GPL30172[RGSE] - GEO DataSets

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Select item 2002663601.

Intratumoral antigen-signalling traps CD8+ T cells to confine exhaustion to the tumour site (bulk TCR-Seq)

(Submitter supplied) Immunotherapy advances have been hindered by difficulties tracking the behaviours of lymphocytes following antigen-signalling. Here we present the antigen-receptor signalling reporter (AgRSR) mouse to fate-map lymphocytes responding to antigen at specific times and locations, to determine the behaviour of T cells involved in the tumour immune response. Contrary to reports of ready egress of T cells out of the tumour, we find that intratumoral antigen-signalling traps CD8+ T cells in the tumour. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL30172
44 Samples

Download data: CSV, TSV

Series

Accession:: GSE266360

ID:: 200266360

Select item 2002661092.

Different developmental pathways generate functionally distinct populations of natural killer cells

(Submitter supplied) Natural killer (NK) cells function by eliminating virus-infected cells or tumor cells. Here, we identified a NK lineage-biased progenitor population, termed early NK progenitors (ENKP), which developed into NK cells independently of common precursors for ILCs (ILCPs). ENKP-derived NK cells (ENKP_ NK cells) and ILCP-derived NK cells (ILCP_ NK cells) were also transcriptionally different. We devised combinations of surface markers that identified highly enriched ENKP_NK and ILCP_NK cell populations in wild-type mice. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL30172
5 Samples

Download data: H5, TXT

Series

Accession:: GSE266109

ID:: 200266109

Select item 2002676233.

Central nervous system-associated macrophages modulate the immune response following stroke in aged mice

(Submitter supplied) To study the differential role of central nervous system-associated macrophages (CAMs) in neuroinflammation after stroke between young and aged mice, we FACS sorted CD3-CD11b+CD45+CD206+ CAMs from brains of C57BL/6 mice aged 2 months (young) and 18 months (old)

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
6 Samples

Download data: SF

Series

Accession:: GSE267623

ID:: 200267623

Select item 2002670214.

Upregulation of inflammatory genes and pathways links obesity to severe COVID-19

(Submitter supplied) Obesity is a risk factor for developing severe COVID-19. However, the mechanism underlying obesity-accelerated COVID-19 remains unclear. Here, we report results from a study in which K18-hACE2 mice were fed an obesity-inducing western diet (WD) for over 3 months before intranasal infection with SARS-CoV2. After infection, the WD-fed K18-hACE2 mice lost more body weight and had more severe lung inflammation than normal chow (NC)-fed mice. more...

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL30172 GPL30173
24 Samples

Download data: TXT

Series

Accession:: GSE267021

ID:: 200267021

Select item 2002524885.

Deciphering lineage specification during early embryogenesis using integrative multi-layered proteomics [RNA-Seq]

(Submitter supplied) Gastrulation is a critical stage in embryonic development during which the germ layers are established. The advances and increasing availability of sequencing technologies led to the identification of gene regulatory programs that control the emergence of the germ layers and its derivatives. However, proteome-based studies of early mammalian development are scarce. To overcome this, we utilized gastruloids and a multilayered mass spectrometry-based proteomics approach to investigate the global dynamics of (phospho)protein expression during gastruloid differentiation. more...

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL30173 GPL30172
24 Samples

Download data: TSV

Series

Accession:: GSE252488

ID:: 200252488

Select item 2002290296.

Deciphering lineage specification during early embryogenesis in mouse gastruloids using integrative multi-layered proteomics

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL30172 GPL19057 GPL30173
44 Samples

Download data: MTX, NARROWPEAK, TSV

Series

Accession:: GSE229029

ID:: 200229029

Select item 2002609227.

Acetylation is not mere a consequence of transcription: histones are acetylated without ongoing transcription [ChIP-seq]

(Submitter supplied) In all eukaryotes, acetylation of histones lysine residues correlates with transcription activation. Whether histone acetylation is a cause or consequence of transcription is debated. One model suggests that transcription promotes the recruitment and/or activation of acetyltransferases and histone acetylation occurs as a consequence of ongoing transcription. However, the extent to which transcription shapes the global acetylation landscapes is not known. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL30172
6 Samples

Download data: BED, BW

Series

Accession:: GSE260922

ID:: 200260922

Select item 2002609698.

Acetylation is not mere a consequence of transcription: histones are acetylated without ongoing transcription

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL19057 GPL30172
8 Samples

Download data

Series

Accession:: GSE260969

ID:: 200260969

Select item 2002678009.

Transcriptomics profile of adipose and adipocyte with Gls perturbation

(Submitter supplied) We generated single nucleus transcriptomic atlas for white and brown adipose tissue from adipocyte-specific Gls knockout mouse, and also generated bulk RNA-seq from in vitro differentiated human white adipocytes with/without GLS knock down.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE267800

ID:: 200267800

Select item 20026727010.

Synthetic trimeric Interleukin-6 receptor complexes with a STAT3 phosphorylation dominated activation profile

(Submitter supplied) In Interleukin (IL)-6 signalling, IL-6 site I binds to the IL-6 receptor (IL-6R) first, following by IL-6 site II interaction to domain 2/3 of gp130 to form premature trimeric IL-6:IL‑6R:gp130 receptor complexes. Formation of the mature hexameric receptor complex is then facilitated by the inter-trimeric interaction of IL-6 site III with domain 1 of the opposing gp130. The two gp130-associated Janus kinases (JAKs) trans-phosphorylate when their spatiotemporal pairing is correct, which causes the activation of STAT, ERK, and AKT pathways in a balanced manner. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
16 Samples

Download data: XLSX

Series

Accession:: GSE267270

ID:: 200267270

Select item 20026231611.

Functional characterization of helminth-associated Clostridiales reveals covariates of Treg differentiation

(Submitter supplied) Background: Parasitic helminths influence the composition of the gut microbiome. However, the microbiomes of individuals living in helminth-endemic regions are understudied. The Orang Asli, an indigenous population in Malaysia with high burdens of the helminth Trichuris trichiura, display microbiotas enriched in Clostridiales, an order of spore-forming obligate anaerobes with immunogenic properties. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
12 Samples

Download data: TXT

Series

Accession:: GSE262316

ID:: 200262316

Select item 20023625812.

Trametinib sensitizes KRAS-mutant lung adenocarcinoma tumors to PD-1/PD-L1 axis blockade via Id1 downregulation

(Submitter supplied) The identification of novel therapeutic strategies to overcome the intrinsic or acquired resistance to trametinib in mutant KRAS lung adenocarcinoma (LUAD) is a major challenge. This study analyzes the effects of trametinib in Id1, a key factor involved in the oncogenic KRAS pathway, and investigates the Id1 role in acquire resistance and synergy with immunotherapy in KRAS-driven LUAD. Restoring the antitumor immune response by blocking programmed-cell death protein 1 (PD-1) and programmed-cell death-ligand 1 (PD-L1) pathway represents a major breakthrough in non-small-cell lung cancer (NSCLC) treatment. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
15 Samples

Download data: TXT

Series

Accession:: GSE236258

ID:: 200236258

Select item 20022799813.

TET2 Promotes Tumor Antigen Presentation and T Cell-Directed Tumor Cell Cytotoxicity Which is Enhanced by Vitamin C Treatment

(Submitter supplied) Immune evasion by tumors is promoted by low T cell infiltration, an immunosuppressive tumor microenvironment, poor T cell activity directed against the tumor, and reduced tumor antigen presentation. We showed previously that tumor expression of the DNA dioxygenase TET2 enhances recruitment of T cells through activating the expression of CXCL9, 10 and 11. Vitamin C treatment was shown to increase these effects in a TET2 dependent manner. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
12 Samples

Download data: H5

Series

Accession:: GSE227998

ID:: 200227998

Select item 20026718314.

GDF15 links beta-adrenergic induced lipolysis with anxiety

(Submitter supplied) Psychological stress activates the autonomic nervous system to protect organisms through an integrated response involving changes to both behavior and metabolism. Epinephrine is an important driver of this response, activating adipose tissue lipolysis3and inducing anxiety-like behavior. Interestingly, anxiety correlates with circulating free fatty acid levels and can be alleviated by a b-blocker that does not cross the blood brain barrier suggesting a peripheral signal linking metabolism with behavior, however, to date this has not been defined. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
12 Samples

Download data: TXT

Series

Accession:: GSE267183

ID:: 200267183

Select item 20026379015.

Single-cell RNAseq of mouse ventral prostate cells in steroid hormone imbalance

(Submitter supplied) We used scRNA-seq to study prostate cellular heterogeneity in mice impanted with testosterone and estradiol pellets.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
4 Samples

Download data: TSV

Series

Accession:: GSE263790

ID:: 200263790

Select item 20024770116.

Salivary Gland Tissue Recombination Can Modify Cell Fate

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL30172 GPL19057
26 Samples

Download data: H5

Series

Accession:: GSE247701

ID:: 200247701

Select item 20024770017.

Salivary Gland Tissue Recombination Can Modify Cell Fate [scRNA-seq]

(Submitter supplied) Although mesenchyme is essential for inducing the epithelium of ectodermal organs, its precise role in organ-specific epithelial fate determination remains poorly understood. To elucidate roles of tissue interactions in cellular differentiation, we performed single cell RNA sequencing and imaging analyses of recombined tissues in which embryonic mouse salivary gland mesenchyme and epithelium were switched ex vivo. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL30172 GPL19057
10 Samples

Download data: H5

Series

Accession:: GSE247700

ID:: 200247700

Select item 20023193118.

RNA-seq analysis of B cells cultured with LPS and IL-12 and/or IFN gamma

(Submitter supplied) Purpose: We aimed to find genes differentially regulated by IL-12 and IFNg alone, and in combination, over 4 and 24 hours of stimulation. Methods : Spleens were processed and B cell cultures prepared, in triplicate, according to the manuscript. After the indicated times, cells were washed in PBS, resuspended in 350 ul RLT Plus Buffer (Qiagen) with 1% 2-Me, and frozen at -80 ⁰C. Results: At 4 hours, the main effect of IL-12 is to induce IFNg production from B cells, whereas IFNg induces many gene changes. more...