Similar studies for GEO DataSets (Select 200075780) - GEO DataSets

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Items: 14

Select item 2000757801.

ofr1 regulates white-to-opaque switching and mating of Candida albicans (MTLa/α)

(Submitter supplied) It has been proposed that the ancestral fungus was mating competent and homothallic. However, many mating competent fungi were initially classified as asexual because their mating capacity was hidden behind layers of regulation. For efficient in vitro mating, the essentially obligate diploid ascomycete pathogen C. albicans has to homozygose its mating type locus from MTLa/α to MTLa/a or MTLα/α, and then undergo an environmentally controlled epigenetic switch to the mating competent opaque form. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL19196
9 Samples

Download data: TXT

Series

Accession:: GSE75780

ID:: 200075780

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000432672.

C. tropicalis a biofilms of opaque and wor1 overexpressers

(Submitter supplied) Transcriptional profiling of C. tropicalis a cells (CAY1503) in opaque state and overexpressing Wor1 in biofilms hybridized against a universal mixed reference sample of a cells in white and opaque states grown in Spider liquid.

Organism:: Candida tropicalis

Type:: Expression profiling by array

Platform:: GPL15925
4 Samples

Download data: GPR

Series

Accession:: GSE43267

ID:: 200043267

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000439383.

White-Opaque Switching in Natural MTLa/alpha Isolates of Candida albicans: Evolutionary Implications for Roles in Host Adaptation, Pathogenesis and Sex

(Submitter supplied) The discovery of white-opaque switching in natural MTLa/alpha isolates of Candida albicans sheds new light on the evolution of phenotypic plasticity and host adaptation.

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15645
2 Samples

Download data: TXT

Series

Accession:: GSE43938

ID:: 200043938

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001191654.

Environment-induced same-sex mating suggests homothallism is a primary mode of sexual reproduction in the yeast Candida albicans

(Submitter supplied) In this study, we report that glucose starvation and oxidative stress, common environmental stresses encountered by the pathogen, induce the development of mating projections and efficiently permit same-sex mating in C. albicans with an “a” mating type (MTLa/a).

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15645
4 Samples

Download data: TXT

Series

Accession:: GSE119165

ID:: 200119165

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000536715.

Discovery of a "White-Gray-Opaque" Tristable Phenotypic Switching System in Candida Albicans: Roles of Non-Genetic Diversity in Host Adaption

(Submitter supplied) The capacity of the commensal yeast Candida albicans to grow in several forms, referred to as phenotypic plasticity, is critical for its survival, and abilities to thrive and cause infection in the human host. In this study, we report a novel phenotype of C. albicans, referred as the “gray” phenotype. The gray cell type, together with the previously discovered “white” and “opaque” cell types, forms a tristable phenotypic switching system. more...

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15645
3 Samples

Download data: TXT

Series

Accession:: GSE53671

ID:: 200053671

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000740116.

Ssn6 defines a new level of regulation of white-opaque switching in Candida albicans and is required for the stochasticity of the switch

(Submitter supplied) The human commensal and opportunistic pathogen Candida albicans can switch between two distinct, heritable cell types, named “white” and “opaque,” which differ in morphology, mating abilities, metabolic preferences, and in their interactions with the host immune system. Previous studies revealed a highly interconnected group of transcriptional regulators that control switching between the two cell types. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL13830
21 Samples

Download data: GPR

Series

Accession:: GSE74011

ID:: 200074011

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000580547.

Ssn6, a new regulator of white-opaque switching in Candida albicans

(Submitter supplied) The human fungal pathogen Candida albicans can switch between two phenotypic cell types, termed “white” and “opaque.” Both cell types are heritable for many generations, and the switch between the two types occurs epigenetically, that is, without a change in the DNA sequence of the genome. In this work we describe that SSN6, the C. albicans functional homolog of Saccharomyces cerevisiae Cyc8, is a regulator of the white-opaque switch. more...

Organism:: Candida albicans

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL16365
9 Samples

Download data: GPR

Series

Accession:: GSE58054

ID:: 200058054

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001256368.

Transcriptional profiling of CAI4 (Wild-type), cpp1Δ/Δ, cek1Δ/Δ, cek2Δ/Δ, cpp1Δ/Δ cek1Δ/Δ, cpp1Δ/Δ cek2Δ/Δ and cek1Δ/Δ cek2Δ/Δ strains in the absence or presence of alpha pheromone in Candida albicans

(Submitter supplied) Twenty-one pheromone-induced genes were selected from the literature (Zhao, Daniels et al. 2005 was the major source) as the reference set for assessing the pheromone response of CAI4 (Wild-type), cpp1Δ/Δ, cek1Δ/Δ, cek2Δ/Δ, cpp1Δ/Δ cek1Δ/Δ, cpp1Δ/Δ cek2Δ/Δ and cek1Δ/Δ cek2Δ/Δ strains.Our aim was to check whether or not these 21 pheromone-induced genes are up-regulated in response to pheromone in each mutant strain.

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23041
28 Samples

Download data: TSV, XLSX

Series

Accession:: GSE125636

ID:: 200125636

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000560399.

White Cells Facilitate Opposite- and Same-Sex Mating of Opaque Cells in Candida albicans

(Submitter supplied) Modes of sexual reproduction in eukaryotic organisms are highly diversified. The human fungal pathogen Candida albicans undergoes a phenotypic switch from the white to the opaque phase in order to become mating-competent. In this study, we report that functionally and morphologically differentiated white and opaque cells show a coordinating behavior in the process of mating. Although white cells are mating-incompetent, they are induced to produce sexual pheromones when treated with opposite pheromones or interacted with opaque cells of an opposite mating type. more...

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15645
2 Samples

Download data: TXT

Series

Accession:: GSE56039

ID:: 200056039

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20024176610.

Variation in transcription regulator expression underlies differences in white-opaque switching between the SC5314 reference strain and the majority of Candida albicans clinical isolates.

(Submitter supplied) Expression of 68 genes was tracked across different C. albicans strains and enviornmenal conditions using a custom 72 probe Nanostring library

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL33714
76 Samples

Download data: RCC, XLSX

Series

Accession:: GSE241766

ID:: 200241766

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004444911.

Pheromone-induced biofilm arrays in the planktonic and pheromone-induced biofilm growth conditions

(Submitter supplied) Candida albicans can stochastically switch between two phenotypes, white and opaque. Opaque cells are the sexually competent form of C. albicans and therefore undergo efficient polarized growth and mating in the presence of pheromone. In contrast, white cells cannot mate, but are induced - under a specialized set of conditions - to form biofilms in response to pheromone. In this work, we compare the genetic regulation of such "pheromone-stimulated" biofilms with that of "conventional" C. more...

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL16385
17 Samples

Download data: GPR

Series

Accession:: GSE44449

ID:: 200044449

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006710112.

pH regulates white-opaque switching and sexual mating in Candida albicans

(Submitter supplied) As a successful commensal and pathogen of humans, Candida albicans encounters a wide range of environmental changes. Among them, ambient pH is an important factor, which changes frequently and affects many biological processes in this species. The ability to adapt to pH changes is tightly linked with pathogenesis and morphogenesis. In this study, we report that pH has a profound effect on white-opaque switching and sexual mating in C. more...

Organism:: Candida albicans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL15645
2 Samples

Download data: TXT

Series

Accession:: GSE67101

ID:: 200067101

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005403113.

Ste18p is a positive control element in the mating process of Candida albicans

(Submitter supplied) Disruption of STE18 gene which encodes a γ subunit of a heterotrimeric G protein in Candida albicans is shown to block pheromone-induced gene expression. Ectopic expression of either the Gα or the Gβ subunit of the heterotrimeric G protein is able to restore pheromone-induced gene expression.

Organism:: Candida albicans

Type:: Expression profiling by array

Platform:: GPL6822
12 Samples

Download data: TXT

Series

Accession:: GSE54031

ID:: 200054031

PubMed Full text in PMC Similar studies

Select item 20007512414.

Identification and characterization of Wor4, a new transcriptional regulator of white-opaque switching

(Submitter supplied) The human fungal pathogen Candida albicans can switch between two cell types, “white” and “opaque,” each of which is heritable through many cell divisions. Switching between these two cell types is regulated by six transcriptional regulators which form a highly interconnected circuit with multiple feedback loops. Here, we identify a seventh regulator of white-opaque switching, which we have named Wor4. more...