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Clostridial infection

MedGen UID:
1008
•Concept ID:
C0009062
•
Disease or Syndrome
Synonyms: Clostridium Infection; Clostridium Infections; Infection, Clostridium; Infections, Clostridium
SNOMED CT: Clostridial infection (56688005)

Definition

Infections with bacteria of the genus CLOSTRIDIUM and closely related CLOSTRIDIOIDES species. [from MeSH]

Professional guidelines

PubMed

Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease.
Basson AR, Zhou Y, Seo B, Rodriguez-Palacios A, Cominelli F
Transl Res 2020 Dec;226:1-11. Epub 2020 Jun 22 doi: 10.1016/j.trsl.2020.05.008. PMID: 32585148Free PMC Article
Conservative management of clostridial endometritis.
Lichtenberg ES, Henning C
Am J Obstet Gynecol 2004 Jul;191(1):266-70. doi: 10.1016/j.ajog.2003.11.022. PMID: 15295377
Gas gangrene and related infection: classification, clinical features and aetiology, management and mortality. A report of 88 cases.
Darke SG, King AM, Slack WK
Br J Surg 1977 Feb;64(2):104-12. doi: 10.1002/bjs.1800640207. PMID: 196711

Recent clinical studies

Etiology

Case-Control Study of Clostridium innocuum Infection, Taiwan.
Chen YC, Kuo YC, Chen MC, Zhang YD, Chen CL, Le PH, Chiu CH
Emerg Infect Dis 2022 Mar;28(3):599-607. doi: 10.3201/eid2803.204421. PMID: 35195517Free PMC Article
Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease.
Basson AR, Zhou Y, Seo B, Rodriguez-Palacios A, Cominelli F
Transl Res 2020 Dec;226:1-11. Epub 2020 Jun 22 doi: 10.1016/j.trsl.2020.05.008. PMID: 32585148Free PMC Article
Necrotizing soft tissue infections.
Hussein QA, Anaya DA
Crit Care Clin 2013 Oct;29(4):795-806. Epub 2013 Jul 25 doi: 10.1016/j.ccc.2013.06.001. PMID: 24094377
Clostridial infection in children.
Brook I
J Med Microbiol 1995 Feb;42(2):78-82. doi: 10.1099/00222615-42-2-78. PMID: 7869351
Clostridial aortic graft infection.
Holland FW, Darling RC 3rd, Chang BB, Shah DM, Leather RP
Ann Vasc Surg 1994 Jul;8(4):387-9. doi: 10.1007/BF02133003. PMID: 7947067

Diagnosis

Case-Control Study of Clostridium innocuum Infection, Taiwan.
Chen YC, Kuo YC, Chen MC, Zhang YD, Chen CL, Le PH, Chiu CH
Emerg Infect Dis 2022 Mar;28(3):599-607. doi: 10.3201/eid2803.204421. PMID: 35195517Free PMC Article
View from the front lines: an emergency medicine perspective on clostridial infections in injection drug users.
Gonzales y Tucker RD, Frazee B
Anaerobe 2014 Dec;30:108-15. Epub 2014 Sep 16 doi: 10.1016/j.anaerobe.2014.09.005. PMID: 25230330
Necrotizing soft tissue infections.
Hussein QA, Anaya DA
Crit Care Clin 2013 Oct;29(4):795-806. Epub 2013 Jul 25 doi: 10.1016/j.ccc.2013.06.001. PMID: 24094377
Clostridial aortic graft infection.
Holland FW, Darling RC 3rd, Chang BB, Shah DM, Leather RP
Ann Vasc Surg 1994 Jul;8(4):387-9. doi: 10.1007/BF02133003. PMID: 7947067
Gas gangrene. A review.
Present DA, Meislin R, Shaffer B
Orthop Rev 1990 Apr;19(4):333-41. PMID: 2185454

Therapy

Case-Control Study of Clostridium innocuum Infection, Taiwan.
Chen YC, Kuo YC, Chen MC, Zhang YD, Chen CL, Le PH, Chiu CH
Emerg Infect Dis 2022 Mar;28(3):599-607. doi: 10.3201/eid2803.204421. PMID: 35195517Free PMC Article
Necrotizing soft tissue infections.
Hussein QA, Anaya DA
Crit Care Clin 2013 Oct;29(4):795-806. Epub 2013 Jul 25 doi: 10.1016/j.ccc.2013.06.001. PMID: 24094377
Clostridial aortic graft infection.
Holland FW, Darling RC 3rd, Chang BB, Shah DM, Leather RP
Ann Vasc Surg 1994 Jul;8(4):387-9. doi: 10.1007/BF02133003. PMID: 7947067
Gas gangrene. A review.
Present DA, Meislin R, Shaffer B
Orthop Rev 1990 Apr;19(4):333-41. PMID: 2185454
Gas gangrene and related infection: classification, clinical features and aetiology, management and mortality. A report of 88 cases.
Darke SG, King AM, Slack WK
Br J Surg 1977 Feb;64(2):104-12. doi: 10.1002/bjs.1800640207. PMID: 196711

Prognosis

Unexpected Death Associated With Clostridial Sepsis.
Olds KL, Gilbert JD, Byard RW
Am J Forensic Med Pathol 2021 Sep 1;42(3):289-291. doi: 10.1097/PAF.0000000000000640. PMID: 33394683
Predictors of mortality and limb loss in necrotizing soft tissue infections.
Anaya DA, McMahon K, Nathens AB, Sullivan SR, Foy H, Bulger E
Arch Surg 2005 Feb;140(2):151-7; discussion 158. doi: 10.1001/archsurg.140.2.151. PMID: 15723996
Antibody responses to clostridial infection in humans.
Johnson S
Clin Infect Dis 1997 Sep;25 Suppl 2:S173-7. doi: 10.1086/516220. PMID: 9310668
Clostridial aortic graft infection.
Holland FW, Darling RC 3rd, Chang BB, Shah DM, Leather RP
Ann Vasc Surg 1994 Jul;8(4):387-9. doi: 10.1007/BF02133003. PMID: 7947067
Clostridial pleuropulmonary infections: case report and review of the literature.
Patel SB, Mahler R
J Infect 1990 Jul;21(1):81-5. doi: 10.1016/0163-4453(90)90738-t. PMID: 2200827

Clinical prediction guides

Vaginal and Rectal Clostridium sordellii and Clostridium perfringens Presence Among Women in the United States.
Chong E, Winikoff B, Charles D, Agnew K, Prentice JL, Limbago BM, Platais I, Louie K, Jones HE, Shannon C; NCT01283828 Study Team
Obstet Gynecol 2016 Feb;127(2):360-8. doi: 10.1097/AOG.0000000000001239. PMID: 26942366Free PMC Article
Predictors of mortality and limb loss in necrotizing soft tissue infections.
Anaya DA, McMahon K, Nathens AB, Sullivan SR, Foy H, Bulger E
Arch Surg 2005 Feb;140(2):151-7; discussion 158. doi: 10.1001/archsurg.140.2.151. PMID: 15723996
Isolated limb perfusion with tumor necrosis factor-alpha and melphalan for patients with unresectable soft tissue sarcoma of the extremities.
Noorda EM, Vrouenraets BC, Nieweg OE, van Coevorden F, van Slooten GW, Kroon BB
Cancer 2003 Oct 1;98(7):1483-90. doi: 10.1002/cncr.11648. PMID: 14508836
Sialidase activity in the sera of patients and rabbits with clostridial myonecrosis.
Schauer R, Sander-Wewer M, Gutschker-Gdaniec GH, Roggentin P, Randow EA, Hobrecht R
Clin Chim Acta 1985 Mar 15;146(2-3):119-27. doi: 10.1016/0009-8981(85)90050-6. PMID: 3987045
Clostridial myonecrosis following intra-articular steroid injection.
Seradge H, Anderson MG
Clin Orthop Relat Res 1980 Mar-Apr;(147):207-9. PMID: 7371297

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