Similar studies for GEO DataSets (Select 200005249) - GEO DataSets

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Items: 15

Select item 2000052491.

Profiling limb muscle degeneration by inducible dominant negative thyroid hormone receptor transgene over-expression

(Submitter supplied) Premetamorphic Xenopus laevis tadpoles limbs develop in response to thyroid hormone by proliferation and subsequent differentiation. We have previously reported that inhibiting the thyroid hormone action using a dominant negative receptor in limbs of developing tadpoles inhibits its growth and the tadpole limb has almost no muscle. The goal of this experiment is to study the role of thyroid hormone in the maintenance of limb muscle using transgenic tadpoles carrying a doxycyline inducible dominant negative thyroid receptor transgene expressed exclusively in the muscle using a muscle specific promoter and identify the genes involved in the degenerative process . more...

Organism:: Xenopus laevis

Type:: Expression profiling by array

Dataset:: GDS2120
Platform:: GPL3936
12 Samples

Download data: TXT

Series

Accession:: GSE5249

ID:: 200005249

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 21202.

Dominant negative thyroid hormone receptor overexpression effect on hind limb muscle development

Analysis of hind limbs of premetamorphic (NF55) and postmetamorphic (NF66) transgenics 2 or 6 weeks following transcriptional induction of a dominant negative thyroid hormone (TH) receptor transgene. Results provide insight into the role of TH in the maintenance of limb muscle during development.

Organism:: Xenopus laevis

Type:: Expression profiling by array, log10 ratio, 2 development stage, 2 genotype/variation, 2 time sets

Platform:: GPL3936
Series:: GSE5249
12 Samples

Download data: TXT

DataSet

Accession:: GDS2120

ID:: 2120

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000034053.

Thyroid hormone induced resorption of tail in Xenopus laevis tadpole

(Submitter supplied) Premetamorphic Xenopus laevis tadpole tail respond to thyroid hormone by resorption. The goal of this experiment is to identify the genes involved in the TH-induced resorption tadpole tail and compare it to TH-induced proliferation and differentiation program in tadpole limb and brain. Xenopus tadpoles (NF54) were treated with 100 nM T3 in 0.1 x MMR for another 24h and 48h or without T3 for 48h (control group). more...

Organism:: unidentified; Xenopus laevis

Type:: Expression profiling by array

Dataset:: GDS1719
Platform:: GPL2901
12 Samples

Download data: TIFF

Series

Accession:: GSE3405

ID:: 200003405

Select item 2000034044.

Thyroid hormone induced changes in Xenopus laevis tadpole limb bud

(Submitter supplied) Premetamorphic Xenopus laevis tadpoles limb bud cells respond to thyroid hormone by proliferation and subsequent differentiation. The goal of this experiment is to identify the genes involved in the TH-induced proliferation pathway in developing tadpole limb bud and compare it to TH-induced proliferation and differentiation program in tadpole brain. Xenopus tadpoles (NF54) were treated with 1 mM methimazole in 0.1 X MMR solution for 1 week to block the endogenous TH production and reduce the TH present in the system of the tadpole. more...

Organism:: unidentified; Xenopus laevis

Type:: Expression profiling by array

Dataset:: GDS1718
Platform:: GPL2901
12 Samples

Download data: TIFF

Series

Accession:: GSE3404

ID:: 200003404

Select item 2000034025.

Thyroid hormone induced changes in Xenopus laevis tadpole brain

(Submitter supplied) Premetamorphic Xenopus laevis tadpoles brain ventricle cells respond to thyroid hormone by proliferation and subsequent differentiation. The goal of this experiment is to identify the genes involved in the TH-induced proliferation pathway in tadpole brain and compare it to TH-induced proliferation and differentiation program in tadpole limb. Xenopus tadpoles (NF54) were treated with 1 mM methimazole in 0.1 X MMR solution for 1 week to block the endogenous TH production and reduce the TH present in the system of the tadpole. more...

Organism:: unidentified; Xenopus laevis

Type:: Expression profiling by array

Dataset:: GDS1717
Platform:: GPL2901
9 Samples

Download data: TIFF

Series

Accession:: GSE3402

ID:: 200003402

Select item 17196.

Thyroid hormone triiodothyronine effect on tadpole tail: time course

Analysis of tails of NF stage 54 (NF54) premetamorphic tadpoles treated with thyroid hormone (TH) triiodothyronine (T3) up to 48 hours. NF61 tadpoles were in 0.1xMMR till they reached NF62. Premetamorphic tails are resorbed in response to TH. Results identify genes involved in TH-induced resorption.

Organism:: Xenopus laevis; unidentified

Type:: Expression profiling by array, log ratio, 2 agent, 2 development stage, 3 time sets

Platform:: GPL2901
Series:: GSE3405
12 Samples

Download data: TIFF

DataSet

Accession:: GDS1719

ID:: 1719

Select item 17187.

Thyroid hormone triiodothyronine effect on tadpole limb bud: time course

Analysis of limb buds of NF stage 54 (NF54) premetamorphic tadpoles treated with thyroid hormone (TH) triiodothyronine (T3) for 14, 24 or 48 hours. Premetamorphic limb buds proliferate and differentiate in response to TH. Results identify genes involved in the TH-induced proliferation pathway.

Organism:: Xenopus laevis; unidentified

Type:: Expression profiling by array, log ratio, 2 agent, 3 time sets

Platform:: GPL2901
Series:: GSE3404
12 Samples

Download data: TIFF

DataSet

Accession:: GDS1718

ID:: 1718

Select item 17178.

Thyroid hormone triiodothyronine effect on tadpole brain: time course

Analysis of brains of NF stage 54 (NF54) premetamorphic tadpoles treated with thyroid hormone (TH) triiodothyronine (T3) for 24 or 48 hours. Premetamorphic brain ventricle cells proliferate and differentiate in response to TH. Results identify genes involved in the TH-induced proliferation pathway.

Organism:: Xenopus laevis; unidentified

Type:: Expression profiling by array, log ratio, 2 agent, 2 time sets

Platform:: GPL2901
Series:: GSE3402
9 Samples

Download data: TIFF

DataSet

Accession:: GDS1717

ID:: 1717

Select item 2000231549.

Responsiveness of a premetamorphic Xenopus tadpole brain to hydroxylated PCBs

(Submitter supplied) Hydroxylated polychlorinated biphenyls are the metabolites produced from polychlorinated biphenyls (PCBs) by drug-metabolizing enzyme cytochrome P450 1A1. These compounds are bound to transthyretin, a major plasma thyroid hormone-binding protein in amphibian tadpoles. The compounds-transthyretin complexes are transferred into the brain across the blood brain barrier in mammals. Thus these compounds are suspected to disrupt neural development in brain. more...

Organism:: Xenopus laevis

Type:: Expression profiling by array

Platform:: GPL10726
17 Samples

Download data: TXT

Series

Accession:: GSE23154

ID:: 200023154

Select item 20000256610.

Reinnervation of rat muscle

(Submitter supplied) Three male 8-week-old Wistar rats were used. The peroneal nerve of the animals was transected and sutured to the biceps femoris muscle. Four weeks later, the proximal stump was sutured to the distal stump. The animals survived for 8 weeks. All experiments were performed under Ketanest (ketamine hydrochloride, Essex Pharma GmbH, Munich, Germany; 100 mg/kg) and Rompun (xylazine hydrochloride, Bayer, Leverkusen, Germany; 10 mg/kg) anesthesia. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Dataset:: GDS2243
Platform:: GPL341
6 Samples

Download data

Series

Accession:: GSE2566

ID:: 200002566

Select item 224311.

Denervated skeletal muscle response to reinnervation

Analysis of reinnervated tibialis anterior muscles that were previously denervated for 4 weeks. Denervation-induced myofiber atrophy can be reversed by reinnervation. Results provide insight into the molecular mechanisms contributing to myofiber growth after reinnervation.

Organism:: Rattus norvegicus

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL341
Series:: GSE2566
6 Samples

Download data

DataSet

Accession:: GDS2243

ID:: 2243

Select item 20001607512.

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Xenopus laevis

Type:: Expression profiling by array

Platforms:: GPL3936 GPL8463 GPL2901
34 Samples

Download data: TXT

Series

Accession:: GSE16075

ID:: 200016075

Select item 20001607413.

Thyroid Hormone (TH) Controls The Remodeling Of The Pancreas And The Liver, Part A

(Submitter supplied) Thyroid hormone (TH) controls the remodeling of the pancreas and the liver. TH-induces dedifferentiation of the exocrine pancreas to a progenitor state (Proc. Nat. Acad Sci. 105, 8962-8967 (2008)) and it remodels the endocrine pancreas (Dev. Biol. 328, 384-391 (2009)). The redifferentiated frog pancreas resembles closely the pancreas of other typical vertebrates. Two pancreas arrays were carried out. more...