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Decreased circulating IgG concentration

MedGen UID:
1720114
Concept ID:
C5234937
Finding
Synonym: IgG deficiency
 
HPO: HP:0004315
Monarch Initiative: MONDO:0045045

Definition

An abnormally decreased level of immunoglobulin G (IgG) in blood. [from HPO]

Conditions with this feature

Professional guidelines

PubMed

Benschop RJ, Chow CK, Tian Y, Nelson J, Barmettler B, Atwell S, Clawson D, Chai Q, Jones B, Fitchett J, Torgerson S, Ji Y, Bina H, Hu N, Ghanem M, Manetta J, Wroblewski VJ, Lu J, Allan BW
MAbs 2019 Aug/Sep;11(6):1175-1190. Epub 2019 Jun 10 doi: 10.1080/19420862.2019.1624463. PMID: 31181988Free PMC Article
Michiels JJ, Budde U, van der Planken M, van Vliet HH, Schroyens W, Berneman Z
Best Pract Res Clin Haematol 2001 Jun;14(2):401-36. doi: 10.1053/beha.2001.0141. PMID: 11686107
Pacifici R, Paris L, Di Carlo S, Pichini S, Zuccaro P
Epilepsia 1991 Jan-Feb;32(1):122-7. doi: 10.1111/j.1528-1157.1991.tb05622.x. PMID: 1985820

Recent clinical studies

Etiology

Roy A, Saade C, Josset L, Clément B, Morfin F, Destras G, Valette M, Icard V, Billaud G, Oblette A, Debombourg M, Garrigou C, Brengel-Pesce K, Generenaz L, Saker K, Hernu R, Pozzetto B, Lina B, Trabaud MA, Trouillet-Assant S, Bal A
J Med Virol 2023 Aug;95(8):e28984. doi: 10.1002/jmv.28984. PMID: 37503561
Cianci R, Mancino G, Galli E, Serone E, Massoud R, D'Addabbo P, Poscia A, Borghetti A, Porzio O, Marmo R, Gambassi G, Frezza D
Gene 2023 Apr 30;862:147254. Epub 2023 Feb 9 doi: 10.1016/j.gene.2023.147254. PMID: 36764340
Borysenko A, Timokhina T, Kononova O
Georgian Med News 2021 Oct;(319):22-27. PMID: 34749317
Cuculiza Henriksen A, Ammitzbøll C, Petersen ER, McWilliam O, Sellebjerg F, von Essen MR, Romme Christensen J
Mult Scler Relat Disord 2021 Jul;52:102987. Epub 2021 May 1 doi: 10.1016/j.msard.2021.102987. PMID: 33984651
Nived P, Pettersson Å, Jönsson G, Bengtsson AA, Settergren B, Skattum L, Johansson Å, Kapetanovic MC
Sci Rep 2021 Apr 28;11(1):9199. doi: 10.1038/s41598-021-88491-2. PMID: 33911135Free PMC Article

Diagnosis

Roy A, Saade C, Josset L, Clément B, Morfin F, Destras G, Valette M, Icard V, Billaud G, Oblette A, Debombourg M, Garrigou C, Brengel-Pesce K, Generenaz L, Saker K, Hernu R, Pozzetto B, Lina B, Trabaud MA, Trouillet-Assant S, Bal A
J Med Virol 2023 Aug;95(8):e28984. doi: 10.1002/jmv.28984. PMID: 37503561
Jamialahmadi T, Baratzadeh F, Reiner Ž, Mannarino MR, Cardenia V, Simental-Mendía LE, Pirro M, Watts GF, Sahebkar A
Oxid Med Cell Longev 2022;2022:7850659. Epub 2022 Aug 1 doi: 10.1155/2022/7850659. PMID: 35958018Free PMC Article
Li X, Wan X, Liu J, Wang H, Li A, Ke C, Tang S, Zhao W, Cai S, Wan C
Microbiol Spectr 2022 Apr 27;10(2):e0149621. Epub 2022 Mar 21 doi: 10.1128/spectrum.01496-21. PMID: 35311573Free PMC Article
Baccarelli A, Mocarelli P, Patterson DG Jr, Bonzini M, Pesatori AC, Caporaso N, Landi MT
Environ Health Perspect 2002 Dec;110(12):1169-73. doi: 10.1289/ehp.021101169. PMID: 12460794Free PMC Article
Gurka G, Rocklin RE
JAMA 1987 Nov 27;258(20):2983-7. PMID: 3312681

Therapy

Zhang X, Wang Y, Yarbrough J, Mathur M, Andrews L, Pereira B, Sloan SE, Schachter AD
Clin Pharmacol Drug Dev 2023 Dec;12(12):1211-1220. Epub 2023 Aug 11 doi: 10.1002/cpdd.1316. PMID: 37565623
Jamialahmadi T, Baratzadeh F, Reiner Ž, Mannarino MR, Cardenia V, Simental-Mendía LE, Pirro M, Watts GF, Sahebkar A
Oxid Med Cell Longev 2022;2022:7850659. Epub 2022 Aug 1 doi: 10.1155/2022/7850659. PMID: 35958018Free PMC Article
Nived P, Pettersson Å, Jönsson G, Bengtsson AA, Settergren B, Skattum L, Johansson Å, Kapetanovic MC
Sci Rep 2021 Apr 28;11(1):9199. doi: 10.1038/s41598-021-88491-2. PMID: 33911135Free PMC Article
Akdis M, Akdis CA
J Allergy Clin Immunol 2007 Apr;119(4):780-91. Epub 2007 Feb 26 doi: 10.1016/j.jaci.2007.01.022. PMID: 17321578
Sinitsyn VV, Mamontova AG, Checkneva YY, Shnyra AA, Domogatsky SP
J Nucl Med 1989 Jan;30(1):66-9. PMID: 2911044

Prognosis

Borysenko A, Timokhina T, Kononova O
Georgian Med News 2021 Oct;(319):22-27. PMID: 34749317
Schiffner J, Backhaus I, Rimmele J, Schulz S, Möhlenkamp T, Klemens JM, Zapf D, Solbach W, Mischnik A
Front Public Health 2021;9:732787. Epub 2021 Sep 27 doi: 10.3389/fpubh.2021.732787. PMID: 34646805Free PMC Article
Dittadi R, Afshar H, Carraro P
Diagn Microbiol Infect Dis 2021 Apr;99(4):115297. Epub 2020 Dec 24 doi: 10.1016/j.diagmicrobio.2020.115297. PMID: 33388574Free PMC Article
Baccarelli A, Mocarelli P, Patterson DG Jr, Bonzini M, Pesatori AC, Caporaso N, Landi MT
Environ Health Perspect 2002 Dec;110(12):1169-73. doi: 10.1289/ehp.021101169. PMID: 12460794Free PMC Article
Hed J
Acta Paediatr Suppl 1998 Jun;424:37-40. doi: 10.1111/j.1651-2227.1998.tb01231.x. PMID: 9736216

Clinical prediction guides

Roy A, Saade C, Josset L, Clément B, Morfin F, Destras G, Valette M, Icard V, Billaud G, Oblette A, Debombourg M, Garrigou C, Brengel-Pesce K, Generenaz L, Saker K, Hernu R, Pozzetto B, Lina B, Trabaud MA, Trouillet-Assant S, Bal A
J Med Virol 2023 Aug;95(8):e28984. doi: 10.1002/jmv.28984. PMID: 37503561
Borysenko A, Timokhina T, Kononova O
Georgian Med News 2021 Oct;(319):22-27. PMID: 34749317
Cuculiza Henriksen A, Ammitzbøll C, Petersen ER, McWilliam O, Sellebjerg F, von Essen MR, Romme Christensen J
Mult Scler Relat Disord 2021 Jul;52:102987. Epub 2021 May 1 doi: 10.1016/j.msard.2021.102987. PMID: 33984651
Benschop RJ, Chow CK, Tian Y, Nelson J, Barmettler B, Atwell S, Clawson D, Chai Q, Jones B, Fitchett J, Torgerson S, Ji Y, Bina H, Hu N, Ghanem M, Manetta J, Wroblewski VJ, Lu J, Allan BW
MAbs 2019 Aug/Sep;11(6):1175-1190. Epub 2019 Jun 10 doi: 10.1080/19420862.2019.1624463. PMID: 31181988Free PMC Article
Nieman DC, Nehlsen-Cannarella SL
Sports Med 1991 Mar;11(3):183-201. doi: 10.2165/00007256-199111030-00003. PMID: 2047622

Recent systematic reviews

Jamialahmadi T, Baratzadeh F, Reiner Ž, Mannarino MR, Cardenia V, Simental-Mendía LE, Pirro M, Watts GF, Sahebkar A
Oxid Med Cell Longev 2022;2022:7850659. Epub 2022 Aug 1 doi: 10.1155/2022/7850659. PMID: 35958018Free PMC Article
Baccarelli A, Mocarelli P, Patterson DG Jr, Bonzini M, Pesatori AC, Caporaso N, Landi MT
Environ Health Perspect 2002 Dec;110(12):1169-73. doi: 10.1289/ehp.021101169. PMID: 12460794Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

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