GEO DataSets

(Submitter supplied) Inhibition of proteasome degradation pathway has been implicated in neuronal cell death leading to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease. Pharmacological proteasomal inhibitors such as lactacystin can induce apoptosis in cultured mouse cortical neurons through the activation of caspase-3. Furthermore, proteasomal inhibitors are also reported to mediate deleterious alterations in cell cycle regulation, inflammatory processes and protein aggregation and trigger the cell death pathway. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4138 GDS4140

Platforms:

GPL81 GPL32

10 Samples

Download data: CEL

Analysis of cultured cortical neurons treated with 1uM lactacystin for up to 48 hr. Lactacystin induces neuronal apoptosis. Results provide insight into molecular mechanisms underlying proteasomal inhibition-induced neuronal death.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL32

Series:

GSE22465

4 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by SAGE

Platforms:

GPL81 GPL32

16 Samples

Download data: CEL, CHP

(Submitter supplied) Identification of host responses at the gene transcription level provides a molecular profile of the events that occur following infection. Brucella abortus is a facultative intracellular pathogen of macrophages that induces chronic infection in humans and domestic animals. Using microarray technology, the response of macrophages 4 hours following B. abortus infection was analyzed to identify early intracellular infection events that occur in macrophages. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL32

5 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL32 GPL339

6 Samples

Download data

(Submitter supplied) Comparison of sense (forward probes) and antisense (reverse probes on U74 v1 gene arrays) transcripts in mouse kidney and brain. Positive calls related to antisense transcripts were compared to the cognate signals on the 430 version of mouse genome arrays to obtain genes that co expressed sense and antisense transcripts. This had to be done manually because divergent probe IDs on the two chip generations. more...

Organism:

Mus musculus

Type:

Expression profiling by array

5 related Platforms

7 Samples

Download data: CEL

(Submitter supplied) Parkinson's disease pathogenesis proceeds through several phases, culminating in the loss of dopaminergic neurons of the substantia nigra (SN). Although the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of oxidative SN injury is frequently used to study degeneration of dopaminergic neurons in mice and non-human primates, an understanding of the temporal sequence of molecular events from inhibition of mitochondrial complex 1 to neuronal cell death is limited. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2053

Platforms:

GPL32 GPL2892

23 Samples

Download data: CEL

Analysis of substantia nigrae (SN) injured by treatment with the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine at 1 and 7 days postlesion. Parkinson's disease (PD) culminates in the loss of dopaminergic neurons of the SN. Results provide insight into the pathogenesis of PD.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 3 time sets

Platform:

GPL32

Series:

GSE4788

12 Samples

Download data: CEL

(Submitter supplied) Cystic fibrosis, the most commonly inherited lethal pulmonary disorder in Caucasians, is caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). To identify genomic responses to the presence or absence of CFTR in pulmonary tissues in vivo, microarray analyses of lung mRNAs were performed on whole lung tissue from mice lacking (CFTR(-)) or expressing mouse CFTR (CFTR(+)). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1843

Platforms:

GPL81 GPL32

12 Samples

Download data

(Submitter supplied) LPS-stimulated macrophages from Pac1+/+ and Pac1-/- mice were compared to assess gene expression changes in the absence of PAC-1 (also known as Dual specificity phosphatase 2). Keywords: Comparison of Pac1+/+ with Pac1-/- activated macrophages

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL32

2 Samples

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(Submitter supplied) Mouse embryonic stem (ES) cells remain pluripotent in vitro when grown in presence of Leukaemia Inhibitory Factor (LIF). LIF starvation leads to apoptosis of some of the ES-derived differentiated cells, together with p38a MAP kinase activation. Apoptosis, but not morphological cell differentiation, is blocked by a p38 inhibitor, PD 169316. To further understand the mechanism of action of this compound, we have identified its specific targets by microarray studies. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1593 GDS1596

Platforms:

GPL32 GPL81

13 Samples

Download data: CEL, EXP

Analysis of embryonic stem cells differentiated in the presence of PD169316, an inhibitor of p38 that blocks apoptosis without altering differentiation. Results identify gene families whose transcriptional regulation correlates with cell fate: differentiation with or without apoptosis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 cell line sets

Platform:

GPL32

Series:

GSE2042

6 Samples

Download data: CEL, EXP

(Submitter supplied) Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, Song Y, Cohen P, Friedman JM, Attie AD. Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA. ntambi@biochem.wisc.edu Stearoyl-CoA desaturase (SCD) is a central lipogenic enzyme catalyzing the synthesis of monounsaturated fatty acids, mainly oleate (C18:1) and palmitoleate (C16:1), which are components of membrane phospholipids, triglycerides, wax esters, and cholesterol esters. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1374

Platform:

GPL32

10 Samples

Download data: CEL, EXP

Analysis of liver of 6 week old stearoyl-CoA desaturase 1 (SCD1) knockout females. SCD1 is a lipogenic enzyme that catalyzes the synthesis of monosaturated fatty acids. SCD1 null mutants have reduced body adiposity, increased insulin sensitivity, and are resistant to diet-induced weight gain.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL32

Series:

GSE2926

10 Samples

Download data: CEL, EXP

(Submitter supplied) This series represent several subgroups of experiments designed to investigate the role of basal immunoglobulin signaling in immature B cell development. The first subgroup of arrays (Ctrl Mhi, Cre Mhi, Cre Mlo) was done to identify the changes in gene expression in immature B cells as a consequence of inducible deletion of surface IgM expression via Cre-LoxP mediated excision of Ig heavy chain. The second subgroup of arrays (GFPneg, GFPpos, FxE Ctrl, FxE HA) was done to identify the changes in gene expression in immature B cells as a consequence of blockade of tyrosine kinase signaling with herbimycin A treatment. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL81 GPL32

49 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) Murine ES cells of different Srf genotype (E14wt, E100-/-, E100-/- rescue (Srf transgene)) were stimulated with FBS for 0-180 min. RNA was harvested and hybridized to Affymetrix MGU74A arrays. Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1015

Platform:

GPL32

15 Samples

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(Submitter supplied) Empty vector, SRF-dM-VP16 (control construct lacking the SRF DNA binding domain), or SRF-VP16 were expressed in wild-type ES cells (E14wt), SRF heterozygotes (E99-/+) or two SRF ko cell lines (E81-/-,E100-/-). RNA was harvested 72h after transfection. Each condition was performed in duplicate, except E100-/- vector transfected. Keywords: ordered

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1014

Platform:

GPL32

23 Samples

Download data

Expression profiling of embryonic stem (ES) cells following stimulation with fetal bovine serum at various time points up to 180 minutes. Expression in wild type ES cells compared to that in Srf homozygous mutants with or without an SRF transgene. Results identify potential targets of SRF.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 protocol, 5 time sets

Platform:

GPL32

Series:

GSE1949

15 Samples

Download data

Expression profiling of embryonic stem (ES) cells overexpressing serum response factor SRF. SRF transiently transfected into ES cells disrupted for both copies of SRF. RNA examined 72 hours after transfection. Results identify potential transcriptional targets of SRF.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 agent, 4 genotype/variation sets

Platform:

GPL32

Series:

GSE1948

23 Samples

Download data

(Submitter supplied) FLT3+CD11b+ DC progenitor was amplified in vitro from mouse bone marrow. DC were differentiated using GM-CSF and analyzed at day 7 and day 10 of differentiation and after 16h TNFalpha stimulation at day 10 Keywords: time-course

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2440

Platform:

GPL32

4 Samples

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