories of AT-III deficiency have been defined on the basis of AT-III antigen levels in the plasma of affected individuals. The majority of AT-III deficiency families belong in the type I (classic) deficiency group and have a quantitatively abnormal phenotype in which antigen and heparin cofactor levels are both reduced to about 50% of normal. The second category of AT-III deficiency has been termed type II (functional) deficiency. Affected individuals from these kindreds produce dysfunctional AT-III molecules; they have reduced heparin cofactor activity levels (about 50% of normal) but levels of AT-III antigen are often normal or nearly normal (summary by Bock and Prochownik, 1987). The 2 categories of antithrombmin III deficiency have been classified further. Type I (low functional and immunologic antithrombin) has been subdivided into subtype Ia (reduced levels of normal antithrombin), and type Ib (reduced levels of antithrombin and the presence of low levels of a variant). Type II (low functional but normal immunologic antithrombin) has been subdivided into subtype IIa (functional abnormalities affecting both the reactive site and the heparin-binding site of AT3); subtype IIb (functional abnormalities limited to the reactive site); and subtype IIc (functional abnormalities limited to the heparin-binding site) (summary by Lane et al., 1992).

Professional guidelines

PubMed

Regenhardt RW, Potter CA, Huang SS, Lev MH
Radiol Clin North Am 2023 May;61(3):445-456. doi: 10.1016/j.rcl.2023.01.003. PMID: 36931761
Martinez Licha CR, McCurdy CM, Maldonado SM, Lee LS
Ann Thorac Cardiovasc Surg 2020 Apr 20;26(2):65-71. Epub 2019 Oct 5 doi: 10.5761/atcs.ra.19-00158. PMID: 31588070Free PMC Article
Lees KR, Bluhmki E, von Kummer R, Brott TG, Toni D, Grotta JC, Albers GW, Kaste M, Marler JR, Hamilton SA, Tilley BC, Davis SM, Donnan GA, Hacke W; ECASS, ATLANTIS, NINDS and EPITHET rt-PA Study Group, Allen K, Mau J, Meier D, del Zoppo G, De Silva DA, Butcher KS, Parsons MW, Barber PA, Levi C, Bladin C, Byrnes G
Lancet 2010 May 15;375(9727):1695-703. doi: 10.1016/S0140-6736(10)60491-6. PMID: 20472172

Recent clinical studies

Etiology

Pillai P, Mitchell PJ, Phan TG, Ma H, Yan B
Cerebrovasc Dis 2023;52(3):353-362. Epub 2022 Nov 24 doi: 10.1159/000526873. PMID: 36423598Free PMC Article
Salerno A, Strambo D, Nannoni S, Dunet V, Michel P
Int J Stroke 2022 Aug;17(7):714-722. Epub 2021 Sep 28 doi: 10.1177/17474930211046758. PMID: 34581223Free PMC Article
Monés J, Srivastava SK, Jaffe GJ, Tadayoni R, Albini TA, Kaiser PK, Holz FG, Korobelnik JF, Kim IK, Pruente C, Murray TG, Heier JS
Ophthalmology 2021 Jul;128(7):1050-1059. Epub 2020 Nov 15 doi: 10.1016/j.ophtha.2020.11.011. PMID: 33207259
Gilliland C, Shah J, Martin JG, Miller MJ Jr
Tech Vasc Interv Radiol 2017 Dec;20(4):274-280. Epub 2017 Oct 12 doi: 10.1053/j.tvir.2017.10.008. PMID: 29224661
Fukui M, Kono S, Sueishi K, Ikezaki K
Neuropathology 2000 Sep;20 Suppl:S61-4. doi: 10.1046/j.1440-1789.2000.00300.x. PMID: 11037190

Diagnosis

Regenhardt RW, Potter CA, Huang SS, Lev MH
Radiol Clin North Am 2023 May;61(3):445-456. doi: 10.1016/j.rcl.2023.01.003. PMID: 36931761
Salerno A, Strambo D, Nannoni S, Dunet V, Michel P
Int J Stroke 2022 Aug;17(7):714-722. Epub 2021 Sep 28 doi: 10.1177/17474930211046758. PMID: 34581223Free PMC Article
Ehlert BA
Surg Clin North Am 2018 Oct;98(5):995-1004. Epub 2018 Jul 29 doi: 10.1016/j.suc.2018.06.002. PMID: 30243457
Sise MJ
Surg Clin North Am 2014 Feb;94(1):165-81. doi: 10.1016/j.suc.2013.10.012. PMID: 24267504
Della-Morte D, Rundek T
Front Neurol Neurosci 2012;30:22-5. Epub 2012 Feb 14 doi: 10.1159/000333379. PMID: 22377855

Therapy

Li X, Li J, Qing L, Wang H, Ma H, Huang P
BMC Musculoskelet Disord 2023 May 8;24(1):360. doi: 10.1186/s12891-023-06483-x. PMID: 37158913Free PMC Article
Jack RA 2nd, Lambert BS, Hedt CA, Delgado D, Goble H, McCulloch PC
Sports Health 2023 May;15(3):361-371. Epub 2022 Jun 27 doi: 10.1177/19417381221101006. PMID: 35762124Free PMC Article
Monés J, Srivastava SK, Jaffe GJ, Tadayoni R, Albini TA, Kaiser PK, Holz FG, Korobelnik JF, Kim IK, Pruente C, Murray TG, Heier JS
Ophthalmology 2021 Jul;128(7):1050-1059. Epub 2020 Nov 15 doi: 10.1016/j.ophtha.2020.11.011. PMID: 33207259
Campbell BC, Mitchell PJ, Kleinig TJ, Dewey HM, Churilov L, Yassi N, Yan B, Dowling RJ, Parsons MW, Oxley TJ, Wu TY, Brooks M, Simpson MA, Miteff F, Levi CR, Krause M, Harrington TJ, Faulder KC, Steinfort BS, Priglinger M, Ang T, Scroop R, Barber PA, McGuinness B, Wijeratne T, Phan TG, Chong W, Chandra RV, Bladin CF, Badve M, Rice H, de Villiers L, Ma H, Desmond PM, Donnan GA, Davis SM; EXTEND-IA Investigators
N Engl J Med 2015 Mar 12;372(11):1009-18. Epub 2015 Feb 11 doi: 10.1056/NEJMoa1414792. PMID: 25671797
Berkhemer OA, Fransen PS, Beumer D, van den Berg LA, Lingsma HF, Yoo AJ, Schonewille WJ, Vos JA, Nederkoorn PJ, Wermer MJ, van Walderveen MA, Staals J, Hofmeijer J, van Oostayen JA, Lycklama à Nijeholt GJ, Boiten J, Brouwer PA, Emmer BJ, de Bruijn SF, van Dijk LC, Kappelle LJ, Lo RH, van Dijk EJ, de Vries J, de Kort PL, van Rooij WJ, van den Berg JS, van Hasselt BA, Aerden LA, Dallinga RJ, Visser MC, Bot JC, Vroomen PC, Eshghi O, Schreuder TH, Heijboer RJ, Keizer K, Tielbeek AV, den Hertog HM, Gerrits DG, van den Berg-Vos RM, Karas GB, Steyerberg EW, Flach HZ, Marquering HA, Sprengers ME, Jenniskens SF, Beenen LF, van den Berg R, Koudstaal PJ, van Zwam WH, Roos YB, van der Lugt A, van Oostenbrugge RJ, Majoie CB, Dippel DW; MR CLEAN Investigators
N Engl J Med 2015 Jan 1;372(1):11-20. Epub 2014 Dec 17 doi: 10.1056/NEJMoa1411587. PMID: 25517348

Prognosis

Ferrer C, Cannizzaro GA, Borlizzi A, Caruso C, Giudice R
Semin Vasc Surg 2023 Jun;36(2):211-223. Epub 2023 Apr 29 doi: 10.1053/j.semvascsurg.2023.04.006. PMID: 37330235
Gokdemir M, Cindik N
Pediatr Cardiol 2023 Aug;44(6):1191-1200. Epub 2023 May 19 doi: 10.1007/s00246-023-03180-3. PMID: 37204488
Saad F, Efstathiou E, Attard G, Flaig TW, Franke F, Goodman OB Jr, Oudard S, Steuber T, Suzuki H, Wu D, Yeruva K, De Porre P, Brookman-May S, Li S, Li J, Thomas S, Bevans KB, Mundle SD, McCarthy SA, Rathkopf DE; ACIS Investigators
Lancet Oncol 2021 Nov;22(11):1541-1559. Epub 2021 Sep 30 doi: 10.1016/S1470-2045(21)00402-2. PMID: 34600602Free PMC Article
Monés J, Srivastava SK, Jaffe GJ, Tadayoni R, Albini TA, Kaiser PK, Holz FG, Korobelnik JF, Kim IK, Pruente C, Murray TG, Heier JS
Ophthalmology 2021 Jul;128(7):1050-1059. Epub 2020 Nov 15 doi: 10.1016/j.ophtha.2020.11.011. PMID: 33207259
Sise MJ
Surg Clin North Am 2014 Feb;94(1):165-81. doi: 10.1016/j.suc.2013.10.012. PMID: 24267504

Clinical prediction guides

Gokdemir M, Cindik N
Pediatr Cardiol 2023 Aug;44(6):1191-1200. Epub 2023 May 19 doi: 10.1007/s00246-023-03180-3. PMID: 37204488
Naval-Baudin P, Rodriguez Caamaño I, Rubio-Maicas C, Pons-Escoda A, Fernández Viñas MM, Nuñez A, Cardona P, Majos C, Cos M, Calvo N
J Neuroimaging 2021 Jan;31(1):62-66. Epub 2020 Sep 28 doi: 10.1111/jon.12790. PMID: 32986907
Núñez-Gómez E, Pericacho M, Ollauri-Ibáñez C, Bernabéu C, López-Novoa JM
Angiogenesis 2017 Feb;20(1):1-24. Epub 2016 Dec 9 doi: 10.1007/s10456-016-9535-4. PMID: 27943030
Berkhemer OA, Fransen PS, Beumer D, van den Berg LA, Lingsma HF, Yoo AJ, Schonewille WJ, Vos JA, Nederkoorn PJ, Wermer MJ, van Walderveen MA, Staals J, Hofmeijer J, van Oostayen JA, Lycklama à Nijeholt GJ, Boiten J, Brouwer PA, Emmer BJ, de Bruijn SF, van Dijk LC, Kappelle LJ, Lo RH, van Dijk EJ, de Vries J, de Kort PL, van Rooij WJ, van den Berg JS, van Hasselt BA, Aerden LA, Dallinga RJ, Visser MC, Bot JC, Vroomen PC, Eshghi O, Schreuder TH, Heijboer RJ, Keizer K, Tielbeek AV, den Hertog HM, Gerrits DG, van den Berg-Vos RM, Karas GB, Steyerberg EW, Flach HZ, Marquering HA, Sprengers ME, Jenniskens SF, Beenen LF, van den Berg R, Koudstaal PJ, van Zwam WH, Roos YB, van der Lugt A, van Oostenbrugge RJ, Majoie CB, Dippel DW; MR CLEAN Investigators
N Engl J Med 2015 Jan 1;372(1):11-20. Epub 2014 Dec 17 doi: 10.1056/NEJMoa1411587. PMID: 25517348
Garcia JH, Lassen NA, Weiller C, Sperling B, Nakagawara J
Stroke 1996 Apr;27(4):761-5. doi: 10.1161/01.str.27.4.761. PMID: 8614945

Recent systematic reviews

Pillai P, Mitchell PJ, Phan TG, Ma H, Yan B
Cerebrovasc Dis 2023;52(3):353-362. Epub 2022 Nov 24 doi: 10.1159/000526873. PMID: 36423598Free PMC Article
Orrapin S, Benyakorn T, Siribumrungwong B, Rerkasem K
Cochrane Database Syst Rev 2022 Aug 3;8(8):CD000160. doi: 10.1002/14651858.CD000160.pub4. PMID: 35920689Free PMC Article
Broderick C, Patel JV
Cochrane Database Syst Rev 2021 Nov 17;11(11):CD000985. doi: 10.1002/14651858.CD000985.pub3. PMID: 34786692Free PMC Article
Nederhoed JH, Tjaberinga M, Otten RHJ, Evers JM, Musters RJP, Wisselink W, Yeung KK
Ultrasound Med Biol 2021 Oct;47(10):2821-2838. Epub 2021 Jul 13 doi: 10.1016/j.ultrasmedbio.2021.06.001. PMID: 34272082
Robertson I, Kessel DO, Berridge DC
Cochrane Database Syst Rev 2013 Dec 19;(12):CD001099. doi: 10.1002/14651858.CD001099.pub3. PMID: 24357258

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