GEO DataSets

(Submitter supplied) It is becoming clear that copy number polymorphism in the human genome is a significant form of genetic variation. We have developed a new method that uses SNP genotype data from parent-offspring trios and applied it to HapMap to conduct high-resolution detection of deletion polymorphism. Of the delections uncovered, approximately 100 have been experimentally validated using comparative genome hybridization on these tiling-resolution oligonucleotide microarrays. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platform:

GPL2988

8 Samples

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(Submitter supplied) Custom fine-tiling array of 385k in situ isothermal oligonucleotide probes (Tm=76oC, 45mer - 85mer). Array allows fine detail aCGH of 131 contiguous chromosomal regions of suspected human copy number polymorphism. Protocol: Maskless Array Synthesis as described in 1) Singh-Gasson et al., (1999) Maskless fabrication of light-directed oligonucleotide microarrays using a digital micromirror array. Nat Biotechnol 17:974-978 and 2) Nuwaysir et al (2002) Gene expression analysis using oligonucleotide arrays produced by maskless photolithography. more...

Organism:

Homo sapiens

1 Series

8 Samples

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