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Locally Advanced Head and Neck Squamous Cell Carcinoma

MedGen UID:
1701136
•Concept ID:
C5206801
•
Neoplastic Process

Definition

A head and neck squamous cell carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

A bioconvergence study on platinum-free concurrent chemoradiotherapy for the treatment of HPV-negative head and neck carcinoma.
Gonnelli A, Sarogni P, Giannini N, Linsalata S, Di Martino F, Zamborlin A, Frusca V, Ermini ML, Puccini P, Voliani V, Paiar F
Artif Cells Nanomed Biotechnol 2024 Dec;52(1):122-129. Epub 2024 Feb 5 doi: 10.1080/21691401.2024.2309233. PMID: 38315518
Pre-treatment risk factors to predict early cisplatin-related nephrotoxicity in locally advanced head and neck cancer patients treated with chemoradiation: A single Institution experience.
Cavalieri S, Platini F, Barretta F, Nuzzolese I, Ottini A, Bergamini C, Resteghini C, Colombo E, Iacovelli NA, Franceschini M, Calareso G, Di Pede P, De Feo G, Gandelli M, Toffolatti L, Guglielmo M, Ripamonti CI, Cosmai L, Licitra L, Alfieri S
Oral Oncol 2023 Nov;146:106579. Epub 2023 Sep 29 doi: 10.1016/j.oraloncology.2023.106579. PMID: 37778228
Adjuvant treatment for post-operative head and neck squamous cell carcinoma.
Kiyota N, Tahara M, Fujii M
Jpn J Clin Oncol 2015 Jan;45(1):2-6. Epub 2014 Nov 19 doi: 10.1093/jjco/hyu195. PMID: 25411434

Recent clinical studies

Etiology

Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial.
Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D, Alves G, Lima IPF, Hughes BGM, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnał M, Delord JP, Mesía R, Taberna M, Waldron JN, Simon C, Grégoire V, Harrington KJ, Swaby RF, Zhang Y, Gumuscu B, Bidadi B, Siu LL; KEYNOTE-412 Investigators
Lancet Oncol 2024 May;25(5):572-587. Epub 2024 Mar 29 doi: 10.1016/S1470-2045(24)00100-1. PMID: 38561010
Multimodal detection of molecular residual disease in high-risk locally advanced squamous cell carcinoma of the head and neck.
Sanz-Garcia E, Zou J, Avery L, Spreafico A, Waldron J, Goldstein D, Hansen A, Cho BCJ, de Almeida J, Hope A, Hosni A, Hahn E, Perez-Ordonez B, Zhao Z, Smith C, Zheng Y, Singaravelan N, Bratman SV, Siu LL
Cell Death Differ 2024 Apr;31(4):460-468. Epub 2024 Feb 26 doi: 10.1038/s41418-024-01272-y. PMID: 38409276Free PMC Article
Results of Phase III Randomized Trial for Use of Docetaxel as a Radiosensitizer in Patients With Head and Neck Cancer, Unsuitable for Cisplatin-Based Chemoradiation.
Patil VM, Noronha V, Menon N, Singh A, Ghosh-Laskar S, Budrukkar A, Bhattacharjee A, Swain M, Mathrudev V, Nawale K, Balaji A, Peelay Z, Alone M, Pathak S, Mahajan A, Kumar S, Purandare N, Agarwal A, Puranik A, Pendse S, Reddy Yallala M, Sahu H, Kapu V, Dey S, Choudhary J, Krishna MR, Shetty A, Karuvandan N, Ravind R, Rai R, Jobanputra K, Chaturvedi P, Pai PS, Chaukar D, Nair S, Thiagarajan S, Prabhash K
J Clin Oncol 2023 May 1;41(13):2350-2361. Epub 2023 Jan 27 doi: 10.1200/JCO.22.00980. PMID: 36706347
Neoadjuvant immunoradiotherapy results in high rate of complete pathological response and clinical to pathological downstaging in locally advanced head and neck squamous cell carcinoma.
Leidner R, Crittenden M, Young K, Xiao H, Wu Y, Couey MA, Patel AA, Cheng AC, Watters AL, Bifulco C, Morris G, Rushforth L, Nemeth S, Urba WJ, Gough M, Bell RB
J Immunother Cancer 2021 May;9(5) doi: 10.1136/jitc-2021-002485. PMID: 33963014Free PMC Article
Concomitant chemoradiotherapy versus acceleration of radiotherapy with or without concomitant chemotherapy in locally advanced head and neck carcinoma (GORTEC 99-02): an open-label phase 3 randomised trial.
Bourhis J, Sire C, Graff P, Grégoire V, Maingon P, Calais G, Gery B, Martin L, Alfonsi M, Desprez P, Pignon T, Bardet E, Rives M, Geoffrois L, Daly-Schveitzer N, Sen S, Tuchais C, Dupuis O, Guerif S, Lapeyre M, Favrel V, Hamoir M, Lusinchi A, Temam S, Pinna A, Tao YG, Blanchard P, Aupérin A
Lancet Oncol 2012 Feb;13(2):145-53. Epub 2012 Jan 18 doi: 10.1016/S1470-2045(11)70346-1. PMID: 22261362

Diagnosis

Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial.
Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D, Alves G, Lima IPF, Hughes BGM, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnał M, Delord JP, Mesía R, Taberna M, Waldron JN, Simon C, Grégoire V, Harrington KJ, Swaby RF, Zhang Y, Gumuscu B, Bidadi B, Siu LL; KEYNOTE-412 Investigators
Lancet Oncol 2024 May;25(5):572-587. Epub 2024 Mar 29 doi: 10.1016/S1470-2045(24)00100-1. PMID: 38561010
Multimodal detection of molecular residual disease in high-risk locally advanced squamous cell carcinoma of the head and neck.
Sanz-Garcia E, Zou J, Avery L, Spreafico A, Waldron J, Goldstein D, Hansen A, Cho BCJ, de Almeida J, Hope A, Hosni A, Hahn E, Perez-Ordonez B, Zhao Z, Smith C, Zheng Y, Singaravelan N, Bratman SV, Siu LL
Cell Death Differ 2024 Apr;31(4):460-468. Epub 2024 Feb 26 doi: 10.1038/s41418-024-01272-y. PMID: 38409276Free PMC Article
Six-MicroRNA Prognostic Signature in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma.
Worakitchanon W, Panvongsa W, Siripoon T, Kitdumrongthum S, Wongpan A, Arsa L, Trachu N, Jinawath N, Chairoungdua A, Ngamphaiboon N
JCO Precis Oncol 2023 May;7:e2300003. doi: 10.1200/PO.23.00003. PMID: 37163716
Induction chemotherapy combined with immunotherapy in locally advanced head and neck squamous cell carcinoma.
Li X, Fang Q, Du W, Zhang X, Dai L, Qiao Y
BMC Cancer 2021 May 27;21(1):622. doi: 10.1186/s12885-021-08373-8. PMID: 34044810Free PMC Article
EGFR monoclonal antibodies in locally advanced head and neck squamous cell carcinoma: What is their current role?
Alorabi M, Shonka NA, Ganti AK
Crit Rev Oncol Hematol 2016 Mar;99:170-9. Epub 2015 Dec 19 doi: 10.1016/j.critrevonc.2015.12.006. PMID: 26797287

Therapy

Pembrolizumab plus concurrent chemoradiotherapy versus placebo plus concurrent chemoradiotherapy in patients with locally advanced squamous cell carcinoma of the head and neck (KEYNOTE-412): a randomised, double-blind, phase 3 trial.
Machiels JP, Tao Y, Licitra L, Burtness B, Tahara M, Rischin D, Alves G, Lima IPF, Hughes BGM, Pointreau Y, Aksoy S, Laban S, Greil R, Burian M, Hetnał M, Delord JP, Mesía R, Taberna M, Waldron JN, Simon C, Grégoire V, Harrington KJ, Swaby RF, Zhang Y, Gumuscu B, Bidadi B, Siu LL; KEYNOTE-412 Investigators
Lancet Oncol 2024 May;25(5):572-587. Epub 2024 Mar 29 doi: 10.1016/S1470-2045(24)00100-1. PMID: 38561010
Results of Phase III Randomized Trial for Use of Docetaxel as a Radiosensitizer in Patients With Head and Neck Cancer, Unsuitable for Cisplatin-Based Chemoradiation.
Patil VM, Noronha V, Menon N, Singh A, Ghosh-Laskar S, Budrukkar A, Bhattacharjee A, Swain M, Mathrudev V, Nawale K, Balaji A, Peelay Z, Alone M, Pathak S, Mahajan A, Kumar S, Purandare N, Agarwal A, Puranik A, Pendse S, Reddy Yallala M, Sahu H, Kapu V, Dey S, Choudhary J, Krishna MR, Shetty A, Karuvandan N, Ravind R, Rai R, Jobanputra K, Chaturvedi P, Pai PS, Chaukar D, Nair S, Thiagarajan S, Prabhash K
J Clin Oncol 2023 May 1;41(13):2350-2361. Epub 2023 Jan 27 doi: 10.1200/JCO.22.00980. PMID: 36706347
Neoadjuvant Chemoimmunotherapy for the Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma: A Single-Arm Phase 2 Clinical Trial.
Zhang Z, Wu B, Peng G, Xiao G, Huang J, Ding Q, Yang C, Xiong X, Ma H, Shi L, Yang J, Hong X, Wei J, Qin Y, Wan C, Zhong Y, Zhou Y, Zhao X, Leng Y, Zhang T, Wu G, Yao M, Zhang X, Yang K
Clin Cancer Res 2022 Aug 2;28(15):3268-3276. doi: 10.1158/1078-0432.CCR-22-0666. PMID: 35766967Free PMC Article
Neoadjuvant immunoradiotherapy results in high rate of complete pathological response and clinical to pathological downstaging in locally advanced head and neck squamous cell carcinoma.
Leidner R, Crittenden M, Young K, Xiao H, Wu Y, Couey MA, Patel AA, Cheng AC, Watters AL, Bifulco C, Morris G, Rushforth L, Nemeth S, Urba WJ, Gough M, Bell RB
J Immunother Cancer 2021 May;9(5) doi: 10.1136/jitc-2021-002485. PMID: 33963014Free PMC Article
Pembrolizumab given concomitantly with chemoradiation and as maintenance therapy for locally advanced head and neck squamous cell carcinoma: KEYNOTE-412.
Machiels JP, Tao Y, Burtness B, Tahara M, Licitra L, Rischin D, Waldron J, Simon C, Gregoire V, Harrington K, Alves GV, Figueiredo Lima IP, Pointreau Y, M Hughes BG, Aksoy S, Hetnal M, Ge JY, Brown H, Cheng J, Bidadi B, Siu LL
Future Oncol 2020 Jun;16(18):1235-1243. Epub 2020 Jun 3 doi: 10.2217/fon-2020-0184. PMID: 32490686

Prognosis

Six-MicroRNA Prognostic Signature in Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma.
Worakitchanon W, Panvongsa W, Siripoon T, Kitdumrongthum S, Wongpan A, Arsa L, Trachu N, Jinawath N, Chairoungdua A, Ngamphaiboon N
JCO Precis Oncol 2023 May;7:e2300003. doi: 10.1200/PO.23.00003. PMID: 37163716
Induction chemotherapy combined with immunotherapy in locally advanced head and neck squamous cell carcinoma.
Li X, Fang Q, Du W, Zhang X, Dai L, Qiao Y
BMC Cancer 2021 May 27;21(1):622. doi: 10.1186/s12885-021-08373-8. PMID: 34044810Free PMC Article
What is the prognostic impact of FDG PET in locally advanced head and neck squamous cell carcinoma treated with concomitant chemo-radiotherapy? A systematic review and meta-analysis.
Bonomo P, Merlotti A, Olmetto E, Bianchi A, Desideri I, Bacigalupo A, Franco P, Franzese C, Orlandi E, Livi L, Caini S
Eur J Nucl Med Mol Imaging 2018 Nov;45(12):2122-2138. Epub 2018 Jun 9 doi: 10.1007/s00259-018-4065-5. PMID: 29948105Free PMC Article
Any place left for induction chemotherapy for locally advanced head and neck squamous cell carcinoma?
Burgy M, Leblanc J, Borel C
Anticancer Drugs 2018 Apr;29(4):287-294. doi: 10.1097/CAD.0000000000000595. PMID: 29420335
EGFR monoclonal antibodies in locally advanced head and neck squamous cell carcinoma: What is their current role?
Alorabi M, Shonka NA, Ganti AK
Crit Rev Oncol Hematol 2016 Mar;99:170-9. Epub 2015 Dec 19 doi: 10.1016/j.critrevonc.2015.12.006. PMID: 26797287

Clinical prediction guides

A Phase I Study of the CDK4/6 Inhibitor Palbociclib in Combination with Cetuximab and Radiotherapy for Locally Advanced Head and Neck Squamous Cell Carcinoma.
Ngamphaiboon N, Pattaranutaporn P, Lukerak S, Siripoon T, Jinawath A, Arsa L, Shantavasinkul PC, Taonam N, Trachu N, Jinawath N, Kositwattanarerk A, Sananmuang T, Jiarpinitnun C
Clin Cancer Res 2024 Jan 17;30(2):294-303. doi: 10.1158/1078-0432.CCR-23-2303. PMID: 37982827
Preexisting tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti-PD-1 in head and neck cancer.
Oliveira G, Egloff AM, Afeyan AB, Wolff JO, Zeng Z, Chernock RD, Zhou L, Messier C, Lizotte P, Pfaff KL, Stromhaug K, Penter L, Haddad RI, Hanna GJ, Schoenfeld JD, Goguen LA, Annino DJ, Jo V, Oppelt P, Pipkorn P, Jackson R, Puram SV, Paniello RC, Rich JT, Webb J, Zevallos JP, Mansour M, Fu J, Dunn GP, Rodig SJ, Ley J, Morris LGT, Dunn L, Paweletz CP, Kallogjeri D, Piccirillo JF, Adkins DR, Wu CJ, Uppaluri R
Sci Immunol 2023 Sep 8;8(87):eadf4968. doi: 10.1126/sciimmunol.adf4968. PMID: 37683037Free PMC Article
Neoadjuvant toripalimab combined with gemcitabine and cisplatin in resectable locally advanced head and neck squamous cell carcinoma (NeoTGP01): An open label, single-arm, phase Ib clinical trial.
Huang X, Liu Q, Zhong G, Peng Y, Liu Y, Liang L, Hong H, Feng W, Yang S, Zhang Y, Xian S, Li Z, Zhou Y, Zhang Z, Jiang W, Liang J, Liu ZG
J Exp Clin Cancer Res 2022 Oct 12;41(1):300. doi: 10.1186/s13046-022-02510-2. PMID: 36224603Free PMC Article
Postoperative radiotherapy may not be necessary for locally advanced head and neck squamous cell carcinoma: a case-match multicentre study.
Ren ZH, Lei JS, Yang ZM, Zhang S, Yu JJ, Wu HJ
BMC Oral Health 2022 Jun 24;22(1):253. doi: 10.1186/s12903-022-02288-x. PMID: 35751079Free PMC Article
PET imaging biomarkers in head and neck cancer.
Differding S, Hanin FX, Grégoire V
Eur J Nucl Med Mol Imaging 2015 Apr;42(4):613-22. Epub 2015 Jan 9 doi: 10.1007/s00259-014-2972-7. PMID: 25573630

Recent systematic reviews

A systematic review of neoadjuvant and definitive immunotherapy in locally advanced head and neck squamous cell carcinoma.
Nindra U, Hurwitz J, Forstner D, Chin V, Gallagher R, Liu J
Cancer Med 2023 May;12(10):11234-11247. Epub 2023 Mar 19 doi: 10.1002/cam4.5815. PMID: 36934434Free PMC Article
Palliative radiotherapy in older adults with head and neck squamous cell carcinoma: A systematic review.
Desideri I, Becherini C, Belgioia L, Merlotti A, Ciccone LP, Franzese C, Loi M, De Felice F, Mazzola R, Caini S, Livi L, Bonomo P
Oral Oncol 2021 Aug;119:105355. Epub 2021 May 24 doi: 10.1016/j.oraloncology.2021.105355. PMID: 34044315
Concurrent cisplatin or cetuximab with radiotherapy in patients with locally advanced head and neck squamous cell carcinoma: A meta-analysis.
Tang WH, Sun W, Long GX
Medicine (Baltimore) 2020 Sep 4;99(36):e21785. doi: 10.1097/MD.0000000000021785. PMID: 32899005Free PMC Article
What is the prognostic impact of FDG PET in locally advanced head and neck squamous cell carcinoma treated with concomitant chemo-radiotherapy? A systematic review and meta-analysis.
Bonomo P, Merlotti A, Olmetto E, Bianchi A, Desideri I, Bacigalupo A, Franco P, Franzese C, Orlandi E, Livi L, Caini S
Eur J Nucl Med Mol Imaging 2018 Nov;45(12):2122-2138. Epub 2018 Jun 9 doi: 10.1007/s00259-018-4065-5. PMID: 29948105Free PMC Article
The evidence on effectiveness of weekly vs triweekly cisplatin concurrent with radiotherapy in locally advanced head and neck squamous cell carcinoma (HNSCC): a systematic review and meta-analysis.
Jacinto JK, Co J, Mejia MB, Regala EE
Br J Radiol 2017 Nov;90(1079):20170442. doi: 10.1259/bjr.20170442. PMID: 29053029Free PMC Article

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