Similar studies for GEO DataSets (Select 200104626) - GEO DataSets

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Items: 20

Select item 2001046261.

Gene expression profiling in Hepa1c1c7 transfected Mst1r or Slpi

(Submitter supplied) To analysis Mst1r and slpi function as a tumor associated gene, we carried out overexpression analysis of Mst1r or Slpi to Hepa1c1c7 and investigated downstream genes expression by microarray.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21163
3 Samples

Download data: TXT

Series

Accession:: GSE104626

ID:: 200104626

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Select item 2001114202.

The DNA methylation profile of liver tumors in C3H mice and identification of differentially methylated regions involved in the regulation of tumorigenic genes

(Submitter supplied) Background: C3H mice have been frequently used in cancer studies as animal models of spontaneous liver tumors and chemically induced hepatocellular carcinoma (HCC). Epigenetic modifications, including DNA methylation, are among pivotal control mechanisms of gene expression leading to carcinogenesis. Although information on somatic mutations in liver tumors of C3H mice is available, epigenetic aspects are yet to be clarified. more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: XLSX

Series

Accession:: GSE111420

ID:: 200111420

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Select item 2001046273.

Gene expression profiling in liver normal and tumor tissues in C3H mice

(Submitter supplied) We have employed microarray analysis to detect tumor-related genes of liver tissues in C3H mice

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
6 Samples

Download data: TXT

Series

Accession:: GSE104627

ID:: 200104627

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Select item 2001325784.

Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Exposure to Ginkgo biloba Extract (GBE) in B6C3F1/N Mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL15761 GPL1261
33 Samples

Download data: CEL, PAIR

Series

Accession:: GSE132578

ID:: 200132578

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Select item 2001325775.

Genome-wide promoter DNA Methylation Profiling of Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Exposure to Ginkgo biloba Extract (GBE) in B6C3F1/N Mice [Methylation]

(Submitter supplied) Epigenetic modifications, such as DNA methylation, play an important role in carcinogenesis. In a recent NTP study, chronic exposure of B6C3F1/N mice to Ginkgo biloba extract (GBE) resulted in a high incidence of hepatocellular carcinomas (HCC). Genome-wide promoter methylation profiling on GBE-exposed HCC (2000 mg/kg group), spontaneous HCC (vehicle-control group) and age-matched vehicle control liver was performed to identify differentially methylated genes in GBE-exposed HCC and spontaneous HCC. more...

Organism:: Mus musculus

Type:: Methylation profiling by genome tiling array

Platform:: GPL15761
15 Samples

Download data: PAIR

Series

Accession:: GSE132577

ID:: 200132577

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Select item 2001325756.

Expression Profiling of Hepatocellular Carcinomas Arising Either Spontaneously or due to Chronic Exposure to Ginkgo biloba Extract (GBE) in B6C3F1/N Mice [Expression]

(Submitter supplied) In a recent NTP study, chronic exposure of B6C3F1/N mice to Ginkgo biloba extract (GBE) resulted in a high incidence of hepatocellular carcinomas (HCC). Genome-wide promoter methylation profiling and Expression profiling on GBE-exposed HCC (2000 mg/kg group), spontaneous HCC (vehicle-control group) and age-matched vehicle control liver was performed to identify differentially methylated genes and differentially expressed genes in GBE-exposed HCC and spontaneous HCC. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
18 Samples

Download data: CEL

Series

Accession:: GSE132575

ID:: 200132575

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Select item 2000505797.

Expression profiling of HCC

(Submitter supplied) 61 human HCCs were analyzed for genome-wide gene expression. Samples were collected at two sites in Germany, Heidelberg (HD) and Hannover (N). The Heidelberg Collection include 40 independent HCC: 19 liver resections and 17 explant liver specimen (4 not determined); median age at surgery was 57 years (range, 16-78), and the male/female ratio was 3:1. All diagnoses were confirmed by histological reevaluation, and use of the samples was approved by the local ethics committee. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL14550
80 Samples

Download data: TXT

Series

Accession:: GSE50579

ID:: 200050579

Select item 2000730038.

Genome-wide DNA methylation analysis in hepatocellular carcinoma

(Submitter supplied) Genome wide DNA methylation profiling of primary HCC tumors and their non-tumor tissue counterparts. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs in 20 paired tumor and non-tumor tissues which were obtained from HCC patients who underwent surgery.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
40 Samples

Download data: TXT

Series

Accession:: GSE73003

ID:: 200073003

Select item 2001134329.

MeDIP-chip result of 10 lung cancer patients

(Submitter supplied) Compared with non-cancerous lung tissues, lung cancer in Xuanwei tissues expressed a total of 6,899 differentially methylated regions, including 5,788 hypermethylated regions and 1,111 hypomethylated regions. Many differentially methylated regions have been found in lung cancer in Xuanwei.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL16378
2 Samples

Download data: GFF, PAIR, XLS

Series

Accession:: GSE113432

ID:: 200113432

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Select item 20003531310.

Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor-suppressor in hepatocellular carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL4126 GPL4133
20 Samples

Download data: TXT

Series

Accession:: GSE35313

ID:: 200035313

Select item 20003531211.

Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor-suppressor in hepatocellular carcinoma (MeDIP)

(Submitter supplied) The analysis of DNA methylation profiles was performed by methylated DNA immunoprecipitation (MeDIP) using anti-5-methylcytidine antibody (Eurogentec, Seraing, Belgium) followed by the Human 244K Agilent CpG island microarray (Agilent, Santa Clara, CA)

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL4126
4 Samples

Download data: TXT

Series

Accession:: GSE35312

ID:: 200035312

Select item 20003531112.

Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor-suppressor in hepatocellular carcinoma (expression)

(Submitter supplied) Gene expression was profiled using a 4x44K Human Whole Genome Ver. 2.0 gene expression array (Agilent Technologies) according to the manufacturer's instructions (Microarray-based gene expression analysis protocol ver. 5.0.1, Agilent Technologies)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
16 Samples

Download data: TXT

Series

Accession:: GSE35311

ID:: 200035311

Select item 20012374913.

The DNA methylation profiles of liver tissues (normal, non-tumor and tumor tisuues) of F2 males of C3H mice born to F1 mice gestationally exposed to arsenite

(Submitter supplied) Background: Previously, we showed that gestational arsenite (As) exposure of F0 females increases hepatic tumors in the F2 males in C3H mice. However, the mechanisms have not yet been clarified. Methods: We detected genome wide site-specific DNA methylation by using reduced representative bisulfite sequence (RRBS) method. We used the data uploaded here and those with GSE Series accession number GSE111420 (CCN and CCTt) to detect differential methyrated cytosines between control groups and arsenite groups. more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: XLSX

Series

Accession:: GSE123749

ID:: 200123749

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Select item 20012373714.

Gene expression profiles of liver tissues (normal, non-tumor and tumor tisuues) of F2 males of C3H mice born to F1 mice gestationally exposed to arsenite

(Submitter supplied) We have employed microarray analysis to detect gene expression changes that were affected in the F2 mice of arsenite group.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
12 Samples

Download data: TXT

Series

Accession:: GSE123737

ID:: 200123737

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Select item 20012371815.

Gene expression profiling in Hepa1c1c7 transfected Cd74 or Tmem54.

(Submitter supplied) To analyse Cd74 and Tmem54 function as tumor associated genes, we carried out overexpression analysis of Cd74 or Tmem54 using Hepa1c1c7 and investigated downstream genes expression by microarray.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21810
3 Samples

Download data: TXT

Series

Accession:: GSE123718

ID:: 200123718

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Select item 20004955416.

The regulation of miRNA expression by DNA methylation in hepatocellular carcinoma

(Submitter supplied) Emerging evidences indicate that microRNAs (miRNAs) are often deregulated and have fundamental roles in hepatocellular carcinoma (HCC). However, the mechanism underlying miRNA dysregulation in HCC is still elusive. In this report, we used an integrated analysis strategy combining methylated DNA immunoprecipitation chip (MeDIP-chip) and miRNA expression microarray data to study the correlation between aberrant methylation and dysregulation of miRNA in HCC. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL17532
6 Samples

Download data: PAIR

Series

Accession:: GSE49554

ID:: 200049554

Select item 20009009317.

Reprogramming oncogene levels through gene body hypermethylation in RTK-driven cancer

(Submitter supplied) While promoter epigenetic modifications have been linked to tumor suppressor silencing in cancers, modifications in gene body regions has been largely neglected. Using a genetic setting in which subtle enhanced levels of non-oncogenic receptor tyrosine kinases (RTKs) become progressively pathological, we show that reprogrammed CpG island (CGI) methylation locks cells into tumorigenicity. By focusing on gene bodies, we found an enrichment of hypermethylated CGI similar to that reported in cancer patients. more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL18480
13 Samples

Download data: BED

Series

Accession:: GSE90093

ID:: 200090093

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005450318.

Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips

(Submitter supplied) We examine genome-wide DNA methylation profiles in 66 pairs of HCC tumor and adjacent non-tumor tissues. After Bonferroni adjustment, a total of 130,512 CpG sites significantly differed in methylation level in tumor compared to non-tumor tissues, with 28,017 CpG sites hypermethylated and 102,495 hypomethylated in tumor tissues. Most (60.1%) significantly hypermethylated CpG sites are located in CpG islands. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
132 Samples

Download data: CSV

Series

Accession:: GSE54503

ID:: 200054503

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007062119.

Analysis of paired primary and metastatic cell lines identifies common DNA methylation changes in melanoma metastasis.

(Submitter supplied) Using 1 melanocyte and 6 melanoma cell line (3 pair of primary and metastatic), we generated base-resolution DNA methylation maps to document DNA methylation drivers of melanoma metastasis.