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Select item 7701.

Long-lived daf-2 insulin/IGF-1 receptor mutant expression profiling

Analysis of gene expression in long-lived daf-2 mutants for the insulin/IGF-1 receptor. daf-2(e1370) and daf-2(m577) alleles each examined as single and as double mutations with the daf-16(df50) allele. DAF-2 regulates DAF-16, a transcription factor. Results provide insight into longevity.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:: GPL200
Series:: GSE1762
20 Samples

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DataSet

Accession:: GDS770

ID:: 770

Select item 51952.

nuo-6;ced-4 double mutation effect on young adults

Analysis of nuo-6;ced-4 double mutants. ced-4 mutation in the intrinsic apoptosis signaling pathway suppresses the longevity of electron transport chain mutant nuo-6. Results provide insight into molecular mechanisms underlying lifespan expansion.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:: GPL200
Series:: GSE54024
13 Samples

Download data: CEL

DataSet

Accession:: GDS5195

ID:: 5195

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 51943.

isp-1;ced-4 double mutation effect on young adults

Analysis of isp-1;ced-4 double mutants. ced-4 mutation in the intrinsic apoptosis signaling pathway suppresses the longevity of electron transport chain mutant isp-1. Results provide insight into molecular mechanisms underlying lifespan expansion.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 4 genotype/variation sets

Platform:: GPL200
Series:: GSE54024
13 Samples

Download data: CEL

DataSet

Accession:: GDS5194

ID:: 5194

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 51934.

isp-1 and nuo-6 mutants and paraquat-treated wildtype young adults

Analysis of wildtype worms treated with the pro-oxidant paraquat and electron transport chain mutants isp-1 and nuo-6. Results provide insight into common molecular mechanisms underlying the increased longevity in all three conditions.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 3 genotype/variation, 3 protocol sets

Platform:: GPL200
Series:: GSE54024
13 Samples

Download data: CEL

DataSet

Accession:: GDS5193

ID:: 5193

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 50125.

ash-2 knockdown effect on germline-deficient glp-1(e2141ts) mutant: day 8 (mid-life stage)

Analysis of day 8 germline-deficient glp-1 mutants treated with ash-2 RNAi. The ASH-2 trithorax complex trimethylates histone H3 at lysine 4 (H3K4); an intact germline is required for ASH-2-induced lifespan extension. Results provide insight into the role of histone methylation in longevity.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:: GPL200
Series:: GSE30505
11 Samples

Download data: CEL

DataSet

Accession:: GDS5012

ID:: 5012

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 50066.

Dietary probiotic Lactobacillus effect on N2 wildtype strain: adult developmental stage

Analysis of adult worms fed live lactic acid bacteria (LAB) Lactobacillus rhamnosus CNCM I-3690 or CNCM I-4317 for 10 days. L. rhamnosus CNCM I-3690 protects against oxidative stress and increases lifespan in worms. Results provide insight into probiotic LAB-induced oxidative stress protection.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 3 protocol sets

Platform:: GPL200
Series:: GSE42192
9 Samples

Download data: CEL

DataSet

Accession:: GDS5006

ID:: 5006

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 45767.

Candida albicans DAY185 infection

Analysis of N2 young adults after 4hr exposure to live or heat-killed C. albicans DAY185. C. albicans hyphae can kill C. elegans in a manner modeling key aspects of mammalian pathogenesis. Results provide insight into molecular mechanisms underlying host immune response to C. albicans infection.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, count, 3 infection sets

Platform:: GPL200
Series:: GSE27401
9 Samples

Download data: CEL, TXT

DataSet

Accession:: GDS4576

ID:: 4576

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 45758.

ash-2 knockdown effect on germline-deficient glp-1(e2141ts) mutant: day 2 (L3 stage)

Analysis of day 2 germline-deficient glp-1 mutants treated with ash-2 RNAi. The ASH-2 trithorax complex trimethylates histone H3 at lysine 4 (H3K4); an intact germline is required for ASH-2-induced lifespan extension. Results provide insight into the role of histone methylation in longevity.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:: GPL200
Series:: GSE30505
12 Samples

Download data: CEL

DataSet

Accession:: GDS4575

ID:: 4575

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 45739.

Transactive response DNA-binding Protein (TDP-1) loss-of-function mutants

Analysis of tdp-1(ok803lf) mutants. TDP-1 loss alleviates proteotoxicity and extends life span. Results provide insight into a role for TDP-1 in the regulation of protein homeostasis and aging.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL200
Series:: GSE34113
6 Samples

Download data: CEL

DataSet

Accession:: GDS4573

ID:: 4573

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 457110.

Toxicogenomic response to gold nanoparticle exposure

Analysis of age-synchronized L3 nematodes exposed to LC10 of gold nanoparticles (Au-NPs). The Au-NPs are used as a model for studying particle-specific effects of manufactured nanomaterials (MNMs). Results provide insight into in vivo particle-specific toxicity of Au-NPs to C. elegans.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 2 agent sets

Platform:: GPL200
Series:: GSE32521
6 Samples

Download data: CEL

DataSet

Accession:: GDS4571

ID:: 4571

Select item 457011.

Mitochondrial stress effect on ATFS-1 mutants

Analysis of atfs-1 mutants raised on spg-7(RNAi) which induces mitochondrial stress (MS). ATFS-1 (activating transcription factor associated with stress-1) senses MS and communicates with the nucleus during the mitochondrial unfolded protein response. Results provide insight into the MS response.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, count, 2 genotype/variation, 2 protocol sets

Platform:: GPL200
Series:: GSE38196
12 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4570

ID:: 4570

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 456812.

Copper sulfate stress effect on kgb-1 mutants

Analysis of kgb-1 mutants incubated with 1mM copper sulfate for 1hr. The conserved KGB-1 JNK mitogen-activated protein kinase pathway regulates the response to heavy metal stress. Results provide insight into molecular mechanisms underlying the heavy metal stress response.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, count, 2 genotype/variation, 2 stress sets

Platform:: GPL200
Series:: GSE42703
4 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4568

ID:: 4568

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 456613.

Dietary probiotic Lactobacillus effect on N2 wildtype strain: young developmental stage

Analysis of young worms fed live lactic acid bacteria (LAB) Lactobacillus rhamnosus CNCM I-3690 or CNCM I-4317 for 3 days. L. rhamnosus CNCM I-3690 protects against oxidative stress and increases lifespan in worms. Results provide insight into probiotic LAB-induced oxidative stress protection.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 3 protocol sets

Platform:: GPL200
Series:: GSE42192
9 Samples

Download data: CEL

DataSet

Accession:: GDS4566

ID:: 4566

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 456514.

Heme-responsive gene-2 deficient mutant

Analysis of heme-cultured HRG-2 mutants. Heme-responsive gene-2 (HRG-2) is a hypodermal, heme-binding, type I membrane protein; cytochrome distribution is abnormal in HRG-2-deficient worms. Results provide insight into molecular mechanisms underlying the regulation of heme homeostasis by HRG-2.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:: GPL200
Series:: GSE34471
12 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4565

ID:: 4565

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 456415.

Nucleotide excision repair mutant xpa-1

Analysis of xpa-1 mutants deficient in nucleotide excision repair (NER). Transcription-blocking DNA damage is believed to contribute to aging and underlie activation of oxidative stress responses (OSR). Results provide insight into the transcriptomic reprogramming response in xpa-1 mutants.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL200
Series:: GSE39252
10 Samples

Download data: CEL

DataSet

Accession:: GDS4564

ID:: 4564

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 424316.

Host immune response of bacterial infected nematode stimulated with small molecule

Analysis of bacterial infected C. elegans treated with 70 μM RPW-24 or DMSO. In a C.elegans-bacterial infection assay screening small molecules, RPW-24 was identified as a putative antimicrobial agent. Results provide insight into C. elegans conserved immune response to bacterial infection.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL200
Series:: GSE37266
6 Samples

Download data: CEL

DataSet

Accession:: GDS4243

ID:: 4243

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 394317.

Effect of aging on nematode

Analysis of C.elegans at 3 points during aging: late larval L4 stage, days 6 and 15 of adulthood. C. elegans exhibits increased susceptibility to bacterial infection with age. Results provide insight into molecular mechanisms underlying the decline in immune function with aging (immunosenescence).

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 3 age, 2 development stage sets

Platform:: GPL200
Series:: GSE21784
9 Samples

Download data: CEL

DataSet

Accession:: GDS3943

ID:: 3943

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 357918.

Fer-1 null mutants

Analysis of fer-1 loss of function C. elegans mutants. The fer-1 gene encodes a homolog for the human Dysferlin gene. Mutations in the human Dysferlin gene results in Limb Girdle Muscular Dystrophy 2B (LGMD2B). Results provide insight into the molecular pathogenesis of LGMD2B.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:: GPL200
Series:: GSE16753
12 Samples

Download data: CEL

DataSet

Accession:: GDS3579

ID:: 3579

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 345319.

Nematode models of primary mitochondrial dysfunction: complex I, II, and III mutants

Analysis of 8 different electron transport chain (ETC) subunit mutants (3 missense and 5 RNAi-induced) in complexes I, II, and III. Results from this validation set provide insight into the contributions of individual complexes or subunits to primary mitochondrial dysfunction.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 4 genotype/variation, 4 protocol sets

Platform:: GPL200
Series:: GSE9897
10 Samples

Download data: CEL

DataSet

Accession:: GDS3453

ID:: 3453

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 345220.

Nematode model of primary mitochondrial dysfunction: complex I mutants

Analysis of gas-1(fc21) electron transport chain complex I mutants. The gas-1(fc21) mutation affects the 49 kD subunit of complex I, decreasing the rate of complex I-dependent oxidative phosphorylation. Results provide insight into molecular mechanisms underlying primary mitochondrial disease .

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL200
Series:: GSE9896
10 Samples

Download data: CEL

DataSet

Accession:: GDS3452

ID:: 3452

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

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