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Midgut Neuroendocrine Tumor

MedGen UID:
1710711
•Concept ID:
C5238463
•
Neoplastic Process

Definition

A well differentiated, low, intermediate, or high grade neoplasm that arises from the jejunum, ileum, proximal colon, or appendix. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMidgut Neuroendocrine Tumor

Professional guidelines

PubMed

Peptide receptor radionuclide therapy for treatment of metastatic neuroendocrine tumors in children.
Foster JH, Sher A, Seghers V, Poston J, Wells D, Delpassand ES, Potter S, Mahajan P, Venkatramani R
Pediatr Blood Cancer 2021 Jul;68(7):e29056. Epub 2021 Apr 12 doi: 10.1002/pbc.29056. PMID: 33844446
Somatostatin Analogues in the Treatment of Neuroendocrine Tumors: Past, Present and Future.
Stueven AK, Kayser A, Wetz C, Amthauer H, Wree A, Tacke F, Wiedenmann B, Roderburg C, Jann H
Int J Mol Sci 2019 Jun 22;20(12) doi: 10.3390/ijms20123049. PMID: 31234481Free PMC Article
Interventional treatment of the carcinoid syndrome.
Ahlman H, Nilsson O, Olausson M
Neuroendocrinology 2004;80 Suppl 1:67-73. doi: 10.1159/000080745. PMID: 15477721

Recent clinical studies

Etiology

Midgut neuroendocrine tumor patients have a depleted gut microbiome with a discriminative signature.
Mulders MCF, Audhoe AS, Van Koetsveld PM, Feelders RA, Hofland LJ, de Herder WW, Kraaij R, Hofland J
Eur J Cancer 2024 Jan;197:113472. Epub 2023 Dec 9 doi: 10.1016/j.ejca.2023.113472. PMID: 38100919
ASO Author Reflections: The Role of Primary Tumor Resection in Metastatic Midgut Neuroendocrine Tumor.
Polcz M, Bailey C
Ann Surg Oncol 2020 Aug;27(8):2804-2805. Epub 2020 May 23 doi: 10.1245/s10434-020-08603-6. PMID: 32447654
Midgut neuroendocrine tumor presenting with acute intestinal ischemia.
Mantzoros I, Savvala NA, Ioannidis O, Parpoudi S, Loutzidou L, Kyriakidou D, Cheva A, Intzos V, Tsalis K
World J Gastroenterol 2017 Dec 7;23(45):8090-8096. doi: 10.3748/wjg.v23.i45.8090. PMID: 29259385Free PMC Article
Systematic review of resecting primary tumor in MNETs patients with unresectable liver metastases.
Guo J, Zhang Q, Bi X, Zhou J, Li Z, Huang Z, Zhang Y, Li M, Chen X, Hu X, Yihebali C, Liang J, Liu J, Zhao J, Cai J, Zhao H
Oncotarget 2017 Mar 7;8(10):17396-17405. doi: 10.18632/oncotarget.14156. PMID: 28030811Free PMC Article

Diagnosis

Midgut neuroendocrine tumor patients have a depleted gut microbiome with a discriminative signature.
Mulders MCF, Audhoe AS, Van Koetsveld PM, Feelders RA, Hofland LJ, de Herder WW, Kraaij R, Hofland J
Eur J Cancer 2024 Jan;197:113472. Epub 2023 Dec 9 doi: 10.1016/j.ejca.2023.113472. PMID: 38100919
Acute Disseminated Intravascular Coagulation Precipitated by (177)Lu-Dotatate in Metastatic Midgut Neuroendocrine Tumor: A Case Report.
Fiocco C, Farooq F, Kaveney A
J Gastrointest Cancer 2023 Dec;54(4):1370-1372. Epub 2023 Feb 16 doi: 10.1007/s12029-023-00918-3. PMID: 36795338
Hemorrhagic disseminated intravascular coagulation after 177Lu-Dotatate in metastatic midgut neuroendocrine tumor: A case report.
Worbe N, Damian L, Le Cam-Duchez V, Levesque H, Michel P, Quak E
Medicine (Baltimore) 2021 Oct 8;100(40):e27455. doi: 10.1097/MD.0000000000027455. PMID: 34622868Free PMC Article
Update: Atypical presentation of a midgut neuroendocrine tumor originally diagnosed as eosinophilic fasciitis.
Shakerdi LA, Al Ghafri A, Swan N, O' Shea D, McGuigan C, Hutchinson M, FitzGerald O
Neurology 2020 Oct 13;95(15):695-697. Epub 2020 Sep 10 doi: 10.1212/WNL.0000000000010715. PMID: 32913012
Midgut neuroendocrine tumor presenting with acute intestinal ischemia.
Mantzoros I, Savvala NA, Ioannidis O, Parpoudi S, Loutzidou L, Kyriakidou D, Cheva A, Intzos V, Tsalis K
World J Gastroenterol 2017 Dec 7;23(45):8090-8096. doi: 10.3748/wjg.v23.i45.8090. PMID: 29259385Free PMC Article

Therapy

203 Pb-VMT-α-NET Scintigraphy of a Patient With Neuroendocrine Tumor.
Müller D, Herrmann H, Schultz MK, Solbach C, Ettrich T, Prasad V
Clin Nucl Med 2023 Jan 1;48(1):54-55. Epub 2022 Oct 18 doi: 10.1097/RLU.0000000000004464. PMID: 36257061Free PMC Article
Hemorrhagic disseminated intravascular coagulation after 177Lu-Dotatate in metastatic midgut neuroendocrine tumor: A case report.
Worbe N, Damian L, Le Cam-Duchez V, Levesque H, Michel P, Quak E
Medicine (Baltimore) 2021 Oct 8;100(40):e27455. doi: 10.1097/MD.0000000000027455. PMID: 34622868Free PMC Article
Systematic review of resecting primary tumor in MNETs patients with unresectable liver metastases.
Guo J, Zhang Q, Bi X, Zhou J, Li Z, Huang Z, Zhang Y, Li M, Chen X, Hu X, Yihebali C, Liang J, Liu J, Zhao J, Cai J, Zhao H
Oncotarget 2017 Mar 7;8(10):17396-17405. doi: 10.18632/oncotarget.14156. PMID: 28030811Free PMC Article
The influence of glutamate receptors on proliferation and metabolic cell activity of neuroendocrine tumors.
Haas HS, Pfragner R, Tabrizi-Wizsy NG, Rohrer K, Lueftenegger I, Horwath C, Allard N, Rinner B, Sadjak A
Anticancer Res 2013 Apr;33(4):1267-72. PMID: 23564764
Case report of a patient with initially inoperable well-differentiated midgut neuroendocrine tumor (WDNT)--PRRT and long-acting somatostatin analogs as the neoadjuvant therapy.
Sowa-Staszczak A, Pach D, Stefańska A, Szybiński P, Kulig J, Tomaszewska R, Chrzan R, Hubalewska-Dydejczyk A
Nucl Med Rev Cent East Eur 2012 Aug 26;15(2):137-9. PMID: 22936508

Prognosis

Midgut neuroendocrine tumor patients have a depleted gut microbiome with a discriminative signature.
Mulders MCF, Audhoe AS, Van Koetsveld PM, Feelders RA, Hofland LJ, de Herder WW, Kraaij R, Hofland J
Eur J Cancer 2024 Jan;197:113472. Epub 2023 Dec 9 doi: 10.1016/j.ejca.2023.113472. PMID: 38100919
Is Laparoscopic CME Right Hemicolectomy an Optimal Indication for NET of the Right Colon and Terminal Ileum?
Pedrazzani C, Conti C, Valdegamberi A, Davì MV, Cingarlini S, Scarpa A, Guglielmi A
J Gastrointest Surg 2021 Jan;25(1):333-336. Epub 2020 Aug 3 doi: 10.1007/s11605-020-04682-8. PMID: 32748337
Midgut neuroendocrine tumor presenting with acute intestinal ischemia.
Mantzoros I, Savvala NA, Ioannidis O, Parpoudi S, Loutzidou L, Kyriakidou D, Cheva A, Intzos V, Tsalis K
World J Gastroenterol 2017 Dec 7;23(45):8090-8096. doi: 10.3748/wjg.v23.i45.8090. PMID: 29259385Free PMC Article
Systematic review of resecting primary tumor in MNETs patients with unresectable liver metastases.
Guo J, Zhang Q, Bi X, Zhou J, Li Z, Huang Z, Zhang Y, Li M, Chen X, Hu X, Yihebali C, Liang J, Liu J, Zhao J, Cai J, Zhao H
Oncotarget 2017 Mar 7;8(10):17396-17405. doi: 10.18632/oncotarget.14156. PMID: 28030811Free PMC Article

Clinical prediction guides

Midgut neuroendocrine tumor patients have a depleted gut microbiome with a discriminative signature.
Mulders MCF, Audhoe AS, Van Koetsveld PM, Feelders RA, Hofland LJ, de Herder WW, Kraaij R, Hofland J
Eur J Cancer 2024 Jan;197:113472. Epub 2023 Dec 9 doi: 10.1016/j.ejca.2023.113472. PMID: 38100919
Applying HDACis to increase SSTR2 expression and radiolabeled DOTA-TATE uptake: from cells to mice.
Klomp MJ, van den Brink L, van Koetsveld PM, de Ridder CMA, Stuurman DC, Löwik CWGM, Hofland LJ, Dalm SU
Life Sci 2023 Dec 1;334:122173. Epub 2023 Oct 29 doi: 10.1016/j.lfs.2023.122173. PMID: 37907154
Is Laparoscopic CME Right Hemicolectomy an Optimal Indication for NET of the Right Colon and Terminal Ileum?
Pedrazzani C, Conti C, Valdegamberi A, Davì MV, Cingarlini S, Scarpa A, Guglielmi A
J Gastrointest Surg 2021 Jan;25(1):333-336. Epub 2020 Aug 3 doi: 10.1007/s11605-020-04682-8. PMID: 32748337
Case report of a patient with initially inoperable well-differentiated midgut neuroendocrine tumor (WDNT)--PRRT and long-acting somatostatin analogs as the neoadjuvant therapy.
Sowa-Staszczak A, Pach D, Stefańska A, Szybiński P, Kulig J, Tomaszewska R, Chrzan R, Hubalewska-Dydejczyk A
Nucl Med Rev Cent East Eur 2012 Aug 26;15(2):137-9. PMID: 22936508

Recent systematic reviews

Systematic review of resecting primary tumor in MNETs patients with unresectable liver metastases.
Guo J, Zhang Q, Bi X, Zhou J, Li Z, Huang Z, Zhang Y, Li M, Chen X, Hu X, Yihebali C, Liang J, Liu J, Zhao J, Cai J, Zhao H
Oncotarget 2017 Mar 7;8(10):17396-17405. doi: 10.18632/oncotarget.14156. PMID: 28030811Free PMC Article

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