GEO DataSets

(Submitter supplied) Obtaining adipose tissue samples are paramount to the understanding of human obesity. We have examined the impact of needle-aspirated and surgical biopsy techniques on the study of subcutaneous adipose tissue (scAT) gene expression in both obese and lean subjects. Biopsy sampling methods have a significant impact on data interpretation and revealed that gene expression profiles derived from surgical tissue biopsies better capture the significant changes in molecular pathways associated with obesity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL7038 GPL7034

36 Samples

Download data: GPR

(Submitter supplied) Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of liver disease affecting 20-30% of the population in developed countries. NAFLD is strongly associated with abdominal obesity and is recognized as the hepatic manifestation of the metabolic syndrome. In a subgroup of patients with NAFLD inflammation and fibrosis develops, this so-called Non-Alcoholic Steatohepatitis (NASH) may progress to cirrhosis and hepatocellular carcinoma. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15207

15 Samples

Download data: CEL

(Submitter supplied) Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of liver disease affecting 20-30% of the population in developed countries. NAFLD is strongly associated with abdominal obesity and is recognized as the hepatic manifestation of the metabolic syndrome. In a subgroup of patients with NAFLD inflammation and fibrosis develops, this so-called Non-Alcoholic Steatohepatitis (NASH) may progress to cirrhosis and hepatocellular carcinoma. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15207

53 Samples

Download data: CEL

(Submitter supplied) Pathological expansion of adipose tissue (AT) in obesity is supported by adipocyte precursors, termed adipose-derived stromal/stem cells (ASCs). Elucidation of mechanisms underlying ASC function may lead to therapeutic interventions to treat fat mass accumulation. Using epigenome-wide association studies, we explored the impact of obesity on the methylation signature of human ASCs.

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL13534

12 Samples

Download data: CSV, IDAT

(Submitter supplied) Background. Differential gene expression in adipose tissue during diet-induced weight loss followed by a weight stability period is not well characterized. Markers of these processes may provide a deeper understanding of the underlying mechanisms. Objective. To identify differentially expressed genes in human adipose tissue during weight loss and weight maintenance after weight loss. Design. RNA from subcutaneous abdominal adipose tissue from nine obese subjects was obtained and analyzed at baseline, after weight reduction on a low calorie diet (LCD), and after a period of group therapy in order to maintain weight stability. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10335

26 Samples

Download data: CEL

(Submitter supplied) We investigated the effect of a saturated (SFA) and a monounsaturated (MUFA) rich diet on insulin sensitivity and adipose tissue gene expression profiles of subjects at risk for metabolic syndrome. A controlled-feeding trial was performed with 20 moderately overweight subjects. Subjects received a SFA-rich or a MUFA-rich diet for 8 weeks. Subcutaneous adipose tissue samples were obtained and insulin sensitivity was measured. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3678

Platform:

GPL7020

40 Samples

Download data: CEL

Analysis of adipose tissue from moderately overweight subjects who consumed a saturated fat (SFA)-rich diet for 2 weeks, followed by SFA or monounsaturated (MUFA)-rich intervention diets for 8 weeks. Results provide insight into role of dietary fat on the risk of developing metabolic syndrome.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 gender, 20 individual, 2 protocol, 2 time sets

Platform:

GPL7020

Series:

GSE14954

40 Samples

Download data: CEL

(Submitter supplied) The aim of this study was to characterize expression profiles of visceral and subcutaneous adipose tissue in children. Adipose tissue samples were collected from children having elective surgery (n=71, [54 boys], 6.0 +- 4.3 years). Affymetrix microarrays (n=20) were performed to characterize the functional profile and identify genes of interest in adipose tissue. Visceral adipose tissue had an overrepresentation of Gene Ontology themes related to immune and inflammatory responses and subcutaneous adipose tissue had an overrepresentation of themes related to adipocyte growth and development. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4276

Platform:

GPL6244

20 Samples

Download data: CEL

Analysis of subcutaneous and visceral adipose tissue (VAT) from lean and obese pre-pubertal children. The inflammatory environment of VAT may promote insulin resistance and type 2 diabetes. Results provide insight into molecular mechanisms underlying the inflammatory milieu of VAT in children.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 2 gender, 2 tissue sets

Platform:

GPL6244

Series:

GSE29718

20 Samples

Download data: CEL

(Submitter supplied) Microarray analysis comparing gene expression profiles of primary cultured preadipocytes from non-diabetic lean vs non-diabetic obese Pima Indian subjects (a subset of the subjects from the adipocyte genechip project, GSE2508). Primary cultured abdominal subcutaneous preadipocytes from 14 lean (7 Males / 7 Females) and 14 obese (7M/7F) subjects were hybridized individually to Affymetrix oligonucleotide arrays HG-U133A and B. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS1480 GDS1481

Platforms:

GPL97 GPL96

56 Samples

Download data

Analysis of cultured abdominal subcutaneous preadipocytes from 7 male and 7 female non-diabetic obese Pima Indians. The prevalence of obesity in Pima Indians is among the highest of any population. Results provide insight into the role of preadipocytes in obesity and obesity-related inflammation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 2 gender sets

Platform:

GPL97

Series:

GSE2510

28 Samples

Download data

Analysis of cultured abdominal subcutaneous preadipocytes from 7 male and 7 female non-diabetic obese Pima Indians. The prevalence of obesity in Pima Indians is among the highest of any population. Results provide insight into the role of preadipocytes in obesity and obesity-related inflammation.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 2 gender sets

Platform:

GPL96

Series:

GSE2510

28 Samples

Download data

(Submitter supplied) Adipose tissue inflammation and atherosclerosis are the main mechanisms behind type 2 diabetes and cardiovascular disease respectively, the major risks associated with the metabolic syndrome. Studies considering more than single factors behind the complexity of the metabolic syndrome are valuable to achieve a better and wider understanding of the metabolic syndrome. In this study common dysregulated pathways between adipose tissue inflammation and atherosclerosis were identified using two different bioinformatic tools to perform pathway analysis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

18 Samples

Download data: CEL

(Submitter supplied) Using RNA isolated from subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) samples obtained from control and class I, II and III obese patients undergoing inguinal hernia repair and laparoscopic cholecystectomy, we compared the gene expression profiles between SAT and VAT using microarrays and validated the findings by real-time quantitative PCR.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL16699

16 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is related to a manuscript published in Genome Biology. The abstract of this manuscript follows here: Background Investigations performed in mice and humans have acknowledged obesity as a low-grade inflammatory disease. Several molecular mechanisms have been convincingly involved in activating inflammatory processes and altering cell composition in white adipose tissue (WAT); however, the overall importance of these alterations, and their long-term impact on the metabolic functions of the WAT and on its morphology, remain unclear. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

9 related Platforms

59 Samples

Download data: GPR

(Submitter supplied) Extracellular matrix (ECM) remodelling occurs during tissue repair and inflammation-related pathologies with deposition of specific proteins. White adipose tissue (WAT) was recently shown to be the site of substantial interstitial fibrosis. ECM components, such as fibronectin, and their receptors integrins control cell migration, proliferation and differentiation. Adipocyte differentiation which is under the control of a specific transcriptional network is associated with decrease of fibronectin-rich matrix. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL5834 GPL5835

8 Samples

Download data: GPR

(Submitter supplied) Human adipose tissue derived stem cells were differentiated to adipocytes in vitro. At the end of differentiation, cells were treated with siRNA targeting CD248 followed by exposure to 1% oxygen levels. Microarray analysis were performed to identify differentially regulated genes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23159

12 Samples

Download data: CEL

(Submitter supplied) Genome wide DNA methylation profiling of adipose tissue of MZ twins discordant and concordant for BMI. The Illumina Infinium 450k Human DNA methylation Beadchip was used to obtain DNA methylation profiles across approximately 485,000 CpGs. Samples included 24 pairs discordant and 11 pairs concordant for BMI.

Organism:

Homo sapiens

Type:

Methylation profiling by genome tiling array

Platform:

GPL13534

70 Samples

Download data: TXT

(Submitter supplied) Objective: Potential regulators of adipogenesis include microRNAs (miRNAs), small non-coding RNAs that have been recently shown related to adiposity and differentially expressed in fat depots. However, to date no study is available regarding the relationship of miRNAs expression profile, biological pathway and cellular phenotype during human adipogenesis. Thereby, the aim of this study was to investigate whether miRNA expression profile in human adipocytes is related to adipogenesis and to test whether miRNA profile in human subcutaneous adipose tissue is associated to human obesity and co-morbidities. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL7731

28 Samples

Download data: TXT

(Submitter supplied) Objective: Potential regulators of adipogenesis include microRNAs (miRNAs), small non-coding RNAs that have been recently shown related to adiposity and differentially expressed in fat depots. However, to date no study is available regarding the relationship of miRNAs expression profile, biological pathway and cellular phenotype during human adipogenesis. Thereby, the aim of this study was to investigate whether miRNA expression profile in human adipocytes is related to adipogenesis and to test whether miRNA profile in human subcutaneous adipose tissue is associated to human obesity and co-morbidities. more...

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL7731

18 Samples

Download data: TXT