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Clostridial infection

MedGen UID:
1008
•Concept ID:
C0009062
•
Disease or Syndrome
Synonyms: Clostridium Infection; Clostridium Infections; Infection, Clostridium; Infections, Clostridium
SNOMED CT: Clostridial infection (56688005)

Definition

Infections with bacteria of the genus CLOSTRIDIUM and closely related CLOSTRIDIOIDES species. [from MeSH]

Professional guidelines

PubMed

Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease.
Basson AR, Zhou Y, Seo B, Rodriguez-Palacios A, Cominelli F
Transl Res 2020 Dec;226:1-11. Epub 2020 Jun 22 doi: 10.1016/j.trsl.2020.05.008. PMID: 32585148Free PMC Article
Conservative management of clostridial endometritis.
Lichtenberg ES, Henning C
Am J Obstet Gynecol 2004 Jul;191(1):266-70. doi: 10.1016/j.ajog.2003.11.022. PMID: 15295377
Gas gangrene and related infection: classification, clinical features and aetiology, management and mortality. A report of 88 cases.
Darke SG, King AM, Slack WK
Br J Surg 1977 Feb;64(2):104-12. doi: 10.1002/bjs.1800640207. PMID: 196711

Recent clinical studies

Etiology

Infection epidemiology in relation to different therapy phases in patients with haematological malignancies receiving CAR T-cell therapy.
Garcia-Pouton N, Ortiz-Maldonado V, Peyrony O, Chumbita M, Aiello TF, Monzo-Gallo P, Lopera C, Puerta-Alcalde P, Magnano L, Martinez-Cibrian N, Pitart C, Juan M, Delgado J, Fernandez De Larrea C, Soriano Á, Urbano-Ispizua Á, Garcia-Vidal C
Eur J Haematol 2024 Mar;112(3):371-378. Epub 2023 Oct 25 doi: 10.1111/ejh.14122. PMID: 37879842
Case-Control Study of Clostridium innocuum Infection, Taiwan.
Chen YC, Kuo YC, Chen MC, Zhang YD, Chen CL, Le PH, Chiu CH
Emerg Infect Dis 2022 Mar;28(3):599-607. doi: 10.3201/eid2803.204421. PMID: 35195517Free PMC Article
Autologous fecal microbiota transplantation for the treatment of inflammatory bowel disease.
Basson AR, Zhou Y, Seo B, Rodriguez-Palacios A, Cominelli F
Transl Res 2020 Dec;226:1-11. Epub 2020 Jun 22 doi: 10.1016/j.trsl.2020.05.008. PMID: 32585148Free PMC Article
Necrotizing soft tissue infections.
Hussein QA, Anaya DA
Crit Care Clin 2013 Oct;29(4):795-806. Epub 2013 Jul 25 doi: 10.1016/j.ccc.2013.06.001. PMID: 24094377
Postoperative clostridial infections in Britain.
Parker MT
Br Med J 1969 Sep 20;3(5672):671-6. doi: 10.1136/bmj.3.5672.671. PMID: 4309215Free PMC Article

Diagnosis

Case-Control Study of Clostridium innocuum Infection, Taiwan.
Chen YC, Kuo YC, Chen MC, Zhang YD, Chen CL, Le PH, Chiu CH
Emerg Infect Dis 2022 Mar;28(3):599-607. doi: 10.3201/eid2803.204421. PMID: 35195517Free PMC Article
Unexpected Death Associated With Clostridial Sepsis.
Olds KL, Gilbert JD, Byard RW
Am J Forensic Med Pathol 2021 Sep 1;42(3):289-291. doi: 10.1097/PAF.0000000000000640. PMID: 33394683
Vaginal and Rectal Clostridium sordellii and Clostridium perfringens Presence Among Women in the United States.
Chong E, Winikoff B, Charles D, Agnew K, Prentice JL, Limbago BM, Platais I, Louie K, Jones HE, Shannon C; NCT01283828 Study Team
Obstet Gynecol 2016 Feb;127(2):360-8. doi: 10.1097/AOG.0000000000001239. PMID: 26942366Free PMC Article
Necrotizing soft tissue infections.
Hussein QA, Anaya DA
Crit Care Clin 2013 Oct;29(4):795-806. Epub 2013 Jul 25 doi: 10.1016/j.ccc.2013.06.001. PMID: 24094377
Clostridial aortic graft infection.
Holland FW, Darling RC 3rd, Chang BB, Shah DM, Leather RP
Ann Vasc Surg 1994 Jul;8(4):387-9. doi: 10.1007/BF02133003. PMID: 7947067

Therapy

Infection epidemiology in relation to different therapy phases in patients with haematological malignancies receiving CAR T-cell therapy.
Garcia-Pouton N, Ortiz-Maldonado V, Peyrony O, Chumbita M, Aiello TF, Monzo-Gallo P, Lopera C, Puerta-Alcalde P, Magnano L, Martinez-Cibrian N, Pitart C, Juan M, Delgado J, Fernandez De Larrea C, Soriano Á, Urbano-Ispizua Á, Garcia-Vidal C
Eur J Haematol 2024 Mar;112(3):371-378. Epub 2023 Oct 25 doi: 10.1111/ejh.14122. PMID: 37879842
Case-Control Study of Clostridium innocuum Infection, Taiwan.
Chen YC, Kuo YC, Chen MC, Zhang YD, Chen CL, Le PH, Chiu CH
Emerg Infect Dis 2022 Mar;28(3):599-607. doi: 10.3201/eid2803.204421. PMID: 35195517Free PMC Article
Vaginal and Rectal Clostridium sordellii and Clostridium perfringens Presence Among Women in the United States.
Chong E, Winikoff B, Charles D, Agnew K, Prentice JL, Limbago BM, Platais I, Louie K, Jones HE, Shannon C; NCT01283828 Study Team
Obstet Gynecol 2016 Feb;127(2):360-8. doi: 10.1097/AOG.0000000000001239. PMID: 26942366Free PMC Article
Iatrogenic non-clostridial gas gangrene - a case report.
Sh J, Yp GC, J R
Med Leg J 2016 Mar;84(1):49-51. Epub 2015 Dec 16 doi: 10.1177/0025817215621690. PMID: 26672772
Necrotizing soft tissue infections.
Hussein QA, Anaya DA
Crit Care Clin 2013 Oct;29(4):795-806. Epub 2013 Jul 25 doi: 10.1016/j.ccc.2013.06.001. PMID: 24094377

Prognosis

Unexpected Death Associated With Clostridial Sepsis.
Olds KL, Gilbert JD, Byard RW
Am J Forensic Med Pathol 2021 Sep 1;42(3):289-291. doi: 10.1097/PAF.0000000000000640. PMID: 33394683
Vaginal and Rectal Clostridium sordellii and Clostridium perfringens Presence Among Women in the United States.
Chong E, Winikoff B, Charles D, Agnew K, Prentice JL, Limbago BM, Platais I, Louie K, Jones HE, Shannon C; NCT01283828 Study Team
Obstet Gynecol 2016 Feb;127(2):360-8. doi: 10.1097/AOG.0000000000001239. PMID: 26942366Free PMC Article
Antibody responses to clostridial infection in humans.
Johnson S
Clin Infect Dis 1997 Sep;25 Suppl 2:S173-7. doi: 10.1086/516220. PMID: 9310668
Clostridial aortic graft infection.
Holland FW, Darling RC 3rd, Chang BB, Shah DM, Leather RP
Ann Vasc Surg 1994 Jul;8(4):387-9. doi: 10.1007/BF02133003. PMID: 7947067
Postoperative clostridial infections in Britain.
Parker MT
Br Med J 1969 Sep 20;3(5672):671-6. doi: 10.1136/bmj.3.5672.671. PMID: 4309215Free PMC Article

Clinical prediction guides

Vaginal and Rectal Clostridium sordellii and Clostridium perfringens Presence Among Women in the United States.
Chong E, Winikoff B, Charles D, Agnew K, Prentice JL, Limbago BM, Platais I, Louie K, Jones HE, Shannon C; NCT01283828 Study Team
Obstet Gynecol 2016 Feb;127(2):360-8. doi: 10.1097/AOG.0000000000001239. PMID: 26942366Free PMC Article
Predictors of mortality and limb loss in necrotizing soft tissue infections.
Anaya DA, McMahon K, Nathens AB, Sullivan SR, Foy H, Bulger E
Arch Surg 2005 Feb;140(2):151-7; discussion 158. doi: 10.1001/archsurg.140.2.151. PMID: 15723996
Primary gas gangrene of the pancreas: report of a case.
Ikegami T, Kido A, Shimokawa H, Ishida T
Surg Today 2004;34(1):80-1. doi: 10.1007/s00595-003-2635-y. PMID: 14714236
Isolated limb perfusion with tumor necrosis factor-alpha and melphalan for patients with unresectable soft tissue sarcoma of the extremities.
Noorda EM, Vrouenraets BC, Nieweg OE, van Coevorden F, van Slooten GW, Kroon BB
Cancer 2003 Oct 1;98(7):1483-90. doi: 10.1002/cncr.11648. PMID: 14508836
Clostridial myonecrosis following intra-articular steroid injection.
Seradge H, Anderson MG
Clin Orthop Relat Res 1980 Mar-Apr;(147):207-9. PMID: 7371297

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