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    rev Rev [ Human immunodeficiency virus 1 ]

    Gene ID: 155908, updated on 10-Oct-2023

    Summary

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    Gene symbol
    rev
    Gene description
    Rev
    Locus tag
    HIV1gp6
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Human immunodeficiency virus 1
    Lineage
    Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Lentivirus; Primate lentivirus group
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    Genomic context

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    Sequence:
    NC_001802.1 (5516..8199)

    NC_001802.1Genomic Context describing neighboring genes Neighboring gene Gag-Pol Neighboring gene Pr55(Gag) Neighboring gene Vif Neighboring gene Vpr Neighboring gene Tat Neighboring gene Vpu Neighboring gene Envelope surface glycoprotein gp160, precursor Neighboring gene Asp Neighboring gene Nef

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001802.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Native mass spectrometry reveals the initial binding events of HIV-1 rev to RRE stem II RNA. Schneeberger EM, et al. Nat Commun, 2020 Nov 13. PMID 33188169, Free PMC Article
    2. Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis. Jackson PEH, et al. Curr HIV Res, 2020. PMID 31906839, Free PMC Article
    3. HIV-1 Rev interacts with HERV-K RcREs present in the human genome and promotes export of unspliced HERV-K proviral RNA. Gray LR, et al. Retrovirology, 2019 Dec 16. PMID 31842941, Free PMC Article
    4. Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B. Wang Z, et al. Virol Sin, 2020 Apr. PMID 31828587, Free PMC Article
    5. Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability. Jayaraman B, et al. Sci Rep, 2019 Mar 26. PMID 30914719, Free PMC Article

    See all (252) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Structural basis of microtubule depolymerization by the kinesin-like activity of HIV-1 Rev.
      Title: Structural basis of microtubule depolymerization by the kinesin-like activity of HIV-1 Rev.
    2. CBP80/20-dependent translation initiation factor (CTIF) inhibits HIV-1 Gag synthesis by targeting the function of the viral protein Rev.
      Title: CBP80/20-dependent translation initiation factor (CTIF) inhibits HIV-1 Gag synthesis by targeting the function of the viral protein Rev.
    3. CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs.
      Title: CRNKL1 Is a Highly Selective Regulator of Intron-Retaining HIV-1 and Cellular mRNAs.
    4. Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis.
      Title: Sequence and Functional Variation in the HIV-1 Rev Regulatory Axis.
    5. HIV-1 resists MxB inhibition of viral Rev protein.
      Title: HIV-1 resists MxB inhibition of viral Rev protein.
    6. Native mass spectrometry reveals the initial binding events of HIV-1 rev to RRE stem II RNA.
      Title: Native mass spectrometry reveals the initial binding events of HIV-1 rev to RRE stem II RNA.
    7. Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B.
      Title: Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B.
    8. Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability.
      Title: Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability.
    9. ANP32A and ANP32B mediate the export of unspliced or partially spliced viral mRNA via interactions with Rev and CRM1.
      Title: ANP32A and ANP32B are key factors in the Rev-dependent CRM1 pathway for nuclear export of HIV-1 unspliced mRNA.
    10. The HIV Rev protein can functionally interact with many HERV-K mRNAs (RcREs) present in the human genome, depending on the RcRE sequence, as well as the Rev sequence.
      Title: HIV-1 Rev interacts with HERV-K RcREs present in the human genome and promotes export of unspliced HERV-K proviral RNA.
    Submit: New GeneRIF Correction See all GeneRIFs (79)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    ATP-binding cassette sub-family F member 1 isoform b ABCF1 interacts with PubMed
    apoptotic chromatin condensation inducer in the nucleus isoform 1 ACIN1 interacts with PubMed
    actin, cytoplasmic 1 ACTB associates with PubMed
    ACTB associates with PubMed
    ACTB associates with PubMed
    double-stranded RNA-specific adenosine deaminase isoform a ADAR interacts with PubMed
    ADAR regulated by PubMed
    arf-GAP domain and FG repeat-containing protein 1 isoform 2 AGFG1 binds PubMed
    AGFG1 binds PubMed
    AGFG1 binds PubMed
    AGFG1 requires PubMed
    arf-GAP domain and FG repeat-containing protein 2 AGFG2 binds PubMed
    AGFG2 binds PubMed
    THO complex subunit 4 ALYREF inhibits PubMed
    S-adenosylmethionine decarboxylase proenzyme isoform 1 AMD1 requires PubMed
    acidic leucine-rich nuclear phosphoprotein 32 family member A ANP32A interacts with PubMed
    ANP32A interacts with PubMed
    acidic leucine-rich nuclear phosphoprotein 32 family member B ANP32B interacts with PubMed
    ANP32B interacts with PubMed
    acidic leucine-rich nuclear phosphoprotein 32 family member E isoform 1 ANP32E interacts with PubMed
    DNA repair nuclease/redox regulator APEX1 APEX1 interacts with PubMed
    serine-protein kinase ATM isoform a ATM stimulated by PubMed
    sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform a ATP2A2 interacts with PubMed
    complement component 1 Q subcomponent-binding protein, mitochondrial precursor C1QBP binds PubMed
    C1QBP inhibits PubMed
    C1QBP binds PubMed
    C1QBP binds PubMed
    ashwin isoform 1 C2orf49 interacts with PubMed
    calreticulin precursor CALR interacts with PubMed
    caprin-1 isoform 1 CAPRIN1 interacts with PubMed
    cell division cycle 5-like protein CDC5L interacts with PubMed
    cyclin-dependent kinase 1 isoform 1 CDK1 phosphorylated by PubMed
    small ribosomal subunit protein mS37 CHCHD1 interacts with PubMed
    cleavage and polyadenylation specificity factor subunit 2 isoform 1 CPSF2 interacts with PubMed
    cleavage and polyadenylation specificity factor subunit 6 isoform 1 CPSF6 interacts with PubMed
    cleavage and polyadenylation specificity factor subunit 7 isoform 1 CPSF7 interacts with PubMed
    casein kinase II subunit alpha isoform a CSNK2A1 interacts with PubMed
    CSNK2A1 modulated by PubMed
    CSNK2A1 activates PubMed
    CSNK2A1 phosphorylated by PubMed
    CSNK2A1 binds PubMed
    CSNK2A1 phosphorylated by PubMed
    casein kinase II subunit alpha' CSNK2A2 interacts with PubMed
    CSNK2A2 modulated by PubMed
    CSNK2A2 activates PubMed
    CSNK2A2 phosphorylated by PubMed
    CSNK2A2 binds PubMed
    CSNK2A2 phosphorylated by PubMed
    casein kinase II subunit beta isoform 1 CSNK2B interacts with PubMed
    CSNK2B activates PubMed
    CSNK2B phosphorylated by PubMed
    CSNK2B binds PubMed
    CSNK2B phosphorylated by PubMed
    CSNK2B modulated by PubMed
    cleavage stimulation factor subunit 2 isoform 2 CSTF2 interacts with PubMed
    cleavage stimulation factor subunit 3 isoform 1 CSTF3 interacts with PubMed
    cullin-4A isoform 2 CUL4A interacts with PubMed
    cullin-4B isoform 1 CUL4B interacts with PubMed
    C-X-C chemokine receptor type 4 isoform b CXCR4 inhibits PubMed
    DAZ-associated protein 1 isoform b DAZAP1 interacts with PubMed
    DNA damage-binding protein 1 DDB1 interacts with PubMed
    ATP-dependent RNA helicase DDX1 DDX1 interacts with PubMed
    DDX1 binds PubMed
    DDX1 co-localizes with PubMed
    DDX1 interacts with PubMed
    DDX1 interacts with PubMed
    DDX1 interacts with PubMed
    DDX1 interacts with PubMed
    DDX1 relocalized by PubMed
    DDX1 relocalized by PubMed
    DDX1 interacts with PubMed
    probable ATP-dependent RNA helicase DDX17 isoform 1 precursor DDX17 cooperates with PubMed
    DDX17 interacts with PubMed
    DDX17 interacts with PubMed
    nucleolar RNA helicase 2 isoform 1 DDX21 enhanced by PubMed
    DDX21 interacts with PubMed
    ATP-dependent RNA helicase DDX24 DDX24 interacts with PubMed
    DDX24 interacts with PubMed
    spliceosome RNA helicase DDX39B DDX39B inhibits PubMed
    ATP-dependent RNA helicase DDX3X isoform 1 DDX3X inhibited by PubMed
    DDX3X interacts with PubMed
    DDX3X cooperates with PubMed
    DDX3X enhanced by PubMed
    DDX3X interacts with PubMed
    DDX3X regulated by PubMed
    DDX3X exported by PubMed
    DDX3X interacts with PubMed
    probable ATP-dependent RNA helicase DDX47 isoform 1 DDX47 interacts with PubMed
    probable ATP-dependent RNA helicase DDX5 isoform a DDX5 enhanced by PubMed
    DDX5 interacts with PubMed
    DDX5 enhanced by PubMed
    DDX5 interacts with PubMed
    probable ATP-dependent RNA helicase DDX56 isoform 1 DDX56 interacts with PubMed
    ATP-dependent DNA/RNA helicase DHX36 isoform 1 DHX36 interacts with PubMed
    ATP-dependent RNA helicase A DHX9 regulated by PubMed
    DHX9 interacts with PubMed
    DHX9 interacts with PubMed
    endoribonuclease Dicer isoform 1 DICER1 inhibits PubMed
    dnaJ homolog subfamily A member 1 isoform 1 DNAJA1 inhibited by PubMed
    dnaJ homolog subfamily B member 6 isoform b DNAJB6 inhibited by PubMed
    cytoplasmic dynein 1 heavy chain 1 DYNC1H1 interacts with PubMed
    elongation factor 1-alpha 1 EEF1A1 interacts with PubMed
    eukaryotic translation initiation factor 2 subunit 2 isoform 1 EIF2S2 interacts with PubMed
    eukaryotic translation initiation factor 2 subunit 3 EIF2S3 interacts with PubMed
    eukaryotic translation initiation factor 3 subunit I isoform 1 EIF3I interacts with PubMed
    eukaryotic translation initiation factor 3 subunit M isoform 1 EIF3M interacts with PubMed
    eukaryotic translation initiation factor 5A-1 isoform B EIF5A binds PubMed
    EIF5A interacts with PubMed
    EIF5A interacts with PubMed
    EIF5A binds PubMed
    EIF5A interacts with PubMed
    EIF5A binds PubMed
    ribosomal RNA small subunit methyltransferase NEP1 isoform 1 EMG1 interacts with PubMed
    epsin-2 isoform a EPN2 interacts with PubMed
    general transcription and DNA repair factor IIH helicase subunit XPD isoform 1 ERCC2 interacts with PubMed
    ERCC2 interacts with PubMed
    general transcription and DNA repair factor IIH helicase subunit XPB isoform a ERCC3 interacts with PubMed
    ERCC3 interacts with PubMed
    enhancer of rudimentary homolog ERH interacts with PubMed
    RNA-binding protein EWS isoform 2 EWSR1 interacts with PubMed
    exosome complex component CSL4 isoform a EXOSC1 interacts with PubMed
    exosome complex component RRP46 EXOSC5 interacts with PubMed
    exosome complex component RRP42 EXOSC7 interacts with PubMed
    protein FAM98B FAM98B interacts with PubMed
    ubiquitin-like FUBI-ribosomal protein eS30 fusion protein precursor FAU interacts with PubMed
    RNA-binding protein FUS isoform 1 FUS interacts with PubMed
    glyceraldehyde-3-phosphate dehydrogenase isoform 1 GAPDH interacts with PubMed
    G patch domain-containing protein 4 isoform 1 GPATCH4 interacts with PubMed
    GPN-loop GTPase 1 isoform a GPN1 interacts with PubMed
    histone H2A.J H2AJ interacts with PubMed
    histone H2B type 1-M H2BC14 interacts with PubMed
    histone H2B type 1-N H2BC15 interacts with PubMed
    histone H2B type 2-F isoform a H2BC18 interacts with PubMed
    histone H2B type 2-E H2BC21 interacts with PubMed
    histone H2B type 3-B H2BC26 interacts with PubMed
    histone H2B type 1-B H2BC3 interacts with PubMed
    histone H2B type 1-C/E/F/G/I H2BC4 interacts with PubMed
    histone H2B type 1-D H2BC5 interacts with PubMed
    histone H2B type 1-H H2BC9 interacts with PubMed
    histone H3.3 H3-3B interacts with PubMed
    histone H3.1t H3-4 co-localizes with PubMed
    histone H4 H4C1 interacts with PubMed
    HCLS1-associated protein X-1 isoform a HAX1 co-localizes with PubMed
    HAX1 binds PubMed
    E3 ISG15--protein ligase HERC5 HERC5 relocalized by PubMed
    hexokinase-2 isoform 1 HK2 interacts with PubMed
    major histocompatibility complex, class I, B precursor HLA-B interacts with PubMed
    HLA class I histocompatibility antigen, C alpha chain precursor HLA-C interacts with PubMed
    heterogeneous nuclear ribonucleoprotein A1 isoform a HNRNPA1 interacts with PubMed
    HNRNPA1 interacts with PubMed
    HNRNPA1 modulated by PubMed
    HNRNPA1 interacts with PubMed
    HNRNPA1 stimulates PubMed
    heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2 HNRNPA2B1 interacts with PubMed
    heterogeneous nuclear ribonucleoprotein A3 isoform a HNRNPA3 interacts with PubMed
    heterogeneous nuclear ribonucleoprotein A/B isoform b HNRNPAB interacts with PubMed
    heterogeneous nuclear ribonucleoproteins C1/C2 isoform b HNRNPC interacts with PubMed
    heterogeneous nuclear ribonucleoprotein D0 isoform d HNRNPD interacts with PubMed
    heterogeneous nuclear ribonucleoprotein D-like isoform a HNRNPDL interacts with PubMed
    heterogeneous nuclear ribonucleoprotein F HNRNPF interacts with PubMed
    heterogeneous nuclear ribonucleoprotein H isoform a HNRNPH1 interacts with PubMed
    heterogeneous nuclear ribonucleoprotein H2 HNRNPH2 interacts with PubMed
    heterogeneous nuclear ribonucleoprotein H3 isoform a HNRNPH3 interacts with PubMed
    heterogeneous nuclear ribonucleoprotein K isoform a HNRNPK interacts with PubMed
    HNRNPK interacts with PubMed
    heterogeneous nuclear ribonucleoprotein M isoform a HNRNPM interacts with PubMed
    heterogeneous nuclear ribonucleoprotein R isoform 2 HNRNPR interacts with PubMed
    HNRNPR binds PubMed
    heterogeneous nuclear ribonucleoprotein U isoform b HNRNPU interacts with PubMed
    HNRNPU interacts with PubMed
    endoplasmin precursor HSP90B1 interacts with PubMed
    E3 ubiquitin-protein ligase HUWE1 HUWE1 interacts with PubMed
    insulin-like growth factor 2 mRNA-binding protein 1 isoform 1 IGF2BP1 interacts with PubMed
    insulin-like growth factor 2 mRNA-binding protein 2 isoform a IGF2BP2 inhibited by PubMed
    protein Red IK interacts with PubMed
    interleukin enhancer-binding factor 2 isoform 1 ILF2 interacts with PubMed
    interleukin enhancer-binding factor 3 isoform a ILF3 interacts with PubMed
    ILF3 inhibited by PubMed
    ILF3 regulated by PubMed
    ILF3 regulated by PubMed
    ILF3 interacts with PubMed
    importin-5 IPO5 binds PubMed
    IPO5 inhibited by PubMed
    importin-7 IPO7 interacts with PubMed
    inosine triphosphate pyrophosphatase isoform a ITPA inhibits PubMed
    KH domain-containing, RNA-binding, signal transduction-associated protein 1 isoform 1 KHDRBS1 requires PubMed
    KHDRBS1 inhibited by PubMed
    KHDRBS1 requires PubMed
    KHDRBS1 modulated by PubMed
    KHDRBS1 inhibited by PubMed
    KHDRBS1 synergizes with PubMed
    KHDRBS1 binds PubMed
    KH domain-containing, RNA-binding, signal transduction-associated protein 2 isoform 2 KHDRBS2 enhanced by PubMed
    KH domain-containing, RNA-binding, signal transduction-associated protein 3 KHDRBS3 enhanced by PubMed
    kinesin-like protein KIF22 isoform 1 KIF22 binds PubMed
    importin subunit alpha-5 KPNA1 interacts with PubMed
    importin subunit alpha-1 KPNA2 interacts with PubMed
    importin subunit alpha-3 KPNA4 interacts with PubMed
    importin subunit alpha-7 KPNA6 interacts with PubMed
    importin subunit beta-1 isoform 1 KPNB1 interacts with PubMed
    KPNB1 binds PubMed
    KPNB1 inhibited by PubMed
    KPNB1 binds PubMed
    KRR1 small subunit processome component homolog KRR1 binds PubMed
    galectin-3 isoform 1 LGALS3 inhibits PubMed
    DNA ligase 3 isoform beta precursor LIG3 interacts with PubMed
    lamin isoform C LMNA binds PubMed
    mitogen-activated protein kinase 1 MAPK1 phosphorylated by PubMed
    mitogen-activated protein kinase 3 isoform 1 MAPK3 phosphorylated by PubMed
    matrin-3 isoform a MATR3 regulated by PubMed
    MATR3 interacts with PubMed
    MATR3 interacts with PubMed
    DNA replication licensing factor MCM3 isoform 1 MCM3 co-localizes with PubMed
    myoD family inhibitor domain-containing protein isoform p40 MDFIC downregulated by PubMed
    MDFIC inhibited by PubMed
    MDFIC interacts with PubMed
    microfibrillar-associated protein 1 MFAP1 interacts with PubMed
    MIT domain-containing protein 1 isoform 1 MITD1 interacts with PubMed
    helicase MOV-10 isoform 1 MOV10 requires PubMed
    MOV10 interacts with PubMed
    MOV10 upregulated by PubMed
    DNA-3-methyladenine glycosylase isoform a MPG interacts with PubMed
    large ribosomal subunit protein uL11m isoform a MRPL11 interacts with PubMed
    large ribosomal subunit protein mL42 precursor MRPL42 interacts with PubMed
    small ribosomal subunit protein bS1m MRPS28 interacts with PubMed
    small ribosomal subunit protein uS9m MRPS9 interacts with PubMed
    magnesium transporter MRS2 homolog, mitochondrial isoform b precursor MRS2 interacts with PubMed
    exosome RNA helicase MTR4 MTREX interacts with PubMed
    myb-binding protein 1A isoform 2 MYBBP1A interacts with PubMed
    nucleosome assembly protein 1-like 1 isoform 1 NAP1L1 interacts with PubMed
    NAP1L1 interacts with PubMed
    nucleosome assembly protein 1-like 4 isoform 1 NAP1L4 interacts with PubMed
    asparagine--tRNA ligase, cytoplasmic NARS1 interacts with PubMed
    RNA cytidine acetyltransferase isoform a NAT10 interacts with PubMed
    NF-kappa-B inhibitor alpha NFKBIA inhibited by PubMed
    nipped-B-like protein isoform B NIPBL interacts with PubMed
    nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 isoform 1 NMNAT1 interacts with PubMed
    non-POU domain-containing octamer-binding protein isoform 1 NONO associates with PubMed
    NONO interacts with PubMed
    nucleolar protein 58 NOP58 interacts with PubMed
    nucleolar protein 9 isoform 1 NOP9 interacts with PubMed
    nucleophosmin isoform 1 NPM1 interacts with PubMed
    NPM1 co-localizes with PubMed
    NPM1 interacts with PubMed
    NPM1 binds PubMed
    NPM1 associates with PubMed
    NPM1 binds PubMed
    NPM1 stimulated by PubMed
    NAD(P)H dehydrogenase NQO1 downregulates PubMed
    nardilysin isoform a NRDC interacts with PubMed
    nuclear pore complex protein Nup153 isoform 2 NUP153 inhibited by PubMed
    NUP153 interacts with PubMed
    nuclear pore complex protein Nup214 isoform 2 NUP214 interacts with PubMed
    NUP214 interacts with PubMed
    NUP214 inhibited by PubMed
    NUP214 recruits PubMed
    NUP214 inhibited by PubMed
    nucleoporin NUP42 isoform 2 NUP42 interacts with PubMed
    NUP42 interacts with PubMed
    nuclear pore glycoprotein p62 NUP62 interacts with PubMed
    nuclear pore complex protein Nup98 isoform 3 precursor NUP98 interacts with PubMed
    NUP98 interacts with PubMed
    NUP98 recruits PubMed
    NUP98 inhibited by PubMed
    nuclear RNA export factor 1 isoform 1 NXF1 inhibits PubMed
    protein disulfide-isomerase precursor P4HB interacts with PubMed
    polyadenylate-binding protein 1 PABPC1 interacts with PubMed
    PABPC1 interacts with PubMed
    phosphofurin acidic cluster sorting protein 1 PACS1 enhanced by PubMed
    PAX3- and PAX7-binding protein 1 isoform 2 PAXBP1 interacts with PubMed
    poly(rC)-binding protein 1 PCBP1 inhibits PubMed
    PCBP1 modulated by PubMed
    PCBP1 interacts with PubMed
    poly(rC)-binding protein 2 isoform a PCBP2 interacts with PubMed
    protein RRP5 homolog isoform 2 PDCD11 interacts with PubMed
    ATP-dependent 6-phosphofructokinase, liver type isoform b PFKL interacts with PubMed
    ATP-dependent 6-phosphofructokinase, platelet type isoform 1 PFKP interacts with PubMed
    procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 isoform 2 precursor PLOD1 interacts with PubMed
    pleiotropic regulator 1 isoform 1 PLRG1 interacts with PubMed
    bifunctional polynucleotide phosphatase/kinase PNKP interacts with PubMed
    serum paraoxonase/arylesterase 2 isoform 1 PON2 interacts with PubMed
    suppressor of SWI4 1 homolog isoform 1 PPAN interacts with PubMed
    PPAN-P2RY11 protein isoform 1 PPAN-P2RY11 interacts with PubMed
    peptidyl-prolyl cis-trans isomerase B precursor PPIB interacts with PubMed
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform 1 PPP2R2A interacts with PubMed
    serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform a PPP2R2D interacts with PubMed
    serine/threonine-protein phosphatase 6 catalytic subunit isoform b PPP6C interacts with PubMed
    protein kinase C alpha type PRKCA phosphorylated by PubMed
    DNA-dependent protein kinase catalytic subunit isoform 1 PRKDC interacts with PubMed
    interferon-inducible double-stranded RNA-dependent protein kinase activator A isoform 1 PRKRA binds PubMed
    protein arginine N-methyltransferase 6 PRMT6 methylated by PubMed
    PRMT6 methylated by PubMed
    serine/threonine-protein kinase PRP4 homolog PRP4K interacts with PubMed
    pre-mRNA-processing factor 19 PRPF19 interacts with PubMed
    U4/U6 small nuclear ribonucleoprotein Prp31 PRPF31 interacts with PubMed
    pre-mRNA-processing factor 6 PRPF6 interacts with PubMed
    pre-mRNA-processing-splicing factor 8 PRPF8 interacts with PubMed
    PC4 and SFRS1-interacting protein isoform 1 PSIP1 complexes with PubMed
    PSIP1 interacts with PubMed
    paraspeckle component 1 isoform 1 PSPC1 interacts with PubMed
    polypyrimidine tract-binding protein 1 isoform a PTBP1 interacts with PubMed
    prostaglandin E synthase 3 isoform a PTGES3 interacts with PubMed
    prothymosin alpha isoform 2 PTMA binds PubMed
    transcriptional activator protein Pur-alpha PURA interacts with PubMed
    PURA co-localizes with PubMed
    transcriptional regulator protein Pur-beta PURB interacts with PubMed
    small ribosomal subunit protein RACK1 RACK1 interacts with PubMed
    GTP-binding nuclear protein Ran isoform 1 RAN binds PubMed
    RAN binds PubMed
    RAN interacts with PubMed
    RAN enhanced by PubMed
    RAN binds PubMed
    ran-specific GTPase-activating protein isoform 2 RANBP1 competes with PubMed
    E3 SUMO-protein ligase RanBP2 isoform 1 RANBP2 regulated by PubMed
    ran GTPase-activating protein 1 RANGAP1 interacts with PubMed
    RNA-binding protein 14 isoform 1 RBM14 enhanced by PubMed
    RBM14 associates with PubMed
    RBM14 enhanced by PubMed
    RNA-binding protein 15 isoform 1 RBM15 interacts with PubMed
    RNA-binding protein 39 isoform b RBM39 interacts with PubMed
    RNA-binding protein 42 isoform 1 RBM42 interacts with PubMed
    ATP-dependent DNA helicase Q1 RECQL interacts with PubMed
    large ribosomal subunit protein uL22 isoform a RPL17 interacts with PubMed
    large ribosomal subunit protein uL14 RPL23 interacts with PubMed
    large ribosomal subunit protein eL27 RPL27 interacts with PubMed
    large ribosomal subunit protein uL3 isoform a RPL3 interacts with PubMed
    large ribosomal subunit protein eL32 RPL32 interacts with PubMed
    large ribosomal subunit protein eL33 RPL35A interacts with PubMed
    large ribosomal subunit protein uL18 RPL5 interacts with PubMed
    large ribosomal subunit protein eL6 isoform 1 RPL6 interacts with PubMed
    small ribosomal subunit protein eS17 RPS17 interacts with PubMed
    small ribosomal subunit protein uS5 RPS2 interacts with PubMed
    small ribosomal subunit protein uS12 RPS23 interacts with PubMed
    small ribosomal subunit protein eS25 RPS25 interacts with PubMed
    ubiquitin-ribosomal protein eS31 fusion protein precursor RPS27A interacts with PubMed
    small ribosomal subunit protein eS1 isoform 1 RPS3A interacts with PubMed
    small ribosomal subunit protein eS4, X isoform RPS4X interacts with PubMed
    small ribosomal subunit protein uS7 RPS5 interacts with PubMed
    small ribosomal subunit protein eS6 RPS6 interacts with PubMed
    small ribosomal subunit protein uS2 isoform 1 RPSA interacts with PubMed
    RNA-splicing ligase RtcB homolog RTCB interacts with PubMed
    RNA transcription, translation and transport factor protein RTRAF interacts with PubMed
    ruvB-like 1 isoform 1 RUVBL1 interacts with PubMed
    scaffold attachment factor B1 isoform 3 SAFB interacts with PubMed
    protein SET isoform 2 SET interacts with PubMed
    splicing factor 3A subunit 1 SF3A1 interacts with PubMed
    splicing factor 3A subunit 2 SF3A2 interacts with PubMed
    splicing factor 3A subunit 3 isoform 1 SF3A3 interacts with PubMed
    splicing factor, proline- and glutamine-rich SFPQ regulated by PubMed
    SFPQ interacts with PubMed
    WD40 repeat-containing protein SMU1 SMU1 interacts with PubMed
    U5 small nuclear ribonucleoprotein 200 kDa helicase SNRNP200 interacts with PubMed
    U5 small nuclear ribonucleoprotein 40 kDa protein SNRNP40 interacts with PubMed
    U1 small nuclear ribonucleoprotein 70 kDa isoform 1 SNRNP70 interacts with PubMed
    U2 small nuclear ribonucleoprotein A' SNRPA1 inhibits PubMed
    U1 small nuclear ribonucleoprotein C SNRPC interacts with PubMed
    small nuclear ribonucleoprotein E isoform 1 SNRPE interacts with PubMed
    small nuclear ribonucleoprotein F isoform 1 SNRPF interacts with PubMed
    small nuclear ribonucleoprotein G isoform a SNRPG interacts with PubMed
    spermatogenesis-associated serine-rich protein 2 SPATS2 interacts with PubMed
    spectrin alpha chain, non-erythrocytic 1 isoform 2 SPTAN1 interacts with PubMed
    spectrin beta chain, non-erythrocytic 1 isoform 1 SPTBN1 interacts with PubMed
    S1 RNA-binding domain-containing protein 1 SRBD1 interacts with PubMed
    signal recognition particle subunit SRP54 isoform 1 SRP54 interacts with PubMed
    signal recognition particle 9 kDa protein isoform 2 SRP9 interacts with PubMed
    serine/arginine-rich splicing factor 1 isoform 1 SRSF1 inhibited by PubMed
    SRSF1 interacts with PubMed
    SRSF1 inhibits PubMed
    SRSF1 requires PubMed
    serine/arginine-rich splicing factor 2 SRSF2 inhibited by PubMed
    SRSF2 co-localizes with PubMed
    serine/arginine-rich splicing factor 5 isoform 1 SRSF5 requires PubMed
    serine/arginine-rich splicing factor 6 SRSF6 inhibited by PubMed
    serine/arginine-rich splicing factor 9 SRSF9 interacts with PubMed
    lupus La protein SSB interacts with PubMed
    SSB interacts with PubMed
    single-stranded DNA-binding protein, mitochondrial precursor SSBP1 interacts with PubMed
    double-stranded RNA-binding protein Staufen homolog 2 isoform e STAU2 interacts with PubMed
    stress-induced-phosphoprotein 1 isoform b STIP1 interacts with PubMed
    activated RNA polymerase II transcriptional coactivator p15 SUB1 interacts with PubMed
    FACT complex subunit SPT16 SUPT16H interacts with PubMed
    heterogeneous nuclear ribonucleoprotein Q isoform 1 SYNCRIP cooperates with PubMed
    SYNCRIP interacts with PubMed
    SYNCRIP binds PubMed
    RISC-loading complex subunit TARBP2 isoform b TARBP2 interacts with PubMed
    TARBP2 binds PubMed
    protein-glutamine gamma-glutamyltransferase 2 isoform a TGM2 inhibited by PubMed
    trimethylguanosine synthase isoform 1 TGS1 associates with PubMed
    THO complex subunit 6 homolog isoform 1 THOC6 interacts with PubMed
    transmembrane emp24 domain-containing protein 10 precursor TMED10 interacts with PubMed
    transmembrane emp24 domain-containing protein 4 isoform 1 precursor TMED4 interacts with PubMed
    transmembrane emp24 domain-containing protein 9 precursor TMED9 interacts with PubMed
    transportin-1 isoform 1 TNPO1 interacts with PubMed
    TNPO1 binds PubMed
    TNPO1 inhibited by PubMed
    transportin-3 isoform 1 TNPO3 disrupts PubMed
    TNPO3 binds PubMed
    target of EGR1 protein 1 TOE1 interacts with PubMed
    cellular tumor antigen p53 isoform a TP53 activates PubMed
    pachytene checkpoint protein 2 homolog isoform 1 TRIP13 interacts with PubMed
    TRMT1-like protein isoform 1 TRMT1L interacts with PubMed
    tubulin alpha-1A chain isoform 1 TUBA1A interacts with PubMed
    TUBA1A depolymerizes PubMed
    tubulin alpha-1B chain TUBA1B interacts with PubMed
    TUBA1B depolymerizes PubMed
    tubulin alpha-1C chain isoform c TUBA1C interacts with PubMed
    TUBA1C depolymerizes PubMed
    tubulin alpha-3C chain TUBA3C depolymerizes PubMed
    tubulin alpha-4A chain isoform 1 TUBA4A interacts with PubMed
    TUBA4A depolymerizes PubMed
    tubulin alpha-8 chain isoform 1 TUBA8 interacts with PubMed
    TUBA8 depolymerizes PubMed
    tubulin beta chain isoform b TUBB interacts with PubMed
    tubulin beta-1 chain TUBB1 depolymerizes PubMed
    tubulin beta-2A chain isoform 1 TUBB2A interacts with PubMed
    TUBB2A depolymerizes PubMed
    tubulin beta-2B chain TUBB2B interacts with PubMed
    tubulin beta-3 chain isoform 1 TUBB3 interacts with PubMed
    TUBB3 depolymerizes PubMed
    tubulin beta-4A chain isoform 3 TUBB4A interacts with PubMed
    TUBB4A depolymerizes PubMed
    tubulin beta-4B chain TUBB4B interacts with PubMed
    TUBB4B depolymerizes PubMed
    tubulin beta-6 chain isoform 1 TUBB6 depolymerizes PubMed
    tubulin beta-8 chain isoform 1 TUBB8 depolymerizes PubMed
    splicing factor U2AF 35 kDa subunit isoform a U2AF1 interacts with PubMed
    polyubiquitin-B precursor UBB ubiquitinated by PubMed
    polyubiquitin-C UBC ubiquitinated by PubMed
    ubiquitin D UBD ubiquitinated by PubMed
    E3 ubiquitin-protein ligase UBR4 UBR4 interacts with PubMed
    ubiquitin carboxyl-terminal hydrolase 39 isoform 1 USP39 interacts with PubMed
    WASH complex subunit 2A isoform 1 WASHC2A inhibited by PubMed
    WASHC2A co-localizes with PubMed
    WASHC2A interacts with PubMed
    WASH complex subunit 2C isoform 1 WASHC2C interacts with PubMed
    WASHC2C inhibited by PubMed
    WASHC2C co-localizes with PubMed
    WD repeat-containing protein 3 WDR3 interacts with PubMed
    WD repeat-containing protein 36 WDR36 interacts with PubMed
    exportin-1 isoform 1 XPO1 binds PubMed
    XPO1 complexes with PubMed
    XPO1 associates with PubMed
    XPO1 cooperates with PubMed
    XPO1 interacts with PubMed
    XPO1 binds PubMed
    XPO1 binds PubMed
    XPO1 interacts with PubMed
    XPO1 co-localizes with PubMed
    XPO1 regulated by PubMed
    XPO1 recruits PubMed
    XPO1 interacts with PubMed
    XPO1 binds PubMed
    XPO1 interacts with PubMed
    XPO1 interacts with PubMed
    XPO1 inhibited by PubMed
    XPO1 modulated by PubMed
    XPO1 interacts with PubMed
    XPO1 regulated by PubMed
    XPO1 regulated by PubMed
    XPO1 co-localizes with PubMed
    XPO1 exported by PubMed
    XPO1 enhanced by PubMed
    XPO1 interacts with PubMed
    XPO1 binds PubMed
    XPO1 interacts with PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

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    Preferred Names
    Rev

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001802.1 Reference assembly

      Range
      5516..8199
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_057854.1 Rev [Human immunodeficiency virus 1]

      See identical proteins and their annotated locations for NP_057854.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P04618
      UniProtKB/TrEMBL
      Q72501, Q77YF8
      Conserved Domains (1) summary
      pfam00424
      Location:1 → 91
      REV; REV protein (anti-repression trans-activator protein)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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