Similar studies for GEO DataSets (Select 200136180) - GEO DataSets

Select item 2001361801.

(Submitter supplied) ZFP36L1 is a tandem zinc-finger RNA-binding protein that recognizes conserved Adenylate-Uridylate-rich Elements (AREs) located in 3' untranslated regions (UTRs) to mediate RNA decay. We hypothesized that ZFP36L1 is a negative regulator of a post-transcriptional hub involved in the RNA half-life regulation of cancer-related transcripts. Forced expression of ZFP36L1 in cancer cells markedly reduced cell proliferation in vitro and in vivo; whereas silencing of ZFP36L1 enhanced tumor cell growth. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
2 Samples

Download data: TXT

Series

Accession:: GSE136180

ID:: 200136180

Select item 2001361812.

Tet-ZFP36L1 in 6 hours and 24 hours

(Submitter supplied) ZFP36L1 is a tandem zinc-finger RNA-binding protein that recognizes conserved Adenylate-Uridylate-rich Elements (AREs) located in 3' untranslated regions (UTRs) to mediate RNA decay. We hypothesized that ZFP36L1 is a negative regulator of a post-transcriptional hub involved in the RNA half-life regulation of cancer-related transcripts. Forced expression of ZFP36L1 in cancer cells markedly reduced cell proliferation in vitro and in vivo; whereas silencing of ZFP36L1 enhanced tumor cell growth. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
6 Samples

Download data: TSV

Series

Accession:: GSE136181

ID:: 200136181

Select item 2001361793.

RNA pull down assay of GST-ZFP36L1 (wildtype and mutant)

(Submitter supplied) ZFP36L1 is a tandem zinc-finger RNA-binding protein that recognizes conserved Adenylate-Uridylate-rich Elements (AREs) located in 3' untranslated regions (UTRs) to mediate RNA decay. We hypothesized that ZFP36L1 is a negative regulator of a post-transcriptional hub involved in the RNA half-life regulation of cancer-related transcripts. Forced expression of ZFP36L1 in cancer cells markedly reduced cell proliferation in vitro and in vivo; whereas silencing of ZFP36L1 enhanced tumor cell growth. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23227
3 Samples

Download data: TSV

Series

Accession:: GSE136179

ID:: 200136179

Select item 2001105814.

Zfp36l1 overexpression/knockdown effect on primary mouse articular chondrocytes

(Submitter supplied) Gene expression profiling of primary mouse articular chondrocyte infected with recombinant adenovirus expressing mouse ZFP36 Ring Finger Protein Like 1(Zfp36l1) or recombinant adenovirus expressing mouse small hairpin RNA of Zfp36l1. In this study, we have attempted to explore the effects of Zfp36l1 gene overexpression or knockdown on mouse transcriptome and have identified numerous genes which are involved in osteoarthritis pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
9 Samples

Download data: CEL

Series

Accession:: GSE110581

ID:: 200110581

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001047955.

Zinc transporter ZIP8 (SLC39A8) overexpression effect on primary mouse articular chondrocytes

(Submitter supplied) Gene expression profiling of primary mouse articular chondrocyte infected with recombinant adenovirus expressing the zinc transporter ZIP8 (SLC39A8) protein. In this study, we have attempted to explore the effects of ZIP8 overexpression on mouse transcriptome and have identified numerous genes which are involved in osteoarthritis pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
8 Samples

Download data: CEL

Series

Accession:: GSE104795

ID:: 200104795

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Select item 2001047946.

Hypoxia inducible factor-2 alpha (HIF-2α) overexpression effect on primary mouse articular chondrocytes

(Submitter supplied) Gene expression profiling of primary mouse articular chondrocyte infected with recombinant adenovirus expressing the hypoxia inducible factor-2 alpha (HIF-2α) protein. In this study, we have attempted to explore the effects of HIF-2α overexpression on mouse transcriptome and have identified numerous genes which are involved in osteoarthritis pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
8 Samples

Download data: CEL

Series

Accession:: GSE104794

ID:: 200104794

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001047937.

Interleukin-1β effect on primary mouse articular chondrocytes

(Submitter supplied) Gene expression profiling of primary mouse articular chondrocyte treated with interleukin-1β. In this study, we have attempted to explore the effects of interleukin-1β on mouse transcriptome and have identified numerous genes which are involved in osteoarthritis pathogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL16570
6 Samples

Download data: CEL

Series

Accession:: GSE104793

ID:: 200104793

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001024028.

Posttranscriptional upregulation of HER3 by HER2 mRNA induces Trastuzumab Resistance in breast cancer

(Submitter supplied) To explore HER2 3’-UTR-dependent transcriptional programs, we analyzed gene-expression profiles of T47D cells transfected with HER2 3’-UTR.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6480
2 Samples

Download data: TXT

Series

Accession:: GSE102402

ID:: 200102402

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001182419.

Genome-wide analysis of enhancer-related DNA methylation in myelofibrosis reveals ZFP36L1 as a potential tumor suppressor gene

(Submitter supplied) In this study we have interrogated the DNA methylome of myelofibrosis (MF) patients using high-density DNA methylation arrays. Interestingly, primary and secondary MF showed no differences in DNA methylation profiles, whereas a total of 35,238 differentially methylated CpGs (DMC) corresponding to 10,904 genes were detected between MF patients and healthy controls. Remarkably, the majority of DMCs were located outside gene promoter regions and significantly associated with enhancer regions. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
45 Samples

Download data: TXT

Series

Accession:: GSE118241

ID:: 200118241

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20020654610.

ZFP36L1 is suppressed in ASCL1-positive lung adenocarcinoma and represses tumorigenic function

(Submitter supplied) To investigate the function of ZFP36L1 in ASCL1-positive lung adenocarcinoma, we established VMRC-LCD cell line in which the target gene has been overexpressed by plasmid vector. We then performed gene expression profiling analysis using data obtained from RNA-seq of 2 different cells.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
2 Samples

Download data: XLSX

Series

Accession:: GSE206546

ID:: 200206546

PubMed Similar studies

Select item 20015694411.

HIF1A signaling selectively supports proliferation of breast cancer in the brain

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
18 Samples

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Series

Accession:: GSE156944

ID:: 200156944

PubMed Full text in PMC Similar studies

Select item 20015694312.

HIF1A signaling selectively supports proliferation of breast cancer in the brain [parental CTCs inVitro]

(Submitter supplied) Blood-borne metastasis to the brain is a major complication of breast cancer, but cellular pathways that enable cancer cells to selectively grow in the brain microenvironment are poorly understood. We find that cultured circulating tumor cells (CTCs), derived from blood samples of women with advanced breast cancer and directly inoculated into the mouse frontal lobe, exhibit striking differences in proliferative potential in the brain. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
7 Samples

Download data: CSV

Series

Accession:: GSE156943

ID:: 200156943

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20015694213.

HIF1A signaling selectively supports proliferation of breast cancer in the brain [HIF1A KD]

(Submitter supplied) Blood-borne metastasis to the brain is a major complication of breast cancer, but cellular pathways that enable cancer cells to selectively grow in the brain microenvironment are poorly understood. We find that cultured circulating tumor cells (CTCs), derived from blood samples of women with advanced breast cancer and directly inoculated into the mouse frontal lobe, exhibit striking differences in proliferative potential in the brain. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: CSV

Series

Accession:: GSE156942

ID:: 200156942

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20015694114.

HIF1A signaling selectively supports proliferation of breast cancer in the brain [brain vs mammary fat pad]

(Submitter supplied) Blood-borne metastasis to the brain is a major complication of breast cancer, but cellular pathways that enable cancer cells to selectively grow in the brain microenvironment are poorly understood. We find that cultured circulating tumor cells (CTCs), derived from blood samples of women with advanced breast cancer and directly inoculated into the mouse frontal lobe, exhibit striking differences in proliferative potential in the brain. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
3 Samples

Download data: CSV

Series

Accession:: GSE156941

ID:: 200156941

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20015694015.

HIF1A signaling selectively supports proliferation of breast cancer in the brain [F1 vs parental]

(Submitter supplied) Blood-borne metastasis to the brain is a major complication of breast cancer, but cellular pathways that enable cancer cells to selectively grow in the brain microenvironment are poorly understood. We find that cultured circulating tumor cells (CTCs), derived from blood samples of women with advanced breast cancer and directly inoculated into the mouse frontal lobe, exhibit striking differences in proliferative potential in the brain. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
4 Samples

Download data: CSV

Series

Accession:: GSE156940

ID:: 200156940

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20013403816.

Single cell sequencing identifies novel sub-populations of breast cancer cells selected under hypoxia

(Submitter supplied) During tumour growth cancer cells are subject to and selected by microenvironmental stress. The selection of such cells allows for continued growth and survival, during hypoxia, acidosis, nutritional deprivation, drug treatment and radiation. However, there is great microenvironmental heterogeneity in every tumour. Must studies of gene regulation in vitro investigate whole cell populations, often by western blotting or mRNA expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
384 Samples

Download data: TSV

Series

Accession:: GSE134038

ID:: 200134038

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013332717.

Chromatin response to hypoxia in MCF7 cells

(Submitter supplied) Oxygen is essential for cell growth, however in tumours quick growth can cause hypoxic conditions. To determine the changes in the chromatin landscape in response to hypoxia in breast cancer we have performed ATAC-seq dugin normoxia and hypoxia.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
11 Samples

Download data: BW

Series

Accession:: GSE133327

ID:: 200133327

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015284518.

IGF2BP1 is a drugable, post-transcriptional super-enhancer of E2F-driven gene expression hallmark in cancer [HepG2 small RNA]

(Submitter supplied) The IGF2 mRNA-binding protein 1 (IGF2BP1) is a post-transcriptional enhancer of tumor growth. However, conserved effector pathway(s) and the feasibility of targeting IGF2BP1 in cancer cells remained elusive. We demonstrate that IGF2BP1 is a conserved regulator of E2F-driven gene expression and cancer cell cycle progression. IGF2BP1 promotes positive regulators of G1/S transition by stabilizing the respective mRNAs. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18573
1 Sample

Download data: CSV

Series

Accession:: GSE152845

ID:: 200152845

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015276219.

IGF2BP1 is a druggable, post-transcriptional super-enhancer of E2F-driven gene expression hallmark in cancer [A549, ES2, MV3, PANC1 small RNA]

(Submitter supplied) The IGF2 mRNA-binding protein 1 (IGF2BP1) is a post-transcriptional enhancer of tumor growth. However, conserved effector pathway(s) and the feasibility of targeting IGF2BP1 in cancer cells remained elusive. We demonstrate that IGF2BP1 is a conserved regulator of E2F-driven gene expression and cancer cell cycle progression. IGF2BP1 promotes positive regulators of G1/S transition by stabilizing the respective mRNAs. more...