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Tumors Derived from Langerhans Cells

MedGen UID:
1660882
Concept ID:
C4725926
Neoplastic Process

Definition

This category includes two main sub-groups, according to the degree of cytological atypia and clinical aggressiveness: Langerhans cell histiocytosis and Langerhans cell sarcoma. (WHO 2017) [from NCI]

Professional guidelines

PubMed

Lian T, Li C, Wang H
Cancer Treat Rev 2019 Dec;81:101907. Epub 2019 Oct 14 doi: 10.1016/j.ctrv.2019.101907. PMID: 31715422
Mimeault M, Batra SK
Gut 2008 Oct;57(10):1456-68. doi: 10.1136/gut.2008.150052. PMID: 18791122Free PMC Article
Jaffe ES
Semin Diagn Pathol 1988 Nov;5(4):376-90. PMID: 3064218

Recent clinical studies

Etiology

Huynh KN, Nguyen BD
Radiographics 2021 Mar-Apr;41(2):576-594. Epub 2021 Feb 19 doi: 10.1148/rg.2021200096. PMID: 33606566
Durham BH
Semin Cell Dev Biol 2019 Feb;86:62-76. Epub 2018 Mar 16 doi: 10.1016/j.semcdb.2018.03.002. PMID: 29526544
Luder CM, Nordmann TM, Ramelyte E, Mühleisen B, Kerl K, Guenova E, Dummer R
J Eur Acad Dermatol Venereol 2018 Jun;32(6):926-934. Epub 2018 Jan 31 doi: 10.1111/jdv.14794. PMID: 29341328
Emile JF, Abla O, Fraitag S, Horne A, Haroche J, Donadieu J, Requena-Caballero L, Jordan MB, Abdel-Wahab O, Allen CE, Charlotte F, Diamond EL, Egeler RM, Fischer A, Herrera JG, Henter JI, Janku F, Merad M, Picarsic J, Rodriguez-Galindo C, Rollins BJ, Tazi A, Vassallo R, Weiss LM; Histiocyte Society
Blood 2016 Jun 2;127(22):2672-81. Epub 2016 Mar 10 doi: 10.1182/blood-2016-01-690636. PMID: 26966089Free PMC Article
Yanofsky VR, Mitsui H, Felsen D, Carucci JA
Clin Dev Immunol 2013;2013:624123. Epub 2013 Mar 28 doi: 10.1155/2013/624123. PMID: 23606870Free PMC Article

Diagnosis

Ozkaya N, Dogan A, Abdel-Wahab O
Hematol Oncol Clin North Am 2017 Aug;31(4):705-719. Epub 2017 May 17 doi: 10.1016/j.hoc.2017.04.008. PMID: 28673397Free PMC Article
Haroche J, Cohen-Aubart F, Rollins BJ, Donadieu J, Charlotte F, Idbaih A, Vaglio A, Abdel-Wahab O, Emile JF, Amoura Z
Lancet Oncol 2017 Feb;18(2):e113-e125. doi: 10.1016/S1470-2045(17)30031-1. PMID: 28214412
Emile JF, Abla O, Fraitag S, Horne A, Haroche J, Donadieu J, Requena-Caballero L, Jordan MB, Abdel-Wahab O, Allen CE, Charlotte F, Diamond EL, Egeler RM, Fischer A, Herrera JG, Henter JI, Janku F, Merad M, Picarsic J, Rodriguez-Galindo C, Rollins BJ, Tazi A, Vassallo R, Weiss LM; Histiocyte Society
Blood 2016 Jun 2;127(22):2672-81. Epub 2016 Mar 10 doi: 10.1182/blood-2016-01-690636. PMID: 26966089Free PMC Article
Wewer Albrechtsen NJ, Challis BG, Damjanov I, Holst JJ
Bosn J Basic Med Sci 2016 Feb 1;16(1):1-7. doi: 10.17305/bjbms.2015.794. PMID: 26773171Free PMC Article
Sautès-Fridman C, Cherfils-Vicini J, Damotte D, Fisson S, Fridman WH, Cremer I, Dieu-Nosjean MC
Cancer Metastasis Rev 2011 Mar;30(1):13-25. doi: 10.1007/s10555-011-9279-y. PMID: 21271351

Therapy

Wang A, Bai Y
J Dermatol 2020 Feb;47(2):104-113. Epub 2019 Dec 13 doi: 10.1111/1346-8138.15184. PMID: 31833093
Ozkaya N, Dogan A, Abdel-Wahab O
Hematol Oncol Clin North Am 2017 Aug;31(4):705-719. Epub 2017 May 17 doi: 10.1016/j.hoc.2017.04.008. PMID: 28673397Free PMC Article
Diamond EL, Durham BH, Haroche J, Yao Z, Ma J, Parikh SA, Wang Z, Choi J, Kim E, Cohen-Aubart F, Lee SC, Gao Y, Micol JB, Campbell P, Walsh MP, Sylvester B, Dolgalev I, Aminova O, Heguy A, Zappile P, Nakitandwe J, Ganzel C, Dalton JD, Ellison DW, Estrada-Veras J, Lacouture M, Gahl WA, Stephens PJ, Miller VA, Ross JS, Ali SM, Briggs SR, Fasan O, Block J, Héritier S, Donadieu J, Solit DB, Hyman DM, Baselga J, Janku F, Taylor BS, Park CY, Amoura Z, Dogan A, Emile JF, Rosen N, Gruber TA, Abdel-Wahab O
Cancer Discov 2016 Feb;6(2):154-65. Epub 2015 Nov 13 doi: 10.1158/2159-8290.CD-15-0913. PMID: 26566875Free PMC Article
McCall M, Shapiro AM
Cold Spring Harb Perspect Med 2012 Jul;2(7):a007823. doi: 10.1101/cshperspect.a007823. PMID: 22762022Free PMC Article
Santana A, Enseñat-Waser R, Arribas MI, Reig JA, Roche E
J Cell Mol Med 2006 Oct-Dec;10(4):866-83. doi: 10.1111/j.1582-4934.2006.tb00531.x. PMID: 17125591

Prognosis

Saeidi V, Doudican N, Carucci JA
Front Immunol 2023;14:1084873. Epub 2023 Jan 30 doi: 10.3389/fimmu.2023.1084873. PMID: 36793738Free PMC Article
Davies J, Vallejo AF, Sirvent S, Porter G, Clayton K, Qumbelo Y, Stumpf P, West J, Gray CM, Chigorimbo-Murefu NTL, MacArthur B, Polak ME
Front Immunol 2021;12:665312. Epub 2021 Jun 15 doi: 10.3389/fimmu.2021.665312. PMID: 34211464Free PMC Article
Gupta S
Med Clin North Am 2012 May;96(3):621-34, xi. Epub 2012 May 24 doi: 10.1016/j.mcna.2012.04.008. PMID: 22703858
Sautès-Fridman C, Cherfils-Vicini J, Damotte D, Fisson S, Fridman WH, Cremer I, Dieu-Nosjean MC
Cancer Metastasis Rev 2011 Mar;30(1):13-25. doi: 10.1007/s10555-011-9279-y. PMID: 21271351
Kaplan RP
Adv Dermatol 1986;1:3-42. PMID: 3079247

Clinical prediction guides

Bock S, Murgueitio MS, Wolber G, Weindl G
Pharmacol Res 2016 Mar;105:44-53. Epub 2016 Jan 18 doi: 10.1016/j.phrs.2016.01.016. PMID: 26794428
Bonnavion R, Teinturier R, Jaafar R, Ripoche D, Leteurtre E, Chen YJ, Rehfeld JF, Lepinasse F, Hervieu V, Pattou F, Vantyghem MC, Scoazec JY, Bertolino P, Zhang CX
Mol Cell Biol 2015 Oct;35(19):3274-83. Epub 2015 Jul 13 doi: 10.1128/MCB.00302-15. PMID: 26169832Free PMC Article
Wranicz J, Szostak-Węgierek D
Rocz Panstw Zakl Hig 2014;65(4):273-9. PMID: 25526571
Dzopalic T, Rajkovic I, Dragicevic A, Colic M
Immunol Res 2012 Apr;52(1-2):20-33. doi: 10.1007/s12026-012-8279-5. PMID: 22392051
Sautès-Fridman C, Cherfils-Vicini J, Damotte D, Fisson S, Fridman WH, Cremer I, Dieu-Nosjean MC
Cancer Metastasis Rev 2011 Mar;30(1):13-25. doi: 10.1007/s10555-011-9279-y. PMID: 21271351

Recent systematic reviews

Pogorzelska-Dyrbuś J, Szepietowski JC
Mediators Inflamm 2020;2020:8745863. Epub 2020 Apr 19 doi: 10.1155/2020/8745863. PMID: 32377167Free PMC Article
Lechien JR, Seminerio I, Descamps G, Mat Q, Mouawad F, Hans S, Julieron M, Dequanter D, Vanderhaegen T, Journe F, Saussez S
Cells 2019 Sep 10;8(9) doi: 10.3390/cells8091061. PMID: 31510065Free PMC Article

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