An unpleasant sensation characterized by physical discomfort (such as pricking, throbbing, or aching) localized to the chest.

Abnormally high level of calcium in the urine.

Broadening of the soft tissues (non-edematous swelling of soft tissues) of the digital tips in all dimensions associated with an increased longitudinal and lateral curvature of the nails.

Accumulation of fluid within the pericardium.

Pulmonary hypertension is defined mean pulmonary artery pressure of 25mmHg or more and pulmonary capillary wedge pressure of 15mmHg or less when measured by right heart catheterisation at rest and in a supine position.

Reduction of total body weight.

Abnormally increased size of the liver.

Inflammation, or an inflammatory state in the large intestine.

Anorexia, or the loss of appetite for food, is a medical condition.

Excessive sensitivity to light with the sensation of discomfort or pain in the eyes due to exposure to bright light.

An abnormal reduction in numbers of all blood cell types (red blood cells, white blood cells, and platelets).

Inflammation of a joint.

A fluid filled cavity that develops with a bone.

Persistent abnormal dilatation of the bronchi owing to localized and irreversible destruction and widening of the large airways.

A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation.

Difficult or labored breathing. Dyspnea is a subjective feeling only the patient can rate, e.g., on a Borg scale.

Coughing up (expectoration) of blood or blood-streaked sputum from the larynx, trachea, bronchi, or lungs.

The presence of an excessive amount of fluid in the pleural cavity.

A subcategory of chronic obstructive pulmonary disease (COPD). It occurs in people who smoke and suffer from chronic bronchitis. It is characterized by inflation of the alveoli, alveolar wall damage, and reduction in the number of alveoli, resulting in difficulty breathing.

Replacement of normal lung tissues by fibroblasts and collagen.

A finding indicating the presence of an inflammatory or neoplastic cellular infiltrate in the lung parenchyma.

An abnormally low level of blood oxygen.

A functional defect characterized by reduced total lung capacity (TLC) not associated with abnormalities of expiratory airflow or airway resistance. Spirometrically, a restrictive defect is defined as FEV1 (forced expiratory volume in 1 second) and FVC (forced vital capacity) less than 80 per cent. Restrictive lung disease may be caused by alterations in lung parenchyma or because of a disease of the pleura, chest wall, or neuromuscular apparatus.

Usually, Lymphoycytes make up less than 15% of all cells found in the bronchoalveloar lavage fluid. This elevated cell proportion can be induced by virus or drugs, or is associated with specific diseases.

Abnormality of the lung parenchyma extending to the pulmonary interstitium and leading to diffuse pulmonary fibrosis.

A type of anterior uveitis, in which there is Inflammation of the iris and the ciliary body.

Abnormal increased size of the spleen.

Inflammation of one or all portions of the uveal tract.

A generalized form of lymphadenopathy.

A functional anomaly of T cells.

An increased level of gamma globulin (immunoglobulin) in the blood.

Body temperature elevated above the normal range.

An increased erythrocyte sedimentation rate (ESR). The ESR is a test that measures the distance that erythrocytes have fallen after one hour in a vertical column of anticoagulated blood under the influence of gravity. The ESR is a nonspecific finding. An elevation may indicate inflammation or may be caused by any condition that elevates fibrinogen.

Any abnormality of the salivary glands, the exocrine glands that produce saliva.

Abnormally big lacrimal glands.

Swelling of lymph nodes within the mediastinum, the central compartment of the thoracic cavities that contains the heart and the great vessels, the esophagus, and trachea and other structures including lymph nodes.

An inflammation of the choroid and retina.

Glaucoma refers loss of retinal ganglion cells in a characteristic pattern of optic neuropathy usually associated with increased intraocular pressure.

Abnormally increased lacrimation, that is, excessive tearing (watering eye).

Lack of sharpness of vision resulting in the inability to see fine detail.

Disorder of the optic nerve.