GEO DataSets

(Submitter supplied) We investigated diurnal changes in gene expression in the retina and choroid at the onset of experimental myopia. We induced visual form deprivation myopia in young chicks, and isolated retinal and choroidal tissues separately in form- deprived and contralateral control eyes every 4 hours over a single 24-hour period.

Organism:

Gallus gallus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26853

142 Samples

Download data: TXT

(Submitter supplied) The retina plays an important regulatory role in ocular growth. To screen for new retinal candidate genes that could be involved in the inhibition of ocular growth, we used chick microarrays to analyze the changes in retinal mRNA expression after myopic defocus was imposed by positive lens-wear. Chicks were raised under a 12h-light/12h-dark cycle (light-onset: 8:00 am and light-offset: 8:00 pm) with unrestricted access to water and food. more...

Organism:

Gallus gallus

Type:

Expression profiling by array

Platform:

GPL3213

8 Samples

Download data: CEL, EXP

(Submitter supplied) Using RNA-Seq, mRNA from 54 retinae were sequenced from male chicks in which myopia development was inhibited by one of five growth inhibitory treatments.

Organism:

Gallus gallus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19787

54 Samples

Download data: CSV

(Submitter supplied) One-day old white Leghorn chicks were housed in brooders with a 12 hr light:dark cycle, using General Electric chroma 50 fluorescent lighting with irradiance of approximately 50μW/cm2 at chick eye level. They received Purina Chick Chow food and water ad libitum. At one week of age and at the onset of the light phase, the chicks were anesthetized with inhalation ether, and a unilateral translucent white plastic goggle was glued to the periorbital feathers to induce ipsilateral form-deprivation myopia, alternating between the left or right eye. more...

Organism:

Gallus gallus

Type:

Expression profiling by array

Platform:

GPL3213

24 Samples

Download data: CEL

(Submitter supplied) Because refractive development is governed largely by the retina, we analyzed the retinal transcriptome in chicks wearing a spectacle lens, a well-established means to induce refractive errors, to identify gene expression alterations and to develop novel mechanistic hypotheses about refractive development.

Organism:

Gallus gallus

Type:

Expression profiling by array

Dataset:

GDS3924

Platform:

GPL3213

48 Samples

Download data: CEL, CHP

Analysis of retina and retinal pigment epithelium (RPE) from 1 week-old chicks wearing a unilateral spectacle lens of + or 15 diopters for 6 hours or 3 days. The spectacle lens induces refractive errors. Results provide insight into molecular mechanisms underlying refractive development.

Organism:

Gallus gallus

Type:

Expression profiling by array, transformed count, 3 protocol, 2 time sets

Platform:

GPL3213

Series:

GSE24641

48 Samples

Download data: CEL, CHP

(Submitter supplied) Development of myopia is associated with large-scale changes in ocular tissue gene expression. Although differential expression of coding genes underlying development of myopia has been a subject of intense investigation, the role of non-coding genes such as microRNAs in the development of myopia is largely unknown. In this study, we explored myopia-associated miRNA expression profiles in the retina and sclera of C57Bl/6J mice with experimentally induced myopia using microarray technology. more...

Organism:

Mus musculus

Type:

Non-coding RNA profiling by array

Platform:

GPL22134

12 Samples

Download data: TXT