GEO DataSets

(Submitter supplied) Investigation of the role of HAC1 using transcriptional profiling of Candida parapsilosis treated with 5 mM dithiothreitol Gene expression of wild type and hac1 deletion strains were compared during growth in YPD only and growth in YPD with 5 mM DTT

Organism:

Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL25585

12 Samples

Download data: TXT

(Submitter supplied) Transcriptional profiling of ER stress condition comparing control (untreated), dithiothreitol (DTT) treated, or tunicamycin (TM) treated conditions on P. angusta DL1 strain.

Organism:

Ogataea angusta

Type:

Expression profiling by array

Platform:

GPL19916

9 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of Control and hac1 deletion mutant in ER stress condition on P. angusta DL1 strain.

Organism:

Ogataea angusta

Type:

Expression profiling by array

Platform:

GPL19916

6 Samples

Download data: GPR

(Submitter supplied) Transcriptional profiling of hac1 deletion mutant compared to wild type (control).

Organism:

Ogataea angusta

Type:

Expression profiling by array

Platform:

GPL19916

2 Samples

Download data: GPR

(Submitter supplied) Investigation of whole genome gene expression level changes in response to tunicamycin, an inhibitor of protein N-glycosylation, in Candida glabrata CBS138 delta-cnb1, delta-crz1, delta-slt2, and delta-ire1 mutants, compared to the wild-type strain. The mutations engineered into these strains render them hypersusceptible to tunicamycin. The mutants analyzed in this study are further described in Miyazaki, T. more...

Organism:

Nakaseomyces glabratus

Type:

Expression profiling by array

Platform:

GPL13707

15 Samples

Download data: CALLS, PAIR

(Submitter supplied) Ribosome-footprint profiling provides genome-wide snapshots of translation, but technical challenges can confound its analysis. Here, we use improved methods to obtain ribosome-footprint profiles and mRNA abundances that more faithfully reflect gene expression in Saccharomyces cerevisiae. Our results support proposals that both the beginning of coding regions and codons matching rare tRNAs are more slowly translated. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by high throughput sequencing; Third-party reanalysis

Platform:

GPL13821

3 Samples

Download data: TXT

(Submitter supplied) Candida parapsilosis has emerged as a frequent cause of invasive candidiasis with increasing evidence of unique biological features relative to C. albicans. As it adapts to conditions within a mammalian host, rapid changes in gene expression are necessary to facilitate colonization and persistence in this environment. Adhesion of the organism to biological surfaces is a key first step in this process and is the focus of this study. more...

Organism:

Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18663

27 Samples

Download data: TXT

(Submitter supplied) The accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER) causes stress and induces the unfolded protein response (UPR) which is characterised in part by the transcriptional induction of genes involved in assisting protein folding. Translational responses to ER stress have been less well described and here we report on a genome-wide analysis of translational regulation in the response to the ER stress-inducing agent dithiothreitol (DTT) in Saccharomyces cerevisiae. more...

Organism:

Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL90

4 Samples

Download data: CEL, EXP

(Submitter supplied) In the yeast Saccharomyces cerevisiae, accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates the unfolded protein response (UPR) mediated by Hac1p, whereas the heat shock response (HSR) mediated by Hsf1p mainly regulates cytosolic processes and protects the cell from different stresses. In this study, we find that a constitutive activation of the HSR by over-expression of a mutant HSF1 gene could relieve ER stress in both wild type and hac1∆ UPR-deficient cells. more...

Organism:

Schizosaccharomyces pombe; Saccharomyces cerevisiae

Type:

Expression profiling by array

Platform:

GPL2529

12 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Candida parapsilosis

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL13192 GPL14718

34 Samples

Download data: GPR, SAM

(Submitter supplied) We used next generation sequencing (RNA-seq) to determine the transcriptional profile of C. parapsilosis growing in several conditions including different media, temperatures and oxygen concentrations.

Organism:

Candida parapsilosis

Type:

Expression profiling by high throughput sequencing

Platform:

GPL14718

26 Samples

Download data: SAM

(Submitter supplied) Whole genome microarray were used to generate the transcriptional profile of C. parapsilosis UPC2 delete in hypoxia.

Organism:

Candida parapsilosis

Type:

Expression profiling by array

Platform:

GPL13192

4 Samples

Download data: GPR

(Submitter supplied) Whole genome microarray were used to generate the transcriptional profile of C. parapsilosis in hypoxic condition.

Organism:

Candida parapsilosis

Type:

Expression profiling by array

Platform:

GPL13192

4 Samples

Download data: GPR

(Submitter supplied) Investigation of centromeres in the pathogenic yeast Candida parapsilosis, shows that the location of two centromeres are polymorphic within this species. The centromeres consist of large inverted repeats (IRs), surrounding unique sequences. New (neo) centromeres have emerged in one C. parapsilosis isolate even though the original CEN location is undamaged. The neocentromeres do not contain IRs, and have no obvious sequence features.

Organism:

Candida parapsilosis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL27421

10 Samples

Download data: BIGWIG

(Submitter supplied) Exposure to certain stresses leads to readthrough transcription downstream of gene ends. Here we found that this phenomenon impacts the expression of genes located downstream to readthrough genes, whereby readthrough transcription proceeds into downstream genes, termed read-in genes. Using polyA-selected RNA-seq data from mouse fibroblasts, we identified widespread read-in in heat shock, oxidative and osmotic stress conditions. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Other

Platforms:

GPL19057 GPL28457

26 Samples

Download data: TXT