Similar studies for GEO DataSets (Select 200143218) - GEO DataSets

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Items: 20

Select item 2001432181.

RNA-seq of knocked-out oocytes and directly induced oocyte-like cells (DIOLs)

(Submitter supplied) During female germline development oocytes become a highly specialized cell type, and form a maternal cytoplasmic store of crucial factors during oocyte growth. Oocyte growth is triggered at the primordial-primary follicle transition accompanied with dynamic changes in gene expression, yet the gene regulatory network underpinning oocyte growth remains elusive. Here we identified a set of transcription factors sufficient to trigger oocyte growth. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL19057 GPL17021
71 Samples

Download data: TXT

Series

Accession:: GSE143218

ID:: 200143218

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Select item 2001432202.

Directly induced oocyte-like Cells (DIOLs)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL17021 GPL21273 GPL19057
77 Samples

Download data: BEDGRAPH

Series

Accession:: GSE143220

ID:: 200143220

PubMed Similar studies

Select item 2001432193.

DNA methylome analysis of directly induced oocyte-like cells (DIOLs)

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL21273
6 Samples

Download data: BEDGRAPH

Series

Accession:: GSE143219

ID:: 200143219

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Select item 2002234794.

Comprehensive comparison of female germ cell development in vitro and in vivo identifies epigenetic gene regulation crucial for oocyte development and embryonic competence

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL17021
171 Samples

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Series

Accession:: GSE223479

ID:: 200223479

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Select item 2002234785.

Comprehensive comparison of female germ cell development in vitro and in vivo identifies epigenetic gene regulation crucial for oocyte development and embryonic competence [bulk RNA-seq]

(Submitter supplied) NOT PROVIDED; REQUESTED

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: CSV

Series

Accession:: GSE223478

ID:: 200223478

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Select item 2002234776.

Comprehensive comparison of female germ cell development in vitro and in vivo identifies epigenetic gene regulation crucial for oocyte development and embryonic competence [scRNA-seq]

(Submitter supplied) Single cell transcriptomics and functional assessment in a stage-specific manner provides a comprehensive comparison of entire female germ cell development in vitro and in vivo.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
163 Samples

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Series

Accession:: GSE223477

ID:: 200223477

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Select item 2001511437.

Generation of ovarian follicles from mouse pluripotent stem cells

(Submitter supplied) Oocytes mature in a specialized fluid-filled sac, the ovarian follicle, which provides signals needed for meiosis and germ cell growth. Methods have been developed to generate functional oocytes from pluripotent stem cell–derived primordial germ cell–like cells (PGCLCs) when placed in culture with embryonic ovarian somatic cells. In this study, we developed culture conditions to recreate the stepwise differentiation process from pluripotent cells to fetal ovarian somatic cell–like cells (FOSLCs). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
6 Samples

Download data: MTX, TSV

Series

Accession:: GSE151143

ID:: 200151143

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Select item 2001399668.

FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation

(Submitter supplied) Germ-cell transcription factors control gene networks that regulate primordial follicle formation and oocyte differentiation during early, postnatal mouse oogenesis. Taking advantage of gene-edited mice lacking transcription factors expressed in female germ cells, we analyzed global gene expression profiles in perinatal ovaries from wildtype, FiglaNull, Lhx8Null and SohlhNull mice. Figla deficiency dysregulates expression of meiosis-related genes (e.g., Sycp3, Rad51 and Msy2) and a variety of genes (e.g., Nobox, Lhx8, Taf4b, Sohlh1, Sohlh2 and Gdf9) associated with oocyte growth and differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
20 Samples

Download data: TXT

Series

Accession:: GSE139966

ID:: 200139966

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Select item 2000797299.

RNA-seq analysis of in vivo- and in vitro-produced mouse oocytes

(Submitter supplied) The female germline undergoes a unique line of differentiation processes that endows totipotency to the egg. During these processes, biologically significant events such as meiosis and oocyte growth are controlled in an orderly manner, with any disorder causing infertility and developmental arrest of the next generation. Reconstitution in vitro of the entire process of oogenesis from pluripotent stem cells is a key achievement in stem cell biology and regenerative medicine, but a robust and reproducible culture system has not been established. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
23 Samples

Download data: TXT

Series

Accession:: GSE79729

ID:: 200079729

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Select item 20004071610.

Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice

(Submitter supplied) Reconstitution of female germ-cell development in vitro is a key challenge in reproductive biology and medicine. We show here that female (XX) embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) in mice are induced into primordial germ cell-like cells (PGCLCs), which, when aggregated with female gonadal somatic cells as reconstituted ovaries, develop pre-meiotic germ cell characteristics, including X-reactivation, imprint erasure, and cyst formation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL

Series

Accession:: GSE40716

ID:: 200040716

Select item 20009738811.

In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells

(Submitter supplied) Understanding the unique mechanisms of human oogenesis necessitates the development of an in vitro system of stem cell differentiation into oocytes. Specialized cell types and organoids have been derived from human pluripotent stem cells in vitro, but generating a human ovarian follicle remains a challenge. Here we report that human embryonic stem cells (hESCs) can be induced to differentiate into ovarian follicle-like cells in vitro. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: TXT

Series

Accession:: GSE97388

ID:: 200097388

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20011412612.

Comparing the Transcriptomes of Wild Type (WT) and Gdf9-Cre or Zp3-Cre mediated Mtor Oocyte-Conditional Knockout (referred to as MG and MZ, respectively) Mouse GV-stage fully-grown oocytes (FGO) by RNA-Seq Analysis

(Submitter supplied) The goal of this study is to identify the differentially expressed genes in Gdf9-Cre and Zp3-Cre mediated Mtor oocyte-specific knockout (CKO) GV-stage fully-grown oocytes (FGO) by comparing their transcriptomes with that of the wild-type (WT) via RNA-Seq Analysis.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
9 Samples

Download data: TXT

Series

Accession:: GSE114126

ID:: 200114126

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Select item 20009849713.

Comparing the Transcriptomes of Wild Type and Mtor-Gdf9-Cre mediated Oocyte-Conditional Knockout Mouse ovaries by RNA-Seq Analysis

(Submitter supplied) The goal of this study is to identify the differentially expressed genes in Gdf9-Cre mediated Mtor oocyte-specific knockout (CKO) ovaries by comparing the transcriptomes of Mtor Wild-Type (WT) and CKO Mouse ovaries via RNA-Seq Analysis.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
12 Samples

Download data: TXT

Series

Accession:: GSE98497

ID:: 200098497

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Select item 20015240714.

Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse oocytes during follicular formation

(Submitter supplied) To delineate the developmental trajectory of oocyte during the process, we performed RNA-seq on single germ cells from newborn (P0.5) ovaries and identified a series of genes that may function between stage transitions. The significant decrease of meiosis-related genes and the dramatic increase of oocyte-specific genes marked the transition of germ cell to a functional oocyte. Our data highlighted the complexity of transcriptional control and depicted the regulatons and their regulatory networks in oocyte development. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
146 Samples

Download data: TXT

Series

Accession:: GSE152407

ID:: 200152407

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Select item 20007198515.

Human oocyte DNA methylome

(Submitter supplied) We used single-cell WGBS to profile DNA methylomes of human oocytes at different maturation stages

Organism:: Homo sapiens

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL11154
30 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE71985

ID:: 200071985

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Select item 20024943416.

Single-cell profiling reveals transcriptome dynamics during bovine oocyte growth

(Submitter supplied) Mammalian follicle development is characterised by extensive changes in morphology, endocrine responsiveness, and function, providing the optimum environment for oocyte growth, development, and resumption of meiosis. In cattle, the first signs of transcription activation in the oocyte are observed in the secondary follicle, later than during mouse and human oogenesis. While many studies have generated extensive datasets characterising gene expression in bovine oocytes, they are mostly limited to the analysis of fully grown and matured oocytes. more...

Organism:: Bos taurus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23055
179 Samples

Download data: TXT

Series

Accession:: GSE249434

ID:: 200249434

PubMed Full text in PMC Similar studies

Select item 20019599017.

Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys [sc3seq_mouse]

(Submitter supplied) In vitro oogenesis is key to elucidating the mechanism of human female germ-cell development and its anomalies. Accordingly, pluripotent stem cells have been induced into primordial germ cell-like cells and into oogonia with epigenetic reprogramming, yet further reconstitutions remain a challenge. Here, we demonstrate ex vivo reconstitution of fetal oocyte development in both humans and cynomolgus monkeys (Macaca fascicularis). more...