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Recurrent Acute Leukemia

MedGen UID:
1668204
•Concept ID:
C4725025
•
Neoplastic Process

Definition

The reemergence of acute leukemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Acute Leukemia

Professional guidelines

PubMed

Leukocytapheresis for the treatment of hyperleukocytosis secondary to acute leukemia.
Aqui N, O'Doherty U
Hematology Am Soc Hematol Educ Program 2014 Dec 5;2014(1):457-60. Epub 2014 Nov 18 doi: 10.1182/asheducation-2014.1.457. PMID: 25696894

Recent clinical studies

Etiology

Clinical characteristics and outcome of invasive fungal infections in pediatric acute myeloid leukemia patients in a medical center in Taiwan.
Lin GL, Chang HH, Lu CY, Chen CM, Lu MY, Lee PI, Jou ST, Yang YL, Huang LM, Chang LY
J Microbiol Immunol Infect 2018 Apr;51(2):251-259. Epub 2016 Dec 19 doi: 10.1016/j.jmii.2016.08.011. PMID: 28089099
Steroid-refractory cutaneous graft-versus-host disease after transplantation of haploidentical parental CD34+ cells in children with Down's syndrome and recurrent acute leukemia.
Mogul MJ, Forte KJ, Holland HK, Turner CW, Benyunes MC, Yeager AM
J Pediatr Hematol Oncol 1997 Mar-Apr;19(2):142-4. doi: 10.1097/00043426-199703000-00009. PMID: 9149745
Ifosfamide with mesna uroprotection and etoposide in recurrent, refractory acute leukemia in childhood. A Pediatric Oncology Group Study.
Bernstein ML, Whitehead VM, Devine S, Grier H, Kung F, Krischer J, Dreyer Z, Bell B, Land V, Buchanan GR
Cancer 1993 Sep 1;72(5):1790-4. doi: 10.1002/1097-0142(19930901)72:5<1790::aid-cncr2820720545>3.0.co;2-4. PMID: 8348510
Therapy of refractory/relapsed acute leukemia with cytosine arabinoside plus tetrahydrouridine (an inhibitor of cytidine deaminase)--a pilot study.
Kreis W, Budman DR, Chan K, Allen SL, Schulman P, Lichtman S, Weiselberg L, Schuster M, Freeman J, Akerman S
Leukemia 1991 Nov;5(11):991-8. PMID: 1961042
Rubidazone in the treatment of recurrent acute leukemia in children. A Pediatric Oncology Group Study.
Ragab AH, Boyett JM, Frankel L, Falletta J
Cancer 1986 Apr 15;57(8):1461-3. doi: 10.1002/1097-0142(19860415)57:8<1461::aid-cncr2820570804>3.0.co;2-r. PMID: 3948126

Diagnosis

A Review of DNA Methylation and microRNA Expression in Recurrent Pediatric Acute Leukemia.
Hale V, Hale GA, Brown PA, Amankwah EK
Oncology 2017;92(2):61-67. Epub 2016 Nov 2 doi: 10.1159/000452091. PMID: 27802447
A case of type B lactic acidosis in acute leukemia.
Lee HS, Kim HJ, Choi S, Kim CK, Lee NS, Lee KT, Won JH, Park HS, Hong DS
Yonsei Med J 2010 May;51(3):460-2. doi: 10.3349/ymj.2010.51.3.460. PMID: 20376904Free PMC Article
Increased expression of the multidrug resistance-associated protein gene in relapsed acute leukemia.
Schneider E, Cowan KH, Bader H, Toomey S, Schwartz GN, Karp JE, Burke PJ, Kaufmann SH
Blood 1995 Jan 1;85(1):186-93. PMID: 7528566

Therapy

Clinical characteristics and outcome of invasive fungal infections in pediatric acute myeloid leukemia patients in a medical center in Taiwan.
Lin GL, Chang HH, Lu CY, Chen CM, Lu MY, Lee PI, Jou ST, Yang YL, Huang LM, Chang LY
J Microbiol Immunol Infect 2018 Apr;51(2):251-259. Epub 2016 Dec 19 doi: 10.1016/j.jmii.2016.08.011. PMID: 28089099
Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia.
Furman WL, Baker SD, Pratt CB, Rivera GK, Evans WE, Stewart CF
J Clin Oncol 1996 May;14(5):1504-11. doi: 10.1200/JCO.1996.14.5.1504. PMID: 8622064
Ifosfamide with mesna uroprotection and etoposide in recurrent, refractory acute leukemia in childhood. A Pediatric Oncology Group Study.
Bernstein ML, Whitehead VM, Devine S, Grier H, Kung F, Krischer J, Dreyer Z, Bell B, Land V, Buchanan GR
Cancer 1993 Sep 1;72(5):1790-4. doi: 10.1002/1097-0142(19930901)72:5<1790::aid-cncr2820720545>3.0.co;2-4. PMID: 8348510
Therapy of refractory/relapsed acute leukemia with cytosine arabinoside plus tetrahydrouridine (an inhibitor of cytidine deaminase)--a pilot study.
Kreis W, Budman DR, Chan K, Allen SL, Schulman P, Lichtman S, Weiselberg L, Schuster M, Freeman J, Akerman S
Leukemia 1991 Nov;5(11):991-8. PMID: 1961042
Rubidazone in the treatment of recurrent acute leukemia in children. A Pediatric Oncology Group Study.
Ragab AH, Boyett JM, Frankel L, Falletta J
Cancer 1986 Apr 15;57(8):1461-3. doi: 10.1002/1097-0142(19860415)57:8<1461::aid-cncr2820570804>3.0.co;2-r. PMID: 3948126

Prognosis

Steroid-refractory cutaneous graft-versus-host disease after transplantation of haploidentical parental CD34+ cells in children with Down's syndrome and recurrent acute leukemia.
Mogul MJ, Forte KJ, Holland HK, Turner CW, Benyunes MC, Yeager AM
J Pediatr Hematol Oncol 1997 Mar-Apr;19(2):142-4. doi: 10.1097/00043426-199703000-00009. PMID: 9149745
Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia.
Furman WL, Baker SD, Pratt CB, Rivera GK, Evans WE, Stewart CF
J Clin Oncol 1996 May;14(5):1504-11. doi: 10.1200/JCO.1996.14.5.1504. PMID: 8622064
Ifosfamide with mesna uroprotection and etoposide in recurrent, refractory acute leukemia in childhood. A Pediatric Oncology Group Study.
Bernstein ML, Whitehead VM, Devine S, Grier H, Kung F, Krischer J, Dreyer Z, Bell B, Land V, Buchanan GR
Cancer 1993 Sep 1;72(5):1790-4. doi: 10.1002/1097-0142(19930901)72:5<1790::aid-cncr2820720545>3.0.co;2-4. PMID: 8348510

Clinical prediction guides

Clinical characteristics and outcome of invasive fungal infections in pediatric acute myeloid leukemia patients in a medical center in Taiwan.
Lin GL, Chang HH, Lu CY, Chen CM, Lu MY, Lee PI, Jou ST, Yang YL, Huang LM, Chang LY
J Microbiol Immunol Infect 2018 Apr;51(2):251-259. Epub 2016 Dec 19 doi: 10.1016/j.jmii.2016.08.011. PMID: 28089099
Steroid-refractory cutaneous graft-versus-host disease after transplantation of haploidentical parental CD34+ cells in children with Down's syndrome and recurrent acute leukemia.
Mogul MJ, Forte KJ, Holland HK, Turner CW, Benyunes MC, Yeager AM
J Pediatr Hematol Oncol 1997 Mar-Apr;19(2):142-4. doi: 10.1097/00043426-199703000-00009. PMID: 9149745
Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia.
Furman WL, Baker SD, Pratt CB, Rivera GK, Evans WE, Stewart CF
J Clin Oncol 1996 May;14(5):1504-11. doi: 10.1200/JCO.1996.14.5.1504. PMID: 8622064
Rubidazone in the treatment of recurrent acute leukemia in children. A Pediatric Oncology Group Study.
Ragab AH, Boyett JM, Frankel L, Falletta J
Cancer 1986 Apr 15;57(8):1461-3. doi: 10.1002/1097-0142(19860415)57:8<1461::aid-cncr2820570804>3.0.co;2-r. PMID: 3948126
Marrow transplantation in aplastic anemia and leukemia.
Weiden PL, Thomas ED, Storb R, Fefer A, Neiman PE, Clift RA, Buckner CD, Lerner KG
Compr Ther 1976 Apr;2(4):57-62. PMID: 4261

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