Similar studies for GEO DataSets (Select 200016002) - GEO DataSets

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Items: 20

Select item 2000160021.

Molecular Events Initiating B Cell Fate Specification

(Submitter supplied) Functional genomics comparison of EBFko, Pax5ko, and RAG2ko cell lines. Identify gene signatures associated with specfication and commitment to the B cell fate.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
9 Samples

Download data: CEL, CHP, XLS

Series

Accession:: GSE16002

ID:: 200016002

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000597622.

Expression data from CpG treated Common Lymphoid Progenitors

(Submitter supplied) Common Lymphoid Progenitors (CLPs) have two subsets, Ly-6d- which are mutli-potent, and Ly-6d, which derive from Ly-6d- and are committeed to the B-cell fate. Treatment of a mouse with CpG DNA causes an inflammatory response that alters both subsets. We used expression data to understand the changes in transcription in the transition of Ly-6d- CLPs to Ly-6d+ CLPs ion the presence and absence of CpG induced inflammation.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
11 Samples

Download data: CEL

Series

Accession:: GSE59762

ID:: 200059762

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000401033.

FLT3 activation cooperates with MLL-AF4 fusion gene to abrogate the hematopoietic specification of human ESCs

(Submitter supplied) MLL-AF4 is a hallmark genomic aberration which arises prenatally in high-risk infant acute lymphoblastic leukemia (ALL). In human embryonic stem cells (hESCs), MLL-AF4 skewed hemato-endothelial specification but was not sufficient for transformation. Additional cooperating genetic insults seem required for MLL-AF4-mediated leukemogenesis. FLT3 is highly expressed in MLL-AF4+ ALL through activating mutations (FLT3-TKD or FLT3-ITD) or increased transcriptional expression, being therefore considered a potential cooperating event in MLL-AF4+ ALL. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13607
18 Samples

Download data: TXT

Series

Accession:: GSE40103

ID:: 200040103

Select item 2000752724.

The role of Hoxa9 and Meis1 in development of acute myeloid leukemia (mRNA)

(Submitter supplied) OBJECTIVE: MEIS1, a HOX cofactor, collaborates with multiple HOX proteins, such as HOXA9, to accelerate the onset of acute myeloid leukemia (AML) through largely unknown molecular mechanisms. To further resolve these mechanisms, we conducted a structure-function analysis of Meis1 and gene expression profiling, in the context of Hoxa9 leukemogenesis. RESULTS: We show, in a murine bone marrow transplantation model, that the homeodomain of Meis1 is required for leukemogenic collaboration with Hoxa9. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6193
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE75272

ID:: 200075272

Select item 2000460045.

Expression data comparing EBF1 versus Pax5 induced genes

(Submitter supplied) We used microarrays to establish whether EBF1 and Pax5 repress similar or unique genes. We found that EBF1 uniquely represses the expression of the T-lineage transcription factor Gata3.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
6 Samples

Download data: CEL, TXT

Series

Accession:: GSE46004

ID:: 200046004

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000007026.

Antigen Presenting Dendritic Cells

(Submitter supplied) Assessing the gene expression repertoire of antigen presenting dendritic cells Keywords: other

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL81
7 Samples

Download data

Series

Accession:: GSE702

ID:: 200000702

Select item 2000006937.

Lin-c-kit+Sca1+ hematopoetic stem cells

(Submitter supplied) sorted hematopoetic stem cells from bone marrow; with two rounds of amplification Keywords: repeat sample

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL81
2 Samples

Download data

Series

Accession:: GSE693

ID:: 200000693

Select item 2000006928.

FLT3+/CD11b+ Dendritic cell (DC) progenitor

(Submitter supplied) FLT3+/CD11b+ Dendritic cell (DC) progenitor was amplified in vitro from mouse bone marrow. Keywords: repeat sample

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL81
5 Samples

Download data

Series

Accession:: GSE692

ID:: 200000692

Select item 2000005759.

DC differentiation from DC progenitor in vitro

(Submitter supplied) FLT3+CD11b+ DC progenitor was amplified in vitro from mouse bone marrow. DC were differentiated using GM-CSF and analyzed at day 7 and day 10 of differentiation and after 16h TNFalpha stimulation at day 10 Keywords: time-course

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2440
Platform:: GPL32
4 Samples

Download data

Series

Accession:: GSE575

ID:: 200000575

Select item 244010.

Dendritic cell development in vitro

Analysis of dendritic cell (DC) development from Flt3(+)CD11b(+) DC progenitors. DC progenitors treated with GM-CSF for 7 and 10 days to induce differentiation. DCs differentiated for 10 days were subsequently treated with TNFalpha to induce maturation.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 4 protocol sets

Platform:: GPL32
Series:: GSE575
4 Samples

Download data

DataSet

Accession:: GDS2440

ID:: 2440

Select item 20006101711.

Gene expression profile of HoxA9 over expressing and empty vector (EV) control Hemato-Endothelial Progenitors (HEPs) subpopulations

(Submitter supplied) During hematopoietic differentiation of hESCs, HOXA9 expression parallels hematopoietic development but is restricted to the hemogenic precursors (HEP, CD31+CD34+CD45-), and diminishes as HEPs differentiate into blood cells (CD45+). Enforced expression of Hoxa9 in hESCs robustly promoted differentiation into primitive (CD34+CD45+) and total (CD45+) blood cells with higher clonogenic (CFU) potential. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13607
3 Samples

Download data: TXT

Series

Accession:: GSE61017

ID:: 200061017

Select item 20008115312.

Fetal and neonatal hematopoietic progenitors are functionally and transcriptionally resistant to Flt3-ITD mutations.

(Submitter supplied) Gene expression in control and Flt3-ITD, Stat5 and Runx1 mutant HSCs and HPCs from different developmental stages.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL10787 GPL21163
117 Samples

Download data: TXT

Series

Accession:: GSE81153

ID:: 200081153

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004627013.

Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo

(Submitter supplied) Bcl11a is a transcription factor known to regulate lymphoid and erythroid development. Recent bioinformatic analysis of global gene expression patterns has suggested a role for Bcl11a in the development of dendritic cell (DC) lineages. We tested this hypothesis by analyzing the development of DC and other lineages in Bcl11a(-/-) mice. We show that Bcl11a is required for expression of IL-7 receptor (IL-7R) and Flt3 in early hematopoietic progenitor cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
4 Samples

Download data: CEL

Series

Accession:: GSE46270

ID:: 200046270

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000987814.

Gene expression analysis of Pax5-/- proB cells transduced with control or EBF retrovirus.

(Submitter supplied) We have determined that sustained expression of EBF suppresses alternate lineage genes independently of Pax5. Keywords: Transcription factor EBF restricts alternate lineage options and promotes B cell fate commitment independently of Pax5.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE9878

ID:: 200009878

Select item 20008964215.

PU.1 is required for the developmental progression of multipotent progenitors to common lymphoid progenitors.

(Submitter supplied) The transcription factor PU.1 is a central regulator of hematopoiesis, required for the normal differentiation of the myeloid and lymphoid lineages. Due to its essential role in early development and the importance of PU.1 in regulating several defining markers of lymphoid progenitors, its precise function in early lymphopoiesis has remained unclear. Using conditional mutagenesis and alternative lineage identification strategies, we demonstrate the developmental stage restricted function for PU.1 in early lymphopoiesis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
6 Samples

Download data: TXT

Series

Accession:: GSE89642

ID:: 200089642

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013324616.

Hi-C profiling of B-cell progenitors from Erg KO and WT mice

(Submitter supplied) Hi-C was used to examine long range chromatin interactions in B cell progenitors in the presence and absence of the Erg transcription factor. Specifically, OP9 cultured B220+ B-cell progenitors derived from the bone marrow of Rag1CreT/+;ErgΔ/Δ mice and from Rag1CreT/+ and Rag1Cre+/+;Erg fl/fl control mice were isolated and DNA interactions were profiled by in situ Hi-C.

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
6 Samples

Download data: BED, MTX

Series

Accession:: GSE133246

ID:: 200133246

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013285417.

The role of Erg in B cell development (RNA-Seq)

(Submitter supplied) RNA-seq of pre-proB, proB and preB populations from Ergfl/fl bone marrow, pre-proB cell population from Rag1CreT/+;ErgΔ/Δ bone marrow

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: TXT

Series

Accession:: GSE132854

ID:: 200132854

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013285318.

The role of Erg in B cell development (ChIP-Seq)

(Submitter supplied) ChIP-seq of B-cell progenitors and Rag1CreT/+;ErgΔ/Δ thymocytes for Erg transcription factor

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
2 Samples

Download data: NARROWPEAK

Series

Accession:: GSE132853

ID:: 200132853

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013285219.

The role of Erg in B cell development (ATAC-Seq)

(Submitter supplied) ATAC-seq of pre-proB, proB and preB populations from Ergfl/fl bone marrow, pre-proB cell population from Rag1CreT/+;ErgΔ/Δ bone marrow, and pre-proB, proB and preB populations from from Rag1CreT/+;ErgΔ/Δ;IgHVH10tar bone marrow.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
7 Samples

Download data: BED

Series

Accession:: GSE132852

ID:: 200132852

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20001471420.

Characterization of early stages of human B cell development by gene expression profiling

(Submitter supplied) We have characterized several stages of normal human B cell development in adult bone marrow by gene expression profiling of hemopoietic stem cells, early B (E-B), pro-B, pre-B, and immature B cells, using RNA amplification and Lymphochip cDNA microarrays (n = 6). Hierarchical clustering of 758 differentially expressed genes clearly separated the five populations. We used gene sets to investigate the functional assignment of the differentially expressed genes. more...