Similar studies for GEO DataSets (Select 200213777) - GEO DataSets

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Items: 18

Select item 2002137771.

MiRNAs array after SH3BP2 silencing in Gastrointestinal stromal tumor cells

(Submitter supplied) Silencing of the adaptor SH3BP2 impairs Gastrointestinal stromal tumors growth through miRNAs We dissected SH3BP2 pathway in Gastrointestinal Stromal Tumor cells (GIST) performing a miRNA array in SH3BP2-silenced GIST cells

Organism:: Human alphaherpesvirus 1; Human betaherpesvirus 5; human gammaherpesvirus 4; Human betaherpesvirus 6B; Betapolyomavirus macacae; Human alphaherpesvirus 2; Betapolyomavirus hominis; Homo sapiens; Macacine alphaherpesvirus 1; Merkel cell polyomavirus; Herpesvirus saimiri (strain 11); JC polyomavirus; Human immunodeficiency virus 1; Human gammaherpesvirus 8

Type:: Non-coding RNA profiling by array

Platform:: GPL21599
12 Samples

Download data: TXT, XLSX

Series

Accession:: GSE213777

ID:: 200213777

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000228522.

Gastrointestinal stromal tumor GIST: gene expresssion and ChIP analyses

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9115 GPL6947
20 Samples

Download data: BED

Series

Accession:: GSE22852

ID:: 200022852

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000224413.

Mapping of ETV1 genomic binding sites in gastrointestinal stromal tumor (GIST).

(Submitter supplied) ETV1 is highly expressed in GIST and their presumed precursors--the interstitial cells of Cajal. ETV1 is required for survival for both GIST and ICC and regulates GIST signature genes. Here, using Illumina-Solexa based next-generation sequencing of ETV1 chromatin immunoprecipates (ChIP-Seq), we define ETV1 binding sites in the GIST48 cell line.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9115
2 Samples

Download data: BED

Series

Accession:: GSE22441

ID:: 200022441

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000224334.

Imatinib Treatment of GIST882

(Submitter supplied) Gastrointestinal Stromal Tumor frequently harbor mutations in the KIT receptor tyrosine kinase and depend on its activity for growth. This underlies the efficacy of imatinib, a inhibitor of KIT activity, in GIST management. GIST882 is a patient derived GIST cell line that harbor a K640E exon 13 KIT mutation and is sensitive to imatinib treatment. To analyze the downstream effect of KIT inhibition, GIST882 cells were treated for 8 hours with 1μM Imatinib.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
6 Samples

Download data: TXT

Series

Accession:: GSE22433

ID:: 200022433

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Select item 2000193965.

ETV1 knockdown in GIST cell lines

(Submitter supplied) ETV1 is highly expressed in GIST cells and required for their survival and growth. To identify genes and pathways regulated by ETV1 in GIST, we performed expression profiles of GIST cells after ETV1 knockdown.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6947
12 Samples

Download data: TXT

Series

Accession:: GSE19396

ID:: 200019396

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Select item 2000646096.

ChIP-Seq of Histone H3K4me1 and H3K4me3 in human GIST48 cells

(Submitter supplied) We previously mapped ETV1 using ChIP-Seq in GIST48 cells (GSE22441). Here, we map the enhancer landscape marked by histone H3K4me1 and the promoter landscape marked by histone H3K4me3 in GIST48 cells.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9115
2 Samples

Download data: BED

Series

Accession:: GSE64609

ID:: 200064609

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000646087.

RNA-Seq of murine GIST-like tumors after Etv1 ablation

(Submitter supplied) We used a mouse expressing three alleles 1) KitV558Delta/+ activating allele that develop GIST-like tumors in the cecum, 2) Etv1 flox/flox conditional knockout allele and 3) Rosa26-CreERT2 tamoxifen activated Cre allele. Mice were treated with either Tamoxifen (to delete Etv1) or corn oil (control). Cecal tumors were isolated for gene expression profiling by RNA-Seq.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: TXT

Series

Accession:: GSE64608

ID:: 200064608

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000687438.

Gene expression signatures in GIST-T1 cells transfected with miR-34a and miR-335 mimic molecules

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16699
8 Samples

Download data: TXT

Series

Accession:: GSE68743

ID:: 200068743

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Select item 2000687429.

Gene expression signatures in GIST-T1 cells transfected with a miR-335 mimic molecule

(Submitter supplied) To clarify the effect of miRNAs, we carried out a gene expression microarray analysis using GIST-T1 cells transfected with a miR-335 mimic or a negative control. We found that 1,095 probe sets (853 unique genes) were downregulated (>1.5-fold) by ectopic miR-335 expression.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16699
4 Samples

Download data: TXT

Series

Accession:: GSE68742

ID:: 200068742

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006874010.

Gene expression signatures in GIST-T1 cells transfected with a miR-34a mimic molecule

(Submitter supplied) To clarify the effect of miRNAs, we carried out a gene expression microarray analysis using GIST-T1 cells transfected with a miR-34a mimic or a negative control. We found that 2,621 probe sets (1,933 unique genes) were downregulated (>1.5-fold) by ectopic miR-34a expression, including PDGFRA gene which was previously reported as a miR-34a target gene.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16699
4 Samples

Download data: TXT

Series

Accession:: GSE68740

ID:: 200068740

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Select item 20008967311.

Transcriptome analysis of GIST430 and GIST882 cells transfected with nontargeting microRNA or with miR-494

(Submitter supplied) Gene expression microarry by using GIST430 and GIST882 cells with or without miR-494 treatment

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
12 Samples

Download data: TXT

Series

Accession:: GSE89673

ID:: 200089673

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Select item 20002678312.

Mast cell microRNAs regulated by KIT signaling

(Submitter supplied) Objective is to identify microRNAs regulated by KIT signaling in mast cells. miRNA profiles of murine bone marrow derived mast cells with and without SCF treatment were compared. In addition, miRNA profiles of the P815 mutant KIT cell line with and without the KIT inhibitor, imatinib, were compared. We identified miRNAs that were differentially regulated by KIT signals.

Organism:: Rattus norvegicus; Homo sapiens; Mus musculus

Type:: Non-coding RNA profiling by array

Platform:: GPL8573
4 Samples

Download data: TXT

Series

Accession:: GSE26783

ID:: 200026783

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Select item 20010662613.

FOXF1 defines the core-regulatory circuitry in gastrointestinal stromal tumor (GIST)

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL16791
38 Samples

Download data: BIGWIG, NARROWPEAK

Series

Accession:: GSE106626

ID:: 200106626

PubMed Full text in PMC Similar studies

Select item 20010662514.

Expression profile of GIST48 cells with siETV1 or siFOXF1 knockdown

(Submitter supplied) To study FOXF1 transcriptome and compare that with ETV1 transcriptome, we knocked down ETV1 or FOXF1 with siRNA in GIST48 cells and studied the transcriptome changes

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: XLS

Series

Accession:: GSE106625

ID:: 200106625

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010662415.

ETV1 and FOXF1 cistrome in wildtype GIST48, GIST-T1, MDA-PCa2b, and ETV1 or FOXF1 knocked-down GIST48 cells

(Submitter supplied) ChIP profiles were generated by deep sequencing using Illumina HiSeq.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
23 Samples

Download data: BIGWIG, NARROWPEAK

Series

Accession:: GSE106624

ID:: 200106624

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010662316.

Chromatin accessibility of GIST48, GIST882 and GIST-T1 cells with ETV1 or FOXF1 knockdown

(Submitter supplied) ATAC profiles were generated by deep sequencing using Illumina HiSeq.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
9 Samples

Download data: BIGWIG

Series

Accession:: GSE106623

ID:: 200106623

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007783917.

Transcriptome analysis of a FACS-sorted human intersitial cells of Cajal (ICC) [array]

(Submitter supplied) Interstitial cells of Cajal (ICC) are electrical pacemakers and mediators of neuromuscular neurotransmission in the gastrointestinal tract. Gastrointestinal stromal tumors (GIST) arise within the ICC lineage due to activating KIT/PDGFRA mutations. In this study we developed a method for isolation of human ICC by immunolabeling and fluorescence-activated cell sorting (FACS). Briefly, human gastric musculature was dissociated and incubated with antibodies against CD45, FCER1A, CD11B, KIT, and CD34. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
14 Samples

Download data: CEL

Series

Accession:: GSE77839

ID:: 200077839

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013148118.

CeRNA Expression Profiling Identifies KIT Related circRNAs-miRNA-mRNA Networks in Gastro-intestinal Stromal Tumors

(Submitter supplied) Gastrointestinal stromal tumors (GISTs) are the most common human sarcomas and typically locate in the stomach or small intestine. circular RNAs (circRNAs) were identified to plays vital roles in tumor oncogenesis and progression. To investigate the involvement of differentially expressing genes and circRNAs in GIST , transcriptomic analyses of differential expression genes and circRNAs were performed for discrimination of GISTs from normal tissues. more...