GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Candida albicans; Homo sapiens

Type:

Expression profiling by high throughput sequencing

5 related Platforms

88 Samples

Download data: TXT

(Submitter supplied) Candida albicans is the major invasive fungal pathogen of humans, causing diseases ranging from superficial mucosal infections to disseminated, systemic infections which are often life threatening. Hematogenously disseminated candidiasis (HDC) has a 47% mortality rate despite current antifungal therapy. An increase in prevalence, as well as an increasing resistance to most of the clinically important antifungal therapies, provides a strong impetus to understand the molecular mechanisms of pathogenesis and the acquisition of drug resistance. more...

Organism:

Candida albicans; Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL18449 GPL13112

32 Samples

Download data: TXT

(Submitter supplied) Candida albicans is the major invasive fungal pathogen of humans, causing diseases ranging from superficial mucosal infections to disseminated, systemic infections which are often life threatening. Hematogenously disseminated candidiasis (HDC) has a 47% mortality rate despite current antifungal therapy. An increase in prevalence, as well as an increasing resistance to most of the clinically important antifungal therapies, provides a strong impetus to understand the molecular mechanisms of pathogenesis and the acquisition of drug resistance. more...

Organism:

Candida albicans; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL18448 GPL11154 GPL15645

56 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida albicans; Danio rerio

Type:

Expression profiling by array

Platforms:

GPL14575 GPL6457

54 Samples

Download data: TXT

(Submitter supplied) The transcription regulators HMS1, RTG1, RTG3, ZCF21, LYS14 and LYS144 play roles in the proliferation of C. albicans in a mammalian host. Chromatin immunoprecipitation (ChIP) of HMS1-MYC, RTG1-MYC, RTG3-MYC, GFP-ZCF21, GFP-LYS14, GFP-LYS144 followed by array hybridization (Agilent) uncovered a network of target genes required for C. albicans to thrive in the host.

Organism:

Candida albicans

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL13696

8 Samples

Download data: GPR

(Submitter supplied) Candida albicans is exposed to a different host environment during different site of infection. Thus, different virulence factors may be active during differenttypes of infection. However,little is known about the C. albicans genes that are required for the initiation and maintenance of candidiasis. To identify potential virulence factors relevant to hematogenously disseminated candidiasis, we determined the transcriptional response of C. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL4007

18 Samples

Download data

(Submitter supplied) Candida albicans is exposed to a different host environment during oropharyngeal candidiasis (OPC) compared to hematogenously disseminated candidiasis. Thus, different virulence factors may be active during these two types of infection. However,little is known about the C. albicans genes that are required for the initiation and maintenance of OPC. To identify potential virulence factors relevant to this disease, we determined the transcriptional response of C. more...

Organism:

Candida albicans

Type:

Expression profiling by array

Platform:

GPL4007

18 Samples

Download data

(Submitter supplied) We perform microarray analysis of HUVECs upon stimulation with virulent wildtype C. albicans strain SC5314 or its efg1/efg1 cph1/cph1 hyphal-deficient derivative strain CAN34 to compare the gene expression profiles elicited from HUVECs in response to these strains. In addition, these responses are compared to that of TNF-alpha induced responses to determine which responses are Candida-specific. Keywords: comparison of host response to different Candida albicans morphologies

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL570

20 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Nakaseomyces glabratus; Homo sapiens; Candida tropicalis; Candida albicans; Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

5 related Platforms

75 Samples

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(Submitter supplied) Homo sapiens fresh whole blood was infected with Candida parapsilosis. RNA-pool of both species extracted at 0min (control), 15, 30, 60, 120, 240 min. Samples are rRNA depleted. Measurement of Homo sapiens gene expression.

Organism:

Homo sapiens; Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24976

18 Samples

Download data: CSV

(Submitter supplied) Homo sapiens fresh whole blood was infected with Candida glabrata. RNA-pool of both species extracted at 0min (control), 15, 30, 60, 120, 240 min. Samples are rRNA depleted. Measurement of Candida glabrata gene expression.

Organism:

Homo sapiens; Nakaseomyces glabratus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24975

18 Samples

Download data: CSV

(Submitter supplied) Homo sapiens fresh whole blood was infected with Candida albicans SC5314. RNA-pool of both species extracted at 0min (control), 15, 30, 60, 120, 240 min. Samples are rRNA depleted. Expression measurement of Homo sapiens genes.

Organism:

Candida albicans; Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24974

18 Samples

Download data: CSV