Similar studies for GEO DataSets (Select 200022178) - GEO DataSets

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Items: 20

Select item 2000221781.

Combinatorial Transcriptional Control in Blood Stem/Progenitor Cells: Genome-wide Analysis of 10 major Transcriptional Regulators

(Submitter supplied) Combinatorial transcription factor (TF) interactions control cellular phenotypes and therefore underpin stem cell formation, maintenance and differentiation. Here we report the genome-wide binding patterns and combinatorial interactions for 10 key regulators of blood stem/progenitor cells (Scl/Tal1, Lyl1, Lmo2, Gata2, Runx1, Meis1, Pu.1, Erg, Fli-1, Gfi1b) thus providing the most comprehensive TF dataset for any adult stem/progenitor cell type to date. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9250
11 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE22178

ID:: 200022178

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000513372.

Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis

(Submitter supplied) Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, TAL1, and FLI1) and three diagnostic histone modification marks with the gene expression changes that occur during development of primary cultured megakaryocytes (MEG) and primary erythroblasts (ERY) from murine fetal liver hematopoietic stem/progenitor cells. more...

Organism:: Mus musculus

Type:: Other

Platforms:: GPL9250 GPL13112 GPL6246
42 Samples

Download data: BEDGRAPH, BIGWIG, BROADPEAK, CEL, TXT

Series

Accession:: GSE51337

ID:: 200051337

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000496643.

Divergent functions of hematopoietic transcription factors in lineage priming and differentiation during erythro-megakaryopoiesis

(Submitter supplied) Combinatorial actions of relatively few transcription factors control hematopoietic differentiation. To investigate this process in erythro-megakaryopoiesis, we correlated the genome-wide chromatin occupancy signatures of four master hematopoietic transcription factors (GATA1, GATA2, SCL/TAL1 and FLI1) and three diagnostic histone modification marks with the gene expression changes that occur during development of primary megakaryocytes (MEG) and erythroblasts (ERY) from murine fetal liver hematopoietic stem/progenitor cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
12 Samples

Download data: CEL

Series

Accession:: GSE49664

ID:: 200049664

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000451444.

Genome-wide Analysis of Transcriptional Regulators in Human Blood Stem/Progenitor Cells reveals a densely interconnected network of coding and non-coding genes.

(Submitter supplied) Combinatorial transcription factor (TF) interactions regulate hematopoietic stem cell formation, maintenance and differentiation, and are increasingly recognised as drivers of stem cell signatures in cancer. However, genome-wide combinatorial binding patterns for key regulators do not exist in primary human hematopoietic stem/progenitor cells (HSPCs) and have constrained analysis of the global architecture of the molecular circuits controlling these cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
10 Samples

Download data: BED

Series

Accession:: GSE45144

ID:: 200045144

Select item 2002314865.

Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:: GPL24676
156 Samples

Download data: BW

Series

Accession:: GSE231486

ID:: 200231486

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Select item 2002314856.

Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC [HiC]

(Submitter supplied) Hematopoietic stem and progenitor cells (HSPCs) rely on a complex interplay of transcription factors (TFs) to regulate their differentiation into mature blood cells. A heptad of TFs - FLI1, ERG, GATA2, RUNX1, TAL1, LYL1, LMO2 - has been shown to bind to regulatory elements in bulk CD34+ HSPCs. However, whether specific combinations of these TFs have distinct roles in regulating hematopoietic differentiation remained unknown. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
8 Samples

Download data: BED, MATRIX

Series

Accession:: GSE231485

ID:: 200231485

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Select item 2002314267.

Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC [HiChIP]

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
8 Samples

Download data: TXT, XLSX

Series

Accession:: GSE231426

ID:: 200231426

PubMed Full text in PMC Similar studies

Select item 2002314258.

Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC [ChIP-seq]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
8 Samples

Download data: BW

Series

Accession:: GSE231425

ID:: 200231425

PubMed Full text in PMC Similar studies

Select item 2002314229.

Genome-wide Transcription Factor binding maps reveal cell-specific changes in the regulatory architecture of human HSPC [ChIPmentation]

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
132 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE231422

ID:: 200231422

PubMed Full text in PMC Similar studies

Select item 20016968910.

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development [zebrafish bulk RNA-seq2]

(Submitter supplied) Here we used RNAsequencing to characterize the transcriptional profile of the kidney of runx1 knock out zebrafish adult compared to wild type.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18413
5 Samples

Download data: TXT

Series

Accession:: GSE169689

ID:: 200169689

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015810111.

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Danio rerio

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL25922 GPL18413
26 Samples

Download data: MTX, TSV, TXT

Series

Accession:: GSE158101

ID:: 200158101

PubMed Full text in PMC Similar studies

Select item 20015810012.

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

(Submitter supplied) Here we used RNA sequencing to characterize the transcriptional profile of the total RNA from c-Kit+ cells of Runx1 KO and control mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TXT

Series

Accession:: GSE158100

ID:: 200158100

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Select item 20015809913.

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

(Submitter supplied) We used single cell-RNA sequencing to investigate the expression and the heterogeneity of wild type and runx1-mutant cd41-GFPLow cd41GFP hematopoietic stem and progenitor cells at embryonic (2.5 days post fertilization, dpf) and larval stages (6, 10 16 dpf).

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25922
9 Samples

Download data: MTX, TSV

Series

Accession:: GSE158099

ID:: 200158099

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015809814.

Redundant mechanisms driven independently by RUNX1 and GATA2 for hematopoietic development

(Submitter supplied) Here we used RNA sequencing to characterize the transcriptional profile of the kidney of runx1 knock out zebrafish adult compared to wild type.

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18413
6 Samples

Download data: TXT

Series

Accession:: GSE158098

ID:: 200158098

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007249115.

The Poly(C) binding protein Pcbp2, and its retrotransposed derivative Pcbp1, are independently essential to mouse development

(Submitter supplied) RNA-binding proteins participate in a complex array of post-transcriptional controls essential to cell-type specification and somatic development. Despite their detailed biochemical characterizations, the degree to which each RNA-binding protein impacts on mammalian embryonic development remains incompletely defined and the level of functional redundancy among subsets of these proteins remains open to question. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
7 Samples

Download data: TXT

Series

Accession:: GSE72491

ID:: 200072491

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20022985016.

Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo

(Submitter supplied) We sequenced 4 sorted cell populations: ECs, HECs, Runx1+ IAHCs and Runx1- IAHCs.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
4 Samples

Download data: XLSX

Series

Accession:: GSE229850

ID:: 200229850

PubMed Full text in PMC Similar studies

Select item 20017898117.

Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo

(Submitter supplied) Hematopoietic stem cells (HSCs) produce all essential cellular components of the blood. Stromal cell lines supporting HSCs follow a vascular smooth muscle cell (vSMC) differentiation pathway, suggesting that some hematopoiesis-supporting cells originate from vSMC precursors. These pericyte-like precursors were recently identified in the aorta-gonad-mesonephros (AGM) region; however, their role in in vivo hematopoietic development remains unknown. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE178981

ID:: 200178981

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002665318.

HoxB4 in hematopoietic stem cells

(Submitter supplied) Ectopic expression of homeodomain transcription factor HoxB4 in mouse ES cells enhances in vitro development of hematopoietic stem cells (HSCs).

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by array

Platforms:: GPL6246 GPL4128 GPL4129
8 Samples

Download data: CEL, TXT

Series

Accession:: GSE26653

ID:: 200026653

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008699419.

Runx1 Circular Chromosome Conformation Capture Sequencing in Mouse Hematopoietic Progenitor Cells

(Submitter supplied) We have performed circular chromosome conformation capture sequencing (4C-seq) with six baits located at the Runx1 locus in the mouse hematopoietic progenitor cell line HPC-7. 4C baits were designed to the P1 and P2 promoters and to the previously characterised +24 hematopoietic enhancer (P1, P2 and 24), with secondary baits located at nearby cohesin/CTCF (cc) binding sites (P1cc, 24cc, P2cc).

Organism:: Mus musculus

Type:: Other

Platform:: GPL13112
18 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE86994

ID:: 200086994

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006895820.

RUNX1B expression distinguishes megakaryocytic and erythroid lineage fate in adult hematopoiesis

(Submitter supplied) The Core Binding Factor (CBF) protein RUNX1 is a master regulator of definitive hematopoiesis, crucial for hematopoietic stem cell (HSC) emergence during ontogeny, which also plays vital roles in adult mice, in regulating the correct specification of numerous blood lineages. Akin to the other mammalian Runx genes, Runx1 has two promoters P1 (distal) and P2 (proximal) which generate distinct protein isoforms. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: TXT

Series

Accession:: GSE68958

ID:: 200068958

PubMed Full text in PMC Similar studies SRA Run Selector

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