GEO DataSets

Analysis of gas-1(fc21) electron transport chain complex I mutants. The gas-1(fc21) mutation affects the 49 kD subunit of complex I, decreasing the rate of complex I-dependent oxidative phosphorylation. Results provide insight into molecular mechanisms underlying primary mitochondrial disease .

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL200

Series:

GSE9896

10 Samples

Download data: CEL

Analysis of nuo-6;ced-4 double mutants. ced-4 mutation in the intrinsic apoptosis signaling pathway suppresses the longevity of electron transport chain mutant nuo-6. Results provide insight into molecular mechanisms underlying lifespan expansion.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:

GPL200

Series:

GSE54024

13 Samples

Download data: CEL

Analysis of isp-1;ced-4 double mutants. ced-4 mutation in the intrinsic apoptosis signaling pathway suppresses the longevity of electron transport chain mutant isp-1. Results provide insight into molecular mechanisms underlying lifespan expansion.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:

GPL200

Series:

GSE54024

13 Samples

Download data: CEL

Analysis of wildtype worms treated with the pro-oxidant paraquat and electron transport chain mutants isp-1 and nuo-6. Results provide insight into common molecular mechanisms underlying the increased longevity in all three conditions.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 genotype/variation, 3 protocol sets

Platform:

GPL200

Series:

GSE54024

13 Samples

Download data: CEL

Analysis of day 8 germline-deficient glp-1 mutants treated with ash-2 RNAi. The ASH-2 trithorax complex trimethylates histone H3 at lysine 4 (H3K4); an intact germline is required for ASH-2-induced lifespan extension. Results provide insight into the role of histone methylation in longevity.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:

GPL200

Series:

GSE30505

11 Samples

Download data: CEL

Analysis of adult worms fed live lactic acid bacteria (LAB) Lactobacillus rhamnosus CNCM I-3690 or CNCM I-4317 for 10 days. L. rhamnosus CNCM I-3690 protects against oxidative stress and increases lifespan in worms. Results provide insight into probiotic LAB-induced oxidative stress protection.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL200

Series:

GSE42192

9 Samples

Download data: CEL

Analysis of N2 young adults after 4hr exposure to live or heat-killed C. albicans DAY185. C. albicans hyphae can kill C. elegans in a manner modeling key aspects of mammalian pathogenesis. Results provide insight into molecular mechanisms underlying host immune response to C. albicans infection.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, count, 3 infection sets

Platform:

GPL200

Series:

GSE27401

9 Samples

Download data: CEL, TXT

Analysis of day 2 germline-deficient glp-1 mutants treated with ash-2 RNAi. The ASH-2 trithorax complex trimethylates histone H3 at lysine 4 (H3K4); an intact germline is required for ASH-2-induced lifespan extension. Results provide insight into the role of histone methylation in longevity.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:

GPL200

Series:

GSE30505

12 Samples

Download data: CEL

Analysis of tdp-1(ok803lf) mutants. TDP-1 loss alleviates proteotoxicity and extends life span. Results provide insight into a role for TDP-1 in the regulation of protein homeostasis and aging.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL200

Series:

GSE34113

6 Samples

Download data: CEL

Analysis of age-synchronized L3 nematodes exposed to LC10 of gold nanoparticles (Au-NPs). The Au-NPs are used as a model for studying particle-specific effects of manufactured nanomaterials (MNMs). Results provide insight into in vivo particle-specific toxicity of Au-NPs to C. elegans.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL200

Series:

GSE32521

6 Samples

Download data: CEL

Analysis of atfs-1 mutants raised on spg-7(RNAi) which induces mitochondrial stress (MS). ATFS-1 (activating transcription factor associated with stress-1) senses MS and communicates with the nucleus during the mitochondrial unfolded protein response. Results provide insight into the MS response.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, count, 2 genotype/variation, 2 protocol sets

Platform:

GPL200

Series:

GSE38196

12 Samples

Download data: CEL, CHP

Analysis of kgb-1 mutants incubated with 1mM copper sulfate for 1hr. The conserved KGB-1 JNK mitogen-activated protein kinase pathway regulates the response to heavy metal stress. Results provide insight into molecular mechanisms underlying the heavy metal stress response.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, count, 2 genotype/variation, 2 stress sets

Platform:

GPL200

Series:

GSE42703

4 Samples

Download data: CEL, CHP

Analysis of young worms fed live lactic acid bacteria (LAB) Lactobacillus rhamnosus CNCM I-3690 or CNCM I-4317 for 3 days. L. rhamnosus CNCM I-3690 protects against oxidative stress and increases lifespan in worms. Results provide insight into probiotic LAB-induced oxidative stress protection.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 protocol sets

Platform:

GPL200

Series:

GSE42192

9 Samples

Download data: CEL

Analysis of heme-cultured HRG-2 mutants. Heme-responsive gene-2 (HRG-2) is a hypodermal, heme-binding, type I membrane protein; cytochrome distribution is abnormal in HRG-2-deficient worms. Results provide insight into molecular mechanisms underlying the regulation of heme homeostasis by HRG-2.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:

GPL200

Series:

GSE34471

12 Samples

Download data: CEL, CHP

Analysis of xpa-1 mutants deficient in nucleotide excision repair (NER). Transcription-blocking DNA damage is believed to contribute to aging and underlie activation of oxidative stress responses (OSR). Results provide insight into the transcriptomic reprogramming response in xpa-1 mutants.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL200

Series:

GSE39252

10 Samples

Download data: CEL

Analysis of bacterial infected C. elegans treated with 70 μM RPW-24 or DMSO. In a C.elegans-bacterial infection assay screening small molecules, RPW-24 was identified as a putative antimicrobial agent. Results provide insight into C. elegans conserved immune response to bacterial infection.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL200

Series:

GSE37266

6 Samples

Download data: CEL

Analysis of C.elegans at 3 points during aging: late larval L4 stage, days 6 and 15 of adulthood. C. elegans exhibits increased susceptibility to bacterial infection with age. Results provide insight into molecular mechanisms underlying the decline in immune function with aging (immunosenescence).

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 age, 2 development stage sets

Platform:

GPL200

Series:

GSE21784

9 Samples

Download data: CEL

Analysis of fer-1 loss of function C. elegans mutants. The fer-1 gene encodes a homolog for the human Dysferlin gene. Mutations in the human Dysferlin gene results in Limb Girdle Muscular Dystrophy 2B (LGMD2B). Results provide insight into the molecular pathogenesis of LGMD2B.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:

GPL200

Series:

GSE16753

12 Samples

Download data: CEL

Analysis of 8 different electron transport chain (ETC) subunit mutants (3 missense and 5 RNAi-induced) in complexes I, II, and III. Results from this validation set provide insight into the contributions of individual complexes or subunits to primary mitochondrial dysfunction.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, transformed count, 4 genotype/variation, 4 protocol sets

Platform:

GPL200

Series:

GSE9897

10 Samples

Download data: CEL

Analysis of daf-2(e1368) loss-of-function mutant and daf-2(e1368);pmk-1(km25) and daf-2(e1368);daf-16(mgDf47) double mutants. PMK-1 and DAF-16 confer enhanced pathogen resistance on daf-2 mutants relative to wild-type. Results suggest DAF-16 and PMK-1 upregulate distinct genes to promote immunity.

Organism:

Caenorhabditis elegans

Type:

Expression profiling by array, count, 3 genotype/variation sets

Platform:

GPL200

Series:

GSE5801

9 Samples

Download data: CEL