GPL26853[Accession] - GEO DataSets

Search results

Items: 1 to 20 of 1154

<< First< Prev

Page of 58

Select item 2002769541.

A single-nucleus census of immune and non-immune cell types for the major immune organ systems of chicken

(Submitter supplied) In the avian host, comprehensively cataloging immune cell types, their transcriptome profiles, and varying molecular responses to pathogen challenges are necessary steps toward a better understanding of the interplay between genetics and disease resilience. We present a first nuclei atlas of immune cell types derived from the three main immune organs of layer chickens, including spleen, bursa, and thymus. more...

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
2 Samples

Download data: H5

Series

Accession:: GSE276954

ID:: 200276954

Select item 2002557602.

Integrative 3D Genomics with Multi-Omics Analysis and Functional Validation of Genetic Regulatory Mechanisms of Abdominal Fat Deposition in Chickens (ATAC-seq).

(Submitter supplied) Chickens are the most abundant agricultural animals globally, with controlling abdominal fat deposition (AFD) being a key objective in poultry breeding. While GWAS can identify genetic variants associated with AFD traits, the precise roles and mechanisms of these variants remain largely unclear. This study used two distinct chicken lines, selectively bred for differing AFD, as experimental models. Through the integration of genomic, epigenomic, 3D genomic, and transcriptomic data, a comprehensive chromatin 3D regulatory network map was developed to reveal the genetic regulatory mechanisms that influence AFD traits. more...

Organism:: Gallus gallus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL26853
6 Samples

Download data: NARROWPEAK

Series

Accession:: GSE255760

ID:: 200255760

Select item 2002722253.

In vitro assessment of the immunomodulatory effects of probiotic Bacillus strains on chicken PBMCs

(Submitter supplied) The beneficial effects of feeding probiotic Bacillus subtilis DSM 32315 (BS) and Bacillus velezensis CECT 5940 (BV) to chickens in vivo are well-documented, with potential immune modulation as a key mechanism. In this study, we investigated the direct interactions of chicken peripheral blood mononuclear cells (PBMCs) with BS or BV in vitro through whole transcriptome profiling and cytokine array analysis. more...

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
24 Samples

Download data: TSV

Series

Accession:: GSE272225

ID:: 200272225

PubMed Full text in PMC Similar studies

Select item 2002588954.

Hox gene activity directs physical forces to differentially shape chick small and large intestinal epithelia

(Submitter supplied) Hox genes are highly conserved, master regulators of spatial patterning in the embryo, but how these factors trigger regional morphogenesis has largely remained a mystery. In the developing gut, Hox genes help demarcate identities of the small and large intestines early in embryogenesis, which ultimately leads to their specialization in both form and function. While the midgut forms villi, the hindgut develops flat, brain-like sulci that resolve into heterogeneous outgrowths. more...

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
5 Samples

Download data: FA, GTF, RDS

Series

Accession:: GSE258895

ID:: 200258895

Select item 2002709135.

Comprehensive transcriptome analysis of CIAV infected MDCC-MSB1 cells [RNA-seq]

(Submitter supplied) Chicken infectious anaemia (CIA) is an immunosuppressive disease caused by chicken infectious anaemia virus (CIAV). Due to immunosuppression, the disease is often leads to mixed infections and secondary infections, exacerbating viral, bacterial, and fungal infections, which can be highly detrimental. Therefore, it is imperative to identify the immune genes involved in regulating CIAV infection. In this study, comprehensive transcriptome sequencing was employed to determine the expression levels of regulated immune genes including mRNAs, microRNAs, lncRNAs, and circRNAs in CIAV-infected MDCC-MSB1 cells. more...

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
6 Samples

Download data: XLSX

Series

Accession:: GSE270913

ID:: 200270913

Select item 2002496526.

Host transcriptomic response to a bacterial toxin at single-nuclei resolution

(Submitter supplied) We are studying the host immune response to a bacterial toxin in the chicken spleen and bursa. We performed snRNAseq to analyze the various immune cell types that play a role in combating the infection and the cell-type transcriptional response.

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
10 Samples

Download data: MTX, TSV

Series

Accession:: GSE249652

ID:: 200249652

Select item 2002661197.

Influence of DNA-methylation at multiple stages of limb chondrogenesis

(Submitter supplied) Limb development is a well-established model for understanding cell fate decisions, and the formation of skeletal elements is coordinated through a sequence of events that control chondrogenesis spatiotemporally. It has been established that epigenetic control participates in cartilage maturation. Our research has shown for the first time that the inhibition of DNA methylation in interdigital tissue with 5-azacytidine results in the formation of an ectopic digit. more...

Organism:: Gallus gallus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL26853
4 Samples

Download data: TXT

Series

Accession:: GSE266119

ID:: 200266119

Select item 2002526168.

SOCS2 contributes to reduction of the third digit during development of the chicken forelimb

(Submitter supplied) We used the RCAS avian retrovirus to overexpress SOCS2 in the developing chicken limb buds and transcriptome sequencing (mRNA-Seq) revealed changes in expression of genes known to be associated with growth and development in forelimbs with overexpressed SOCS2.

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
2 Samples

Download data: TXT

Series

Accession:: GSE252616

ID:: 200252616

PubMed Full text in PMC Similar studies

Select item 2002546599.

Centromeric chromatin in mitosis reorganizes into a functional structure stabilized by cohesin [NG-Capture-C]

(Submitter supplied) Three-dimensional organization of mitotic chromosomes is established by cohesin and condensin complexes. In the centromere, cohesin maintains sister chromatid pairing until anaphase onset, while condensin provides elastic resistance to spindle forces. However, how condensin and cohesin structure vertebrate centromeres remains unclear. By super-resolution imaging, Capture-C analysis and polymer modeling we show that vertebrate centromeres are partitioned into two condensin-dependent subdomains during mitosis. more...

Organism:: Gallus gallus

Type:: Other

Platforms:: GPL19005 GPL26853
60 Samples

Download data: BEDGRAPH

Series

Accession:: GSE254659

ID:: 200254659

Select item 20025418210.

Centromeric chromatin in mitosis reorganizes into a functional structure stabilized by cohesin

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Gallus gallus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL32831 GPL19005 GPL26853
100 Samples

Download data: BEDGRAPH, BW

Series

Accession:: GSE254182

ID:: 200254182

Select item 20025418111.

Centromeric chromatin in mitosis reorganizes into a functional structure stabilized by cohesin [CENPA-ChIP-seq]

Organism:: Gallus gallus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL26853 GPL19005
8 Samples

Download data: BW

Series

Accession:: GSE254181

ID:: 200254181

Select item 20022645812.

Bulk RNA-sequencing of MYCN-overexpressing chicken retinal cell lines

(Submitter supplied) Background: MYCN gene is a transcription factor whose amplification and overexpression can lead to tumorigenesis. In retina, MYCN overexpression is related to tumorigenesis of retinoblastoma, a childhood cancer. Purpose: To find out differentially expressed genes in MYCN-overexpressing cells, which will give information of MYCN-related gene expression and possibly find out new pathways in mechanism of retinoblastoma tumorigenesis with MYCN overexpression. more...

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
12 Samples

Download data: TXT

Series

Accession:: GSE226458

ID:: 200226458

PubMed Full text in PMC Similar studies

Select item 20022432913.

Single-cell RNA seq mapping of chicken leukocytes

(Submitter supplied) The immune system is a complex infrastructure where many cells interact with each other and perform duties depending on their type and function. When using traditional immunological methods in studying non-traditional model organisms, such as birds, challenges arise. These are often associated with a lack of knowledge surrounding the organism in question—particularly, the expected leukocytes, their cell-specific marker genes, and associated reagents. more...

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
4 Samples

Download data: MTX, TSV, XLSX

Series

Accession:: GSE224329

ID:: 200224329

PubMed Full text in PMC Similar studies

Select item 20024699614.

Aberrant expression of the DCT gene is implicated in the hyperpigmentation of the visceral peritoneum of the chicken

(Submitter supplied) Hyperpigmentation of the visceral peritoneum (HVP) has recently garnered significant attention within the poultry industry due to its potential implications for the health of afflicted animals and its adverse effects on the appearance of commercial chicken carcasses. Unfortunately, the heritable characteristics of HVP are not yet fully understood. Motivated by poultry industry demand, we deployed multi-omics comparing the clinical HVP and normal samples profiling the potential regulating molecular landscape in cell and genome resolution, specifically, aiming to decipher the precise molecular genomic marker. more...

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE246996

ID:: 200246996

Select item 20022092115.

Newcastle disease virus activates methylation-related enzymes to reprogram m6A Methylation in infected cells

(Submitter supplied) To investigate the role of m6A modification during Newcastle disease virus (NDV) infection We then performed gene expression profiling analysis using data obtained from RNA-seq and MeRIP-seq of NDV infected CEF cells and normal cells.

Organism:: Gallus gallus

Type:: Other

Platform:: GPL26853
12 Samples

Download data: TXT

Series

Accession:: GSE220921

ID:: 200220921

Select item 20023690516.

Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL24517 GPL26853
37 Samples

Download data

Series

Accession:: GSE236905

ID:: 200236905

PubMed Similar studies

Select item 20023690317.

Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology [Multiome snRNA/snATAC]

(Submitter supplied) Ocular lens development entails epithelial to fiber cell differentiation, defects in which cause congenital cataract. We report the first single-cell multiomic atlas of lens development, leveraging snRNA-seq, snATAC-seq, and CUT&RUN-seq to discover novel mechanisms of cell fate determination and cataract-linked regulatory networks. A comprehensive profile of cis- and trans-regulatory interactions, including for the cataract-linked transcription factor MAF, is established across a temporal trajectory of fiber cell differentiation. more...

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL26853
4 Samples

Download data: H5

Series

Accession:: GSE236903

ID:: 200236903

PubMed Similar studies

Select item 20023690218.

Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology [scRNA-seq]

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24517 GPL26853
13 Samples

Download data: CSV, MTX

Series

Accession:: GSE236902

ID:: 200236902

PubMed Similar studies

Select item 20025168219.

Single-cell RNA transcriptome reveals heterogeneity and dynamics of cells during skeletal muscle development in different chicken breeds

(Submitter supplied) Different chicken breeds exhibit distinct muscle phenotypes resulting from selective breeding, but little is known about the molecular mechanisms responsible for this phenotypic difference. Skeletal muscle is composed of a large number of heterogeneous cell populations. Differences in differentiation and interaction of cell populations play a key role in the difference of skeletal muscle phenotype. Here, skeletal muscle single-cell RNA sequencing in three developmental stages was performed on Daheng broiler (cultivated breed) and Tibetan chicken (native breed).

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
6 Samples

Download data: MTX, TSV

Series

Accession:: GSE251682

ID:: 200251682

Select item 20022772420.

Daily Patterns of Retinal and Choroidal Gene Expression and Circadian Biology in Myopia Pathogenesis

(Submitter supplied) We investigated diurnal changes in gene expression in the retina and choroid at the onset of experimental myopia. We induced visual form deprivation myopia in young chicks, and isolated retinal and choroidal tissues separately in form- deprived and contralateral control eyes every 4 hours over a single 24-hour period.

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL26853
142 Samples

Download data: TXT

Series

Accession:: GSE227724

ID:: 200227724

PubMed Full text in PMC Similar studies

<< First< Prev

Page of 58

Next >Last >>

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Search results

Items: 1 to 20 of 1154

Send to:

Supplemental Content

Find related data

Search details

Important Links

Recent activity