Similar studies for GEO DataSets (Select 200208762) - GEO DataSets

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Items: 19

Select item 2002087621.

Gene expression profile at single cell level of colonic epithelial cells from the distal colon

(Submitter supplied) The colon is densely innervated by nociceptor neurons. Single cell RNA sequencing (scRNA-seq) of colon epithelial cells was performed to analyze the role of nociceptor neurons and Ramp1 signaling in regulating colonic epithelial cells.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE208762

ID:: 200208762

PubMed Full text in PMC Similar studies

Select item 2002085942.

Gene expression profile at single cell level of small intestine epithelial cells from the distal ileum

(Submitter supplied) Small intestine is highly innervated by nociceptor neurons. Single cell RNA sequencing (scRNA-seq) of ileal epithelial cells was performed to analyze the role of nociceptor neurons in regulating small intestinal epithelial cells.

Organism:: Mus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23642
2 Samples

Download data: XLSX

Series

Accession:: GSE208594

ID:: 200208594

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Select item 2002216813.

Bacteria hijack a neuro-immune axis in meninges to facilitate brain invasion

(Submitter supplied) The meninges are densely innervated by nociceptive sensory neurons that mediate pain and headache. How pain and neuro-immune interactions impact meningeal host defenses is unclear. Bacterial meningitis causes life-threatening infections of the meninges and central nervous system (CNS), affecting over one million people a year. Here we find that Nav1.8+ neuron signaling to immune cells in the meninges via the neuropeptide calcitonin gene-related peptide (CGRP) exacerbates bacterial meningitis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
31 Samples

Download data: H5, RDA

Series

Accession:: GSE221681

ID:: 200221681

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Select item 2002058664.

Nociceptor neurons affect cancer immunosurveillance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
48 Samples

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Series

Accession:: GSE205866

ID:: 200205866

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Select item 2002058655.

Nociceptor neurons affect cancer immunosurveillance [RNA-seq 3]

(Submitter supplied) Sequecing tumor-innervating neurons

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
8 Samples

Download data: XLSX

Series

Accession:: GSE205865

ID:: 200205865

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Select item 2002058646.

Nociceptor neurons affect cancer immunosurveillance [RNA-seq 2]

(Submitter supplied) Sequencing Neuron, melanoma and CD8 when culture alone or co-culture with one another

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
36 Samples

Download data: CSV

Series

Accession:: GSE205864

ID:: 200205864

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Select item 2002058637.

Nociceptor neurons affect cancer immunosurveillance [RNA-seq 1]

(Submitter supplied) Neuron, melanoma and CD8 co-cultures

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: XLSX

Series

Accession:: GSE205863

ID:: 200205863

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Select item 2002550498.

CGRP sensory neurons promote tissue healing by modulating neutrophils and macrophages

(Submitter supplied) Since the immune system plays a critical role in orchestrating tissue healing, regenerative strategies that control immune components have proven effective. This is particularly relevant when immune dysregulation resulting from conditions such as diabetes or advanced age impairs tissue healing following injury. Nociceptive sensory neurons play a crucial role as immunoregulators, exerting both protective and harmful effects depending on the context. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30172
12 Samples

Download data: CSV

Series

Accession:: GSE255049

ID:: 200255049

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Select item 2002530639.

The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota

(Submitter supplied) The somatosensory nervous system surveils external stimuli at barrier tissues, regulating innate immune cells under infection and inflammation. The roles of sensory neurons in controlling the adaptive immune system, and more specifically immunity to the microbiota, however, remain elusive. Here, we identified a novel mechanism for direct neuroimmune communication between commensal-specific T lymphocytes and somatosensory neurons mediated by the neuropeptide calcitonin gene-related peptide (CGRP) in the skin. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL19057
2 Samples

Download data: CSV, MTX, RDS, TSV

Series

Accession:: GSE253063

ID:: 200253063

Select item 20025304110.

The neuroimmune CGRP-RAMP1 axis tunes cutaneous adaptive immunity to the microbiota.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL21626 GPL21103
12 Samples

Download data: TXT

Series

Accession:: GSE253041

ID:: 200253041

Select item 20017865011.

Mouse intestinal epithelial cells in the deficiency of Foxo1

(Submitter supplied) Mucus produced by goblet cells in the gastrointestinal (GI) tract forms a biological barrier that protects the intestine from invasion by commensals and pathogens. However, the host-derived regulatory network that controls mucus secretion and thereby changing gut microbiota has not been well studied. We found Forkhead box protein O1 (Foxo1) regulates mucus secretion by goblet cells and determines intestinal homeostasis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TXT

Series

Accession:: GSE178650

ID:: 200178650

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Select item 20015644912.

Nociceptive nerves regulate haematopoietic stem cell mobilization

(Submitter supplied) Nociceptive neuropeptide CGRP acts directly on HSCs via the its receptor RAMP1/CALCRL, to promote egress by activating Gαs/Adenylyl cyclase/cAMP pathway.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TXT

Series

Accession:: GSE156449

ID:: 200156449

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20022088413.

Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress super

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: synthetic construct; mouse gut metagenome; Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL21626 GPL21051 GPL17769
26 Samples

Download data: TSV, XLSX

Series

Accession:: GSE220884

ID:: 200220884

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Select item 20022088314.

Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress [16S]

(Submitter supplied) To determine how constitutively active autophagy in Becn1F121A mice affects the fecal microbiota, we performed a 16s analysis.

Organism:: synthetic construct; mouse gut metagenome

Type:: Other

Platforms:: GPL17769 GPL21051
2 Samples

Download data: TSV, XLSX

Series

Accession:: GSE220883

ID:: 200220883

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Select item 20022045715.

Autophagy controls mucus secretion from intestinal goblet cells by alleviating ER stress [RNA-seq]

(Submitter supplied) To determine how constitutively active autophagy in Becn1F121A mice affects the colonic tissue, we performed a transcriptional analysis.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21626
24 Samples

Download data: XLSX

Series

Accession:: GSE220457

ID:: 200220457

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Select item 20015818616.

Gene expression profile of colonic goblet cells (GCs) from SpdefKO_RedMUC298trTg and RedMUC298trTg mice

(Submitter supplied) Spdef is a transcription factor involved in differentiation of goblet cells. Goblet cells from RedMUC298trTg and Spdef -/-RedMUC298trTg were sorted to analyse the differential gene expression in the absence of Spdef.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
16 Samples

Download data: TXT

Series

Accession:: GSE158186

ID:: 200158186

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014443617.

Intestinal goblet cells are a heterogeneous lineage with diverse funcional potential

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
36 Samples

Download data: HTML, MTX, TSV

Series

Accession:: GSE144436

ID:: 200144436

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Select item 20014436418.

Gene expression profile at single cell level of goblet cells (GCs) from the distal colon (DC) and the 8th portion of the small intestine (Si8)

(Submitter supplied) Goblet cells are considered as a homogeneous population in the intestinal epithelium. We used single cell RNA sequencing (scRNA-seq) to analyze the diversity of GCs in the intestine.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: MTX, TSV

Series

Accession:: GSE144364

ID:: 200144364

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014436319.

Gene expression profile of goblet cells (GCs) from the distal colon (DC) and the 8th portion of the small intestine (Si8)

(Submitter supplied) Goblet cells together other cell types make up the intestinal epithelium and are responsible for mucus production. The goal of this project is to fully characterize the gene expression profile of the GCs in the colon and small intestine.