GEO DataSets

(Submitter supplied) Aminoglycosides remain in current use because of the benefits, including the broad-spectrum, inexpensiveness to produce, and a relatively small incidence of allergic reactions. However, aminoglycosides may induce irreversible hearing loss. Recently, tacrine, an acetylcholineesterase inhibitor originally developed to treat Alzheimer’s disease, was found to be protective to neomycin-induced hair cell damage in zebrafish and mouse. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

9 Samples

Download data: TXT

(Submitter supplied) To investigate the effects of Aflatoxin B1 on gene expressions in zebrafish embryos.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

2 Samples

Download data: TXT

(Submitter supplied) We compared transcriptional changes between 1) Control vs. 96 hours post cardiac cryoinjury (hpci) and 2) Control vs. 96 hours post physical exercise.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

2 Samples

Download data: TXT

(Submitter supplied) Zebrafish gata4/5/6 are known to lie on the apex of the regulatory hierarchy in primitive myelopoiesis. However, little is known about the roles of microRNAs in this process. Performing microarray analysis on the expression changes of microRNAs in the gata4/5/6 knockdown embryos, we found that miR-210-5p is a novel regulator in zebrafish primitive myelopoiesis. To uncover the target genes of miR-210-5p to mediate its role in inhibiting zebrafish primitive myelopoiesis, we performed microarray analysis to identify differentially expressed genes in gata4/5/6 knockdown embryos.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

5 Samples

Download data: TXT

(Submitter supplied) IGF2BPs, a subclass of RNA-binding proteins, regulate cellular differentiation, proliferation and migration during mutiple organs development, but its function still remains unclear. Here, we provide the in vivo evidence that Igf2bp1 is pivotal during liver development by using zebrafish as a model organism. Whole-mount in situ hybridization showed that igf2bp1 was highly expressed in liver, and the morpholino knockdown had no effect on hepatoblast differentiation, but the liver size was significantly reduced. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

2 Samples

Download data: TXT

(Submitter supplied) The lens of the eye is consisted of lens fiber cells that undergo large-scale organelle degradation during terminal differentiation. To understand the molecular mechanism of large-scale organelle degradation, we compared the gene expression profiles between the lens and body without eyes of larval zebrafish using a microarray analysis.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

2 Samples

Download data: TXT

(Submitter supplied) Imatinib mesylate (IM) a protein kinase inhibitor drug that selectively inhibits certain oncogenic mutant protein tyrosine kinases. After application, IM is via hospital and municipal waste water effluents released into the aquatic environment, where it can harm non-target organisms. The aim of this study was to evaluate changes in gene transcription in liver of adult F1 zebrafish (Danio rerio) continuously exposed to IM at environmentaly relevant concentrations of 0.01 µg/L and 1 µg/L.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

18 Samples

Download data: TXT

(Submitter supplied) RNASET2-deficient leukoencephalophathy is a severe leukodystrophy affecting children with psychomotor impairements in their forst year of life. We generated the first zebrafish model for a human leukodystrophy by targetting the ortholog rnaset2 gene using mutagenesis. This zebrafish mutant recapitulated the human clinical manisfestations and developed white matter defects detectable by MRI. Additionally, this zebrafish mutant identified this disease as a lysosomal storage disorders, with RNA accumulating in neurons. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

20 Samples

Download data: TXT

(Submitter supplied) We employed DNA microarray to figure out the possible mechanism of BBR on zebrafish NAFLD model

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

3 Samples

Download data: TXT

(Submitter supplied) Synthetic progestins are widely used in human and veterinary medicine. They can enter aquatic environments mainly via wastewater discharge and agricultural runoff, thus affecting fish populations in receiving waters. Here we investigated the chronic effects of dydrogesterone (DDG) on zebrafish from 21 days post fertilization (dpf) to 140 dpf at 5, 50 and 500 ng L-1.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

32 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Danio rerio

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL18413 GPL14664

16 Samples

Download data: TXT

(Submitter supplied) Zebrafish can regenerate their hearts. As a first response to injury, the epicardium reacts by upregulalion of developmental marker genes. Here we compared in an unbiased manner the expression of the epicardium from uninjured zebrafish hearts and hearts at 3 days postcryoinjury. To label epicardial cells of uninjured hearts we usd pard3:GFP (POon et al 2010) and to label epicardium of the injured heart wt1b:eGFP (Perner et al 2007)

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

8 Samples

Download data: TXT, XLS

(Submitter supplied) Few works have addressed the effects provoked by the exposure to cadmium containing nanoparticles (NPs) on adult zebrafish (Danio rerio). We studied the effects of CdS NPs (5 nm) or ionic cadmium (10 µg Cd/L) after 3 and 21 d of exposure and at 6 months post-exposure (mpe). Acute toxicity was recorded after exposure to both forms of cadmium. Significant cadmium accumulation was measured in the whole fish after both treatments and autometallography showed a higher accumulation of metal in the intestine than that in the liver. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

22 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

28 Samples

Download data: GPR, PDF

(Submitter supplied) Vertebrate eye devlopment is partially regulated by thyroid hormones. TBBPA is a chemical that interacts with thyroid receptors. We investigated the effects of TBBPA on eye development of zebrafish. We expected TBBPA exposure to cause transcriptional changes of visual-system-related genes, which find their phenotypic anchoring in eye malformations and dysfunction, as observed in our previous studies. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

14 Samples

Download data: GPR

(Submitter supplied) Vertebrate eye devlopment is partially regulated by thyroid hormones. Propylthiouracyl is a pharmaceutical that lowers thyroid hormone levels. We investigated the effects of PTU on eye development of zebrafish. We expected PTU exposure to cause transcriptional changes of visual-system-related genes, which find their phenotypic anchoring in eye malformations and dysfunction, as observed in our previous studies. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

14 Samples

Download data: GPR

(Submitter supplied) We applied zebrafish whole genome microarrays to identify molecular effects of suvorexant, imipramine and a orexin antagonist from natural plant. Behavioral assays were performed to analyze for correlations between altered gene expression with effects on the organism level. Central nervous system drug induced gene expression in larval zebrafish brain was measured at 3 hours after exposure of 1uM suvorexant, 1uM imipramine, 10uM 8beta-(4'-Hydroxytigloyloxy) costunolide or 100uM 8beta-(4'-Hydroxytigloyloxy) costunolide. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

15 Samples

Download data: TXT

(Submitter supplied) For the toxicological risk assessment of genetically modified (GM) food components, the European Food Safety Agency advises to use an adapted version of the 90-day oral toxicity study in rodents, originally designed for the toxicity testing of chemicals. Since in GM crop testing scenarios the crop under evaluation is specifically intended as a food / feed component, some testing aspects are conceptually different from testing chemical compounds and thus need careful consideration. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

12 Samples

Download data: GPR

(Submitter supplied) Adult zebrafish hepatic mRNA expression following 24 hour static exposure to 130 ng/L PCB-126 or 20 ppm (v/v) acetone vehicle control.

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

36 Samples

Download data: TXT

(Submitter supplied) Zebrafish Mycobacterium marinum infection has been widely used to model human tuberculosis because these two diseases share common features, e.g. latency, granuloma formation and reactivation. Here we infected adult zebrafish with a low dose of M. marinum, which usually leads to a chronic infection. At 14 days post infection we performed microarray analysis to characterize the immune response against this infection. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL14664

5 Samples

Download data: TXT