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Chondroma

MedGen UID:
181701
•Concept ID:
C0936248
•
Neoplastic Process
Synonym: Chondromas
SNOMED CT: Chondroma (31186001)
 
Monarch Initiative: MONDO:0002360

Definition

A benign well circumscribed neoplasm of hyaline cartilage arising from bone or soft tissue. It is characterized by the presence of chondrocytes. [from NCI]

Professional guidelines

PubMed

The Application of Arthroscopic Techniques in the Diagnosis and Treatment of Hip-Related Conditions in China.
Zhao FY, Dong HM, Huang HJ, Gao GY, Wu RQ, Shi YY, Ju XD, Li CB, Xu Y, Wang JQ
Orthop Surg 2021 Aug;13(6):1697-1706. Epub 2021 Aug 5 doi: 10.1111/os.13043. PMID: 34351067Free PMC Article
Strategies of treatment of chest wall tumors and our experience.
Chudacek J, Bohanes T, Szkorupa M, Klein J, Stasek M, Zalesak B, Stehlik D, Ctvrtlík F, Neoral C
Rozhl Chir 2015 Jan;94(1):17-23. PMID: 25604980
Cartilaginous tumors of the larynx: endoscopic laser management using YAG/KTP.
Merrot O, Gleizal A, Poupart M, Pignat JC
Head Neck 2009 Feb;31(2):145-52. doi: 10.1002/hed.20932. PMID: 18972422

Recent clinical studies

Etiology

Solitary enchondromas-diagnosis and surveillance : Danish guidelines.
Jurik AG, Hansen BH, Weber K
Radiologe 2020 Nov;60(Suppl 1):26-32. doi: 10.1007/s00117-020-00681-7. PMID: 32322923
A pragmatic approach to the imaging and follow-up of solitary central cartilage tumours of the proximal humerus and knee.
Patel A, Davies AM, Botchu R, James S
Clin Radiol 2019 Jul;74(7):517-526. Epub 2019 Mar 1 doi: 10.1016/j.crad.2019.01.025. PMID: 30827492
Cartilage-forming tumors.
Qasem SA, DeYoung BR
Semin Diagn Pathol 2014 Jan;31(1):10-20. Epub 2014 Jan 23 doi: 10.1053/j.semdp.2014.01.006. PMID: 24680178
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056
Extraskeletal chondromas.
Marcial-Seoane RA, Marcial-Seoane MA, Ramos E, Marcial-Rojas RA
Bol Asoc Med P R 1990 Sep;82(9):394-402. PMID: 2076144

Diagnosis

Benign Cartilage-forming Tumors.
Kerr DA, Cipriani NA
Surg Pathol Clin 2021 Dec;14(4):585-603. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.004. PMID: 34742482
Solitary enchondromas-diagnosis and surveillance : Danish guidelines.
Jurik AG, Hansen BH, Weber K
Radiologe 2020 Nov;60(Suppl 1):26-32. doi: 10.1007/s00117-020-00681-7. PMID: 32322923
Breast Chondroma.
AbdullGaffar B, Abdulrahim MM
Breast J 2017 Mar;23(2):234-236. Epub 2016 Oct 31 doi: 10.1111/tbj.12714. PMID: 27797122
Endobronchial chondromas.
Fernandez-Bussy S, Labarca G, Descalzi F, Pires Y, Santos M, Folch E, Majid A
Respir Care 2014 Dec;59(12):e193-6. Epub 2014 Jul 15 doi: 10.4187/respcare.02673. PMID: 25233382
Soft-tissue chondroma.
Gentles C, Perin J, Berrey H, Griffiths HJ
Orthopedics 2007 Mar;30(3):180, 241-3. doi: 10.3928/01477447-20070301-13. PMID: 17375540

Therapy

Clinical and radiological response of Maffucci related enchondromas to mutant IDH1 inhibitor Ivosidenib.
Funck-Brentano T, Cohen-Solal M, Ducray F, Mandonnet E
Bone 2024 Nov;188:117221. Epub 2024 Aug 2 doi: 10.1016/j.bone.2024.117221. PMID: 39097182
Limitations of Transoral Robotic Total Laryngectomy.
Chebib E, Lechien JR, Chekkoury-Idrissi Y, Circiu MP, Distinguin L, Pouliquen C, Hans S
J Voice 2021 Sep;35(5):681-682. Epub 2020 Dec 15 doi: 10.1016/j.jvoice.2020.12.004. PMID: 33339704
Gastrointestinal stromal tumour.
Joensuu H, Hohenberger P, Corless CL
Lancet 2013 Sep 14;382(9896):973-83. Epub 2013 Apr 24 doi: 10.1016/S0140-6736(13)60106-3. PMID: 23623056
Complications of radiation therapy.
Dalinka MK, Mazzeo VP Jr
Crit Rev Diagn Imaging 1985;23(3):235-67. PMID: 3891233
Radiation-induced osteochondromas.
Libshitz HI, Cohen MA
Radiology 1982 Mar;142(3):643-7. doi: 10.1148/radiology.142.3.6278535. PMID: 6278535

Prognosis

Succinate Dehydrogenase-Deficient Gastrointestinal Stromal Tumors.
Ibrahim A, Chopra S
Arch Pathol Lab Med 2020 May;144(5):655-660. Epub 2019 Jun 6 doi: 10.5858/arpa.2018-0370-RS. PMID: 31169996
A pragmatic approach to the imaging and follow-up of solitary central cartilage tumours of the proximal humerus and knee.
Patel A, Davies AM, Botchu R, James S
Clin Radiol 2019 Jul;74(7):517-526. Epub 2019 Mar 1 doi: 10.1016/j.crad.2019.01.025. PMID: 30827492
Common Tumors and Tumor-like Lesions of the Shoulder.
Lee DH, Hills JM, Jordanov MI, Jaffe KA
J Am Acad Orthop Surg 2019 Apr 1;27(7):236-245. doi: 10.5435/JAAOS-D-17-00449. PMID: 30320728
Succinate dehydrogenase (SDH)-deficient neoplasia.
Gill AJ
Histopathology 2018 Jan;72(1):106-116. doi: 10.1111/his.13277. PMID: 29239034
Chondrosarcomas of the head and neck.
Coca-Pelaz A, Rodrigo JP, Triantafyllou A, Hunt JL, Fernández-Miranda JC, Strojan P, de Bree R, Rinaldo A, Takes RP, Ferlito A
Eur Arch Otorhinolaryngol 2014 Oct;271(10):2601-9. Epub 2013 Nov 10 doi: 10.1007/s00405-013-2807-3. PMID: 24213203

Clinical prediction guides

Benign Cartilage-forming Tumors.
Kerr DA, Cipriani NA
Surg Pathol Clin 2021 Dec;14(4):585-603. Epub 2021 Oct 7 doi: 10.1016/j.path.2021.06.004. PMID: 34742482
Solitary enchondromas-diagnosis and surveillance : Danish guidelines.
Jurik AG, Hansen BH, Weber K
Radiologe 2020 Nov;60(Suppl 1):26-32. doi: 10.1007/s00117-020-00681-7. PMID: 32322923
Differential Diagnosis of Cartilaginous Lesions of Bone.
Suster D, Hung YP, Nielsen GP
Arch Pathol Lab Med 2020 Jan;144(1):71-82. doi: 10.5858/arpa.2019-0441-RA. PMID: 31877083
Chondroma of the Tongue.
Dimitrijevic MV, Sopta J, Ivisevic TB, Dudvarski Z
J Craniofac Surg 2019 Jun;30(4):e315-e317. doi: 10.1097/SCS.0000000000005230. PMID: 30845089
Succinate dehydrogenase (SDH)-deficient neoplasia.
Gill AJ
Histopathology 2018 Jan;72(1):106-116. doi: 10.1111/his.13277. PMID: 29239034

Recent systematic reviews

A Systematic Review of Cavernous Sinus Chondromas and an Illustrative Case Treated With Subtotal Resection Followed by Gamma Knife Radiosurgery.
Demir MK, Yapıcıer O, Ertem O, Paker B, Zorlu E, Kılıc T
World Neurosurg 2023 Aug;176:66-73. Epub 2023 Apr 26 doi: 10.1016/j.wneu.2023.04.079. PMID: 37116785
Can MRI differentiate between atypical cartilaginous tumors and high-grade chondrosarcoma? A systematic review.
Deckers C, Steyvers MJ, Hannink G, Schreuder HWB, de Rooy JWJ, Van Der Geest ICM
Acta Orthop 2020 Aug;91(4):471-478. Epub 2020 May 20 doi: 10.1080/17453674.2020.1763717. PMID: 32429792Free PMC Article
Intracranial Dural Parafalcine Chondroma: Case Report and Systematic Review of the Literature.
Sullivan JC, Goldsmith J, Rojas R, Varma H, Kasper EM
World Neurosurg 2019 Feb;122:1-7. Epub 2018 Sep 29 doi: 10.1016/j.wneu.2018.09.169. PMID: 30273721
Imaging pediatric gastrointestinal stromal tumor (GIST).
Herzberg M, Beer M, Anupindi S, Vollert K, Kröncke T
J Pediatr Surg 2018 Sep;53(9):1862-1870. Epub 2018 Mar 29 doi: 10.1016/j.jpedsurg.2018.03.022. PMID: 29685489
F-18 FDG PET differentiation of benign from malignant chondroid neoplasms: a systematic review of the literature.
Subhawong TK, Winn A, Shemesh SS, Pretell-Mazzini J
Skeletal Radiol 2017 Sep;46(9):1233-1239. Epub 2017 Jun 12 doi: 10.1007/s00256-017-2685-7. PMID: 28608242

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