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Childhood Acute Myeloid Leukemia Not Otherwise Specified

MedGen UID:
889446
•Concept ID:
C4055251
•
Neoplastic Process
Synonym: Childhood Acute Myeloid Leukemia Defined by Differentiation

Definition

Acute myeloid leukemias that occur in childhood and do not fulfill the criteria for inclusion in the group of acute myeloid leukemias which have recurrent genetic abnormalities or myelodysplastic changes, or are therapy-related. This category includes entities classified according to the French-American-British classification scheme. [from NCI]

Professional guidelines

PubMed

Diagnosis and management of acute myeloid leukemia in children and adolescents: recommendations from an international expert panel.
Creutzig U, van den Heuvel-Eibrink MM, Gibson B, Dworzak MN, Adachi S, de Bont E, Harbott J, Hasle H, Johnston D, Kinoshita A, Lehrnbecher T, Leverger G, Mejstrikova E, Meshinchi S, Pession A, Raimondi SC, Sung L, Stary J, Zwaan CM, Kaspers GJ, Reinhardt D; AML Committee of the International BFM Study Group
Blood 2012 Oct 18;120(16):3187-205. Epub 2012 Aug 9 doi: 10.1182/blood-2012-03-362608. PMID: 22879540
Towards individualised treatment in childhood leukaemia.
Veerman AJ, Kaspers GJ
Lancet Oncol 2010 Jun;11(6):502-3. doi: 10.1016/S1470-2045(10)70108-X. PMID: 20522371
Progress in the curative treatment of childhood hematologic malignancies.
Wayne AS, Reaman GH, Helman LJ
J Natl Cancer Inst 2008 Sep 17;100(18):1271-3. Epub 2008 Sep 9 doi: 10.1093/jnci/djn306. PMID: 18780861

Recent clinical studies

Etiology

A 4-gene prognostic index for enhancing acute myeloid leukaemia survival prediction.
Ortiz Rojas CA, Pereira-Martins DA, Bellido More CC, Sternadt D, Weinhäuser I, Hilberink JR, Coelho-Silva JL, Thomé CH, Ferreira GA, Ammatuna E, Huls G, Valk PJ, Schuringa JJ, Rego EM
Br J Haematol 2024 Jun;204(6):2287-2300. Epub 2024 Apr 23 doi: 10.1111/bjh.19472. PMID: 38651345
Early Life Nutrition Factors and Risk of Acute Leukemia in Children: Systematic Review and Meta-Analysis.
Kintossou AK, Blanco-Lopez J, Iguacel I, Pisanu S, Almeida CCB, Steliarova-Foucher E, Sierens C, Gunter MJ, Ladas EJ, Barr RD, Van Herck K, Kozlakidis Z, Huybrechts I
Nutrients 2023 Aug 29;15(17) doi: 10.3390/nu15173775. PMID: 37686807Free PMC Article
Relapsed pediatric acute myeloid leukaemia: state-of-the-art in 2023.
Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy.
Elgarten CW, Aplenc R
Curr Opin Pediatr 2020 Feb;32(1):57-66. doi: 10.1097/MOP.0000000000000855. PMID: 31815781
Epidemiology of acute myelogenous leukemia.
Sandler DP
Semin Oncol 1987 Dec;14(4):359-64. PMID: 3321440

Diagnosis

A 4-gene prognostic index for enhancing acute myeloid leukaemia survival prediction.
Ortiz Rojas CA, Pereira-Martins DA, Bellido More CC, Sternadt D, Weinhäuser I, Hilberink JR, Coelho-Silva JL, Thomé CH, Ferreira GA, Ammatuna E, Huls G, Valk PJ, Schuringa JJ, Rego EM
Br J Haematol 2024 Jun;204(6):2287-2300. Epub 2024 Apr 23 doi: 10.1111/bjh.19472. PMID: 38651345
Relapsed pediatric acute myeloid leukaemia: state-of-the-art in 2023.
Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy.
Elgarten CW, Aplenc R
Curr Opin Pediatr 2020 Feb;32(1):57-66. doi: 10.1097/MOP.0000000000000855. PMID: 31815781
Hematologic malignancies and Li-Fraumeni syndrome.
Swaminathan M, Bannon SA, Routbort M, Naqvi K, Kadia TM, Takahashi K, Alvarado Y, Ravandi-Kashani F, Patel KP, Champlin R, Kantarjian H, Strong L, DiNardo CD
Cold Spring Harb Mol Case Stud 2019 Feb;5(1) Epub 2019 Feb 1 doi: 10.1101/mcs.a003210. PMID: 30709875Free PMC Article
CBFA2T3-GLIS2-positive acute myeloid leukaemia. A peculiar paediatric entity.
Masetti R, Bertuccio SN, Pession A, Locatelli F
Br J Haematol 2019 Feb;184(3):337-347. Epub 2018 Dec 28 doi: 10.1111/bjh.15725. PMID: 30592296Free PMC Article

Therapy

Targeting N-cadherin (CDH2) and the malignant bone marrow microenvironment in acute leukaemia.
Parker J, Hockney S, Blaschuk OW, Pal D
Expert Rev Mol Med 2023 May 3;25:e16. doi: 10.1017/erm.2023.13. PMID: 37132370Free PMC Article
Relapsed pediatric acute myeloid leukaemia: state-of-the-art in 2023.
Egan G, Tasian SK
Haematologica 2023 Sep 1;108(9):2275-2288. doi: 10.3324/haematol.2022.281106. PMID: 36861399Free PMC Article
A global study for acute myeloid leukemia with RARG rearrangement.
Zhu HH, Qin YZ, Zhang ZL, Liu YJ, Wen LJ, You MJ, Zhang C, Such E, Luo H, Yuan HJ, Zhou HS, Liu HX, Xu R, Li J, Li JH, Hao JP, Jin J, Yu L, Zhang JY, Liu LP, Zhang LP, Huang RB, Shen SH, Gao SJ, Wang W, Yan XJ, Zhang XY, Du X, Chu XX, Yu YF, Wang Y, Mi YC, Lu Y, Cai Z, Su Z, Taussig DC, MacMahon S, Ball ED, Wang HY, Welch JS, Yin CC, Borthakur G, Sanz MA, Kantarjian HM, Huang JY, Hu J, Chen SN
Blood Adv 2023 Jul 11;7(13):2972-2982. doi: 10.1182/bloodadvances.2022008364. PMID: 36799929Free PMC Article
Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy.
Elgarten CW, Aplenc R
Curr Opin Pediatr 2020 Feb;32(1):57-66. doi: 10.1097/MOP.0000000000000855. PMID: 31815781
What is the optimal therapy for childhood AML?
Loeb DM, Arceci RJ
Oncology (Williston Park) 2002 Aug;16(8):1057-66; discussion 1066, 1068-70. PMID: 12201645

Prognosis

Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging.
Bandyopadhyay S, Duffy MP, Ahn KJ, Sussman JH, Pang M, Smith D, Duncan G, Zhang I, Huang J, Lin Y, Xiong B, Imtiaz T, Chen CH, Thadi A, Chen C, Xu J, Reichart M, Martinez Z, Diorio C, Chen C, Pillai V, Snaith O, Oldridge D, Bhattacharyya S, Maillard I, Carroll M, Nelson C, Qin L, Tan K
Cell 2024 Jun 6;187(12):3120-3140.e29. Epub 2024 May 6 doi: 10.1016/j.cell.2024.04.013. PMID: 38714197Free PMC Article
A 4-gene prognostic index for enhancing acute myeloid leukaemia survival prediction.
Ortiz Rojas CA, Pereira-Martins DA, Bellido More CC, Sternadt D, Weinhäuser I, Hilberink JR, Coelho-Silva JL, Thomé CH, Ferreira GA, Ammatuna E, Huls G, Valk PJ, Schuringa JJ, Rego EM
Br J Haematol 2024 Jun;204(6):2287-2300. Epub 2024 Apr 23 doi: 10.1111/bjh.19472. PMID: 38651345
Pediatric acute myeloid leukemia: updates on biology, risk stratification, and therapy.
Elgarten CW, Aplenc R
Curr Opin Pediatr 2020 Feb;32(1):57-66. doi: 10.1097/MOP.0000000000000855. PMID: 31815781
CBFA2T3-GLIS2-positive acute myeloid leukaemia. A peculiar paediatric entity.
Masetti R, Bertuccio SN, Pession A, Locatelli F
Br J Haematol 2019 Feb;184(3):337-347. Epub 2018 Dec 28 doi: 10.1111/bjh.15725. PMID: 30592296Free PMC Article
Childhood leukaemia.
Greaves M
BMJ 2002 Feb 2;324(7332):283-7. doi: 10.1136/bmj.324.7332.283. PMID: 11823363Free PMC Article

Clinical prediction guides

Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging.
Bandyopadhyay S, Duffy MP, Ahn KJ, Sussman JH, Pang M, Smith D, Duncan G, Zhang I, Huang J, Lin Y, Xiong B, Imtiaz T, Chen CH, Thadi A, Chen C, Xu J, Reichart M, Martinez Z, Diorio C, Chen C, Pillai V, Snaith O, Oldridge D, Bhattacharyya S, Maillard I, Carroll M, Nelson C, Qin L, Tan K
Cell 2024 Jun 6;187(12):3120-3140.e29. Epub 2024 May 6 doi: 10.1016/j.cell.2024.04.013. PMID: 38714197Free PMC Article
Absolute lymphocyte count recovery following initial acute myelogenous leukemia therapy: Implications for adoptive cell therapy.
Molina JC, Li Y, Otto WR, Miller TP, Getz KD, Mccoubrey C, Ramos M, Krause E, Cao L, Gramatges MM, Rabin K, Scheurer M, Elgarten CW, Myers RM, Seif AE, Fisher BT, Shah NN, Aplenc R
Pediatr Blood Cancer 2023 Jan;70(1):e30062. Epub 2022 Nov 12 doi: 10.1002/pbc.30062. PMID: 36370087Free PMC Article
RUNX1 and the endothelial origin of blood.
Gao L, Tober J, Gao P, Chen C, Tan K, Speck NA
Exp Hematol 2018 Dec;68:2-9. Epub 2018 Oct 31 doi: 10.1016/j.exphem.2018.10.009. PMID: 30391350Free PMC Article
How I treat myelodysplastic syndromes of childhood.
Locatelli F, Strahm B
Blood 2018 Mar 29;131(13):1406-1414. Epub 2018 Feb 8 doi: 10.1182/blood-2017-09-765214. PMID: 29438960
Comprehensive mutational profiling of core binding factor acute myeloid leukemia.
Duployez N, Marceau-Renaut A, Boissel N, Petit A, Bucci M, Geffroy S, Lapillonne H, Renneville A, Ragu C, Figeac M, Celli-Lebras K, Lacombe C, Micol JB, Abdel-Wahab O, Cornillet P, Ifrah N, Dombret H, Leverger G, Jourdan E, Preudhomme C
Blood 2016 May 19;127(20):2451-9. Epub 2016 Mar 15 doi: 10.1182/blood-2015-12-688705. PMID: 26980726Free PMC Article

Recent systematic reviews

Early Life Nutrition Factors and Risk of Acute Leukemia in Children: Systematic Review and Meta-Analysis.
Kintossou AK, Blanco-Lopez J, Iguacel I, Pisanu S, Almeida CCB, Steliarova-Foucher E, Sierens C, Gunter MJ, Ladas EJ, Barr RD, Van Herck K, Kozlakidis Z, Huybrechts I
Nutrients 2023 Aug 29;15(17) doi: 10.3390/nu15173775. PMID: 37686807Free PMC Article
Role of Maternal Diet in the Risk of Childhood Acute Leukemia: A Systematic Review and Meta-Analysis.
Blanco-Lopez J, Iguacel I, Pisanu S, Almeida CCB, Steliarova-Foucher E, Sierens C, Gunter MJ, Ladas EJ, Barr RD, Van Herck K, Huybrechts I
Int J Environ Res Public Health 2023 Apr 6;20(7) doi: 10.3390/ijerph20075428. PMID: 37048042Free PMC Article
Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines.
de Baat EC, Mulder RL, Armenian S, Feijen EA, Grotenhuis H, Hudson MM, Mavinkurve-Groothuis AM, Kremer LC, van Dalen EC
Cochrane Database Syst Rev 2022 Sep 27;9(9):CD014638. doi: 10.1002/14651858.CD014638.pub2. PMID: 36162822Free PMC Article
Exposure to pesticides and childhood leukemia risk: A systematic review and meta-analysis.
Karalexi MA, Tagkas CF, Markozannes G, Tseretopoulou X, Hernández AF, Schüz J, Halldorsson TI, Psaltopoulou T, Petridou ET, Tzoulaki I, Ntzani EE
Environ Pollut 2021 Sep 15;285:117376. Epub 2021 May 18 doi: 10.1016/j.envpol.2021.117376. PMID: 34380208
Measurable residual disease in pediatric acute myeloid leukemia: a systematic review.
Segerink WH, de Haas V, Kaspers GJL
Expert Rev Anticancer Ther 2021 Apr;21(4):451-459. Epub 2021 Mar 11 doi: 10.1080/14737140.2021.1860763. PMID: 33706635

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