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Series GSE12051 Query DataSets for GSE12051
Status Public on Oct 02, 2009
Title Microarray predictor of response to infliximab in rheumatoid arthritis (RA) patients
Organism Homo sapiens
Experiment type Expression profiling by array
Summary We sought to find a gene-expression multigene predictor of response to infliximab therapy in Rheumatoid Arthritis patients. Using internal and external cross-validation systems we have built and validated an 8-gene predictor for response to infliximab.
Overall design Blood RNA from 48 Rheumatoid Arthritis patients was extracted at baseline of anti-TNF alpha treatment with infliximab. From these 44 reached week 14 of treatment at which the clinical response was determined. Using 2/3 of the sample we built a multigene predictor using kNearest-Neighbour algorithm and Leave-One Out cross validation. The remaining 1/3 of the sample was used to estimate the precision accuracy of the predictor model.
Web link
Contributor(s) Marsal S, Julià A
Citation(s) 19847310
Submission date Jul 09, 2008
Last update date Mar 20, 2012
Contact name Antonio Julià
Phone +34 934029082
Organization name Vall d'Hebron Hospital Research Institute
Department Rheumatology Research Group
Lab Rheumatology Research Group
Street address c/ Baldiri Reixac nº15
City Barcelona
State/province Barcelona
ZIP/Postal code 08028
Country Spain
Platforms (1)
GPL2507 Sentrix Human-6 Expression BeadChip
Samples (44)
GSM304385 blood_nonresponder_patient1
GSM304386 blood_nonresponder_patient2
GSM304387 blood_nonresponder_patient3
BioProject PRJNA113377

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12051_RAW.tar 13.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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