Similar studies for GEO DataSets (Select 200132923) - GEO DataSets

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Items: 15

Select item 2001329231.

Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B-cell Responses to Influenza Hemagglutinin

(Submitter supplied) Understanding human vaccine-induced memory B cell responses is critical to developing effective vaccines to evolving viruses like Influenza A. B cell responses to influenza exposure involve activation of pre-existing immunity and generation of new responses. To characterize these two types of responses, we analyzed the response to H7N9 vaccination in H7N9 naïve adults. This allowed us to distinguish responses of pre-existing B cells towards conserved epitopes versus newly generated H7-specific epitopes using hemagglutinin (HA) probes by flow cytometry. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
34 Samples

Download data: CSV, TXT

Series

Accession:: GSE132923

ID:: 200132923

Select item 2000682452.

Transcriptomic analysis of human B cell responses to vaccination

(Submitter supplied) Analysis of the gene expression profiles of naïve B cells, resting memory B cells (MBCs), activated B cells (ABCs) and antibody-secreting cells (ASCs) isolated from peripheral blood one week following influenza vaccination. Upon antigen exposure B cells eventually bifurcate into two distinct lineages, plasmablasts and memory B cells. We previously reported that plasmablasts or antibody-secreting cells (ASCs) could be transiently detected in blood shortly after infection or vaccination of humans. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
16 Samples

Download data: TXT

Series

Accession:: GSE68245

ID:: 200068245

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000632493.

Identification of H3N2 specific antibodies cross-reacting with H7 strains

(Submitter supplied) Binding profile of H3N2 hemagglutinin (HA) reactive antibodies for various H3N2 and H7 HA proteins

Organism:: Homo sapiens; Capra hircus; Influenza A virus

Type:: Protein profiling by protein array

Platform:: GPL19411
9 Samples

Download data: XLSX

Series

Accession:: GSE63249

ID:: 200063249

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001486334.

Human B cell response to influenza vaccination

(Submitter supplied) We used ultrasound-guided fine needle aspiration of the draining axillary lymph nodes to interrogate influenza vaccine-induced GC responses in humans.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
21 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE148633

ID:: 200148633

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002118755.

Affinity maturation broadens influenza vaccine-induced antibody responses in humans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24676 GPL15520
247 Samples

Download data: TAR

Series

Accession:: GSE211875

ID:: 200211875

PubMed Similar studies

Select item 2001617886.

CD4+ follicular regulatory T cells optimize the influenza virus-specific B cell response

(Submitter supplied) CD4+ follicular regulatory T cells (Tfr cells) control B cell responses through the modulation of follicular helper T (Tfh) cells and germinal center development, while suppressing autoreactivity; however, their role in the regulation of productive germinal center B cell responses and humoral memory is incompletely defined. We show that Tfr cells promote antigen-specific germinal center B cell responses upon influenza virus infection. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
10 Samples

Download data: TXT

Series

Accession:: GSE161788

ID:: 200161788

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002228887.

Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans [scRNA-Seq]

(Submitter supplied) BCR repertoire sequencing data from influenza vaccinated subjects

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL18573
2 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE222888

ID:: 200222888

PubMed Full text in PMC Similar studies

Select item 2002224768.

Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL18573 GPL15520
92 Samples

Download data: CSV, MTX, TSV

Series

Accession:: GSE222476

ID:: 200222476

PubMed Full text in PMC Similar studies

Select item 2002224749.

Influenza-specific effector memory B cells predict long-lived antibody responses to vaccination in humans [Rep-Seq]

(Submitter supplied) BCR repertoire sequencing data from influenza vaccinated subjects.

Organism:: Homo sapiens

Type:: Other

Platform:: GPL15520
23 Samples

Download data: TXT

Series

Accession:: GSE222474

ID:: 200222474

PubMed Full text in PMC Similar studies

Select item 20020311210.

Accessible chromatin differences in FCRL5 positive and negative influenza-specific memory B cells

(Submitter supplied) We examined the accessible chromatin differences between circulating B cell subsets post-vaccination. Using FCRL5 as a marker of Tbet expressing B cells, we sorted FCRL5+ (Tbet+) and FCRL5- (Tbet-) memory B cells, and antibody secreting plasmablasts at day 7 and day 14 post-vaccination. Additionally, we used H1 B cell tetramers to track cells responding to the influenza vaccine in a subset of samples. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
27 Samples

Download data: TXT

Series

Accession:: GSE203112

ID:: 200203112

PubMed Full text in PMC Similar studies

Select item 20016398911.

Transcriptome differences in FCRL5 positive and negative Influenza-specific memory B cells

(Submitter supplied) We examined the transcriptional differences between circulating B cell subsets post-vaccination. Using FCRL5 as a marker of Tbet expressing B cells, we sorted FCRL5+ (Tbet+) and FCRL5- (Tbet-) memory B cells, naïve B cells, and antibody secreting plasmablasts at day 7 and day 14 post-vaccination. Additionally, we used H1 B cell tetramers to track cells responding to the influenza vaccine. These data provide insights into the transcriptional programming of distinct B cell subsets that respond to influenza vaccination.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
40 Samples

Download data: CSV

Series

Accession:: GSE163989

ID:: 200163989

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20017552412.

High-throughput Single-cell Profiling of B cell Responses Following Inactivated Influenza Vaccination in Young and Older Adults

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL24676
24 Samples

Download data: TAR, TXT

Series

Accession:: GSE175524

ID:: 200175524

PubMed Full text in PMC Similar studies

Select item 20017552313.

High-throughput Single-cell Profiling of B cell Responses Following Inactivated Influenza Vaccination in Young and Older Adults (single-cell BCR)

(Submitter supplied) Seasonal influenza contributes to a substantial disease burden annually, resulting in approximately 10 million hospital visits and 50 thousand deaths in a typical year in the US. 90% of the annual mortality from influenza occurs in people over the age of 65. While influenza vaccination is the best protection against the virus, it is less effective for the elderly. This may be due to differences in the quantity or type of B cells induced by vaccination in older individuals. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
12 Samples

Download data: TAR, TXT

Series

Accession:: GSE175523

ID:: 200175523

PubMed Full text in PMC Similar studies

Select item 20017552214.

High-throughput Single-cell Profiling of B cell Responses Following Inactivated Influenza Vaccination in Young and Older Adults (single-cell Gene Expression)

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: RDS, TAR

Series

Accession:: GSE175522

ID:: 200175522

PubMed Full text in PMC Similar studies

Select item 20004735315.

Global Analyses of Human Immune Variation Reveal Baseline Predictors of Postvaccination Responses

(Submitter supplied) A major goal of systems biology is the development of models that accurately predict responses to perturbation. Constructing such models requires the collection of dense measurements of system states, yet transformation of data into predictive constructs remains a challenge. To begin to model human immunity, we analyzed immune parameters in depth both at baseline and in response to influenza vaccination. more...