GEO DataSets

(Submitter supplied) Bone marrow-derived macrophages were generated from wild type and Junb knockout mice and tested for their responses to LPS treatment.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

15 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL21103 GPL13112

14 Samples

Download data: XLS

(Submitter supplied) Here we identify the activator protein-1 (AP-1) factor JunB as an essential regulator of Th17 cell identity. JunB activates the expression of Th17 lineage-specifying genes, and coordinately represses genes controlling Th1 and Treg fate. Through regulatory analysis, we find that JunB is a core regulator of global transcriptional programs that promote Th17 cell identity and restrict alternative CD4+ T cell potential.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

4 Samples

Download data: TAB

(Submitter supplied) Here we identify the activator protein-1 (AP-1) factor JunB as an essential regulator of Th17 cell identity. JunB activates the expression of Th17 lineage-specifying genes, and coordinately represses genes controlling Th1 and Treg fate. Through regulatory analysis, we find that JunB is a core regulator of global transcriptional programs that promote Th17 cell identity and restrict alternative CD4+ T cell potential.

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL21103 GPL13112

10 Samples

Download data: XLS

(Submitter supplied) To investigate the plasticity of Lipolysaccharide (LPS) tolerance, we employed microarray profiling to analyse the gene expression profile in macrophage. Four macrophage populations were induced; Untreated macrophages (Control group), Acute response to LPS (LPS activation group), LPS tolerance (T – Tolerant group) and recovered (R = recovered macrophage group) Using transcriptional analysis we demonstrate that recovery from LPS tolerance (R – Recovery), as defined by cytokine gene expression, is associated with a global change in the transcriptional profile of macrophage. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

12 Samples

Download data: TXT

(Submitter supplied) Comparison of gene expression in wildtype and MyD88-/- C57BL/6J mouse macrophages treated with 10 ng/mL LPS for 2 hours versus media treated control macrophages, and, wildtype and MyD88-/- C57BL/6J mouse macrophages treated with live E. coli bacteria (log phase; 1 bact per 1 macrophage) for 2 hours versus media treated control macrophages. Cells from 4 mice of each geneotype were used and each individual provided its own control. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1705 GDS1706

Platform:

GPL1226

31 Samples

Download data

Analysis of MyD88 null mutant macrophages treated with LPS or live E. coli. MyD88 transduces cell signaling events downstream of Toll-like receptors, a key component of host defense. Results suggest most of the host response to endotoxin or live bacteria is actually regulated independently of MyD88.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 2 agent, 2 genotype/variation sets

Platform:

GPL1226

Series:

GSE1405

15 Samples

Download data

Analysis of MyD88 null mutant macrophages treated with LPS or live E. coli. MyD88 transduces cell signaling events downstream of Toll-like receptors, a key component of host defense. Results suggest most of the host response to endotoxin or live bacteria is actually regulated independently of MyD88.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 2 agent, 2 genotype/variation sets

Platform:

GPL1226

Series:

GSE1405

16 Samples

Download data

(Submitter supplied) We applied next-generation sequencing to investigate the gene expression profiles in mouse bone-marrow derived macrophages with or without IRF2 knockdown. We identified a number of differentially regulated genes in cells with IRF2 knockdown.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

4 Samples

Download data: XLSX

(Submitter supplied) PU.1 is a key transcription factor for macrophage differentiation. Novel PU.1 target genes were identified by mRNA profiling of PU.1-deficient progenitor cells (PUER) before and after PU.1 activation. We used two different types of Affymetrix DNA-microarrays (430 2.0 arrays and ST 1.0 exon arrays) to characterize the global PU.1-regulated transcriptional program underlying the early processes of macrophage differentiation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6096 GPL1261

12 Samples

Download data: CEL

(Submitter supplied) We used Affymetrix Mouse Promoter 1.0R arrays to analyse PU.1-dependent promoters in mouse macrophages Keywords: PU.1 ChIP versus IgG ChIP, ChIP-Chip

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL5811

1 Sample

Download data: BAR, BED, CEL, TXT

(Submitter supplied) Genome-wide expression profiling of the retinoschisin deficient retina in C57CL/6 mice. Keywords: Genetic modification

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2636

Platform:

GPL339

6 Samples

Download data

Analysis of retinas from postnatal day 7 mutants lacking retinoschisin (RS1h), an animal model for retinoschisis (RS). RS is a recessive retinal dystrophy accompanied by macular disease often resulting in early-onset vision loss. Results provide insight into the pathogenesis of RS.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE5581

6 Samples

Download data

(Submitter supplied) We characterized the NELFE occupancy on gene loci in conditions of unstimuated and LPS stimualtion in BMDMs

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL17021

7 Samples

Download data: BEDGRAPH

(Submitter supplied) We characterized active transcription in conditions of resting and LPS stimualtion in BMDMs

Organism:

Mus musculus

Type:

Other

Platform:

GPL21273

4 Samples

Download data: BEDGRAPH

(Submitter supplied) We characterized the CDK9 occupancy on gene loci in conditions of unstimuated and LPS stimualtion in BMDMs

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL17021

2 Samples

Download data: BEDGRAPH

(Submitter supplied) We performed the transcriptomic analysis of RNA-seq of BMDMs generated from WT and Nelfb KO in conditions of unstimuated and LPS stimualtion to identify gene expression changes.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

15 Samples

Download data: XLSX

(Submitter supplied) We characterized the PolII occupancy on gene loci in conditions of unstimuated and LPS stimualtion in BMDMs

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL13112

4 Samples

Download data: BEDGRAPH

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL11002 GPL22486

23 Samples

Download data: TXT

(Submitter supplied) Monocytes and macrophages are essential components of the innate immune system. Herein, we report that intron retention (IR) plays an important role in the development and function of these cells. Using mRNA sequencing, bioinformatics analyses and RT-qPCR validation, we identified differential IR and altered expression of key genes involved in macrophage development and function, both in vitro and in vivo. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:

GPL24106 GPL20795 GPL16791

23 Samples

Download data: BW, TAB, TSV, TXT, XLSX