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Decreased circulating IgA concentration

MedGen UID:
57934
Concept ID:
C0162538
Disease or Syndrome
Synonym: IgA deficiency
SNOMED CT: Immunoglobulin A deficiency (29260007); IgA deficiency (29260007)
 
HPO: HP:0002720

Definition

Decreased levels of immunoglobulin A (IgA). [from HPO]

Conditions with this feature

Professional guidelines

PubMed

McCulloch L, Allan SM, Emsley HC, Smith CJ, McColl BW
F1000Res 2019;8:1039. Epub 2019 Jul 10 doi: 10.12688/f1000research.19308.2. PMID: 31700615Free PMC Article
Pacifici R, Paris L, Di Carlo S, Pichini S, Zuccaro P
Epilepsia 1991 Jan-Feb;32(1):122-7. doi: 10.1111/j.1528-1157.1991.tb05622.x. PMID: 1985820
Wieczorek E, Hańczyc P, Prastowska E
Arch Immunol Ther Exp (Warsz) 1988;36(3):367-76. PMID: 3250358

Recent clinical studies

Etiology

Gaber M, Wilson AS, Millen AE, Hovey KM, LaMonte MJ, Wactawski-Wende J, Ochs-Balcom HM, Cook KL
Microbiome 2024 Oct 4;12(1):192. doi: 10.1186/s40168-024-01901-1. PMID: 39367431Free PMC Article
Williams LD, Shen X, Sawant SS, Akapirat S, Dahora LC, Tay MZ, Stanfield-Oakley S, Wills S, Goodman D, Tenney D, Spreng RL, Zhang L, Yates NL, Montefiori DC, Eller MA, Easterhoff D, Hope TJ, Rerks-Ngarm S, Pittisuttithum P, Nitayaphan S, Excler JL, Kim JH, Michael NL, Robb ML, O'Connell RJ, Karasavvas N, Vasan S, Ferrari G, Tomaras GD; RV305 study team
PLoS Pathog 2023 May;19(5):e1011359. Epub 2023 May 31 doi: 10.1371/journal.ppat.1011359. PMID: 37256916Free PMC Article
Cianci R, Mancino G, Galli E, Serone E, Massoud R, D'Addabbo P, Poscia A, Borghetti A, Porzio O, Marmo R, Gambassi G, Frezza D
Gene 2023 Apr 30;862:147254. Epub 2023 Feb 9 doi: 10.1016/j.gene.2023.147254. PMID: 36764340
Borysenko A, Timokhina T, Kononova O
Georgian Med News 2021 Oct;(319):22-27. PMID: 34749317
Araújo RS, Silveira ALM, de Sales E Souza ÉL, Freire RH, de Souza CM, Reis DC, Costa BRC, Sugimoto MA, Silveira JN, Dos Santos Martins F, Cassali GD, Leite JIA, Sousa LP, Ferreira AVM, Oliveira MC, Cardoso VN
Eur J Pharm Sci 2017 Aug 30;106:142-151. Epub 2017 May 22 doi: 10.1016/j.ejps.2017.05.046. PMID: 28546107

Diagnosis

Chen XQ, Tu L, Zou JS, Zhu SQ, Zhao YJ, Qin YH
Front Immunol 2021;12:668974. Epub 2021 Sep 3 doi: 10.3389/fimmu.2021.668974. PMID: 34539623Free PMC Article
Araújo RS, Silveira ALM, de Sales E Souza ÉL, Freire RH, de Souza CM, Reis DC, Costa BRC, Sugimoto MA, Silveira JN, Dos Santos Martins F, Cassali GD, Leite JIA, Sousa LP, Ferreira AVM, Oliveira MC, Cardoso VN
Eur J Pharm Sci 2017 Aug 30;106:142-151. Epub 2017 May 22 doi: 10.1016/j.ejps.2017.05.046. PMID: 28546107
Mumcuoglu KY, Akilov OE
Dermatology 2005;210(2):109-14. doi: 10.1159/000082565. PMID: 15724092
Van Der Helm-Van Mil AH, Smith AC, Pouria S, Tarelli E, Brunskill NJ, Eikenboom HC
Br J Haematol 2003 Sep;122(6):915-7. doi: 10.1046/j.1365-2141.2003.04539.x. PMID: 12956761
Baccarelli A, Mocarelli P, Patterson DG Jr, Bonzini M, Pesatori AC, Caporaso N, Landi MT
Environ Health Perspect 2002 Dec;110(12):1169-73. doi: 10.1289/ehp.021101169. PMID: 12460794Free PMC Article

Therapy

Zhang X, Wang Y, Yarbrough J, Mathur M, Andrews L, Pereira B, Sloan SE, Schachter AD
Clin Pharmacol Drug Dev 2023 Dec;12(12):1211-1220. Epub 2023 Aug 11 doi: 10.1002/cpdd.1316. PMID: 37565623
Williams LD, Shen X, Sawant SS, Akapirat S, Dahora LC, Tay MZ, Stanfield-Oakley S, Wills S, Goodman D, Tenney D, Spreng RL, Zhang L, Yates NL, Montefiori DC, Eller MA, Easterhoff D, Hope TJ, Rerks-Ngarm S, Pittisuttithum P, Nitayaphan S, Excler JL, Kim JH, Michael NL, Robb ML, O'Connell RJ, Karasavvas N, Vasan S, Ferrari G, Tomaras GD; RV305 study team
PLoS Pathog 2023 May;19(5):e1011359. Epub 2023 May 31 doi: 10.1371/journal.ppat.1011359. PMID: 37256916Free PMC Article
Araújo RS, Silveira ALM, de Sales E Souza ÉL, Freire RH, de Souza CM, Reis DC, Costa BRC, Sugimoto MA, Silveira JN, Dos Santos Martins F, Cassali GD, Leite JIA, Sousa LP, Ferreira AVM, Oliveira MC, Cardoso VN
Eur J Pharm Sci 2017 Aug 30;106:142-151. Epub 2017 May 22 doi: 10.1016/j.ejps.2017.05.046. PMID: 28546107
Akdis M, Akdis CA
J Allergy Clin Immunol 2007 Apr;119(4):780-91. Epub 2007 Feb 26 doi: 10.1016/j.jaci.2007.01.022. PMID: 17321578
Baccarelli A, Mocarelli P, Patterson DG Jr, Bonzini M, Pesatori AC, Caporaso N, Landi MT
Environ Health Perspect 2002 Dec;110(12):1169-73. doi: 10.1289/ehp.021101169. PMID: 12460794Free PMC Article

Prognosis

Borysenko A, Timokhina T, Kononova O
Georgian Med News 2021 Oct;(319):22-27. PMID: 34749317
Borysenko A, Timokhina T, Kononova O
Georgian Med News 2021 Jan;(310):48-54. PMID: 33658409
Li XH, Huang XP, Pan L, Wang CY, Qin J, Nong FW, Luo YZ, Wu Y, Huang YM, Peng X, Yang ZH, Liao YH
BMC Nephrol 2016 Nov 2;17(1):164. doi: 10.1186/s12882-016-0378-4. PMID: 27806690Free PMC Article
Oh YJ, An JN, Kim CT, Yang SH, Lee H, Kim DK, Joo KW, Paik JH, Kang SW, Park JT, Lim CS, Kim YS, Lee JP
PLoS One 2015;10(7):e0132826. Epub 2015 Jul 15 doi: 10.1371/journal.pone.0132826. PMID: 26177311Free PMC Article
Baccarelli A, Mocarelli P, Patterson DG Jr, Bonzini M, Pesatori AC, Caporaso N, Landi MT
Environ Health Perspect 2002 Dec;110(12):1169-73. doi: 10.1289/ehp.021101169. PMID: 12460794Free PMC Article

Clinical prediction guides

Gaber M, Wilson AS, Millen AE, Hovey KM, LaMonte MJ, Wactawski-Wende J, Ochs-Balcom HM, Cook KL
Microbiome 2024 Oct 4;12(1):192. doi: 10.1186/s40168-024-01901-1. PMID: 39367431Free PMC Article
Ma EZ, Deng J, Parthasarathy V, Lee KK, Pritchard T, Guo S, Zhang C, Kwatra MM, Le A, Kwatra SG
Front Immunol 2024;15:1354128. Epub 2024 Mar 15 doi: 10.3389/fimmu.2024.1354128. PMID: 38558806Free PMC Article
Williams LD, Shen X, Sawant SS, Akapirat S, Dahora LC, Tay MZ, Stanfield-Oakley S, Wills S, Goodman D, Tenney D, Spreng RL, Zhang L, Yates NL, Montefiori DC, Eller MA, Easterhoff D, Hope TJ, Rerks-Ngarm S, Pittisuttithum P, Nitayaphan S, Excler JL, Kim JH, Michael NL, Robb ML, O'Connell RJ, Karasavvas N, Vasan S, Ferrari G, Tomaras GD; RV305 study team
PLoS Pathog 2023 May;19(5):e1011359. Epub 2023 May 31 doi: 10.1371/journal.ppat.1011359. PMID: 37256916Free PMC Article
Borysenko A, Timokhina T, Kononova O
Georgian Med News 2021 Oct;(319):22-27. PMID: 34749317
Chen XQ, Tu L, Zou JS, Zhu SQ, Zhao YJ, Qin YH
Front Immunol 2021;12:668974. Epub 2021 Sep 3 doi: 10.3389/fimmu.2021.668974. PMID: 34539623Free PMC Article

Recent systematic reviews

Baccarelli A, Mocarelli P, Patterson DG Jr, Bonzini M, Pesatori AC, Caporaso N, Landi MT
Environ Health Perspect 2002 Dec;110(12):1169-73. doi: 10.1289/ehp.021101169. PMID: 12460794Free PMC Article

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