Similar studies for GEO DataSets (Select 200142131) - GEO DataSets

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Items: 20

Select item 2001421311.

Genome wide RNA-sequencing of human pluripotent stem-cell derived endothelial cells 48h after transduction with adenoviruses expressing either empty vector of different combination of transcription factors

(Submitter supplied) To induce barrier of stem-cell derived endothelial cells in vitro cells have been transduced with a mixture of adenovirus overexpressing transcription factors with potential role in endothelial cell barrier stabilization. Adenoviruses overexpressing ETS1, SOX18 and SOX7 have been part of both transcription factor mixtures. As fourth transcription factor in the mixture included TAL1 while the other mixture included LEF1. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
10 Samples

Download data: TXT

Series

Accession:: GSE142131

ID:: 200142131

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Select item 2001421322.

Genome wide RNA-sequencing of human pluripotent stem-cell derived endothelial cells 48h after transduction with adenoviruses expressing either empty vector, single or multiple transcription factors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
40 Samples

Download data

Series

Accession:: GSE142132

ID:: 200142132

PubMed Full text in PMC Similar studies

Select item 2001421303.

Genome wide RNA-sequencing of human pluripotent stem-cell derived endothelial cells 48h after transduction with adenoviruses expressing either empty vector or single transcription factor

(Submitter supplied) To induce barrier of stem-cell derived endothelial cells in vitro cells have been transduced with adenoviruses overexpressing transcription factors with potential role in endothelial cell barrier stabilization. Adenoviruses overexpressing either ETS1 or FOXC1 or FOXF2 or KLF11 or SOX18 or SOX7 or TAL1 or LEF1 or LMO2 have been been used at 80 MOI. As control adenovirus overexpressing empty vectors has been used (80 MOI).

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
30 Samples

Download data: TXT

Series

Accession:: GSE142130

ID:: 200142130

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Select item 2001423224.

Genome wide RNA-sequencing of human pluripotent stem-cell derived endothelial cells treated with TGF-beta receptor inhbitors with or without VEGFA stimulation

(Submitter supplied) Transcriptional response to TGF-beta receptor inhibtion with or without VEGFA stimulation

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
42 Samples

Download data: XLSX

Series

Accession:: GSE142322

ID:: 200142322

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Select item 2001423215.

Genome wide RNA-sequencing of sorted human pluripotent stem-cell derived endothelial cells with CLDN5-GFP reporter (GFP+ and GFP-)

(Submitter supplied) CLDN5-GFP reporter has been engineered in hPSCs. These cells have been differentiated to Ecs. Differentaited Ecs were sorted into GFP+ and GFP- corresponding to CLDN5+ and CLDN5- to study gene expression of high-barrier resistance.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
24 Samples

Download data: XLSX

Series

Accession:: GSE142321

ID:: 200142321

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Select item 2001732066.

RNA-sequencing of human pluripotent stem-cell derived endothelial cells under control and Wnt-activating conditions

(Submitter supplied) Endothelial cells (ECs) in the central nervous system (CNS) acquire specialized barrier properties in response to extrinsic signals, with Wnt/β-catenin signaling coordinating multiple aspects of endothelial barrier function. We used human pluripotent stem cell (hPSC)-derived endothelial progenitor cells to profile the EC response to Wnt activation using multiple strategies, including the small molecule GSK-3 inhibitor CHIR 99021, and the CNS-derived ligands Wnt7a and Wnt7b.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
20 Samples

Download data: XLSX

Series

Accession:: GSE173206

ID:: 200173206

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Select item 2000975757.

Quantitative analysis of primary human and pluripotent stem cell-derived brain microvascular endothelial cells transcriptomes via next generation sequencing

(Submitter supplied) Next-generation sequencing (NGS) has significantly facilitated the analysis of the gene profile and elucidated the molecular mechanisms important for specific cell lineage differentiated from human pluripotent stem cells (hPSCs). Here we report the application of RNA-sequencing technology for transcriptome profile of primary human brain microvascular endothelial cells (BMECs) and hPSC-derived BMECs, and comparison of transcriptomes among cells, including hPSCs, mesodermal progenitors, ectodermal progenitors, endodermal progenitors, hBMECs and hPSC-derived BMECs from hPSCs. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
5 Samples

Download data: TXT

Series

Accession:: GSE97575

ID:: 200097575

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Select item 2001419268.

Transcriptome analysis of brain endothelial cells from EC-specific Glut1 knock-out mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL21103
14 Samples

Download data: TXT

Series

Accession:: GSE141926

ID:: 200141926

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Select item 2001419249.

Transcriptome analysis of brain endothelial cells from EC-specific Glut1 knock-out pups (P6) as compared to wild type controls

(Submitter supplied) To explore the mechanisms through which GLUT1 controls EC function, we compared transcriptomic alterations induced by loss of GLUT1 by performing RNA sequencing analysis on freshly isolated ECs from P6 GLUT1EC-/- brains. At P6, 447 genes were differentially expressed between WT and GLUT1-/- ECs. Subsequent gene set enrichment analysis showed that within the most differentially expressed pathways, several ones were related to p53, as well as inflammatory related pathways.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
8 Samples

Download data: TXT

Series

Accession:: GSE141924

ID:: 200141924

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Select item 20014192310.

Transcriptome analysis of brain endothelial cells from adult EC-specific Glut1 knock-out mice as compared to wild type controls

(Submitter supplied) To explore the mechanisms through which GLUT1 controls EC function, we compared transcriptomic alterations induced by loss of GLUT1 by performing RNA sequencing analysis on freshly isolated ECs from adult (8 week old) GLUT1EC-/- brains. In adult brains ECs, 1494 genes were differentially expressed between WT and GLUT1-/- ECs but we did not observe compensatory upregulation of other GLUTs. Interestingly, pathway analysis revealed that ECs from GLUT1EC-/- mice were characterized by a robust activation of inflammatory and extracellular matrix pathways.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: TXT

Series

Accession:: GSE141923

ID:: 200141923

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Select item 20016795911.

Vascular fate in misidentified pluripotent-derived blood-brain-barrier endothelial cells rescued by transcriptional reprogramming

(Submitter supplied) Total RNA, greater than 100ng, from cultured cells was isolated in TRIzol L and purified using Qiagen RNeasy Mini Kit per manufacturer’s protocols. Agilent Technologies 2100 Bioanalyzer was used to assess the RNA quality. RNA libraries were prepared and multiplexed using Illumina TruSeq RNA Library Preparation Kit v2 (non-stranded and poly-A selection) and 10 nM of cDNA was used as the input for high-throughput sequencing via Illumina’s HiSeq 2500 platform, producing 50 bp paired end reads.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE167959

ID:: 200167959

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Select item 20013802512.

Vascular fate in misidentified pluripotent-derived blood-brain-barrier endothelial cells rescued by transcriptional reprogramming.

(Submitter supplied) A single-cell suspension was loaded into the Bio-Rad ddSEQ Single-Cell Isolator on which cells were isolated, lysed and barcoded in droplets. Droplets were then disrupted and cDNA was pooled for second strand synthesis. Libraries were generated with direct tagmentation followed by 3’ enrichment and sample indexing using Illumina Nextera library prep kit. Pooled libraries were sequenced on the Illumina NextSeq500 sequencer. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21697
28 Samples

Download data: CSV

Series

Accession:: GSE138025

ID:: 200138025

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Select item 20010801213.

RNA-seq of induced brain microvascular endothelial cells from cerebral childhood adrenoleukodystrophy patients and wild-type controls

(Submitter supplied) The goal of this study is to compare gene expression differences between induced brain microvascular endothelial cells from cerebral childhood adrenoleukodystrophy patients and wild-type controls

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL22790
18 Samples

Download data: TXT

Series

Accession:: GSE108012

ID:: 200108012

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Select item 20014447414.

Contribution of brain pericytes in blood-brain barrier formation and maintenance: A transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells

(Submitter supplied) The formation, maintenance, and repair of the blood-brain barrier (BBB) are critical for central nervous system homeostasis. The interaction of endothelial cells with brain pericytes is known to induce BBB characteristics in brain endothelial cells during embryogenesis and could be used to differentiate human endothelial cells from stem cell source in in vitro BBB models. However, the molecular events involved in BBB maturation are not fully understood. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
27 Samples

Download data: CSV

Series

Accession:: GSE144474

ID:: 200144474

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Select item 20015600915.

RNA sequencing on stem cell-derived endothelial cells

(Submitter supplied) We generated a stable H9 stem cell line with an FRT cassette in the AAVS1 safe harbour locus, which allows recombinase-mediated cassette exchange. We used this system to overexpress ETV2, a master regulator of endothelial fating. This study contains gene expression characterisation of endothelial cells derived through overexpression of ETV2, at day 10 of differentiation. These endothelial cells are referred to as ETV2-ECs.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
3 Samples

Download data: TXT

Series

Accession:: GSE156009

ID:: 200156009

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Select item 20011183916.

Transcriptional and Epigenomic Landscapes of CNS and non-CNS Vascular Endothelial Cells

(Submitter supplied) Vascular endothelial cell (EC) function depends on appropriate organ-specific molecular and cellular specializations. To explore genomic mechanisms that control this specialization, we have analyzed and compared the transcriptome, accessible chromatin, and DNA methylome landscapes from mouse brain, liver, lung, and kidney ECs. Analysis of transcription factor (TF) motifs at candidate cis-regulatory elements together with TF gene expression reveals both shared and organ-specific EC TFs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL21103 GPL17021 GPL19057
42 Samples

Download data: BW, MTX, NARROWPEAK, TAR, TSV, TXT

Series

Accession:: GSE111839

ID:: 200111839

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Select item 20005866317.

Molecular Mechanisms of Endothelial Hyperpermeability

(Submitter supplied) Vascular permeability reflects changes in the function of the endothelium, its interendothelial junctions and transcellular delivery. Here, we show that common molecular mechanisms exist between VEGF and histamine in regulating vascular hyperpermeability. Crosstalk between downstream signaling of VEGF and histamine receptors are involved in calcium signaling and cell proliferation. Understanding the molecular mechanisms of vascular permeability is crucial in order to reduce vascular hyperpermeability and oedema in various pathological conditions and in VEGF therapy.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE58663

ID:: 200058663

Select item 20004347518.

UNRAVELING A NOVEL TRANSCRIPTION FACTOR CODE INDUCTIVE FOR THE HUMAN ARTERIAL-SPECIFIC ENDOTHELIAL CELL SIGNATURE

(Submitter supplied) Endothelial cells (EC) lining arteries and veins have distinct molecular and functional signatures. The (epi)genetic regulatory mechanisms underlying this heterogeneity in human EC are incompletely understood. Using genome-wide microarray screening we established a specific fingerprint of freshly isolated arterial (HUAEC) and venous EC (HUVEC) from human umbilical cord comprising 64 arterial and 12 venous genes, representing distinct functions and pathways. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS4777 GDS4778
Platform:: GPL570
38 Samples

Download data: CEL

Series

Accession:: GSE43475

ID:: 200043475

Select item 477819.

Freshly-isolated umbilical cord arterial and venous endothelial cells

Analysis of freshly-isolated endothelial cells (EC) from umbilical arteries (HUAEC) and veins (HUVEC). ECs lining different vessels differ in morphology and function. Results provide insight into molecular mechanisms underlying arteriovenous EC heterogeneity.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 cell type sets

Platform:: GPL570
Series:: GSE43475
8 Samples

Download data: CEL

DataSet

Accession:: GDS4778

ID:: 4778

Select item 477720.

Freshly-isolated and cultured arterial and venous endothelial cells

Analysis of freshly-isolated endothelial cells (EC) from umbilical arteries and veins and cultured arterial and venous ECs from different vascular regions. Culturing leads to loss of the arterial phenotype. Results provide insight into molecular mechanisms underlying arteriovenous EC heterogeneity.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 10 cell type, 2 protocol, 2 tissue sets

Platform:: GPL570
Series:: GSE43475
38 Samples

Download data: CEL

DataSet

Accession:: GDS4777

ID:: 4777

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