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Metastatic Malignant Thoracic Neoplasm

MedGen UID:
1788985
•Concept ID:
C5447478
•
Neoplastic Process

Definition

A malignant thoracic neoplasm that has spread from its original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Malignant Pleural Effusion: Presentation, Diagnosis, and Management.
Gayen S
Am J Med 2022 Oct;135(10):1188-1192. Epub 2022 May 14 doi: 10.1016/j.amjmed.2022.04.017. PMID: 35576996
International Spine Radiosurgery Consortium consensus guidelines for target volume definition in spinal stereotactic radiosurgery.
Cox BW, Spratt DE, Lovelock M, Bilsky MH, Lis E, Ryu S, Sheehan J, Gerszten PC, Chang E, Gibbs I, Soltys S, Sahgal A, Deasy J, Flickinger J, Quader M, Mindea S, Yamada Y
Int J Radiat Oncol Biol Phys 2012 Aug 1;83(5):e597-605. Epub 2012 May 19 doi: 10.1016/j.ijrobp.2012.03.009. PMID: 22608954
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Recent clinical studies

Etiology

Immune checkpoint inhibitors in lung tumors with rare histologies and other thoracic malignancies.
Andrini E, Federico AD, Sisi M, Rosellini M, Palladini A, Lamberti G, Giglio A, Gelsomino F
Immunotherapy 2022 Nov;14(16):1329-1340. Epub 2022 Nov 16 doi: 10.2217/imt-2022-0060. PMID: 36382476
MR Imaging of Primary Chest Wall Neoplasms.
Bueno J, Lichtenberger JP 3rd, Rauch G, Carter BW
Top Magn Reson Imaging 2018 Apr;27(2):83-93. doi: 10.1097/RMR.0000000000000164. PMID: 29613963
Spectrum of CT Findings in Thoracic Extranodal Non-Hodgkin Lymphoma.
Bligh MP, Borgaonkar JN, Burrell SC, MacDonald DA, Manos D
Radiographics 2017 Mar-Apr;37(2):439-461. doi: 10.1148/rg.2017160077. PMID: 28287948
Prosthetic reconstruction of the chest wall.
Picciocchi A, Granone P, Cardillo G, Margaritora S, Benzoni C, D'Ugo D
Int Surg 1993 Jul-Sep;78(3):221-4. PMID: 8276545
The ultrastructure and immunocytochemistry of renal cell carcinoma.
Mackay B, Ordónez NG, Khoursand J, Bennington JL
Ultrastruct Pathol 1987;11(5-6):483-502. doi: 10.3109/01913128709048445. PMID: 3318057

Diagnosis

Metastatic melanoma.
Kudchadkar RR, Lowe MC, Khan MK, McBrien SM
CA Cancer J Clin 2020 Mar;70(2):78-85. Epub 2020 Feb 26 doi: 10.3322/caac.21599. PMID: 32101327
MR Imaging of Primary Chest Wall Neoplasms.
Bueno J, Lichtenberger JP 3rd, Rauch G, Carter BW
Top Magn Reson Imaging 2018 Apr;27(2):83-93. doi: 10.1097/RMR.0000000000000164. PMID: 29613963
Metastatic osteosarcoma: a challenging multidisciplinary treatment.
Meazza C, Scanagatta P
Expert Rev Anticancer Ther 2016 May;16(5):543-56. Epub 2016 Apr 6 doi: 10.1586/14737140.2016.1168697. PMID: 26999418
Pulmonary metastasectomy.
Nichols FC
Thorac Surg Clin 2012 Feb;22(1):91-9, vii. doi: 10.1016/j.thorsurg.2011.08.017. PMID: 22108693
Purulent pericarditis.
Kennedy C, McEvoy S
Ir J Med Sci 2009 Mar;178(1):97-9. Epub 2008 Jan 23 doi: 10.1007/s11845-008-0119-1. PMID: 18214575

Therapy

HERTHENA-Lung01: a phase II study of patritumab deruxtecan (HER3-DXd) in previously treated metastatic EGFR-mutated NSCLC.
Yu HA, Yang JC, Hayashi H, Goto Y, Felip E, Reck M, Vigliotti M, Dong Q, Cantero F, Fan PD, Kanai M, Sternberg DW, Jänne PA
Future Oncol 2023 Jun;19(19):1319-1329. Epub 2023 May 22 doi: 10.2217/fon-2022-1250. PMID: 37212796
INSIGHT 2: a phase II study of tepotinib plus osimertinib in MET-amplified NSCLC and first-line osimertinib resistance.
F Smit E, Dooms C, Raskin J, Nadal E, Tho LM, Le X, Mazieres J, S Hin H, Morise M, W Zhu V, Tan D, H Holmberg K, Ellers-Lenz B, Adrian S, Brutlach S, Schumacher KM, Karachaliou N, Wu YL
Future Oncol 2022 Mar;18(9):1039-1054. Epub 2021 Dec 17 doi: 10.2217/fon-2021-1406. PMID: 34918545
Oligometastatic breast cancer.
Kwapisz D
Breast Cancer 2019 Mar;26(2):138-146. Epub 2018 Oct 15 doi: 10.1007/s12282-018-0921-1. PMID: 30324552
Multidisciplinary treatment of malignant thymoma.
Spaggiari L, Casiraghi M, Guarize J
Curr Opin Oncol 2012 Mar;24(2):117-22. doi: 10.1097/CCO.0b013e32834ea6bb. PMID: 22143371
Pulmonary metastasectomy.
Nichols FC
Thorac Surg Clin 2012 Feb;22(1):91-9, vii. doi: 10.1016/j.thorsurg.2011.08.017. PMID: 22108693

Prognosis

Imaging and Management of Intrathoracic Renal Cell Carcinoma Metastases.
Price M, Wu CC, Genshaft S, Sadow PM, Xie L, Shepard JO, McDermott S
AJR Am J Roentgenol 2018 Jun;210(6):1181-1191. Epub 2018 Apr 9 doi: 10.2214/AJR.18.19645. PMID: 29629809
Preoperative Evaluation and Indications for Pulmonary Metastasectomy.
Erhunmwunsee L, Tong BC
Thorac Surg Clin 2016 Feb;26(1):7-12. doi: 10.1016/j.thorsurg.2015.09.002. PMID: 26611505Free PMC Article
Purulent pericarditis.
Kennedy C, McEvoy S
Ir J Med Sci 2009 Mar;178(1):97-9. Epub 2008 Jan 23 doi: 10.1007/s11845-008-0119-1. PMID: 18214575
Palliation of thoracic malignancies.
Gasper WJ, Jamshidi R, Theodore PR
Surg Oncol 2007 Dec;16(4):259-65. Epub 2007 Sep 27 doi: 10.1016/j.suronc.2007.08.009. PMID: 17904357
Lymphadenectomy in metastasectomy.
Dominguez-Ventura A, Nichols FC 3rd
Thorac Surg Clin 2006 May;16(2):139-43. doi: 10.1016/j.thorsurg.2005.12.001. PMID: 16805203

Clinical prediction guides

Malignant Pleural Effusion and Its Current Management: A Review.
Skok K, Hladnik G, Grm A, Crnjac A
Medicina (Kaunas) 2019 Aug 15;55(8) doi: 10.3390/medicina55080490. PMID: 31443309Free PMC Article
Metastatic osteosarcoma: a challenging multidisciplinary treatment.
Meazza C, Scanagatta P
Expert Rev Anticancer Ther 2016 May;16(5):543-56. Epub 2016 Apr 6 doi: 10.1586/14737140.2016.1168697. PMID: 26999418
Benign cardiac tumors: a review.
Bruckner BA, Reardon MJ
Methodist Debakey Cardiovasc J 2010 Jul-Sep;6(3):20-6. doi: 10.14797/mdcj-6-3-20. PMID: 20834207
Therapeutic sentinel lymph node imaging.
Kachala SS, Servais EL, Park BJ, Rusch VW, Adusumilli PS
Semin Thorac Cardiovasc Surg 2009 Winter;21(4):327-38. doi: 10.1053/j.semtcvs.2009.11.002. PMID: 20226346
Patterns of lymphadenopathy in thoracic malignancies.
Sharma A, Fidias P, Hayman LA, Loomis SL, Taber KH, Aquino SL
Radiographics 2004 Mar-Apr;24(2):419-34. doi: 10.1148/rg.242035075. PMID: 15026591

Recent systematic reviews

A Systematic Review on Intensity Modulated Radiation Therapy for Mediastinal Hodgkin's Lymphoma.
Buglione M, Guerini AE, Filippi AR, Spiazzi L, Pasinetti N, Magli A, Toraci C, Borghetti P, Triggiani L, Alghisi A, Costantino G, Bertagna F, Giaj Levra N, Pegurri L, Magrini SM
Crit Rev Oncol Hematol 2021 Nov;167:103437. Epub 2021 Aug 3 doi: 10.1016/j.critrevonc.2021.103437. PMID: 34358649
Toxicity profile of epidermal growth factor receptor tyrosine kinase inhibitors for patients with lung cancer: A systematic review and network meta-analysis.
Zhao Y, Cheng B, Chen Z, Li J, Liang H, Chen Y, Zhu F, Li C, Xu K, Xiong S, Lu W, Chen Z, Zhong R, Zhao S, Xie Z, Liu J, Liang W, He J
Crit Rev Oncol Hematol 2021 Apr;160:103305. Epub 2021 Mar 20 doi: 10.1016/j.critrevonc.2021.103305. PMID: 33757838
O(6)-Methylguanine-DNA methyltransferase (MGMT): A drugable target in lung cancer?
Hiddinga BI, Pauwels P, Janssens A, van Meerbeeck JP
Lung Cancer 2017 May;107:91-99. Epub 2016 Jul 18 doi: 10.1016/j.lungcan.2016.07.014. PMID: 27492578
Randomized Trials of Systemic Medically-treated Malignant Mesothelioma: A Systematic Review.
Blomberg C, Nilsson J, Holgersson G, Edlund P, Bergqvist M, Adwall L, Ekman S, Brattström D, Bergström S
Anticancer Res 2015 May;35(5):2493-501. PMID: 25964522
Gemcitabine-induced severe pulmonary toxicity.
Barlési F, Villani P, Doddoli C, Gimenez C, Kleisbauer JP
Fundam Clin Pharmacol 2004 Feb;18(1):85-91. doi: 10.1046/j.0767-3981.2003.00206.x. PMID: 14748759

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