GPL21272[Accession] - GEO DataSets

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Select item 2001094281.

Primary mesenchymal cells from the human fallopian tube infected with Chlamydia trachomatis

(Submitter supplied) We profiled metabolite changes upon C.trachomatis infection in primary human cells in order to identify rewiring of metabolite networks due to infection. In addition, gene expression micro array analyses were used to determine concurrent transcriptional regulation.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21272
9 Samples

Download data: TXT

Series

Accession:: GSE109428

ID:: 200109428

Analyze with GEO2R

Select item 2001724262.

Gene expression profiles of human patient derived ectocervical stem cells and 3D organoids with and without Chlamydia trachomatis infection

(Submitter supplied) Coinfections with pathogenic microbes continually confront cervical mucosa, yet their implications in pathogenesis remain unclear. Lack of in-vitro models recapitulating cervical epithelium has been a bottleneck to study coinfections. Using patient-derived ectocervical organoids, we systematically modelled individual and coinfection dynamics of Human papillomavirus (HPV)16 E6E7 and Chlamydia, associated with carcinogenesis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21272
24 Samples

Download data: TXT

Series

Accession:: GSE172426

ID:: 200172426

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001250193.

Gene expression signatures after immunisation with an HIV-1 recombinant Vesicular Stomatitis Virus (VSV) vaccine following three priming doses of IL-12 pDNA enhanced HIV-1 multi-antigen pDNA vaccine (BIOVACSAFE protocol HVTN087)

(Submitter supplied) The time course of whole blood gene expression was measured after the fourth immunisation at month 6 in participants who had been randomised into vaccine or placebo group 1 of the clinical protocol HVTN087 - A phase 1 trial to evaluate the safety, tolerability, and immunogenicity of an IL-12 pDNA enhanced HIV-1 multi-antigen pDNA vaccine delivered intramuscularly with electroporation, with an HIV-1 rVSV vaccine boost, in healthy HIV-uninfected adult participants (NCT01578889).

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21272
108 Samples

Download data: TXT

Series

Accession:: GSE125019

ID:: 200125019

Analyze with GEO2R

Select item 2001248424.

Gene expression signatures after immunisation with Boostrix - alum adsorbed tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine (BIOVACSAFE protocol 305D2)

(Submitter supplied) The time course of whole blood gene expression was determined in healthy adult human participants who were randomised to receive either a single intramuscular immunisation with Boostrix vaccine (characteristics: treatment = BOOSTRIX) or equivalent volume saline control (characteristics: treatment = PLACEBOD2). Participants are identified who reported having had an immunisation with Boostrix within the past 5 years (characteristics: recent boostrix = 1).

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21272
1197 Samples

Download data: CSV, TXT

Series

Accession:: GSE124842

ID:: 200124842

Analyze with GEO2R

Select item 2001565445.

Epithelial response to IFN-γ promotes SARS-CoV-2 infection

(Submitter supplied) SARS-CoV-2, the agent causing COVID-19, invades epithelial cells, including those of the respiratory and gastrointestinal mucosa, using angiotensin-converting enzyme-2 (ACE2) as a receptor. Subsequent inflammation can promote rapid virus clearance. However, severe cases of COVID-19 are characterized by an inefficient immune response that fails to clear infection. Using primary epithelial organoids from the colon, we explored how IFN-γ, a central antiviral mediator elevated in COVID-19, affects differentiation, ACE2 expression, and infectivity with SARS-CoV-2. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21272
8 Samples

Download data: TXT

Series

Accession:: GSE156544

ID:: 200156544

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001006566.

Gene expression profiles of primary human gall bladder epithelial cells with and without infection with S.paratyphi WT and ∆cdtB mutant for 2 and 7 days

(Submitter supplied) We have successfully established organoid culture model for human and murine gall bladder (GB) epithelial cells allowing long-time culture of primary epithelial cells. This model was used to analyze factors influencing stemness and to study infection with Salmonella paratyphi and its toxin Cdtb.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL21272 GPL4133
20 Samples

Download data: TXT

Series

Accession:: GSE100656

ID:: 200100656

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001247197.

Gene expression signatures in blood and muscle biopsy after intramuscular immunization of healthy adult humans with adjuvanted vaccines (BIOVACSAFE protocol 305E)

(Submitter supplied) The gene expression in whole blood and simultaneous muscle biopsy (site of immunization and control contralateral non-injected leg) was measured in healthy adult male humans attending a research unit (CRC, University of Surrey, UK), who were randomized to receive a single immunization with an adjuvanted licensed vaccine or saline placebo control.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21272
179 Samples

Download data: TXT

Series

Accession:: GSE124719

ID:: 200124719

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001246898.

Gene expression signatures after immunisation with MF59C adjuvanted trivalent inactivated influenza vaccine for season 2014-2015 Northern hemisphere (BIOVACSAFE protocol 305D)

(Submitter supplied) The time course of whole blood gene expression was determined in healthy adult participants who were randomised to receive either a single intramuscular immunisation with MF59C adjuvanted influenza vaccine (FLUADD) or equivalent volume saline control (PLACEBOD).

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21272
598 Samples

Download data: CSV, TXT

Series

Accession:: GSE124689

ID:: 200124689

Analyze with GEO2R

Select item 2000870769.

Gene expression profiles of cultured stem cells and organoids from the uterine cervix of human and mouse

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL13912 GPL21272
24 Samples

Download data: TXT

Series

Accession:: GSE87076

ID:: 200087076

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008707410.

Gene expression profiles of human cervical primary cells from ecto- and endocervix

(Submitter supplied) The cellular origin of cervical cancers remains unclear. Revealing molecular details of transformation in this tissue has been hampered by the lack of culture systems, resembling the in vivo cervical architecture. Here we established a long-term in vitro 3D cervical organoid model derived from stem cells of human or mouse cervical tissue which recapitulates the in vivo stratified ectocervical and columnar endocervical epithelium. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21272
16 Samples

Download data: TXT

Series

Accession:: GSE87074

ID:: 200087074

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010771211.

Chronic Chlamydia infection in fallopian tube organoids alters epithelial differentiation and accelerate methylation changes

(Submitter supplied) Chlamydia trachomatis (Ctr) is able to colonize the human fallopian tube, causing scarring and inflammation, which can lead to infertility. Here we describe a chronic Ctr infection model using human fallopian tube organoids. The defense response of the organoids to infection includes active expulsion of the bacteria from the apical side of the epithelium and compensatory cellular proliferation, clearly demonstrating a role for core mechanisms of epithelial homeostasis in defense against this invading pathogen. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL10332 GPL6480 GPL21272
46 Samples

Download data: TXT

Series

Accession:: GSE107712

ID:: 200107712

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012453312.

Gene expression signatures after immunisation with a range of live, inactivated and adjuvanted vaccines (BIOVACSAFE protocols 305A, 305B and 305C)

(Submitter supplied) The time course of whole blood gene expression was determined in healthy adult participants residing in an inpatient unit (CRC, University of Surrey, UK) to minimise background environmental variation, who were randomised into three protocols (305A, 305B and 305C) with study groups within each protocol (n = 20/21) receiving a single immunisation with a licensed vaccine or saline placebo control.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21272
1606 Samples

Download data: CSV, TXT

Series

Accession:: GSE124533

ID:: 200124533

Analyze with GEO2R

Select item 20008644913.

Gene expression profile of human lung epithelial cells with different culture methods.

(Submitter supplied) The goal of our study is to establish a method to propagate human pneumocytes efficiently in a large scale. While human pneumectomy-derived lung epithelial cells (LECs) showed efficient long-term growth when co-cultured with irradiated NIH-3T3, they do not express molecular markers of mature pneumocytes or airway cells in this condition. Removal of feeders causes differentiation toward airway club cell-like phenotype, and an induction treatment with combination of small molecules and growth factors is required to differentiate them toward pneumocytes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21272
8 Samples

Download data: TXT

Series

Accession:: GSE86449

ID:: 200086449

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009403214.

Air Liquid Interface Model of Gastric Mucosa and H.pylori Infection

(Submitter supplied) The Air Liquid Interface Model of Gastric Mucosa allows to provide a fully polarized epithelium accessible to infection experiments with H.pylori. The influence of several factors on immune response has been studied.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21272
12 Samples

Download data: TXT

Series

Accession:: GSE94032

ID:: 200094032

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010375515.

Cell Cycle Proteins Control Production of Neutrophil Extracellular Traps (NETs)

(Submitter supplied) Microarray expression profiling of unstimulated human neutrophils from 8 healthy donors

Organism:: Homo sapiens

Type:: Expression profiling by array; Non-coding RNA profiling by array

Platform:: GPL21272
8 Samples

Download data: TXT

Series

Accession:: GSE103755

ID:: 200103755

Select item 20008662716.

Safety and immunogenicity of the recombinant BCG vaccine VPM1002, in South African infants

(Submitter supplied) Differential gene expression in human whole blood before and at 5 different timepoints following vaccination with BCG or VPM1002

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL21272
119 Samples

Download data: TXT

Series

Accession:: GSE86627

ID:: 200086627

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 10002357217.

Agilent-048908 8x60K whole genome incl V1-V2 linc BioVacSafe final 048908 [Probe Name version]

(Submitter supplied) Mattick linc BROAD linc Arrays of this design have barcodes that begin with 16048908 or 2548908. Protocol: See manufacturer's web site at: http://www.agilent.com/

Organism:: Homo sapiens

5 Series
1 Related Platform
290 Samples

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Platform

Accession:: GPL23572

ID:: 100023572

Select item 10002127218.

Agilent-048908 8x60K whole genome incl V1-V2 linc BioVacSafe final 048908 [Feature Number version]

(Submitter supplied) Mattick linc BROAD linc Arrays of this design have barcodes that begin with 16048908 or 2548908. Orientation: Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software. The ID column represents the Agilent Feature Extraction feature number. more...